D:"congenital, Hereditary, And Neonatal Diseases And Abnormalities"

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Disease Term
Synonyms Congenital Disorder, Congenital Disorders, CONGENITAL HEREDITARY NEONATAL DISEASES ABNORMALITIES, Disorder Congenital, Disorders Congenital, Neonatal Diseases Abnormalities
Documents 114
Hot Single Events 11
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for "congenital, Hereditary, And Neonatal Diseases And Abnormalities". They are ordered first by their relevance to "congenital, Hereditary, And Neonatal Diseases And Abnormalities" and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT317843 Binding of TNC and TPSAB1 1 0.01 0.64 0 81.20
2 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65 5.00
3 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54 5.00
4 INT302469 F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.82 0.62 5.00
5 INT236489 Gtf3a Regulation of Pain1 1 0.00 0.52 0.56 5.00
6 INT236492 Gtf3a Regulation of SNRNP70 1 0.00 0.52 0.56 5.00
7 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56 5.00
8 INT230437 Binding of PDX1 and HRCT1 1 0.04 2.45 0.43 5.00
9 INT230438 Binding of PDX1 and HAUS7 1 0.02 2.29 0.35 5.00
10 INT302466 Positive_regulation of F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.1 0.35 5.00
11 INT306323 Tlr4 Positive_regulation of Ticam1 3 0.25 0.55 0.3 5.00
12 INT302467 TIMP1 Positive_regulation of Negative_regulation of COL5A2 1 0.00 1.1 0.29 5.00
13 INT302468 INCENP Positive_regulation of Gene_expression of MMP9 1 0.01 0.72 0.26 5.00
14 INT354544 Avp Positive_regulation of ADCY1 1 0.24 2.23 0.22 5.00
15 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21 5.00
16 INT254219 Binding of Myd88 and Tlr2 2 0.16 0.6 0.2 5.00
17 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19 5.00
18 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 5.00
19 INT298641 PPARA Regulation of STAT3 1 0.23 0.98 0.16 5.00
20 INT298639 GDE1 Negative_regulation of AKT1 1 0.00 1.14 0.14 5.00
21 INT298634 Binding of IL6 and STAT3 1 0.04 1.41 0.08 5.00
22 INT350482 Tirap Regulation of TICAM2 1 0.05 0.06 0.06 5.00
23 INT350477 Tlr4 Positive_regulation of Positive_regulation of Irf3 1 0.22 0.12 0.06 5.00
24 INT350481 Tlr4 Positive_regulation of Gene_expression of Myd88 1 0.26 0.06 0.06 5.00
25 INT350478 Tirap Regulation of Ticam1 1 0.07 0.06 0.05 5.00
26 INT298638 IL6 Positive_regulation of IL6R 1 0.00 0.9 0.05 5.00
27 INT298635 PPARA Negative_regulation of Localization of ZDHHC2 1 0.01 0.21 0.05 5.00
28 INT298683 ecs Positive_regulation of Gene_expression of VEGFA 1 0.02 1.41 0.04 5.00
29 INT298637 ZDHHC2 Negative_regulation of Gene_expression of VEGFA 1 0.01 0.27 0.04 5.00
30 INT298633 STAT3 Regulation of MCL1 1 0.04 0.85 0.03 5.00
31 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03 5.00
32 INT350483 Binding of Myd88 and Tlr2 Positive_regulation of Binding of Tirap 1 0.18 0.05 0.03 5.00
33 INT350484 Binding of Myd88 and Tlr4 Positive_regulation of Binding of Tirap 1 0.21 0.05 0.03 5.00
34 INT298640 IL6R Positive_regulation of STAT3 1 0.01 0.73 0.03 5.00
35 INT298684 ecs Positive_regulation of Gene_expression of KDR 1 0.01 1.2 0 5.00
36 INT311658 Spry1 Regulation of Regulation of Slc12a3 1 0.13 0.81 0 5.00
37 INT311660 Binding of Gt(ROSA)26Sor and Spry1 1 0.03 0.91 0 5.00
38 INT311661 Spry1 Regulation of Slc12a3 1 0.30 1.44 0 5.00
39 INT144032 STAT3 Regulation of BCL2 2 0.07 0.86 0 5.00
40 INT311656 Binding of Wnt1 and Spry1 1 0.30 0.39 0 5.00
41 INT311659 Egfr Positive_regulation of Mapk1 1 0.08 0.18 0 5.00
42 INT298632 STAT3 Positive_regulation of MIR21 1 0.03 0.84 0 5.00
43 INT311657 Binding of Cbl and Spry2 1 0.10 0.18 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for "congenital, Hereditary, And Neonatal Diseases And Abnormalities". They are ordered first by their pain relevance and then by number of times they were reported in "congenital, Hereditary, And Neonatal Diseases And Abnormalities". Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1166 Negative_regulation of Dbh 56 0.59 12.54 28.26 99.76
2 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 99.40
3 INT27236 Negative_regulation of F13a1 17 0.53 10.79 1.99 98.76
4 INT187286 Binding of HEY1 17 0.32 31.21 4.52 97.94
5 INT133842 Binding of SOX10 3 0.38 5.79 1.02 96.32
6 INT23598 Binding of SCN5A 32 0.40 16 5.35 95.84
7 INT14436 Gene_expression of Dbh 42 0.72 9.9 19.85 94.56
8 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 91.92
9 INT37380 Negative_regulation of Sis 31 0.55 19.89 3.92 91.12
10 INT66792 Binding of TPSAB1 7 0.16 4.93 1.45 81.60
11 INT20632 Gene_expression of TNC 72 0.78 30.43 13.16 80.12
12 INT133841 Gene_expression of SOX10 18 0.67 9.96 0.8 78.28
13 INT17033 Positive_regulation of Trf 21 0.62 11.76 2.68 75.00
14 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 75.00
15 INT20624 Regulation of Gene_expression of TNC 5 0.60 2.49 0.87 73.16
16 INT2919 Negative_regulation of F8 47 0.59 23.48 5.1 73.00
17 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 67.24
18 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 60.16
19 INT30817 Gene_expression of Th 142 0.76 33.56 38.12 57.96
20 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 57.52
21 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 55.08
22 INT92311 Regulation of SIL1 7 0.44 6.2 1.61 52.96
23 INT228403 Binding of Slc12a3 2 0.16 0.52 0.07 47.24
24 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 34.24
25 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 34.24
26 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 34.24
27 INT228404 Gene_expression of Slc12a3 6 0.35 7.18 1 34.24
28 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 32.00
29 INT125384 Positive_regulation of Pain1 23 0.49 17.1 14.83 27.84
30 INT311651 Positive_regulation of Fgf8 1 0.46 0.26 0 27.64
31 INT245157 Negative_regulation of Gene_expression of DMD 8 0.57 4.79 0.09 25.76
32 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 25.44
33 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 24.24
34 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 22.00
35 INT303538 Positive_regulation of Fgfr1 3 0.65 0.92 0.03 21.48
36 INT311636 Positive_regulation of Gene_expression of Slc12a3 1 0.23 0.62 0 21.12
37 INT35642 Regulation of BPIFA4P 4 0.26 3.85 1.6 12.16
38 INT176618 Gene_expression of HEY1 29 0.59 36 4.37 9.76
39 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 5.00
40 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
41 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
42 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
43 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
44 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
45 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 5.00
46 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
47 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
48 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
49 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
50 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
51 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
52 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
53 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
54 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
55 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
56 INT117601 Positive_regulation of Trpa1 174 0.70 72.41 71.9 5.00
57 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
58 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
59 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85 5.00
60 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
61 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
62 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
63 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
64 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
65 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
66 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
67 INT21737 Binding of MC1R 129 0.48 45.45 56.54 5.00
68 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
69 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 5.00
70 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
71 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 5.00
72 INT55671 Gene_expression of Ik 151 0.27 80.1 48.49 5.00
73 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
74 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33 5.00
75 INT1564 Localization of OPRM1 41 0.80 8.03 44.67 5.00
76 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
77 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
78 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.00
79 INT5454 Localization of CRH 124 0.79 79.18 41.53 5.00
80 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98 5.00
81 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53 5.00
82 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
83 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
84 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
85 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 5.00
86 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 5.00
87 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
88 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
89 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 5.00
90 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
91 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
92 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 5.00
93 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
94 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
95 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 5.00
96 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
97 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12 5.00
98 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
99 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
100 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
101 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
102 INT60779 Negative_regulation of CYP3A 63 0.59 8.38 21.27 5.00
103 INT24569 Negative_regulation of Pain1 26 0.41 21.82 21.08 5.00
104 INT66923 Localization of Ik 54 0.07 19.78 20.84 5.00
105 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
106 INT69877 Positive_regulation of Positive_regulation of Nfkb1 53 0.68 31.44 20.7 5.00
107 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
108 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 5.00
109 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
110 INT101188 Gene_expression of Rela 81 0.56 23.43 19.15 5.00
111 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97 5.00
112 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97 5.00
113 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 5.00
114 INT61626 Transcription of IL6 73 0.72 42.04 17.86 5.00
115 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53 5.00
116 INT24209 Negative_regulation of Ifng 37 0.57 16.52 17.15 5.00
117 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 5.00
118 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 5.00
119 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17 5.00
120 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
121 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 5.00
122 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 5.00
123 INT178828 Regulation of Pain1 12 0.14 16.1 15.64 5.00
124 INT52591 Gene_expression of KCNMA1 78 0.76 13.95 15.55 5.00
125 INT129 Localization of OXTR 51 0.80 11.08 15.36 5.00
126 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 5.00
127 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 5.00
128 INT93482 Localization of Rela 56 0.78 24.52 14.82 5.00
129 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
130 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 5.00
131 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 5.00
132 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
133 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 5.00
134 INT72127 Protein_catabolism of MMRN1 68 0.52 56 14.13 5.00
135 INT16919 Gene_expression of IL36RN 48 0.48 32.78 13.83 5.00
136 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
137 INT67653 Gene_expression of Om 46 0.36 15.28 13.32 5.00
138 INT144646 Positive_regulation of Rela 53 0.67 27.78 13.2 5.00
139 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
140 INT113490 Gene_expression of SCN9A 22 0.77 5.45 12.27 5.00
141 INT21987 Positive_regulation of Rorb 30 0.33 12.7 12.24 5.00
142 INT102731 Regulation of ABCB1 29 0.62 5.36 11.67 5.00
143 INT11479 Positive_regulation of KCNMA1 30 0.68 10.07 10.82 5.00
144 INT1708 Gene_expression of OXTR 56 0.78 6.92 10.69 5.00
145 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66 5.00
146 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 5.00
147 INT173159 Localization of PPARA 96 0.74 64.55 10.26 5.00
148 INT139443 Positive_regulation of GCH1 9 0.69 8.2 10.14 5.00
149 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79 5.00
150 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 5.00
151 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
152 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37 5.00
153 INT149138 Binding of PDX1 27 0.37 32.62 9.33 5.00
154 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96 5.00
155 INT10879 Positive_regulation of Avp 39 0.65 14.01 8.76 5.00
156 INT61399 Positive_regulation of Ik 21 0.22 10.17 8.75 5.00
157 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 5.00
158 INT621 Positive_regulation of SERPINH1 19 0.57 21.52 8.44 5.00
159 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42 5.00
160 INT61599 Positive_regulation of CYP2C9 43 0.69 11.1 8.33 5.00
161 INT193663 Binding of Pain1 9 0.36 8.84 8.04 5.00
162 INT94122 Negative_regulation of Mmp23 21 0.37 15.81 8.03 5.00
163 INT12334 Positive_regulation of CYP3A 34 0.70 6.77 7.85 5.00
164 INT6957 Positive_regulation of OXTR 38 0.70 6.55 7.81 5.00
165 INT1150 Gene_expression of ecs 42 0.59 29.38 7.73 5.00
166 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41 5.00
167 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41 5.00
168 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24 5.00
169 INT5864 Localization of IL36RN 19 0.44 14.5 6.87 5.00
170 INT170381 Transcription of Gopc 59 0.60 15.96 6.82 5.00
171 INT173639 Positive_regulation of INCENP 40 0.14 20.97 6.7 5.00
172 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 5.00
173 INT63822 Gene_expression of Mmp23 23 0.43 14.15 5.96 5.00
174 INT181194 Regulation of Gene_expression of PPARA 31 0.44 21.27 5.96 5.00
175 INT64724 Positive_regulation of Transcription of IL6 26 0.69 13.63 5.96 5.00
176 INT93684 Gene_expression of STAT3 66 0.78 34.42 5.94 5.00
177 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92 5.00
178 INT112530 Localization of Ptgs2 13 0.70 7.77 5.86 5.00
179 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 5.00
180 INT86025 Positive_regulation of Positive_regulation of PPARA 34 0.52 22.89 5.74 5.00
181 INT52695 Regulation of Ptgs2 20 0.42 8.72 5.71 5.00
182 INT57502 Positive_regulation of Gene_expression of CRH 30 0.70 23.37 5.7 5.00
183 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61 5.00
184 INT187133 Protein_catabolism of TIMP1 19 0.73 11.3 5.51 5.00
185 INT174851 Positive_regulation of COL5A2 46 0.54 12.73 5.48 5.00
186 INT142595 Negative_regulation of Tlr2 24 0.52 19.17 5.43 5.00
187 INT63957 Positive_regulation of Tnnt2 33 0.69 18.56 5.41 5.00
188 INT81796 Binding of AGRP 62 0.36 37.19 5.3 5.00
189 INT197491 Gene_expression of Myd88 32 0.74 14.59 5.29 5.00
190 INT97693 Gene_expression of REST 29 0.75 5.51 5.26 5.00
191 INT174688 Binding of Tlr2 45 0.42 36.65 5.25 5.00
192 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
193 INT55669 Negative_regulation of Gene_expression of Ik 14 0.13 11.28 5 5.00
194 INT130 Negative_regulation of OXTR 19 0.43 4.63 4.96 5.00
195 INT1285 Localization of Mmp13 12 0.78 8.98 4.93 5.00
196 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 5.00
197 INT58766 Gene_expression of ANGPT2 41 0.67 21.65 4.82 5.00
198 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73 5.00
199 INT102237 Positive_regulation of Gene_expression of MMP3 22 0.44 7.77 4.71 5.00
200 INT14126 Gene_expression of Grina 13 0.67 4.63 4.57 5.00
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