D:Abdominal Cramps

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Disease Term
Synonyms Abdominal Cramp, Colic, Colic Infantile, COLICKY PAIN, Cramp Abdominal, Cramps Abdominal, Infantile Colic, Pain Colicky
Documents 1229
Hot Single Events 66
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Abdominal Cramps. They are ordered first by their relevance to Abdominal Cramps and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT191240 SAE1 Regulation of Localization of INS 1 0.08 1.15 0.3 59.40
2 INT215904 IL36B Regulation of PRL 1 0.01 0.22 0.03 31.52
3 INT7656 Binding of SST and Gs 1 0.02 0.27 0.46 25.00
4 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 13.08
5 INT19633 GNRH1 Regulation of Localization of CGA 4 0.44 0.82 1.33 5.00
6 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31 5.00
7 INT44442 GNRH1 Positive_regulation of Localization of PLOD1 3 0.50 0.78 0.86 5.00
8 INT226371 IL18 Positive_regulation of IL4 4 0.05 2.49 0.79 5.00
9 INT313778 Gene_expression of Crhq1 Negative_regulation of Localization of Crh 1 0.05 0.66 0.71 5.00
10 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59 5.00
11 INT300551 TBX21 Regulation of Hand1 2 0.10 0.44 0.48 5.00
12 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34 5.00
13 INT300727 IL25 Positive_regulation of IL33 Positive_regulation of IL13 1 0.00 0 0.34 5.00
14 INT300732 IL33 Positive_regulation of IL13 1 0.00 0 0.34 5.00
15 INT300728 IL33 Positive_regulation of IL4 1 0.00 0 0.33 5.00
16 INT300729 IL18 Positive_regulation of IL13 1 0.00 0 0.33 5.00
17 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3 5.00
18 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3 5.00
19 INT277705 SMAP2 Regulation of TNF 1 0.01 1.23 0.25 5.00
20 INT348637 Binding of TLE4 and OLFM1 1 0.01 1.67 0.24 5.00
21 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2 5.00
22 INT191241 SST Regulation of SAE1 1 0.05 0.89 0.18 5.00
23 INT300753 Binding of Cd28 and Positive_regulation of Transcription of IL13 1 0.00 0 0.17 5.00
24 INT243524 Positive_regulation of Binding of NTF3 and SOX10 1 0.01 0.54 0.14 5.00
25 INT243525 Binding of NTF3 and SOX10 1 0.01 0.54 0.14 5.00
26 INT310412 Binding of CP and TF 1 0.14 1.66 0.13 5.00
27 INT300731 IL10 Negative_regulation of Gene_expression of IGHE 1 0.03 0.23 0.13 5.00
28 INT172568 Gene_expression of GNRH1 Regulation of Localization of CGA 1 0.05 0.66 0.08 5.00
29 INT353070 ADAM17 Positive_regulation of TNF 1 0.19 1.66 0.08 5.00
30 INT214437 NCAM1 Regulation of CHGA 1 0.05 1.21 0.07 5.00
31 INT288099 Binding of APP and App 1 0.01 1.04 0.05 5.00
32 INT339779 IGF1 Regulation of GHRH 1 0.08 0.38 0.05 5.00
33 INT339778 Binding of EDNRA and PTH 1 0.12 0.35 0.05 5.00
34 INT198620 CRH Negative_regulation of GH1 1 0.05 0.47 0.05 5.00
35 INT198619 CRH Negative_regulation of TRH 1 0.18 0.47 0.05 5.00
36 INT198618 CRH Negative_regulation of Localization of SST 1 0.07 0.53 0.05 5.00
37 INT355906 MAPK1 Positive_regulation of Localization of IL8 1 0.02 0.67 0.05 5.00
38 INT294065 ANGPT2 Positive_regulation of VEGFA 1 0.02 0.1 0 5.00
39 INT234612 Binding of KIT and STIP1 1 0.04 1 0 5.00
40 INT271101 PIK3CB Regulation of Akt1 1 0.01 0.72 0 5.00
41 INT294066 ANGPT1 Positive_regulation of VEGFA 1 0.01 0.1 0 5.00
42 INT271096 Pcna Positive_regulation of Akt1 1 0.00 0.34 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Abdominal Cramps. They are ordered first by their pain relevance and then by number of times they were reported in Abdominal Cramps. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98 100.00
2 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 99.80
3 INT182810 Gene_expression of Cuzd1 5 0.44 1.49 0.53 99.58
4 INT4715 Positive_regulation of Xdh 20 0.69 6.57 2.28 99.54
5 INT74977 Binding of FGFR1 6 0.41 4.66 1.02 99.48
6 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 98.96
7 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 98.68
8 INT46152 Positive_regulation of CYP4F22 7 0.46 4.05 5.56 98.60
9 INT15237 Protein_catabolism of Mme 31 0.96 10.26 16.69 98.40
10 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 98.12
11 INT2365 Positive_regulation of Cck 354 0.70 87.8 277.41 97.88
12 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 97.60
13 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 97.52
14 INT96542 Negative_regulation of SMN1 14 0.51 10.72 3.11 97.44
15 INT293 Protein_catabolism of Penk 161 1.00 11.71 98.45 97.36
16 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 96.96
17 INT73992 Gene_expression of Hspa1b 41 0.78 37.26 6.88 96.80
18 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 96.80
19 INT22455 Binding of Nbr1 8 0.21 10.57 0.93 95.56
20 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 95.24
21 INT125226 Binding of Nf2 7 0.48 5.94 2.02 95.12
22 INT2978 Gene_expression of Tbxa2r 76 0.77 28.4 21.27 94.96
23 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 94.32
24 INT7653 Regulation of Gs 3 0.21 1.87 0.87 93.08
25 INT574 Negative_regulation of C1S 9 0.47 11.25 1.41 91.28
26 INT5587 Regulation of Fos 191 0.62 40.81 99.7 91.20
27 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 91.16
28 INT2884 Positive_regulation of CCK 66 0.69 25.25 30.6 91.12
29 INT72805 Negative_regulation of CFHR4 1 0.10 0.27 0 90.80
30 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 90.64
31 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 90.40
32 INT12339 Localization of IL8 437 0.81 251.87 117.39 89.92
33 INT74423 Localization of IL10 91 0.80 61.6 22.95 89.92
34 INT233330 Localization of LEFTY2 4 0.15 4.46 0.99 89.92
35 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 89.80
36 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 89.80
37 INT134909 Positive_regulation of TRIM21 1 0.67 0.95 0.16 89.80
38 INT118217 Regulation of Cuzd1 2 0.30 2.36 0.91 89.52
39 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 89.28
40 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 89.28
41 INT22715 Positive_regulation of Gene_expression of Pth 29 0.64 22.53 2.31 89.28
42 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9 88.72
43 INT17421 Negative_regulation of Alox5 41 0.57 15.23 10.05 87.72
44 INT146792 Negative_regulation of Nf2 2 0.59 3.49 0.3 87.64
45 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 87.52
46 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38 87.52
47 INT182806 Binding of Cuzd1 3 0.24 1.45 0.53 86.84
48 INT8775 Binding of IGHE 167 0.48 102.61 23.54 86.60
49 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 85.92
50 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 85.20
51 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 84.96
52 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 84.24
53 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 84.00
54 INT16165 Regulation of DMD 114 0.60 35.13 3.64 83.56
55 INT154732 Positive_regulation of Pip 7 0.41 5.93 0.6 83.28
56 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 82.80
57 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 82.80
58 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 82.56
59 INT115982 Positive_regulation of KRT7 18 0.50 19.81 1.14 82.40
60 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 82.36
61 INT105781 Positive_regulation of Krt7 4 0.04 3.34 0.3 82.08
62 INT986 Negative_regulation of Localization of GHRH 16 0.58 8.57 3.16 81.88
63 INT249 Localization of GHRH 215 0.80 78.02 51.87 81.40
64 INT19433 Gene_expression of FCGR2A 4 0.57 2.04 0.72 80.64
65 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 80.04
66 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 80.04
67 INT40189 Localization of IFNA2 6 0.74 7.7 1.04 79.84
68 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 79.12
69 INT120515 Gene_expression of Otc 13 0.66 4.33 2.6 79.12
70 INT96499 Gene_expression of FES 5 0.65 2.26 0.48 77.36
71 INT96498 Negative_regulation of Gene_expression of FES 1 0.41 0.5 0.18 77.36
72 INT96500 Negative_regulation of FES 1 0.42 0.5 0.18 77.36
73 INT110816 Gene_expression of Mefv 2 0.07 2.98 0.31 77.08
74 INT397 Localization of SST 232 0.81 58.05 101.19 76.80
75 INT79425 Gene_expression of SMN1 42 0.65 36.37 6.1 76.56
76 INT12717 Binding of Pck1 85 0.47 12.49 54.81 76.52
77 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 76.36
78 INT19639 Negative_regulation of Gene_expression of Tbxa2r 17 0.55 7.69 5.01 76.12
79 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 75.84
80 INT104442 Transcription of ATF1 5 0.06 4.96 0.65 75.76
81 INT7654 Binding of Gs 3 0.10 1.62 2.16 75.76
82 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 75.00
83 INT355463 Gene_expression of SPRED1 1 0.56 6.96 0.24 74.64
84 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92 74.56
85 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84 74.08
86 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 73.44
87 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 73.04
88 INT183207 Negative_regulation of USE1 14 0.18 10.97 4 72.60
89 INT49520 Gene_expression of P2rx3 121 0.78 61.15 49.24 72.24
90 INT37335 Gene_expression of Nsdhl 45 0.51 24.36 4.58 70.76
91 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 70.72
92 INT597 Positive_regulation of PON1 26 0.62 19.14 2.87 70.08
93 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 69.52
94 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 69.00
95 INT178048 Gene_expression of NOV 5 0.63 1.13 0.1 68.40
96 INT153371 Binding of Cfp 27 0.47 7.33 7.48 67.96
97 INT94004 Negative_regulation of Lox 31 0.59 13.76 10.45 67.16
98 INT268240 Positive_regulation of Gene_expression of CDAN1 1 0.10 1.16 0.09 66.88
99 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 66.64
100 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 66.64
101 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 66.64
102 INT159494 Gene_expression of CDAN1 8 0.65 4.55 0.58 66.32
103 INT48513 Positive_regulation of MMEL1 2 0.38 0.6 0.15 65.80
104 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 65.44
105 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 64.68
106 INT27455 Positive_regulation of C2 18 0.60 4.3 3.93 64.64
107 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 64.64
108 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 64.32
109 INT147464 Binding of Ptprc 13 0.36 15.18 0.98 64.24
110 INT101412 Negative_regulation of CDAN1 16 0.57 6.41 1.61 63.76
111 INT143489 Gene_expression of Ggt6 3 0.24 1.67 0.28 63.36
112 INT812 Localization of INS 1026 0.81 515.6 145.31 63.16
113 INT62850 Negative_regulation of COP 8 0.37 0.18 0.38 63.04
114 INT14572 Binding of INS 205 0.48 175.43 13.38 62.80
115 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 62.68
116 INT22329 Gene_expression of Ptprc 36 0.66 15.84 1.59 62.68
117 INT101209 Gene_expression of Wt1 19 0.72 25.77 0.7 62.68
118 INT271098 Negative_regulation of Positive_regulation of JUND 1 0.01 1.69 0.16 62.68
119 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 62.52
120 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 62.20
121 INT75133 Positive_regulation of JUND 15 0.51 6.69 3.26 62.20
122 INT33008 Gene_expression of Dync1h1 41 0.68 23.85 3.82 60.72
123 INT341865 Negative_regulation of Nhlrc1 1 0.09 0.54 0.32 60.72
124 INT341866 Negative_regulation of Positive_regulation of Nhlrc1 1 0.09 0.54 0.32 60.72
125 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 60.56
126 INT118102 Positive_regulation of Nhlrc1 4 0.40 1.19 1.21 60.48
127 INT60764 Positive_regulation of PPIG 39 0.67 17.08 13.48 59.80
128 INT217253 Positive_regulation of Positive_regulation of PPIG 2 0.08 0.55 2.33 59.80
129 INT60196 Binding of FOS 33 0.47 13.11 6.95 59.68
130 INT29421 Positive_regulation of CDS1 7 0.46 3.16 1.47 58.72
131 INT89445 Gene_expression of MEPE 17 0.58 18.07 1.55 57.68
132 INT195060 Gene_expression of ALPL 9 0.73 4.82 1.3 57.36
133 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 56.80
134 INT10763 Localization of IL2 157 0.80 81.11 33.21 56.56
135 INT4931 Localization of IFNG 53 0.78 33.25 13.65 56.56
136 INT68725 Regulation of Cyp11a1 6 0.19 2.62 0.44 56.56
137 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 56.08
138 INT355462 Negative_regulation of SPRED1 1 0.36 1.34 0.16 55.44
139 INT339786 Gene_expression of FSD1L 1 0.03 0.41 0.03 54.88
140 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 54.72
141 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 54.16
142 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 53.60
143 INT93169 Binding of Ttf1 3 0.30 2.04 0.03 50.80
144 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 50.76
145 INT264580 Binding of Grhl2 1 0.05 0.35 0.08 50.24
146 INT4207 Regulation of Avp 267 0.62 63.72 115.33 50.00
147 INT894 Binding of Avp 84 0.48 29.16 29.63 50.00
148 INT355461 Localization of SPRED1 1 0.63 3.48 0.04 48.40
149 INT25353 Negative_regulation of F8 22 0.59 18.51 1.4 47.52
150 INT191243 Binding of SAE1 4 0.35 2.88 0.29 44.44
151 INT74446 Positive_regulation of Dync1h1 25 0.59 13 2.38 44.08
152 INT206532 Localization of mc 3 0.20 0.93 0.73 43.76
153 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 43.40
154 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 43.40
155 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 43.40
156 INT85829 Gene_expression of CA9 14 0.68 12.59 1.4 43.40
157 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 43.12
158 INT12194 Gene_expression of Trf 38 0.69 18.1 4.56 42.72
159 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 42.04
160 INT19590 Localization of cod 2 0.17 0.27 0.09 41.92
161 INT223064 Binding of RBT 1 0.21 0.2 0 41.76
162 INT223063 Positive_regulation of Binding of 1 0.28 0.2 0 41.76
163 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 41.36
164 INT96447 Regulation of SMN1 4 0.17 2.59 0.57 41.20
165 INT230 Positive_regulation of GGTLC1 14 0.68 11.78 1.55 40.96
166 INT336003 Binding of HADH 1 0.07 0.35 0 40.72
167 INT41314 Gene_expression of GGTLC1 9 0.59 5.61 1.79 40.60
168 INT70622 Binding of Hypism 9 0.04 14.9 0.59 39.36
169 INT2432 Positive_regulation of Cp 41 0.67 31.1 16.68 38.80
170 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26 37.12
171 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 36.88
172 INT165213 Regulation of Gene_expression of Cd4 12 0.40 9.14 1.57 36.88
173 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 36.40
174 INT546 Binding of ALB 311 0.48 85.98 60.14 33.68
175 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 33.12
176 INT107400 Localization of Das 4 0.28 2.95 1 33.12
177 INT182621 Localization of MLH1 9 0.64 9.31 0.12 30.68
178 INT5502 Positive_regulation of Gene_expression of Crh 69 0.70 43.06 42.23 30.56
179 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 30.44
180 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 30.00
181 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 29.68
182 INT32025 Gene_expression of mc 7 0.25 3.45 0.76 29.04
183 INT91158 Regulation of Ros1 26 0.25 17 4.23 27.28
184 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9 26.88
185 INT205005 Transcription of SPECC1 3 0.59 1.28 0.14 26.64
186 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91 25.40
187 INT125771 Localization of CP 9 0.73 6.14 1.84 25.40
188 INT159543 Localization of SOD1 29 0.75 8.62 1.06 25.40
189 INT215910 Negative_regulation of Gene_expression of SHE 4 0.19 0.24 0.04 25.20
190 INT5118 Regulation of SST 97 0.62 34.35 51.74 25.00
191 INT691 Binding of SST 67 0.48 24.66 32.67 25.00
192 INT7414 Regulation of Localization of SST 31 0.60 4.85 17.46 25.00
193 INT4282 Regulation of Msr1 11 0.45 2.51 5.75 25.00
194 INT87741 Localization of Msr1 5 0.60 4.77 0.5 25.00
195 INT87742 Regulation of Localization of Msr1 1 0.03 0.44 0.22 25.00
196 INT81796 Binding of AGRP 62 0.36 37.19 5.3 24.48
197 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 24.20
198 INT172677 Gene_expression of SHE 65 0.59 25.86 3.85 24.16
199 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 23.56
200 INT98392 Positive_regulation of Spt 6 0.39 2.35 0.54 22.96
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