D:Absence Epilepsy

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Disease Term
Synonyms Absence Epilepsies Childhood, Absence Epilepsies Juvenile, Absence Epilepsy Childhood, Absence Epilepsy Juvenile, Absence Seizure, ABSENCE SEIZURE ATONIC, Absence Seizure Disorder, ABSENCE SEIZURE DISORDERS, Absence Seizures, Absence Seizures Atonic, Akinetic Petit Mal
Documents 138
Hot Single Events 70
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Absence Epilepsy. They are ordered first by their relevance to Absence Epilepsy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT234301 Gria3 Regulation of Swd1 1 0.01 0.09 0 94.60
2 INT234307 Binding of Gria4 and Gopc 1 0.14 0.16 0 81.88
3 INT101551 Binding of CACNA1A and CACNA1F 1 0.07 1.51 0.33 80.96
4 INT234302 Negative_regulation of Gria3 Positive_regulation of Swd1 1 0.01 0.47 0.1 77.92
5 INT234303 Gria3 Negative_regulation of Gria4 1 0.36 0 0.16 50.00
6 INT234304 Magt1 Regulation of Gopc 1 0.05 0.28 0 50.00
7 INT234306 Binding of Gria4 and Hc 1 0.01 0 0 50.00
8 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 25.00
9 INT97207 Binding of Gabrg1 and Ptar1 1 0.00 0.07 0.55 25.00
10 INT264209 Binding of Igh-Lev and Sv2a 1 0.17 1.78 0.38 18.96
11 INT262336 Binding of Abat and Tmem132a 1 0.00 1.39 1.14 5.00
12 INT264775 Binding of Gabbr1 and Abat 1 0.03 0 0.64 5.00
13 INT262354 TRIP10 Negative_regulation of Cyp4a3 1 0.00 0.8 0.26 5.00
14 INT279828 Binding of Scn1a and Scn9a 1 0.39 1.64 0.26 5.00
15 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26 5.00
16 INT262329 TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26 5.00
17 INT262330 Positive_regulation of TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26 5.00
18 INT264776 Abat Positive_regulation of Gabbr1 1 0.03 0.06 0.22 5.00
19 INT264778 Binding of CA2 and Gabbr1 1 0.02 0 0.21 5.00
20 INT279829 Scn1a Regulation of Gene_expression of Scn9a 1 0.42 1.52 0.15 5.00
21 INT315030 Binding of Cav1 and Tmie 1 0.03 0.25 0.14 5.00
22 INT315032 Binding of Cav1 and Ryr1 1 0.27 0.2 0.14 5.00
23 INT252421 Gja1 Regulation of P2ry1 1 0.00 0.28 0.09 5.00
24 INT262335 Binding of Sv2a and Bri3 1 0.01 0.71 0.08 5.00
25 INT337072 Binding of Fmr1 and Gusb 1 0.19 1.55 0.08 5.00
26 INT315034 Ass1 Positive_regulation of Cacna1f 1 0.00 0 0.03 5.00
27 INT315033 Binding of Calm3 and Vsig2 1 0.00 0 0 5.00
28 INT227399 Binding of D5Mit424 and Alms1 1 0.01 0.71 0 5.00
29 INT315029 Binding of Calm3 and Cacna1f 1 0.04 0 0 5.00
30 INT264210 Binding of Aes and Igh-Lev 1 0.07 0.41 0 5.00
31 INT315035 Binding of NAE1 and Cav1 1 0.01 0.7 0 5.00
32 INT315031 Binding of Cacna1f and Vsig2 1 0.02 0 0 5.00
33 INT227398 Binding of H2afy and Alms1 1 0.01 1.42 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Absence Epilepsy. They are ordered first by their pain relevance and then by number of times they were reported in Absence Epilepsy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5573 Negative_regulation of Gene_expression of Penk 113 0.59 21.83 64.66 99.98
2 INT211027 Gene_expression of Celf4 1 0.78 4.72 0.82 99.92
3 INT262348 Gene_expression of Lgsn 12 0.58 12.64 2.08 99.48
4 INT264035 Regulation of Lgsn 5 0.39 6.2 0.86 99.48
5 INT69018 Regulation of ESM1 1 0.05 0.49 0.66 99.40
6 INT76715 Gene_expression of Gria3 16 0.75 1.89 2.77 99.36
7 INT33944 Regulation of Helt 13 0.24 2.86 8.49 99.26
8 INT118916 Gene_expression of SBDS 12 0.53 5.11 1.51 99.08
9 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65 98.84
10 INT211033 Binding of Celf4 1 0.37 1.64 0.15 98.64
11 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 98.40
12 INT64918 Gene_expression of Gria2 108 0.74 29.95 29.67 98.20
13 INT187789 Positive_regulation of Positive_regulation of Bace1 18 0.50 16.18 1.87 97.16
14 INT44717 Gene_expression of TNFSF14 12 0.75 13.44 3.72 97.04
15 INT97367 Gene_expression of Nav1 243 0.78 132.97 286.66 96.72
16 INT117675 Transcription of Nav1 46 0.72 30.23 44.01 96.72
17 INT117676 Positive_regulation of Transcription of Nav1 8 0.53 4.37 7.75 96.72
18 INT115909 Positive_regulation of Gene_expression of Nav1 25 0.70 16.58 27.63 96.72
19 INT27492 Gene_expression of Swd1 4 0.50 2.07 0.68 96.58
20 INT48122 Regulation of Cacna1h 5 0.42 3 3.37 96.48
21 INT7692 Positive_regulation of PENK 71 0.70 20.34 32.54 96.44
22 INT12156 Positive_regulation of MET 43 0.67 17.75 12.64 96.44
23 INT12157 Positive_regulation of SELL 16 0.67 14.54 5.74 96.44
24 INT224807 Gene_expression of Gria4 35 0.78 4.63 4.02 96.32
25 INT234297 Negative_regulation of Gene_expression of Gria4 1 0.59 1.49 0.5 96.20
26 INT131296 Positive_regulation of Bace1 208 0.70 170.1 15.79 96.16
27 INT49477 Gene_expression of Htr2c 12 0.75 3.26 5.73 96.12
28 INT2531 Positive_regulation of Cebpz 166 0.00 43.08 38.86 96.08
29 INT55709 Negative_regulation of Gria4 7 0.51 1.28 1.6 95.92
30 INT156373 Binding of Sv2a 4 0.39 1.54 2.3 95.64
31 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 94.04
32 INT156626 Gene_expression of Kcnt2 1 0.25 0.31 0.14 93.72
33 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 93.48
34 INT146355 Negative_regulation of Aes 15 0.51 7.83 4.25 93.00
35 INT5595 Positive_regulation of Pdyn 223 0.70 48.37 130.14 92.76
36 INT118918 Negative_regulation of SBDS 4 0.16 2.05 2.05 92.24
37 INT4829 Positive_regulation of Localization of Abat 199 0.55 20.91 150.48 91.20
38 INT3439 Localization of Abat 1017 0.78 112.39 727.06 90.68
39 INT118917 Negative_regulation of Gene_expression of SBDS 1 0.16 0.17 0.73 90.08
40 INT45844 Gene_expression of Mlst8 2 0.67 0.09 0.22 89.80
41 INT6034 Binding of Gabrg1 115 0.47 17.48 51.92 89.44
42 INT45812 Protein_catabolism of Gabrg1 12 0.79 1.93 8.76 89.44
43 INT170444 Binding of Gopc 172 0.39 45.05 20.71 89.40
44 INT264204 Regulation of Igh-Lev 1 0.20 3.17 0.1 88.80
45 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57 88.48
46 INT12228 Positive_regulation of Gene_expression of Abat 44 0.65 17.51 40.55 87.60
47 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 87.04
48 INT117674 Regulation of Gene_expression of Nav1 16 0.62 11.5 22.01 86.32
49 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 86.24
50 INT11279 Positive_regulation of Penk 65 0.70 18.72 30.29 86.12
51 INT52132 Positive_regulation of Negative_regulation of Abat 9 0.50 0.53 7.03 85.88
52 INT156625 Regulation of Cav3 1 0.58 0.35 0.17 85.84
53 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 85.36
54 INT243325 Gene_expression of TPT1 3 0.45 1.38 1.03 85.36
55 INT267679 Negative_regulation of EJM2 1 0.04 1.15 0.14 84.24
56 INT100965 Positive_regulation of Nav1 85 0.70 37.74 75.35 83.52
57 INT14109 Positive_regulation of Mtr 1 0.03 0.49 0.6 83.52
58 INT264206 Gene_expression of Igh-Lev 1 0.30 5.68 0.87 83.20
59 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 82.76
60 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93 82.72
61 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65 82.48
62 INT12440 Regulation of Gpr156 11 0.45 3.2 6.07 82.24
63 INT174844 Binding of Fig4 81 0.41 18.03 12.87 81.92
64 INT225131 Negative_regulation of Binding of Fig4 5 0.19 1.43 0.08 81.92
65 INT71629 Negative_regulation of Swd1 6 0.15 1.42 1.1 81.36
66 INT224806 Negative_regulation of Gria3 2 0.56 1.09 0.5 81.00
67 INT96128 Localization of Eef1a2 4 0.14 1.59 0.47 80.80
68 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32 80.32
69 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91 80.32
70 INT234293 Regulation of Gene_expression of Gria4 1 0.45 0.31 0.38 80.08
71 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1 79.80
72 INT62861 Regulation of Gria2 45 0.60 13.35 16.07 79.20
73 INT234298 Positive_regulation of Negative_regulation of Gria3 1 0.48 0.47 0.1 77.92
74 INT264027 Positive_regulation of Positive_regulation of Flvcr2 2 0.08 2.67 7.27 77.60
75 INT80790 Positive_regulation of Flvcr2 22 0.45 4.92 12.35 77.60
76 INT17824 Positive_regulation of Gene_expression of Flvcr2 15 0.41 6.66 10.23 77.60
77 INT267678 Positive_regulation of Positive_regulation of Slc1a1 1 0.07 1.34 3.65 77.60
78 INT53063 Positive_regulation of Slc1a1 10 0.70 3.23 9.89 77.52
79 INT63444 Regulation of Gene_expression of Abat 26 0.51 14.65 26.29 77.48
80 INT92017 Regulation of Gene_expression of Flvcr2 3 0.18 1.69 3.75 77.48
81 INT119193 Positive_regulation of Fmr1 3 0.67 2.48 0.43 76.80
82 INT70738 Negative_regulation of Gabrg2 7 0.57 4 2.96 75.64
83 INT279826 Negative_regulation of Scn1b 1 0.35 1.31 0.04 75.64
84 INT279820 Negative_regulation of Scn2a1 1 0.35 1.31 0.04 75.64
85 INT279816 Negative_regulation of Scn1a 1 0.40 1.31 0.04 75.64
86 INT52606 Positive_regulation of Swd1 3 0.42 0.93 1.24 75.00
87 INT95930 Negative_regulation of Gria2 63 0.56 18.37 17.04 75.00
88 INT6826 Transcription of Pdyn 130 0.71 22.19 54.88 75.00
89 INT2480 Negative_regulation of Got1 43 0.51 14.47 16.09 75.00
90 INT94095 Negative_regulation of BCAT1 9 0.49 0.97 4.91 75.00
91 INT61248 Negative_regulation of Arid4b 3 0.33 0.48 3.19 75.00
92 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 75.00
93 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58 75.00
94 INT6870 Positive_regulation of Oprk1 14 0.70 4 10.91 75.00
95 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 75.00
96 INT4803 Transcription of Penk 435 0.72 59.09 182.4 75.00
97 INT5594 Regulation of Pdyn 137 0.62 27.04 86.63 75.00
98 INT12751 Gene_expression of Pigm 91 0.58 22.42 29.2 75.00
99 INT28544 Regulation of Gene_expression of Pigm 6 0.24 1.04 3.96 75.00
100 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 74.84
101 INT111056 Negative_regulation of Gene_expression of Flvcr2 9 0.13 4.15 7.18 74.84
102 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 74.44
103 INT95313 Gene_expression of Slc6a1 6 0.76 3.96 6.14 74.44
104 INT13145 Positive_regulation of Car1 60 0.70 16.32 23.23 74.44
105 INT256447 Regulation of Regulation of SBDS 1 0.07 0.22 0.46 73.64
106 INT135955 Positive_regulation of Cav1 17 0.48 7.73 1.61 72.20
107 INT231587 Regulation of SBDS 5 0.16 1.1 0.93 71.88
108 INT81052 Gene_expression of Hoxb7 1 0.58 0.28 0.22 71.68
109 INT315011 Gene_expression of Cacna1d 1 0.57 4.47 0.29 70.88
110 INT315015 Regulation of Gene_expression of Cacna1d 1 0.20 0.67 0.07 70.88
111 INT211034 Transcription of Celf4 1 0.60 1.18 0.35 70.72
112 INT24452 Regulation of Swd1 2 0.05 1.55 0.33 70.40
113 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 69.68
114 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 69.68
115 INT21131 Negative_regulation of Gene_expression of ABAT 6 0.42 4.93 2.83 69.68
116 INT6351 Positive_regulation of Gabbr1 40 0.64 11.99 19 68.88
117 INT2912 Positive_regulation of Positive_regulation of Abat 29 0.66 6.48 27.54 68.20
118 INT111675 Regulation of TNFSF14 3 0.26 3.41 1.85 68.04
119 INT2498 Positive_regulation of Mlst8 2 0.47 0.73 1.56 67.96
120 INT328535 Localization of Nacc1 1 0.15 0.68 0 67.04
121 INT115130 Gene_expression of PDZK1IP1 5 0.65 1.95 1.79 66.88
122 INT115129 Positive_regulation of Gene_expression of PDZK1IP1 2 0.49 0.91 0.14 66.88
123 INT54495 Binding of GABBR1 9 0.35 1.82 2.76 66.52
124 INT262343 Binding of Lgsn 6 0.32 10.1 1.65 66.12
125 INT258081 Protein_catabolism of ABAT 5 0.10 2.57 2.86 65.44
126 INT258051 Negative_regulation of Protein_catabolism of ABAT 3 0.04 1.86 1.52 65.44
127 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 65.44
128 INT256445 Negative_regulation of Negative_regulation of TPT1 1 0.04 0.06 0.43 64.96
129 INT256438 Negative_regulation of Negative_regulation of Foxg1 1 0.16 0.06 0.43 64.96
130 INT5359 Protein_catabolism of Abat 12 0.62 5.11 8.54 64.32
131 INT262344 Negative_regulation of Lgsn 4 0.37 3.6 0.67 64.04
132 INT256439 Negative_regulation of Foxg1 1 0.16 0.06 0.54 63.84
133 INT256444 Negative_regulation of TPT1 1 0.04 0.06 0.42 63.84
134 INT234289 Binding of Swd1 1 0.03 5.79 0.23 63.44
135 INT315008 Negative_regulation of Gene_expression of Cacna1d 1 0.31 0.73 0.04 63.00
136 INT111066 Regulation of Bace1 40 0.61 31.47 4.28 62.88
137 INT51530 Negative_regulation of Adk 11 0.56 3.83 9.07 62.24
138 INT130422 Positive_regulation of Gene_expression of TNFSF14 1 0.28 2.79 0.85 60.36
139 INT101552 Binding of CACNA1F 2 0.17 1.95 0.26 58.64
140 INT216977 Gene_expression of Lpar4 7 0.35 3.93 1.66 58.00
141 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 57.28
142 INT220594 Localization of Bace1 48 0.79 20.22 4.16 56.16
143 INT263678 Negative_regulation of Igh-Lev 2 0.19 0.81 0.58 55.80
144 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 55.36
145 INT172853 Positive_regulation of Localization of Cyct 14 0.67 10.48 2.65 54.32
146 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 54.24
147 INT69020 Gene_expression of Htr2c 9 0.74 6.09 2.22 52.76
148 INT211029 Negative_regulation of Gene_expression of Htr2c 1 0.56 2.54 0.25 52.76
149 INT85767 Gene_expression of Scn9a 11 0.76 9.27 2.74 51.76
150 INT98376 Gene_expression of tk 27 0.51 21.9 2.23 51.76
151 INT199566 Positive_regulation of Gene_expression of tk 4 0.39 3.06 0.31 51.76
152 INT279815 Positive_regulation of Gene_expression of Scn9a 1 0.43 0.67 0.03 51.76
153 INT260734 Gene_expression of Acin1 2 0.16 1 0.03 51.76
154 INT279819 Positive_regulation of Gene_expression of Acin1 1 0.12 0.67 0.03 51.76
155 INT172852 Localization of Cyct 28 0.78 21.42 3.34 51.68
156 INT8481 Regulation of PIAS1 4 0.45 0.47 3.44 50.68
157 INT234292 Phosphorylation of Gria4 2 0.71 2.58 1.5 50.00
158 INT234294 Positive_regulation of Gria4 2 0.44 0.16 0.3 50.00
159 INT170380 Positive_regulation of Magt1 6 0.30 4.84 0.18 50.00
160 INT234296 Phosphorylation of Gria3 1 0.68 0 0.1 50.00
161 INT234300 Regulation of Gria4 1 0.39 0.07 0.05 50.00
162 INT234295 Positive_regulation of Negative_regulation of Gria4 1 0.44 0.16 0 50.00
163 INT234299 Binding of Gria4 1 0.37 0.25 0 50.00
164 INT234290 Negative_regulation of Positive_regulation of Gria4 1 0.37 0.16 0 50.00
165 INT2212 Binding of Abat 89 0.48 18.36 63.99 49.56
166 INT116126 Positive_regulation of Olfr544 13 0.38 5.23 4.52 49.44
167 INT311479 Gene_expression of Mllt1 4 0.58 4.92 2.39 48.24
168 INT174055 Negative_regulation of Htr2c 5 0.41 2.63 0.45 48.24
169 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 47.20
170 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 46.56
171 INT35742 Positive_regulation of tk 8 0.43 5.53 1.33 46.08
172 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37 45.80
173 INT126200 Negative_regulation of Bace1 73 0.58 50.19 7.44 43.36
174 INT211030 Regulation of Celf4 1 0.45 0.62 0.35 43.00
175 INT211031 Regulation of Gene_expression of Celf4 1 0.27 0.09 0 43.00
176 INT45427 Positive_regulation of Cacna2d2 20 0.49 11.89 4.85 40.96
177 INT315020 Positive_regulation of Gene_expression of Cacna1d 1 0.51 2.24 0.08 39.68
178 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97 39.36
179 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 38.80
180 INT146340 Localization of Mllt1 10 0.69 4.6 5.45 38.80
181 INT17561 Localization of Car2 303 0.79 60.95 44.52 37.84
182 INT9516 Negative_regulation of Gabrg1 149 0.53 27.83 91.02 36.08
183 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47 34.08
184 INT4360 Gene_expression of Hypism 29 0.22 38.1 4.07 33.76
185 INT211028 Positive_regulation of Transcription of Celf4 1 0.47 0.73 0.11 30.24
186 INT328545 Binding of Hdac9 1 0.11 0.09 0 29.88
187 INT128563 Binding of Mllt1 8 0.41 6.7 5.63 28.64
188 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36 25.68
189 INT133648 Regulation of HDAC9 14 0.60 10.01 2.18 25.68
190 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 25.00
191 INT6437 Binding of YY1 154 0.47 26.3 90.46 25.00
192 INT2761 Regulation of Gabrg1 119 0.61 18.8 60.52 25.00
193 INT33327 Positive_regulation of Gene_expression of Gabrg1 39 0.69 9.68 18.82 25.00
194 INT6356 Binding of Gabbr1 30 0.48 4.62 9.82 25.00
195 INT45813 Negative_regulation of Negative_regulation of Gabrg1 10 0.46 0.66 4.51 25.00
196 INT97204 Binding of Ptar1 1 0.00 0.07 0.55 25.00
197 INT123595 Regulation of Snca 7 0.62 4.3 3.06 24.72
198 INT158140 Regulation of Nsf 3 0.45 2.85 1.09 24.72
199 INT126406 Regulation of Syn2 2 0.41 1.05 0.89 24.72
200 INT97885 Regulation of LOC500077 7 0.16 2.93 4.33 22.88
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