D:Acanthamoeba Keratitis

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Disease Term
Synonyms Acanthamoeba Keratitides, Keratitides Acanthamoeba, Keratitis Acanthamoeba
Documents 50
Hot Single Events 15
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Acanthamoeba Keratitis. They are ordered first by their relevance to Acanthamoeba Keratitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT147112 LYZ Regulation of Binding of LTF 1 0.14 1.02 0.07 95.92

Single Events

The table below shows the top 200 pain related interactions that have been reported for Acanthamoeba Keratitis. They are ordered first by their pain relevance and then by number of times they were reported in Acanthamoeba Keratitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT81226 Gene_expression of Adk 9 0.64 9.28 4.81 100.00
2 INT291575 Negative_regulation of Gene_expression of Adk 1 0.32 1.05 0.03 100.00
3 INT291574 Protein_catabolism of Adk 1 0.49 0.99 0 100.00
4 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 99.16
5 INT147113 Binding of LTF 14 0.29 18.24 0.98 95.40
6 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 93.92
7 INT93620 Positive_regulation of Gene_expression of Fasl 51 0.66 59.45 12.04 93.92
8 INT99942 Positive_regulation of Fasl 37 0.68 32.61 6.92 93.92
9 INT81628 Positive_regulation of Gene_expression of Fas 32 0.67 38.13 4.23 93.92
10 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 92.80
11 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 92.80
12 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 90.96
13 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 90.40
14 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 83.52
15 INT192589 Negative_regulation of NEFM 1 0.00 1.13 0.03 83.04
16 INT166126 Gene_expression of MYD88 5 0.54 2.67 0.84 76.40
17 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 76.40
18 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 76.40
19 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 76.40
20 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04 76.40
21 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9 76.40
22 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21 76.40
23 INT94083 Gene_expression of NFASC 8 0.19 4.19 1.52 76.40
24 INT166125 Gene_expression of PHOSPHO1 4 0.75 3.06 0.24 76.40
25 INT107302 Negative_regulation of Gene_expression of Fasl 7 0.42 8.52 2.54 73.20
26 INT89967 Negative_regulation of Gene_expression of Fas 19 0.58 19.28 1.1 73.20
27 INT133766 Negative_regulation of Fasl 11 0.56 11.28 2.27 72.24
28 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 71.52
29 INT187050 Localization of RENBP 8 0.35 6.92 0.61 61.52
30 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 60.68
31 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 51.04
32 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 50.48
33 INT166127 Negative_regulation of Gene_expression of IFNB1 1 0.25 1.06 0.21 48.60
34 INT145001 Gene_expression of IFNB1 6 0.68 4.36 1.77 48.04
35 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62 32.40
36 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 31.28
37 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 30.60
38 INT22159 Gene_expression of AMT 11 0.75 2.19 1.5 20.28
39 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
40 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
41 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
42 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
43 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
44 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
45 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 5.00
46 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 5.00
47 INT35406 Localization of Tnf 94 0.81 64.63 31.65 5.00
48 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 5.00
49 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
50 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 5.00
51 INT72127 Protein_catabolism of MMRN1 68 0.52 56 14.13 5.00
52 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
53 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 5.00
54 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
55 INT25381 Localization of Csf2 62 0.76 47.48 9.03 5.00
56 INT25392 Positive_regulation of Gene_expression of Csf2 41 0.49 34.28 8.36 5.00
57 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71 5.00
58 INT112986 Positive_regulation of S100b 19 0.70 17.61 6.86 5.00
59 INT86805 Localization of HGF 49 0.71 28.48 6.35 5.00
60 INT4561 Gene_expression of PLG 32 0.75 17.59 6.21 5.00
61 INT8106 Gene_expression of GGT1 31 0.75 18.65 6.1 5.00
62 INT88545 Localization of MMRN1 21 0.78 16.67 4.01 5.00
63 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16 5.00
64 INT180971 Protein_catabolism of GOPC 21 0.77 6.15 2.98 5.00
65 INT98554 Positive_regulation of Casp8 20 0.67 21.32 2.9 5.00
66 INT195085 Gene_expression of S100b 12 0.56 12.26 2.33 5.00
67 INT4560 Protein_catabolism of PLG 18 0.96 11.64 2.32 5.00
68 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3 5.00
69 INT31118 Localization of Casp3 17 0.73 11.55 2.3 5.00
70 INT116194 Gene_expression of Casp8 14 0.75 14.61 2.13 5.00
71 INT175655 Regulation of MMRN1 16 0.12 9.96 2.12 5.00
72 INT25286 Localization of IL1RL1 7 0.56 3.17 2.07 5.00
73 INT121784 Regulation of Gene_expression of Fas 7 0.38 5.68 1.86 5.00
74 INT22871 Gene_expression of ELN 30 0.68 14.86 1.33 5.00
75 INT115948 Regulation of Gene_expression of MMRN1 7 0.26 10.37 1.33 5.00
76 INT190190 Protein_catabolism of ELN 5 0.22 2.81 1.27 5.00
77 INT81043 Negative_regulation of Kctd1 9 0.57 7.68 1.06 5.00
78 INT31117 Binding of Casp3 14 0.23 5.27 0.93 5.00
79 INT139180 Regulation of Positive_regulation of Fas 2 0.43 2.19 0.69 5.00
80 INT100822 Localization of Fas 8 0.74 6.13 0.48 5.00
81 INT192587 Negative_regulation of Protein_catabolism of GOPC 4 0.22 1.15 0.41 5.00
82 INT192590 Gene_expression of CA4 3 0.75 1.57 0.41 5.00
83 INT142872 Regulation of Casp8 6 0.29 3.11 0.39 5.00
84 INT265607 Gene_expression of TAF8 11 0.32 9.91 0.35 5.00
85 INT22873 Positive_regulation of ELN 6 0.45 3.74 0.33 5.00
86 INT201453 Protein_catabolism of Hmox1 3 0.95 4.25 0.23 5.00
87 INT88128 Positive_regulation of Localization of HGF 7 0.45 2.74 0.17 5.00
88 INT347940 Regulation of Positive_regulation of Fasl 1 0.30 1.95 0.13 5.00
89 INT227406 Regulation of Bcl2l10 2 0.03 2.99 0.13 5.00
90 INT192591 Protein_catabolism of RENBP 1 0.02 0.94 0.12 5.00
91 INT256923 Regulation of Gene_expression of Casp8 2 0.11 2.31 0.04 5.00
92 INT190027 Regulation of Apaf1 2 0.16 2.59 0.04 5.00
93 INT192593 Protein_catabolism of ECM1 1 0.03 0.63 0.04 5.00
94 INT321555 Negative_regulation of Vcl 3 0.12 2.41 0.03 5.00
95 INT154990 Negative_regulation of TJP1 2 0.20 1.74 0.03 5.00
96 INT255408 Protein_catabolism of Pymr 2 0.06 1.71 0 5.00
97 INT192594 Positive_regulation of Protein_catabolism of ELN 1 0.08 0.3 0 5.00
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