D:Achlorhydria

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Disease Term
Synonyms Achylia Gastrica, HYPOCHLORHYDRIA
Documents 82
Hot Single Events 20
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Achlorhydria. They are ordered first by their relevance to Achlorhydria and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT301079 Binding of GNAT1 and INPP5E 1 0.00 0.59 0.89 97.52
2 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 70.68
3 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41 20.64
4 INT303650 Binding of IGF1 and SSTR1 1 0.12 2.17 0.4 19.20
5 INT30905 SST Negative_regulation of Localization of GCG 2 0.12 1.56 1.04 5.00
6 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96 5.00
7 INT303656 SST Negative_regulation of Localization of GAST 1 0.12 1.45 0.82 5.00
8 INT303652 Binding of SST and SSTR2 1 0.26 0.46 0.57 5.00
9 INT303654 Binding of SST and SSTR5 1 0.22 0.46 0.57 5.00
10 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54 5.00
11 INT303651 Binding of SSTR2 and SSTR5 1 0.24 0.23 0.45 5.00
12 INT197811 Binding of SMS and SST 1 0.00 0.98 0.21 5.00
13 INT303659 SSTR2 Negative_regulation of Gene_expression of SST 1 0.30 0.94 0.16 5.00
14 INT303657 Gene_expression of SSTR2 Negative_regulation of Gene_expression of SST 1 0.30 0.94 0.16 5.00
15 INT197808 Binding of MEN1 and NME1 1 0.00 1.81 0 5.00
16 INT197809 Binding of MEN1 and VIM 1 0.04 0.52 0 5.00
17 INT197810 Binding of MEN1 and MUC1 1 0.06 0.47 0 5.00
18 INT197816 Binding of MEN1 and NFKB1 1 0.05 0.07 0 5.00
19 INT197813 Binding of AMBP and MEN1 1 0.00 0.51 0 5.00
20 INT197812 Binding of AMBP and RDBP 1 0.00 0.51 0 5.00
21 INT197817 Binding of JUND and MEN1 1 0.18 0.14 0 5.00
22 INT197844 Binding of MEN1 and Nfkb1 1 0.06 0.26 0 5.00
23 INT197815 Binding of MEN1 and TGFB1 1 0.16 0.13 0 5.00
24 INT197814 Binding of MEN1 and RELA 1 0.42 0.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Achlorhydria. They are ordered first by their pain relevance and then by number of times they were reported in Achlorhydria. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT8154 Positive_regulation of Positive_regulation of Gast 13 0.54 6.59 3.49 99.98
2 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 99.76
3 INT29 Negative_regulation of Gast 74 0.59 24.85 24.96 98.36
4 INT397 Localization of SST 232 0.81 58.05 101.19 97.52
5 INT301080 Binding of GNAT1 1 0.10 2.04 1.85 97.52
6 INT4075 Positive_regulation of Gene_expression of Gast 24 0.68 19.99 4.02 97.48
7 INT30 Gene_expression of Gast 158 0.78 99 41.45 96.88
8 INT20129 Regulation of Il1 53 0.53 44.14 19.89 96.60
9 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 95.96
10 INT30629 Regulation of Positive_regulation of SST 2 0.37 1.35 0.59 91.76
11 INT150117 Localization of P4HB 3 0.78 3.81 0.91 91.60
12 INT150118 Negative_regulation of Localization of P4HB 1 0.42 1.26 0.19 91.60
13 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 91.24
14 INT67195 Negative_regulation of Gene_expression of SST 7 0.42 6.98 4.88 91.24
15 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 90.60
16 INT5743 Localization of NA 104 0.59 14.35 35.29 83.04
17 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 82.16
18 INT24724 Positive_regulation of Gene_expression of SST 11 0.67 7.51 6.12 80.48
19 INT3395 Negative_regulation of VIP 15 0.59 4.23 5.62 80.36
20 INT303680 Negative_regulation of Positive_regulation of VIP 1 0.15 1.2 0.28 80.36
21 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 79.60
22 INT34626 Binding of Cbs 2 0.37 3.27 1.27 79.28
23 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 79.00
24 INT2364 Localization of Sct 134 0.80 26.21 41.47 77.44
25 INT72747 Localization of IgG 55 0.53 30.88 4.19 75.92
26 INT14930 Regulation of Gene_expression of SST 12 0.45 6.86 3.89 75.60
27 INT701 Localization of IGHE 87 0.80 40.5 10.62 75.40
28 INT323977 Phosphorylation of PTGFRN 1 0.01 0.81 0.22 75.36
29 INT197832 Localization of MEN1 1 0.80 11.01 0.63 70.48
30 INT425 Localization of PRL 455 0.81 189.64 144.8 69.12
31 INT1893 Localization of Gh 1041 0.79 340.23 256.58 69.12
32 INT252 Localization of GH1 529 0.80 227.4 122.05 69.12
33 INT443 Localization of POMC 1020 0.81 284.52 443.17 69.12
34 INT232791 Localization of Kcnq1 1 0.28 0.21 0 63.84
35 INT243480 Gene_expression of SSTR5 1 0.55 4.25 0.85 61.92
36 INT303676 Regulation of Gene_expression of SSTR5 1 0.32 1.69 0.28 61.92
37 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 52.44
38 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 52.44
39 INT301081 Positive_regulation of GNAT1 1 0.12 4.16 3 48.28
40 INT354026 Positive_regulation of ICOS 1 0.17 2.32 0 46.88
41 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 44.28
42 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38 43.44
43 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 43.12
44 INT303672 Negative_regulation of Gene_expression of SSTR2 1 0.49 0.95 0.21 33.88
45 INT812 Localization of INS 1026 0.81 515.6 145.31 33.68
46 INT140542 Gene_expression of SSTR2 18 0.65 13.58 3.94 33.40
47 INT4853 Regulation of Hrh2 42 0.45 22.34 16.65 33.08
48 INT144461 Negative_regulation of SSTR2 2 0.49 1.03 0.98 28.20
49 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44 24.20
50 INT4494 Regulation of GCG 41 0.45 18.38 9.68 23.52
51 INT303671 Negative_regulation of Regulation of GCG 1 0.13 1.44 0.22 23.52
52 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26 23.40
53 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 22.60
54 INT158 Localization of Prl 2431 0.81 378.96 952.2 22.16
55 INT14681 Negative_regulation of GCG 31 0.57 13.55 4.98 22.00
56 INT243477 Binding of SSTR1 3 0.26 3.49 0.65 19.20
57 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 17.72
58 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 17.72
59 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 15.88
60 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16 15.20
61 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 13.00
62 INT26492 Negative_regulation of Localization of GCG 73 0.58 22.2 9.48 11.20
63 INT17625 Localization of GCG 210 0.80 55.69 24.97 9.76
64 INT155973 Positive_regulation of Pgc 3 0.28 0.41 0.16 7.72
65 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 6.44
66 INT232793 Gene_expression of Pgc 2 0.31 3.9 0.2 6.32
67 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
68 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
69 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
70 INT90 Localization of Gast 400 0.81 137.67 113 5.00
71 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
72 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
73 INT249 Localization of GHRH 215 0.80 78.02 51.87 5.00
74 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
75 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
76 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
77 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
78 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
79 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
80 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
81 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
82 INT693 Negative_regulation of Localization of SST 46 0.59 8.57 21.75 5.00
83 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22 5.00
84 INT28642 Gene_expression of CXCR2 60 0.78 38.69 18.11 5.00
85 INT7414 Regulation of Localization of SST 31 0.60 4.85 17.46 5.00
86 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
87 INT2243 Localization of GAST 67 0.81 34.54 16.19 5.00
88 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8 5.00
89 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
90 INT66606 Gene_expression of CXCR1 34 0.75 27.79 11.36 5.00
91 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8 5.00
92 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21 5.00
93 INT65058 Binding of Nfkb1 36 0.45 19.87 10.02 5.00
94 INT224964 Localization of Ghrl 30 0.59 7.71 8.77 5.00
95 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 5.00
96 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35 5.00
97 INT2093 Gene_expression of GAST 50 0.78 32.32 7.98 5.00
98 INT6596 Positive_regulation of HLA-DRB1 33 0.61 27.01 7.26 5.00
99 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 5.00
100 INT79425 Gene_expression of SMN1 42 0.65 36.37 6.1 5.00
101 INT17551 Positive_regulation of Gene_expression of HLA-DRA 31 0.70 15.39 6 5.00
102 INT90350 Gene_expression of Gast 27 0.78 14.07 4.74 5.00
103 INT138872 Gene_expression of SPINK5 21 0.58 30.11 4.12 5.00
104 INT20303 Regulation of Cyp2e1 11 0.61 2.46 3.84 5.00
105 INT123908 Positive_regulation of HLA-DQB1 12 0.21 10.5 3.71 5.00
106 INT226114 Binding of Ghrl 18 0.36 4.34 3.54 5.00
107 INT986 Negative_regulation of Localization of GHRH 16 0.58 8.57 3.16 5.00
108 INT96542 Negative_regulation of SMN1 14 0.51 10.72 3.11 5.00
109 INT28640 Positive_regulation of Gene_expression of CXCR2 8 0.69 5.51 2.91 5.00
110 INT112166 Localization of Gast 15 0.72 8.86 2.91 5.00
111 INT1557 Binding of Dnahc8 6 0.48 1.5 2.51 5.00
112 INT13733 Localization of SSTR1 8 0.65 3.11 2.49 5.00
113 INT9473 Binding of MUC1 66 0.48 46.77 2.36 5.00
114 INT49769 Binding of SSTR2 4 0.48 1.39 2.14 5.00
115 INT37216 Binding of SMN1 11 0.36 6.66 1.86 5.00
116 INT44783 Gene_expression of Chga 3 0.75 1.72 1.45 5.00
117 INT212466 Regulation of EPHB1 7 0.37 5.72 1.42 5.00
118 INT124407 Gene_expression of SSTR1 4 0.55 5.55 1.41 5.00
119 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 5.00
120 INT303667 Regulation of BCL2L11 3 0.16 1.03 1.21 5.00
121 INT219879 Positive_regulation of SPINK5 4 0.30 7.64 1.16 5.00
122 INT94396 Regulation of Cyp1a2 4 0.60 0.37 1.15 5.00
123 INT92291 Localization of CXCR1 4 0.73 3.06 0.98 5.00
124 INT28641 Regulation of Gene_expression of CXCR2 1 0.45 1.9 0.91 5.00
125 INT24327 Gene_expression of Tgfa 6 0.64 3.61 0.86 5.00
126 INT2244 Positive_regulation of Localization of GAST 7 0.68 5.28 0.73 5.00
127 INT118350 Negative_regulation of Chga 2 0.42 1.64 0.71 5.00
128 INT41555 Gene_expression of GRN 8 0.52 10.94 0.69 5.00
129 INT246036 Positive_regulation of GRN 3 0.17 2.04 0.69 5.00
130 INT136531 Binding of Men1 8 0.47 9.62 0.65 5.00
131 INT115423 Gene_expression of Men1 4 0.47 14.08 0.64 5.00
132 INT96447 Regulation of SMN1 4 0.17 2.59 0.57 5.00
133 INT300623 Positive_regulation of Men1 1 0.35 10.65 0.57 5.00
134 INT202187 Regulation of GRN 3 0.09 1.47 0.53 5.00
135 INT303669 Regulation of SPINK5 1 0.24 0.65 0.53 5.00
136 INT91209 Binding of VIM 15 0.36 12.02 0.53 5.00
137 INT300621 Localization of Men1 1 0.56 4.63 0.52 5.00
138 INT303674 Positive_regulation of Regulation of BCL2L11 1 0.02 0.28 0.5 5.00
139 INT61102 Gene_expression of MEN1 12 0.78 17.7 0.43 5.00
140 INT133819 Localization of CXCR2 3 0.61 1.64 0.37 5.00
141 INT246502 Negative_regulation of Men1 2 0.30 8.9 0.33 5.00
142 INT287775 Transcription of Ghrl 3 0.41 1.27 0.31 5.00
143 INT303673 Gene_expression of C10orf81 1 0.01 0.58 0.24 5.00
144 INT323976 Regulation of Gene_expression of CXCR1 1 0.06 1.52 0.21 5.00
145 INT158763 Binding of GRN 3 0.36 0.94 0.2 5.00
146 INT274731 Binding of EPHB1 3 0.22 0.76 0.2 5.00
147 INT303678 Regulation of Gene_expression of SSTR1 1 0.19 0.84 0.18 5.00
148 INT197842 Gene_expression of PHPT1 1 0.06 5.89 0.16 5.00
149 INT303677 Positive_regulation of SSTR2 1 0.42 0.56 0.16 5.00
150 INT303668 Positive_regulation of Gene_expression of SSTR2 1 0.42 0.66 0.16 5.00
151 INT67181 Positive_regulation of Positive_regulation of SERPINE1 3 0.49 3.02 0.14 5.00
152 INT303649 Gene_expression of Ptprf 1 0.58 0.96 0.11 5.00
153 INT197840 Binding of NME1 2 0.04 1.14 0.11 5.00
154 INT197827 Regulation of PHPT1 1 0.03 2.54 0.08 5.00
155 INT197836 Positive_regulation of Gene_expression of MEN1 1 0.50 3.16 0.07 5.00
156 INT197835 Positive_regulation of Gene_expression of PHPT1 1 0.04 3.17 0.07 5.00
157 INT232792 Negative_regulation of Pgc 1 0.01 0.12 0.06 5.00
158 INT197839 Negative_regulation of PHPT1 1 0.04 2.88 0.06 5.00
159 INT197828 Negative_regulation of MEN1 1 0.43 5.06 0.06 5.00
160 INT287774 Negative_regulation of Transcription of Ghrl 1 0.02 1.28 0.05 5.00
161 INT232797 Negative_regulation of Atp12a 1 0.01 0.49 0.05 5.00
162 INT276403 Regulation of MALT1 3 0.34 3.37 0.03 5.00
163 INT197841 Positive_regulation of MEN1 1 0.41 2.38 0 5.00
164 INT197843 Regulation of Localization of MEN1 1 0.45 0.24 0 5.00
165 INT197838 Transcription of MEN1 1 0.69 0.13 0 5.00
166 INT197825 Transcription of JUND 2 0.29 0.43 0 5.00
167 INT197829 Positive_regulation of Transcription of JUND 2 0.21 0.82 0 5.00
168 INT300622 Binding of Jund 1 0.04 1.57 0 5.00
169 INT197824 Positive_regulation of Transcription of MEN1 1 0.50 0.13 0 5.00
170 INT197834 Binding of MEN1 1 0.48 3.32 0 5.00
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