D:Acne

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Disease Term
Synonyms ACNE EXOCRIEE, Acne Fulminans, Acne Unspecified, Acne Vulgaris, CONGLOBATE ACNE, DEEP ACNE, Excess Sebum Production, P Acnes, Propionibacterium Acnes, Rosacea, Sebocytes
Documents 676
Hot Single Events 199
Hot Interactions 10

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Acne. They are ordered first by their relevance to Acne and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT101381 POMC Regulation of Localization of IL8 1 0.28 1.49 1.02 99.80
2 INT329794 TLR2 Positive_regulation of Positive_regulation of IL12A 1 0.01 1.05 0.44 99.58
3 INT329800 TLR2 Positive_regulation of Positive_regulation of IL8 1 0.01 0.99 0.41 99.58
4 INT329803 TLR2 Positive_regulation of Positive_regulation of IL6 1 0.01 0.94 0.41 99.58
5 INT150392 Binding of MEFV and PSTPIP1 2 0.51 10.49 1.44 98.72
6 INT317834 Binding of Pstpip1 and Il1 1 0.00 2.03 0.48 96.44
7 INT278379 Binding of Pstpip1 and Mefv 3 0.03 2.02 0.48 96.44
8 INT317832 Binding of Mefv and Il1 1 0.03 3.89 0.7 91.88
9 INT44441 GNRH1 Positive_regulation of Localization of FSHR 2 0.15 0.86 0.26 80.64
10 INT270758 GNRHR Positive_regulation of Localization of FSHR 1 0.08 0.68 0 80.64
11 INT197051 Binding of HLA-E and ATP8A1 1 0.00 6.52 1.14 78.48
12 INT284461 Gtf3a Positive_regulation of Gene_expression of IFN1@ 1 0.01 0.56 0.57 77.60
13 INT350120 FSHR Regulation of CYP19A1 1 0.01 3.02 0 65.68
14 INT274569 Binding of PSTPIP2 and PSTPIP1 1 0.50 2.07 0.31 64.96
15 INT274584 Binding of PSTPIP1 and PYCARD 1 0.13 1.34 0.22 63.00
16 INT350116 FSHR Positive_regulation of Gene_expression of CGA 1 0.01 1.28 0 59.32
17 INT274578 Binding of ABL1 and PSTPIP1 1 0.07 1.55 0.21 58.76
18 INT284891 FSHR Positive_regulation of Gene_expression of PLOD1 2 0.03 1.32 0.11 58.48
19 INT274583 Binding of ABL1 and PSTPIP2 1 0.06 0.79 0.11 58.08
20 INT150393 Binding of CASP1 and MEFV 2 0.16 2.48 0.45 57.76
21 INT334879 CASP1 Regulation of IL1B 1 0.03 1.63 0.31 56.56
22 INT350117 GNRHR Negative_regulation of Localization of FSHR 1 0.01 1.06 0 54.76
23 INT350113 GNRHR Negative_regulation of Localization of PLOD1 1 0.01 1.06 0 54.76
24 INT350115 GNRH1 Negative_regulation of Localization of PLOD1 1 0.04 0.99 0 53.48
25 INT350122 GNRH1 Negative_regulation of Localization of FSHR 1 0.05 0.99 0 53.48
26 INT261579 Serpinc1 Negative_regulation of Gene_expression of CYBB 1 0.00 1.69 0.18 50.64
27 INT350119 Positive_regulation of GNRH1 Positive_regulation of PLOD1 1 0.04 0.86 0.03 50.60
28 INT350114 Positive_regulation of GNRH1 Positive_regulation of FSHR 1 0.05 0.86 0.03 50.60
29 INT45780 GNRH1 Positive_regulation of PLOD1 3 0.07 1.02 0.63 50.20
30 INT54584 GNRH1 Positive_regulation of FSHR 3 0.48 2.02 0.54 49.76
31 INT334918 GNRH1 Positive_regulation of Gene_expression of FSHR 2 0.11 1.27 0.03 49.76
32 INT257397 Binding of FGD1 and INS 1 0.07 0.27 0.21 21.32
33 INT257398 Binding of FGD1 and GHRH 1 0.03 0.27 0.2 21.32
34 INT303600 IGF1 Regulation of Gene_expression of GH1 1 0.39 0.83 0.14 17.28
35 INT197050 Binding of HLA-DOA and HLA-E 2 0.08 1.73 0.58 13.36
36 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87 5.00
37 INT199593 Binding of TRPV1 and Myoz1 1 0.10 1.7 1.23 5.00
38 INT291377 Binding of CX3CR1 and Cx3cl1 2 0.36 3.57 1.02 5.00
39 INT317836 Binding of Fibp and Pycard 1 0.00 2.68 0.98 5.00
40 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87 5.00
41 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83 5.00
42 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77 5.00
43 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69 5.00
44 INT339794 Sstr2 Positive_regulation of Gene_expression of Sstr5 1 0.08 0.25 0.64 5.00
45 INT25248 GNRH1 Regulation of CGA 4 0.30 1.22 0.62 5.00
46 INT173555 TIMP1 Negative_regulation of MMP7 1 0.01 0 0.56 5.00
47 INT173556 TIMP1 Negative_regulation of MMP9 1 0.02 0 0.56 5.00
48 INT173557 TIMP1 Negative_regulation of MMP3 1 0.02 0 0.56 5.00
49 INT173554 TIMP1 Negative_regulation of MMP1 1 0.03 0 0.55 5.00
50 INT173553 TIMP1 Negative_regulation of MMP2 1 0.05 0 0.55 5.00
51 INT316546 Binding of GH1 and SST 2 0.03 0.55 0.54 5.00
52 INT173597 Negative_regulation of Binding of MMP2 and Mmp13 1 0.14 0.83 0.48 5.00
53 INT150391 Binding of MEFV and PYCARD 4 0.14 3 0.48 5.00
54 INT173595 Binding of MMP2 and Mmp13 1 0.12 0.83 0.48 5.00
55 INT173596 Binding of MMP3 and Mmp13 1 0.06 0.84 0.48 5.00
56 INT173598 Negative_regulation of Binding of MMP3 and Mmp13 1 0.06 0.84 0.48 5.00
57 INT311587 CXCL10 Regulation of Gene_expression of VEGFA 1 0.23 0.45 0.43 5.00
58 INT311590 EGF Regulation of Gene_expression of CXCL10 1 0.23 0.51 0.43 5.00
59 INT311589 EGF Regulation of Gene_expression of VEGFA 1 0.18 0.51 0.43 5.00
60 INT311591 CXCL10 Regulation of Gene_expression of EGF 1 0.23 0.51 0.43 5.00
61 INT329801 Binding of CAMP and IFNA1 1 0.03 1.48 0.4 5.00
62 INT329799 Binding of CD14 and LY96 2 0.04 1.02 0.39 5.00
63 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37 5.00
64 INT245328 Binding of Esr2 and Pgr 1 0.03 0.41 0.37 5.00
65 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37 5.00
66 INT317835 Nlrp3 Positive_regulation of Il18 1 0.08 1.49 0.31 5.00
67 INT182771 ROS1 Positive_regulation of NFKB1 Positive_regulation of CRP 1 0.00 3.83 0.28 5.00
68 INT177961 Binding of CCR3 and CCL11 1 0.04 0.73 0.26 5.00
69 INT317833 Nlrp3 Positive_regulation of Localization of Il1 1 0.06 1.38 0.26 5.00
70 INT177957 CCL11 Regulation of Binding of IL5 and CCL11 1 0.01 0.71 0.25 5.00
71 INT177960 Binding of IL5 and CCL11 1 0.03 0.71 0.25 5.00
72 INT325028 TNF Negative_regulation of Ptgs1 1 0.00 1.79 0.23 5.00
73 INT325008 TNF Negative_regulation of Gene_expression of NOSTRIN 1 0.00 1.78 0.23 5.00
74 INT325007 TNF Negative_regulation of NOSTRIN 1 0.00 1.78 0.23 5.00
75 INT173558 CTSK Positive_regulation of Protein_catabolism of COL5A2 1 0.00 0.53 0.22 5.00
76 INT317831 Binding of Mefv and Nlrx1 1 0.00 1.77 0.2 5.00
77 INT177962 IL4 Positive_regulation of VCAM1 1 0.02 0.97 0.2 5.00
78 INT287145 Binding of PNN and Shbg 1 0.07 0.14 0.18 5.00
79 INT329795 IL6 Positive_regulation of Transcription of CCL5 1 0.02 0.59 0.17 5.00
80 INT261577 Nos2 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.16 5.00
81 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16 5.00
82 INT173599 Binding of MMP1 and Mmp1a 1 0.06 0.5 0.15 5.00
83 INT329796 TICAM1 Positive_regulation of IFNA1 2 0.02 0.89 0.15 5.00
84 INT182772 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL1B 1 0.00 1.89 0.14 5.00
85 INT182773 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL6 1 0.00 1.9 0.14 5.00
86 INT182780 NFKB1 Positive_regulation of IL1B 1 0.00 1.8 0.14 5.00
87 INT257937 Binding of CSF2 and INVS 1 0.04 1.1 0.14 5.00
88 INT182782 NFKB1 Positive_regulation of IL6 1 0.00 1.8 0.14 5.00
89 INT274568 Binding of MEFV and PSTPIP2 1 0.45 0.61 0.13 5.00
90 INT315829 Binding of EGFR and TKT 1 0.03 1.14 0.12 5.00
91 INT329797 Positive_regulation of TLR2 Positive_regulation of Gene_expression of IL6 1 0.02 1.67 0.11 5.00
92 INT329802 Positive_regulation of TLR2 Regulation of Gene_expression of IL6 1 0.01 1.67 0.11 5.00
93 INT329798 Binding of MYD88 and TICAM1 2 0.01 0.24 0.1 5.00
94 INT316543 GH1 Regulation of Gene_expression of IGF1 1 0.03 1.32 0.09 5.00
95 INT249117 Binding of Abl1 and Bcr 4 0.36 2.22 0.09 5.00
96 INT346073 Binding of Alb and Shbg 1 0.00 0 0.09 5.00
97 INT316552 Binding of SST and Sst1 1 0.03 0.53 0.09 5.00
98 INT346074 Binding of Alb and Serpina6 1 0.00 0 0.09 5.00
99 INT251469 INS Negative_regulation of Gene_expression of SHBG 2 0.11 4.11 0.08 5.00
100 INT220697 Binding of CHRNE and DBP 1 0.02 1.15 0.08 5.00
101 INT213933 AR Negative_regulation of Cyp19a1 1 0.07 0.79 0.07 5.00
102 INT213261 TNF Positive_regulation of CRP 1 0.24 1.59 0.06 5.00
103 INT323043 Binding of CYP21A1P and HLA-DOA 1 0.04 1.48 0.06 5.00
104 INT323042 Binding of CYP21A2 and HLA-DOA 1 0.04 1.49 0.06 5.00
105 INT220698 Binding of CHRNE and SFTPA1 1 0.01 0.75 0.06 5.00
106 INT342887 Binding of IFNG and IFNGR1 1 0.02 0.65 0.05 5.00
107 INT342886 Binding of C3 and CD40 1 0.02 0.66 0.05 5.00
108 INT274553 MEFV Positive_regulation of Binding of PSTPIP1 and PYCARD 1 0.13 0.19 0.05 5.00
109 INT182775 Binding of PTH and ROS1 1 0.04 1.73 0.04 5.00
110 INT213263 INS Positive_regulation of EDN1 1 0.12 0.54 0.04 5.00
111 INT274574 MEFV Regulation of Localization of PSTPIP1 1 0.48 0.17 0.04 5.00
112 INT325027 Apoc3 Negative_regulation of Pnlip 1 0.01 1.02 0.04 5.00
113 INT274567 Positive_regulation of Binding of MEFV and PSTPIP1 1 0.46 0.22 0.04 5.00
114 INT274587 Binding of PSTPIP1 and BFAR 1 0.17 0.08 0.04 5.00
115 INT274585 Binding of PSTPIP1 and TRIP10 1 0.15 0.08 0.04 5.00
116 INT327162 Binding of SERPING1 and F12 1 0.05 0.29 0.04 5.00
117 INT274577 Binding of MEFV and SASH3 1 0.01 0.45 0.04 5.00
118 INT350121 INS Negative_regulation of Positive_regulation of SHBG 1 0.09 1.48 0.04 5.00
119 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04 5.00
120 INT274589 Binding of MEFV and Regulation of Localization of PSTPIP1 1 0.48 0.17 0.04 5.00
121 INT325026 Apoc3 Negative_regulation of Lpl 1 0.03 1.01 0.04 5.00
122 INT350118 INS Negative_regulation of SHBG 1 0.09 1.42 0.04 5.00
123 INT325025 Apoa2 Positive_regulation of Hdl1 1 0.05 1.03 0.04 5.00
124 INT185756 Binding of ITIH4 and Cd4 2 0.05 1.22 0.04 5.00
125 INT279632 Positive_regulation of Binding of Ar and Nr4a1 1 0.01 0.86 0.03 5.00
126 INT213262 IL6 Positive_regulation of CYP19A1 1 0.11 1.63 0.03 5.00
127 INT347165 Binding of NOTCH1 and PAX5 1 0.05 0.86 0.03 5.00
128 INT274588 Binding of PSTPIP1 and Positive_regulation of MEFV 1 0.46 0.05 0.03 5.00
129 INT279634 Binding of Ar and Nr4a1 1 0.01 0.85 0.03 5.00
130 INT274573 Positive_regulation of Binding of MEFV and PYCARD 1 0.09 0.06 0.03 5.00
131 INT347163 NOTCH1 Positive_regulation of MSC 1 0.03 0.85 0.03 5.00
132 INT274575 MEFV Regulation of PSTPIP1 1 0.42 0.2 0.03 5.00
133 INT347164 NOTCH1 Negative_regulation of Gene_expression of EBF1 1 0.03 0.85 0.03 5.00
134 INT274552 PSTPIP1 Positive_regulation of Binding of PSTPIP1 and PYCARD 1 0.13 0.06 0.03 5.00
135 INT274591 Binding of PSTPIP1 and SASH3 1 0.01 0 0 5.00
136 INT266925 Regulation of Binding of EGFR and ERBB2 1 0.26 0.5 0 5.00
137 INT182784 IGF1 Positive_regulation of Gene_expression of INS 1 0.02 1.87 0 5.00
138 INT194002 TRGC1 Negative_regulation of Mdk 1 0.00 0.14 0 5.00
139 INT288983 Binding of DEFB1 and HPR 1 0.01 0 0 5.00
140 INT347162 MDM2 Negative_regulation of TP53 1 0.02 1.09 0 5.00
141 INT182804 Binding of ETV3 and T2DM 1 0.10 2.62 0 5.00
142 INT327101 Binding of AREG and EGF 1 0.05 0.35 0 5.00
143 INT193971 TRGC1 Negative_regulation of Phosphorylation of MAPK1 1 0.01 0.14 0 5.00
144 INT193973 TRGC1 Negative_regulation of Positive_regulation of MAPK1 1 0.01 0.09 0 5.00
145 INT270759 Binding of HSD11B1 and TERT 1 0.07 1.67 0 5.00
146 INT288982 Binding of CD79A and SFTPA2 1 0.00 0.06 0 5.00
147 INT194003 MAPK1 Regulation of Positive_regulation of Akt1 1 0.01 0 0 5.00
148 INT331909 Binding of ALB and SPARC 1 0.06 2.01 0 5.00
149 INT182778 IGF1 Positive_regulation of Gene_expression of ETV3 1 0.03 1.89 0 5.00
150 INT256400 GLP1R Positive_regulation of Localization of GCG 1 0.02 0.15 0 5.00
151 INT288981 Binding of DEFB1 and PTPN22 1 0.11 0 0 5.00
152 INT193972 SPANXB1 Positive_regulation of Positive_regulation of MAPK1 1 0.01 0 0 5.00
153 INT274623 Binding of TRIP10 and Amph 1 0.17 0 0 5.00
154 INT274586 Binding of TRIP10 and BFAR 1 0.06 0 0 5.00
155 INT274570 Binding of MEFV and Regulation of BFAR 1 0.09 0.05 0 5.00
156 INT327100 Binding of BTC and EGF 1 0.04 0.35 0 5.00
157 INT213264 INS Positive_regulation of Localization of IGF1 1 0.16 1.77 0 5.00
158 INT182774 Binding of ETV3 and SAE1 1 0.00 1.17 0 5.00
159 INT182783 INS Positive_regulation of Gene_expression of ETV3 1 0.01 1.89 0 5.00
160 INT177958 IGHE Positive_regulation of TNF 1 0.03 2.23 0 5.00
161 INT182777 IAPP Positive_regulation of Gene_expression of ETV3 1 0.06 1.88 0 5.00
162 INT279635 Ar Regulation of Abpe 1 0.01 1.55 0 5.00
163 INT274576 MEFV Positive_regulation of PSTPIP1 1 0.46 0 0 5.00
164 INT277803 Regulation of GNRH1 Regulation of CGA 1 0.00 0.61 0 5.00
165 INT327099 Binding of EGF and EREG 1 0.05 0.35 0 5.00
166 INT274590 Positive_regulation of Binding of MEFV and SASH3 1 0.01 0.27 0 5.00
167 INT277766 EGFR Regulation of Gene_expression of VEGFA 1 0.54 0.14 0 5.00
168 INT274622 Binding of CLIP1 and Amph 1 0.40 0 0 5.00
169 INT177959 Positive_regulation of IGHE Positive_regulation of TNF 1 0.03 2.23 0 5.00
170 INT279633 Binding of Ar and Abpe 1 0.01 0.99 0 5.00
171 INT288984 DEFB1 Positive_regulation of GGH 1 0.01 0 0 5.00
172 INT274581 Binding of CLIP1 and BFAR 1 0.15 0 0 5.00
173 INT182776 IAPP Positive_regulation of Gene_expression of INS 1 0.03 1.87 0 5.00
174 INT277772 Binding of EGFR and fc 1 0.01 0.57 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Acne. They are ordered first by their pain relevance and then by number of times they were reported in Acne. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 99.98
2 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26 99.98
3 INT2606 Localization of NEU1 10 0.41 4.6 1.82 99.98
4 INT14450 Binding of NEU1 7 0.14 5.1 0.5 99.88
5 INT49238 Protein_catabolism of COL1A2 30 0.97 15.64 3.45 99.84
6 INT63550 Positive_regulation of Protein_catabolism of COL1A2 4 0.25 3.22 0.38 99.84
7 INT45208 Regulation of NEU1 2 0.10 3.79 0.58 99.82
8 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 99.80
9 INT274601 Regulation of PSTPIP1 3 0.45 3.76 0.28 99.80
10 INT221131 Localization of Tlr2 17 0.80 13.82 1.28 99.78
11 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 99.68
12 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 99.66
13 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 99.66
14 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 99.66
15 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 99.66
16 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9 99.66
17 INT12339 Localization of IL8 437 0.81 251.87 117.39 99.64
18 INT215107 Gene_expression of Spir1 17 0.50 10.38 0.25 99.64
19 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55 99.60
20 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 99.60
21 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34 99.60
22 INT150540 Binding of TLR2 50 0.45 35.86 10.43 99.42
23 INT287144 Negative_regulation of Gene_expression of PNN 1 0.17 0.82 0.12 99.36
24 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 99.32
25 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 99.12
26 INT222205 Positive_regulation of PSTPIP1 8 0.69 4.69 0.62 99.12
27 INT136271 Gene_expression of PNN 9 0.63 5.44 1 99.08
28 INT97138 Positive_regulation of Gene_expression of CD14 17 0.48 9.07 3.35 99.04
29 INT133030 Positive_regulation of Gene_expression of TLR2 53 0.65 38.15 10.65 99.04
30 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 98.98
31 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 98.98
32 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 98.92
33 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 98.92
34 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 98.92
35 INT118585 Binding of PNN 6 0.25 2.47 0.56 98.80
36 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 98.74
37 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 98.70
38 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65 98.68
39 INT51757 Gene_expression of COBRA1 4 0.51 2.71 0.75 98.64
40 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 98.52
41 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 98.44
42 INT80419 Gene_expression of Kdm5d 50 0.62 22.49 6.1 98.40
43 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 98.40
44 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 98.38
45 INT58875 Positive_regulation of FGD1 20 0.60 3.88 4.19 98.16
46 INT17493 Binding of Ar 14 0.48 3.62 0.6 98.16
47 INT15982 Positive_regulation of NLRP3 25 0.65 23.19 3.57 98.08
48 INT45878 Gene_expression of NEU1 14 0.65 7.28 0.47 98.00
49 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 98.00
50 INT230429 Positive_regulation of Gene_expression of SHE 8 0.26 2.75 0.72 98.00
51 INT180531 Positive_regulation of Positive_regulation of TLR2 4 0.32 4.28 0.62 97.98
52 INT131619 Positive_regulation of Positive_regulation of Dgat1 1 0.13 0.41 0.21 97.92
53 INT107107 Gene_expression of DEFA1 4 0.01 3.37 1 97.84
54 INT123142 Gene_expression of DEFB4A 54 0.76 36.14 10.02 97.84
55 INT266354 Gene_expression of S100A7 9 0.58 7.35 0.75 97.84
56 INT329817 Gene_expression of DEFB103B 1 0.01 1.18 0.43 97.84
57 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09 97.80
58 INT152730 Positive_regulation of S100a8 48 0.68 47.67 15.4 97.80
59 INT75833 Negative_regulation of Positive_regulation of IL8 15 0.53 6.69 5.59 97.76
60 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 97.76
61 INT172677 Gene_expression of SHE 65 0.59 25.86 3.85 97.72
62 INT137206 Positive_regulation of TLR2 47 0.65 33.36 6.4 97.62
63 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 97.60
64 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 97.60
65 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 97.60
66 INT320644 Binding of Egfr 7 0.34 5.9 0.56 97.50
67 INT52106 Negative_regulation of Localization of IL8 57 0.52 22.81 20.8 97.28
68 INT294788 Regulation of Positive_regulation of TLR2 2 0.36 1.41 0.21 97.18
69 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 97.16
70 INT16622 Positive_regulation of PLXNA3 6 0.67 5.2 1.69 97.02
71 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 96.88
72 INT99289 Localization of STS 8 0.79 6.5 0.92 96.84
73 INT131620 Positive_regulation of Dgat1 1 0.18 0.4 0.2 96.12
74 INT223597 Negative_regulation of Binding of EGFR 12 0.43 7.97 0.23 96.12
75 INT52899 Positive_regulation of TNFRSF1A 16 0.46 19.04 3.34 96.04
76 INT16616 Negative_regulation of SRD5A1 44 0.57 34.81 2.96 96.00
77 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 95.76
78 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 95.76
79 INT32688 Positive_regulation of Gene_expression of Shbg 14 0.45 7.01 1.6 95.76
80 INT11154 Binding of EGFR 149 0.48 96.23 6.29 95.76
81 INT6849 Localization of IL1B 229 0.81 112.56 69.63 95.76
82 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63 95.76
83 INT14448 Localization of COL5A2 34 0.67 17.35 2.85 95.76
84 INT52962 Binding of ERBB2 77 0.47 50.03 1.49 95.76
85 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 95.72
86 INT149669 Positive_regulation of MEFV 12 0.46 14.17 2.07 95.64
87 INT1530 Regulation of Gh 382 0.61 115.96 112.47 95.60
88 INT180264 Positive_regulation of BCC1 11 0.59 12.81 0.2 95.44
89 INT97598 Negative_regulation of Localization of S100a8 8 0.42 6.52 4.31 95.36
90 INT45230 Regulation of CD79A 20 0.44 9.3 1.59 95.32
91 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 95.20
92 INT46383 Negative_regulation of TRGC1 42 0.55 44.03 6.2 95.04
93 INT62061 Gene_expression of TRGC1 32 0.69 17.43 3.37 95.04
94 INT221132 Positive_regulation of Localization of Cxcl2 4 0.44 3.39 0.64 94.92
95 INT117465 Positive_regulation of Localization of S100a8 8 0.42 10.04 3.89 94.92
96 INT287 Localization of Cck 518 0.81 86.84 364.04 94.72
97 INT195206 Binding of BCC1 15 0.41 21.3 0.62 94.68
98 INT87823 Positive_regulation of Cxcl2 51 0.66 35.47 14.79 94.64
99 INT117147 Negative_regulation of Gene_expression of Cxcl2 19 0.55 15.33 6.57 94.64
100 INT104388 Positive_regulation of Gene_expression of Cxcl2 31 0.66 25.68 7.49 94.64
101 INT59194 Gene_expression of STS 18 0.59 6.74 1.89 94.64
102 INT17686 Negative_regulation of Hdl1 72 0.36 81.85 7.74 94.20
103 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 94.20
104 INT3128 Negative_regulation of PON1 30 0.59 26.19 4.57 94.00
105 INT123890 Localization of Cxcl2 11 0.67 8.03 3.65 93.72
106 INT97596 Localization of S100a8 94 0.78 90.69 40.41 93.72
107 INT5135 Negative_regulation of GNRH1 106 0.58 36.63 27.71 92.72
108 INT9884 Localization of CD79A 41 0.78 21.75 3.06 92.56
109 INT133172 Gene_expression of Il12b 98 0.75 52.16 10.68 92.24
110 INT177438 Negative_regulation of GNRHR 3 0.18 3.39 0.4 92.24
111 INT1941 Binding of PSTPIP1 36 0.48 5.92 1.16 92.04
112 INT19775 Localization of Il1 183 0.78 145.5 50.91 91.92
113 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 91.88
114 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 91.84
115 INT119506 Negative_regulation of Egfr 32 0.55 23.75 3.67 91.72
116 INT159248 Positive_regulation of Binding of MEFV 2 0.46 2.54 0.2 91.72
117 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 91.52
118 INT44419 Transcription of CD79A 5 0.67 3.83 0.6 91.40
119 INT150395 Binding of MEFV 55 0.44 31.18 3.42 91.40
120 INT341687 Negative_regulation of PNN 1 0.35 1.98 0.33 91.12
121 INT221134 Positive_regulation of NEU1 1 0.19 2.51 0.11 90.92
122 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 90.88
123 INT17049 Localization of CD4 57 0.75 35.33 6.89 90.76
124 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 90.48
125 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35 90.32
126 INT164418 Protein_catabolism of CSH1 2 0.75 1.41 0.08 90.24
127 INT334555 Positive_regulation of Protein_catabolism of CSH1 1 0.04 0.48 0 90.24
128 INT65305 Gene_expression of MC2R 6 0.22 2.44 1.58 89.96
129 INT92383 Gene_expression of KRAS 38 0.65 32.94 1.32 89.68
130 INT107541 Positive_regulation of MSD 7 0.43 5.41 1.45 89.60
131 INT4395 Positive_regulation of CSH1 20 0.50 6.27 1.52 89.56
132 INT346948 Negative_regulation of OASD 1 0.04 0.97 0.2 89.56
133 INT10763 Localization of IL2 157 0.80 81.11 33.21 89.36
134 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 88.96
135 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 88.96
136 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 88.96
137 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 88.92
138 INT18857 Negative_regulation of Positive_regulation of Cck 8 0.59 2.62 5.06 88.88
139 INT284764 Positive_regulation of Transcription of BCC1 1 0.42 1.58 0 88.88
140 INT284767 Transcription of BCC1 1 0.57 1.58 0 88.88
141 INT213275 Positive_regulation of Gene_expression of SHBG 6 0.46 4.24 0.19 88.72
142 INT276437 Binding of Spir1 4 0.12 6.56 0 88.60
143 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 88.48
144 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 88.40
145 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 88.40
146 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 88.36
147 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 88.28
148 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 88.04
149 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 87.84
150 INT111533 Positive_regulation of Gene_expression of Nfkb1 27 0.52 17.32 7.89 87.84
151 INT88873 Negative_regulation of Gene_expression of Nfkb1 24 0.56 9.93 5.97 87.84
152 INT68496 Binding of PGR 26 0.48 16.36 2.09 87.76
153 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 87.64
154 INT34777 Localization of IGF1 82 0.80 42.68 8.62 87.64
155 INT194479 Phosphorylation of Ppara 47 0.81 30.36 6.6 87.60
156 INT2365 Positive_regulation of Cck 354 0.70 87.8 277.41 87.56
157 INT34184 Localization of FGD1 7 0.65 2.68 4.21 87.48
158 INT167856 Gene_expression of Nfasc 74 0.71 39.29 23.64 87.36
159 INT4146 Binding of SHBG 49 0.47 31 4.71 87.32
160 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 87.32
161 INT62400 Positive_regulation of Localization of Il1 34 0.67 35.53 7.96 87.24
162 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 86.92
163 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 86.68
164 INT1893 Localization of Gh 1041 0.79 340.23 256.58 86.24
165 INT274612 Phosphorylation of KPTN 1 0.02 1.25 0.18 85.76
166 INT17492 Negative_regulation of Binding of Ar 3 0.59 0.76 0.28 85.44
167 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 85.32
168 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 85.32
169 INT323215 Regulation of Binding of ZC3H15 1 0.03 0.99 0 85.04
170 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 84.96
171 INT125829 Binding of VAC14 2 0.31 2.02 0.38 84.84
172 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 84.60
173 INT287143 Regulation of SKP1 2 0.04 0.84 0.34 84.08
174 INT3925 Negative_regulation of HLA-B 29 0.42 20.19 9.46 84.08
175 INT323217 Binding of ZC3H15 1 0.03 0.98 0 84.04
176 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34 83.96
177 INT2055 Regulation of Gnrh1 185 0.62 23.65 71.26 83.92
178 INT6133 Negative_regulation of Serpinc1 56 0.58 42.8 8.35 83.84
179 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 83.76
180 INT21156 Binding of PLXNA3 21 0.36 7.95 3.3 83.60
181 INT61714 Binding of FGD1 12 0.35 7.72 2.91 83.60
182 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55 83.60
183 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 83.32
184 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14 83.32
185 INT16478 Positive_regulation of Plg 29 0.45 18.07 4.07 83.16
186 INT1512 Binding of Prl 73 0.48 26.22 20.63 83.12
187 INT2972 Negative_regulation of Olfr525 3 0.36 0.95 1.2 82.80
188 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 82.44
189 INT146914 Negative_regulation of TLR2 12 0.53 7.41 1.23 82.32
190 INT181848 Negative_regulation of CD14 16 0.43 8.14 2.95 81.92
191 INT242895 Negative_regulation of Gene_expression of TLR1 3 0.38 0.95 0.34 81.56
192 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67 81.32
193 INT912 Localization of FSHR 91 0.79 23.61 15.58 81.04
194 INT144481 Gene_expression of SERPING1 55 0.77 50.4 4.75 80.96
195 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 80.96
196 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 80.36
197 INT148210 Positive_regulation of Positive_regulation of SHBG 3 0.45 1.89 0.18 80.32
198 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 80.28
199 INT222903 Gene_expression of TLR1 20 0.60 8.77 1.9 80.12
200 INT230965 Positive_regulation of AREG 4 0.24 2.48 0.15 79.76
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