D:Acth-secreting Pituitary Adenoma

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Disease Term
Synonyms Acth Producing Pituitary Adenoma, Acth Producing Pituitary Adenomas, Acth Secreting Pituitary Adenoma, ACTH SECRETING PITUITARY ADENOMAS, Adenoma Corticotroph, Adenomas Corticotroph, Corticotroph Adenoma, Corticotroph Adenomas, Corticotropin Secreting Adenoma Pituitary, Corticotropin Secreting Adenomas Pituitary, Pituitary Adenoma Acth Producing
Documents 11
Hot Single Events 39
Hot Interactions 7

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Acth-secreting Pituitary Adenoma. They are ordered first by their relevance to Acth-secreting Pituitary Adenoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT12521 Binding of PLOD1 and POMC 1 0.26 1.96 0.17 90.80
2 INT12524 Binding of LHB and POMC 1 0.12 1.96 0.17 90.48
3 INT12523 Binding of FSHR and LHB 1 0.11 0.98 0.09 90.48
4 INT12522 Binding of FSHR and POMC 1 0.33 3.89 0.34 88.48
5 INT12520 Binding of FSHR and GANAB 1 0.03 0.97 0.09 88.48
6 INT316552 Binding of SST and Sst1 1 0.03 0.53 0.09 85.00
7 INT12525 Binding of POMC and GANAB 1 0.04 1.9 0.17 81.68
8 INT243467 PCSK1 Positive_regulation of POMC 1 0.08 1.62 0 77.04
9 INT339794 Sstr2 Positive_regulation of Gene_expression of Sstr5 1 0.08 0.25 0.64 71.52
10 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69 23.24
11 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77 5.00
12 INT316546 Binding of GH1 and SST 2 0.03 0.55 0.54 5.00
13 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37 5.00
14 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37 5.00
15 INT243468 Binding of SSTR1 and SSTR5 1 0.05 0.99 0.1 5.00
16 INT243465 Binding of GH1 and GOPC 1 0.02 0.99 0.09 5.00
17 INT316543 GH1 Regulation of Gene_expression of IGF1 1 0.03 1.32 0.09 5.00
18 INT243466 POU1F1 Regulation of GH1 1 0.11 1.26 0.08 5.00
19 INT243464 POU1F1 Regulation of PRL 1 0.28 1.26 0.08 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Acth-secreting Pituitary Adenoma. They are ordered first by their pain relevance and then by number of times they were reported in Acth-secreting Pituitary Adenoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT27266 Regulation of Gene_expression of Pomc 41 0.62 6.74 14.59 100.00
2 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61 99.98
3 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 99.88
4 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09 99.76
5 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 99.58
6 INT443 Localization of POMC 1020 0.81 284.52 443.17 99.32
7 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8 99.00
8 INT1438 Localization of Pomc 360 0.81 101.26 116.47 98.20
9 INT11628 Regulation of Localization of Pomc 44 0.61 10.46 18.66 98.20
10 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02 97.52
11 INT920 Localization of PLOD1 223 0.81 42.25 78.7 97.20
12 INT917 Positive_regulation of Localization of PLOD1 51 0.69 8.53 22.87 97.20
13 INT912 Localization of FSHR 91 0.79 23.61 15.58 97.16
14 INT12531 Localization of GANAB 3 0.09 2.79 0.26 97.16
15 INT923 Positive_regulation of Localization of FSHR 14 0.43 2.48 4.96 96.56
16 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 96.40
17 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 96.40
18 INT12526 Positive_regulation of Localization of GANAB 1 0.05 0.88 0.07 96.16
19 INT1893 Localization of Gh 1041 0.79 340.23 256.58 96.00
20 INT691 Binding of SST 67 0.48 24.66 32.67 94.60
21 INT102064 Binding of Sstr5 3 0.20 0.86 1.55 92.80
22 INT278006 Binding of Sstr3 2 0.33 1.07 0.71 92.40
23 INT173236 Binding of Sstr2 8 0.25 1.64 2.41 92.16
24 INT316547 Binding of Sst1 2 0.10 0.84 0.74 91.92
25 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 91.88
26 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 91.52
27 INT335719 Positive_regulation of Gene_expression of DIO2 3 0.23 0.59 0.61 90.92
28 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 90.80
29 INT4147 Gene_expression of LHB 8 0.49 3.94 2.88 90.48
30 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 88.48
31 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 87.88
32 INT1436 Negative_regulation of Localization of Pomc 41 0.58 10.85 11.26 86.60
33 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 85.84
34 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 84.92
35 INT61363 Positive_regulation of TFAM 43 0.69 26.43 8.14 83.80
36 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97 83.04
37 INT6019 Positive_regulation of NEUROD1 37 0.67 17.3 8.89 82.96
38 INT15347 Positive_regulation of Localization of Pomc 81 0.70 28.1 31.01 81.28
39 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 80.80
40 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 79.20
41 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 77.92
42 INT31780 Binding of DIO2 17 0.36 10.07 10 73.76
43 INT26751 Regulation of Nr3c1 13 0.61 6.58 8.65 72.68
44 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 72.56
45 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 72.56
46 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86 72.56
47 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 72.56
48 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 72.00
49 INT76428 Gene_expression of Sstr2 24 0.76 6.09 12.32 71.52
50 INT149451 Gene_expression of Sstr5 3 0.39 1.5 2.24 71.52
51 INT339791 Negative_regulation of Gene_expression of Sstr2 1 0.14 0.25 0.63 71.52
52 INT325236 Positive_regulation of Localization of Sstr2 2 0.25 0.81 0.22 71.32
53 INT123802 Localization of Sstr2 8 0.80 3.54 3.01 70.80
54 INT173238 Negative_regulation of Sstr2 2 0.16 0.68 0.34 70.80
55 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 64.40
56 INT11288 Negative_regulation of CRH 44 0.00 16.69 12.37 63.96
57 INT5455 Negative_regulation of Localization of CRH 16 0.49 7.31 6.41 63.96
58 INT5454 Localization of CRH 124 0.79 79.18 41.53 63.40
59 INT20922 Positive_regulation of Localization of CRH 18 0.67 11.12 6.79 63.40
60 INT1530 Regulation of Gh 382 0.61 115.96 112.47 61.92
61 INT425 Localization of PRL 455 0.81 189.64 144.8 57.32
62 INT8740 Localization of Gcg 65 0.78 19 9.81 55.92
63 INT8744 Regulation of Localization of Gcg 14 0.60 2.06 4.3 55.92
64 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 55.00
65 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 51.68
66 INT252 Localization of GH1 529 0.80 227.4 122.05 27.32
67 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 22.64
68 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 19.60
69 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 19.60
70 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 19.24
71 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 18.40
72 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69 18.40
73 INT440 Regulation of Gene_expression of Crh 44 0.62 17.71 20.73 16.48
74 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 12.00
75 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 9.84
76 INT1562 Localization of Crh 499 0.81 126.74 236.68 5.00
77 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 5.00
78 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
79 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 5.00
80 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
81 INT462 Regulation of Pomc 157 0.62 41.67 67.27 5.00
82 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
83 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
84 INT249 Localization of GHRH 215 0.80 78.02 51.87 5.00
85 INT921 Regulation of GH1 172 0.60 52.88 51.04 5.00
86 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 5.00
87 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 5.00
88 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
89 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 5.00
90 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 5.00
91 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
92 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58 5.00
93 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 5.00
94 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
95 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
96 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
97 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 5.00
98 INT6278 Negative_regulation of Gene_expression of Pomc 35 0.59 11.07 14.8 5.00
99 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 5.00
100 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
101 INT91774 Gene_expression of Nr3c1 27 0.78 16.14 10.7 5.00
102 INT34777 Localization of IGF1 82 0.80 42.68 8.62 5.00
103 INT12292 Negative_regulation of Positive_regulation of GH1 22 0.58 5.02 8.28 5.00
104 INT110599 Gene_expression of Bglap 49 0.74 41.23 6.97 5.00
105 INT28861 Binding of Gh 61 0.46 25.61 6.38 5.00
106 INT9683 Binding of GH1 57 0.47 21.14 5.99 5.00
107 INT120335 Gene_expression of SNAP25 24 0.65 9.44 5.83 5.00
108 INT67195 Negative_regulation of Gene_expression of SST 7 0.42 6.98 4.88 5.00
109 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61 5.00
110 INT6021 Binding of PRL 18 0.48 12.55 4.3 5.00
111 INT140542 Gene_expression of SSTR2 18 0.65 13.58 3.94 5.00
112 INT14930 Regulation of Gene_expression of SST 12 0.45 6.86 3.89 5.00
113 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 5.00
114 INT131165 Positive_regulation of Gene_expression of Nr3c1 8 0.70 7.18 3.44 5.00
115 INT155983 Gene_expression of Cyp11a1 7 0.58 2.6 3.38 5.00
116 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05 5.00
117 INT15606 Localization of FSHB 24 0.78 9.16 2.49 5.00
118 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45 5.00
119 INT27644 Gene_expression of BRD2 23 0.65 6.97 2.23 5.00
120 INT49769 Binding of SSTR2 4 0.48 1.39 2.14 5.00
121 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94 5.00
122 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 5.00
123 INT23491 Positive_regulation of FSHB 14 0.65 7.2 1.79 5.00
124 INT184303 Positive_regulation of Bglap 16 0.66 8.66 1.25 5.00
125 INT243480 Gene_expression of SSTR5 1 0.55 4.25 0.85 5.00
126 INT243477 Binding of SSTR1 3 0.26 3.49 0.65 5.00
127 INT173234 Gene_expression of Sst1 2 0.14 0.88 0.63 5.00
128 INT243481 Gene_expression of GATA2 3 0.50 3.34 0.62 5.00
129 INT112327 Positive_regulation of Gene_expression of FSHB 5 0.44 3.64 0.39 5.00
130 INT211968 Localization of Best1 11 0.40 9.33 0.38 5.00
131 INT163151 Gene_expression of POU1F1 2 0.53 3.08 0.16 5.00
132 INT243478 Binding of SSTR5 1 0.29 0.99 0.1 5.00
133 INT243479 Phosphorylation of FSHB 1 0.17 1.43 0 5.00
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