D:Acute-phase Reaction

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Disease Term
Synonyms Acute Phase Reaction, Acute Phase Response, Acute Phase State, Reaction Acute Phase, Response Acute Phase, State Acute Phase
Documents 239
Hot Single Events 200
Hot Interactions 49

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Acute-phase Reaction. They are ordered first by their relevance to Acute-phase Reaction and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT269057 Il6 Positive_regulation of Crp 1 0.37 1.83 0.51 100.00
2 INT267623 IL6 Positive_regulation of Crp 1 0.00 1.6 0.24 100.00
3 INT248271 IL6 Regulation of Gene_expression of Crp 3 0.27 1.7 0.73 100.00
4 INT295268 S100a8 Positive_regulation of Stat3 1 0.00 0.5 0.18 100.00
5 INT346196 AMELX Negative_regulation of CRP 1 0.04 0.36 0.26 99.86
6 INT346195 AMELX Negative_regulation of ESR1 1 0.02 0.36 0.26 99.86
7 INT284300 Tlr4 Positive_regulation of Gene_expression of Mir155 1 0.18 0.91 0.47 98.80
8 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95 98.28
9 INT343853 IRF6 Positive_regulation of PECAM1 1 0.00 0.53 0.43 98.28
10 INT284299 Adrb3 Positive_regulation of Gene_expression of Mir155 1 0.01 0.51 0.24 98.24
11 INT204893 Regulation of Tlr4 Positive_regulation of gr 1 0.11 0.9 0.38 97.76
12 INT204905 Tlr4 Positive_regulation of gr 1 0.18 0.9 0.38 97.76
13 INT64717 Pomc Positive_regulation of Il6 1 0.13 0.19 0.9 97.24
14 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4 96.80
15 INT300779 STAT3 Positive_regulation of CRP 1 0.41 0.62 0.26 96.76
16 INT300778 STAT3 Positive_regulation of Transcription of CRP 1 0.38 0.62 0.26 96.76
17 INT269061 Binding of Il6 and Il6ra 3 0.04 2.59 0.45 96.60
18 INT269066 Binding of Hspa8 and Il6 1 0.00 0.74 0.23 96.60
19 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36 96.50
20 INT275562 Il1 Regulation of Gene_expression of Cxcl2 1 0.02 1.41 0.64 95.72
21 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09 95.28
22 INT57981 Regulation of Il1b Positive_regulation of Crh 1 0.22 0.1 0.44 95.28
23 INT284570 Binding of Avp and Il6 1 0.04 2.17 0.13 94.76
24 INT284306 Tlr4 Positive_regulation of Adrb3 1 0.00 1.19 0.74 93.84
25 INT71525 Oprd1 Regulation of Il6 1 0.16 0.19 0.6 93.72
26 INT66257 Negative_regulation of Ptgs1 Positive_regulation of Gene_expression of Tnf 1 0.03 0.44 0.25 93.60
27 INT298638 IL6 Positive_regulation of IL6R 1 0.00 0.9 0.05 93.04
28 INT57983 Il1b Regulation of Crh 1 0.37 0.09 0.44 92.92
29 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41 92.56
30 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09 92.56
31 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53 92.20
32 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05 91.36
33 INT277832 Binding of TNFRSF1B and NPEPPS 1 0.01 1.1 0.88 90.52
34 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87 90.52
35 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56 89.68
36 INT220902 Binding of C4b and C4bp 1 0.45 1.02 0 89.16
37 INT117203 Binding of IL1B and IL6 2 0.20 1.4 0.51 89.04
38 INT172825 Binding of Crp and T2dm2 1 0.00 4.5 0.62 89.00
39 INT183698 Binding of Cxcr2 and Cxcl1 3 0.33 3.26 0.76 88.28
40 INT172822 Binding of Fga and T2dm2 1 0.01 2.24 0.31 87.92
41 INT284297 Mir155 Positive_regulation of Adrb3 1 0.01 0.51 0.24 87.60
42 INT35172 IL2 Positive_regulation of Gene_expression of IFNG 1 0.01 0.27 0.04 87.08
43 INT267585 TNF Regulation of IL6 2 0.16 2.44 0.37 86.92
44 INT220907 Binding of C4bp and Cfb 1 0.08 0.52 0 85.04
45 INT94745 Tlr4 Positive_regulation of Transcription of Il1b 1 0.15 0.48 0.56 84.56
46 INT317895 Fos Regulation of Transcription of Egr1 1 0.41 1.03 0.17 84.36
47 INT317897 Egr1 Regulation of Transcription of Fosb 1 0.34 1.08 0.17 84.36
48 INT317889 Fos Regulation of Transcription of Fosb 1 0.30 1.08 0.17 84.36
49 INT317892 Egr1 Regulation of Transcription of Fos 1 0.41 1.03 0.17 84.36
50 INT269071 Binding of IL6 and Il6 1 0.40 0.73 0.19 78.24
51 INT71527 Negative_regulation of OPRD1 Negative_regulation of Positive_regulation of Il6 1 0.00 0.15 0.62 77.68
52 INT172829 Binding of Nfkb1 and ISYNA1 1 0.00 2.06 0.17 76.84
53 INT172820 Binding of Nfkb1 and T2dm2 1 0.00 2.14 0.17 76.84
54 INT267592 IL6 Positive_regulation of Localization of MUC1 1 0.00 1.24 0.07 76.08
55 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65 75.68
56 INT343834 Binding of CD14 and IRF6 1 0.02 2.08 0.9 75.68
57 INT343844 Binding of IRF6 and LY96 1 0.01 1.03 0.4 75.68
58 INT114754 Il6 Positive_regulation of Gene_expression of Crp 2 0.08 1.67 0.47 75.00
59 INT114755 Il6 Positive_regulation of Crp 1 0.08 0.41 0.35 75.00
60 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03 74.08
61 INT329799 Binding of CD14 and LY96 2 0.04 1.02 0.39 74.08
62 INT172837 ROS1 Positive_regulation of Nfkb1 1 0.00 2.11 0.16 71.44
63 INT172827 ROS1 Positive_regulation of Tnf 1 0.01 2.1 0.16 70.88
64 INT71526 Regulation of Il1b Positive_regulation of Il6 1 0.17 0.14 0.62 69.36
65 INT343916 Hspa1a Positive_regulation of Gene_expression of TNF 1 0.16 1.17 0.41 68.12
66 INT343919 Hspa1a Positive_regulation of Gene_expression of IL6 1 0.02 1.17 0.4 68.12
67 INT343907 Hspa1a Positive_regulation of Gene_expression of Cxcl2 1 0.01 1.17 0.4 68.12
68 INT8677 Binding of F8 and ANGPTL5 1 0.03 0.48 0.1 61.36
69 INT8676 Positive_regulation of Binding of F8 and ANGPTL5 1 0.04 0.48 0.1 61.36
70 INT8673 Binding of F2 and F8 1 0.08 0.48 0.1 61.36
71 INT8672 Positive_regulation of Binding of F2 and F8 1 0.11 0.48 0.1 61.36
72 INT212526 Binding of PROC and Apcs 1 0.01 2.54 0 60.68
73 INT8674 Positive_regulation of Binding of F3 and ANGPTL5 1 0.06 0.48 0.09 60.32
74 INT8678 Binding of F3 and ANGPTL5 1 0.04 0.48 0.09 60.32
75 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28 58.80
76 INT8675 Positive_regulation of Binding of F2 and F3 2 0.17 0.43 0.09 58.24
77 INT8671 Binding of F2 and F3 2 0.13 0.42 0.09 58.24
78 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27 57.68
79 INT274531 Il6 Regulation of Localization of Lpl 1 0.04 1.49 0.33 54.72
80 INT274530 Il6 Regulation of Lpl 1 0.07 1.48 0.32 54.72
81 INT57787 Binding of PLG and SGCG 1 0.02 0.13 0.03 54.40
82 INT284307 Mir155 Regulation of Adrb3 1 0.00 3.44 0.73 48.68
83 INT327382 Oxt Positive_regulation of Positive_regulation of Oxtr 1 0.30 0.41 0.2 48.32
84 INT329722 Binding of Il10rb and Il10 1 0.00 0.79 0.51 46.32
85 INT329721 Positive_regulation of Binding of Il10rb and Il10 1 0.00 0.79 0.51 46.32
86 INT284308 Mir155 Regulation of Gene_expression of Csf3 1 0.36 0.8 0.36 44.12
87 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 40.28
88 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 40.28
89 INT297424 Gene_expression of Stat6 Regulation of Ppara 1 0.17 1.19 0.38 37.36
90 INT297426 Stat6 Regulation of Ppara 1 0.17 1.19 0.38 37.36
91 INT297423 Gene_expression of Il4 Regulation of Ppara 1 0.07 1.19 0.38 37.12
92 INT220903 Regulation of Binding of Crp and Cd40 1 0.05 0.37 0.05 36.24
93 INT220906 Binding of Crp and Cd40 1 0.04 0.37 0.05 36.24
94 INT220901 Regulation of Binding of Saa1 and Cd40 1 0.04 0.36 0 36.24
95 INT220908 Binding of Saa1 and Cd40 1 0.04 0.36 0 36.24
96 INT297425 Il4 Regulation of Ppara 1 0.07 1.17 0.38 35.80
97 INT57794 Binding of PLAT and Plg 1 0.00 0.15 0 31.60
98 INT295478 IRF6 Positive_regulation of Positive_regulation of TLR4 2 0.20 0.78 0.39 30.80
99 INT284305 Mir155 Regulation of Csf3 1 0.19 0.29 0.18 30.16
100 INT15685 Binding of PLAT and Serpine1 3 0.36 1.01 0.31 25.00
101 INT57788 Hrg Regulation of Binding of F13A1 and Plg 1 0.00 0.07 0 25.00
102 INT57792 Binding of Plg and Plat 1 0.00 0.07 0 25.00
103 INT57791 Binding of Serpine1 and Plat 1 0.00 0.07 0 25.00
104 INT57795 Binding of F13A1 and Plg 1 0.00 0.07 0 25.00
105 INT297427 Flg Positive_regulation of Gene_expression of Il13 1 0.11 1.2 0.3 24.72
106 INT297428 Lvs Positive_regulation of Gene_expression of Il13 1 0.06 1.2 0.3 24.60
107 INT297422 Lvs Positive_regulation of Gene_expression of Il4 1 0.04 1.2 0.3 24.60
108 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32 18.60
109 INT343847 IRF6 Positive_regulation of TBCE 1 0.01 1.11 0.87 18.60
110 INT222022 Binding of Mmp8 and Mmp9 1 0.28 1.98 0.15 16.08
111 INT187468 Alms1 Positive_regulation of H2-D1 1 0.02 0.32 0.11 13.84
112 INT343829 TLR1 Positive_regulation of TBCE 1 0.03 0.96 0.85 13.12
113 INT316689 Gene_expression of Cd14 Negative_regulation of Gene_expression of Il1 1 0.09 1.31 0.35 6.60
114 INT316691 Negative_regulation of Cd14 Negative_regulation of Gene_expression of Il1 1 0.09 1.31 0.35 6.60
115 INT249347 Binding of FOS and JUN 4 0.19 6.15 0.89 5.60
116 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 5.00
117 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95 5.00
118 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
119 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65 5.00
120 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54 5.00
121 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33 5.00
122 INT172141 IL10 Negative_regulation of Gene_expression of HLA-DRA 2 0.14 0.89 1.23 5.00
123 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18 5.00
124 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15 5.00
125 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11 5.00
126 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1 5.00
127 INT185373 IRF6 Positive_regulation of Gene_expression of TLR2 1 0.08 2.96 1.04 5.00
128 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98 5.00
129 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91 5.00
130 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91 5.00
131 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79 5.00
132 INT182814 Binding of ICAM1 and PECAM1 2 0.02 3.32 0.77 5.00
133 INT172134 Binding of IL6 and IL15 2 0.01 1.18 0.72 5.00
134 INT172147 Binding of IL15 and TNF 2 0.05 1.19 0.72 5.00
135 INT267630 Il1 Regulation of Gene_expression of IL8 1 0.00 0.44 0.71 5.00
136 INT172143 IL4 Positive_regulation of Protein_catabolism of TNF 2 0.11 1.7 0.69 5.00
137 INT172146 IL10 Positive_regulation of Protein_catabolism of TNF 2 0.15 1.69 0.69 5.00
138 INT172142 IL10 Positive_regulation of Protein_catabolism of IL1B 2 0.03 1.69 0.68 5.00
139 INT172132 IL4 Positive_regulation of Protein_catabolism of IL1B 2 0.02 1.69 0.68 5.00
140 INT316690 Binding of Myd88 and Il1 2 0.06 1.75 0.66 5.00
141 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66 5.00
142 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63 5.00
143 INT172139 IL4 Negative_regulation of IL1B 1 0.02 0.85 0.63 5.00
144 INT316695 Binding of Il1 and gout 1 0.00 1.55 0.62 5.00
145 INT220155 IL1RN Regulation of IL1B 2 0.50 0.93 0.61 5.00
146 INT339393 Tlr4 Positive_regulation of Nfkb1 1 0.24 2.06 0.61 5.00
147 INT267625 Binding of KNG1 and Klk1 2 0.21 2.23 0.61 5.00
148 INT172145 IL10 Negative_regulation of Gene_expression of CSF2 1 0.04 0.69 0.59 5.00
149 INT172144 IL4 Negative_regulation of Transcription of PLA2G4A 1 0.02 0.82 0.58 5.00
150 INT172133 IL4 Negative_regulation of Gene_expression of HMOX2 1 0.00 0.81 0.58 5.00
151 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57 5.00
152 INT333476 IL12B Positive_regulation of Localization of AFP 1 0.03 0.26 0.57 5.00
153 INT333477 CXCL10 Positive_regulation of TH1L 1 0.14 0.32 0.56 5.00
154 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54 5.00
155 INT171905 TNF Positive_regulation of Gene_expression of Il1 2 0.23 1.08 0.54 5.00
156 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53 5.00
157 INT343838 EDA Positive_regulation of TLR4 1 0.11 0.87 0.51 5.00
158 INT343859 Binding of IRF6 and TBCE 1 0.01 1.1 0.51 5.00
159 INT343860 Binding of CD14 and TBCE 1 0.03 1.1 0.51 5.00
160 INT343825 IRF6 Regulation of Gene_expression of FUT1 1 0.00 1.74 0.5 5.00
161 INT299785 CTLA4 Negative_regulation of Binding of CD28 2 0.17 1.8 0.5 5.00
162 INT295270 S100a8 Regulation of Il6 1 0.01 0.56 0.48 5.00
163 INT115186 IL6 Positive_regulation of Phosphorylation of STAT3 2 0.19 0.35 0.48 5.00
164 INT172137 IL11 Negative_regulation of Gene_expression of TNF 1 0.09 0.73 0.47 5.00
165 INT327386 TNF Regulation of Gene_expression of Oxtr 1 0.20 0.98 0.45 5.00
166 INT316694 Binding of BLZF1 and Nlrp2 1 0.00 0.75 0.45 5.00
167 INT343846 MAPK1 Positive_regulation of FOS 1 0.04 1.29 0.44 5.00
168 INT220188 EC Positive_regulation of CADM1 1 0.00 1.72 0.44 5.00
169 INT172149 IL17A Positive_regulation of Gene_expression of IL1B 1 0.01 0.5 0.43 5.00
170 INT172138 IL17A Positive_regulation of Gene_expression of TNF 1 0.07 0.5 0.43 5.00
171 INT283714 Positive_regulation of Binding of Id2 and Homer1 1 0.08 1.34 0.42 5.00
172 INT172136 IL18 Positive_regulation of Gene_expression of IFN1@ 1 0.09 0.63 0.42 5.00
173 INT283713 Binding of Id2 and Homer1 1 0.06 1.34 0.42 5.00
174 INT181862 Binding of MPO and PRTN3 2 0.16 1.18 0.38 5.00
175 INT169507 Oxt Regulation of Gene_expression of Oxtr 2 0.20 0.84 0.38 5.00
176 INT172135 Binding of IL2 and IL6 1 0.01 0.57 0.37 5.00
177 INT172148 Binding of IL2 and TNF 2 0.05 0.67 0.37 5.00
178 INT267595 IL12A Positive_regulation of IFN1@ 1 0.03 0.69 0.36 5.00
179 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36 5.00
180 INT183786 IL6 Negative_regulation of INS 1 0.09 1.61 0.35 5.00
181 INT327381 Il13 Regulation of Gene_expression of Oxtr 1 0.37 0.88 0.35 5.00
182 INT343912 Fgg Positive_regulation of Gene_expression of IL6 1 0.00 0.83 0.35 5.00
183 INT343857 Binding of ABCC8 and LY96 1 0.02 0.96 0.34 5.00
184 INT183784 INS Negative_regulation of Binding of TBK1 1 0.01 1.81 0.34 5.00
185 INT183783 INS Negative_regulation of TBK1 1 0.01 1.81 0.34 5.00
186 INT183793 INS Negative_regulation of Binding of Ros1 1 0.16 1.66 0.34 5.00
187 INT183785 INS Positive_regulation of Gene_expression of NFKBIB 1 0.03 1.83 0.34 5.00
188 INT183780 INS Negative_regulation of Gene_expression of CYBB 1 0.02 1.74 0.34 5.00
189 INT267589 IL2 Positive_regulation of Gene_expression of IL12A 1 0.01 0.69 0.34 5.00
190 INT183782 INS Negative_regulation of Gene_expression of TBK1 1 0.01 1.81 0.34 5.00
191 INT174266 TNF Regulation of Gene_expression of F3 1 0.00 3.2 0.33 5.00
192 INT318299 Binding of F2 and PRTN3 1 0.01 1.92 0.33 5.00
193 INT323352 Binding of F8 and VWF 5 0.08 2.22 0.33 5.00
194 INT174265 IL18 Regulation of Gene_expression of F3 1 0.00 3.21 0.33 5.00
195 INT327380 Il13 Positive_regulation of Oxt 1 0.29 0.13 0.32 5.00
196 INT269064 Il6 Positive_regulation of Gene_expression of Cybb 1 0.75 0.79 0.31 5.00
197 INT327379 S100a8 Regulation of Oxt 1 0.00 0.95 0.29 5.00
198 INT343856 Binding of S100A9 and ABCC8 1 0.04 0.9 0.28 5.00
199 INT267628 IL4 Positive_regulation of IgG 1 0.00 1.42 0.27 5.00
200 INT343832 Positive_regulation of EDA Positive_regulation of TLR4 1 0.11 0.43 0.27 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Acute-phase Reaction. They are ordered first by their pain relevance and then by number of times they were reported in Acute-phase Reaction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 100.00
2 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 100.00
3 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 100.00
4 INT109005 Gene_expression of Proc 61 0.75 37.86 8.49 100.00
5 INT69702 Positive_regulation of PMAIP1 7 0.35 8.81 1.98 100.00
6 INT192946 Gene_expression of PMAIP1 2 0.27 1.77 0.52 100.00
7 INT231317 Localization of ERN1 1 0.65 0.45 0.14 100.00
8 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 99.98
9 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 99.98
10 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 99.96
11 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 99.96
12 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 99.96
13 INT96269 Positive_regulation of Mcpt1 71 0.61 52.38 20.4 99.96
14 INT10923 Positive_regulation of Lipg 30 0.50 22.87 4.26 99.96
15 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.94
16 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 99.92
17 INT100861 Binding of CRP 179 0.48 175.2 26.45 99.92
18 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69 99.92
19 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 99.88
20 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 99.88
21 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 99.84
22 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 99.84
23 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 99.82
24 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.80
25 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 99.76
26 INT11030 Binding of LPA 70 0.48 40.35 4.81 99.76
27 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 99.76
28 INT10706 Regulation of Il6 150 0.62 93.23 62.34 99.68
29 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 99.66
30 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 99.66
31 INT20230 Negative_regulation of Positive_regulation of Alb 15 0.56 12.44 4.11 99.66
32 INT15724 Negative_regulation of Fn1 15 0.53 5.61 3.87 99.66
33 INT16919 Gene_expression of IL36RN 48 0.48 32.78 13.83 99.64
34 INT21013 Regulation of Gene_expression of IL36RN 4 0.11 1.71 2.11 99.64
35 INT6852 Localization of TNF 883 0.81 705.95 270.84 99.62
36 INT12082 Localization of IL6 365 0.81 241.78 105.78 99.62
37 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 99.56
38 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 99.44
39 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 99.40
40 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 99.40
41 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 99.34
42 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 99.24
43 INT10763 Localization of IL2 157 0.80 81.11 33.21 99.16
44 INT68707 Gene_expression of C4BPB 1 0.11 0.32 0.13 99.16
45 INT68706 Regulation of C4BPB 1 0.05 0.32 0.13 99.16
46 INT9210 Regulation of IL6 166 0.62 125.61 49.95 99.14
47 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33 99.12
48 INT146758 Gene_expression of LCN2 45 0.78 38.29 2.97 99.04
49 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 99.04
50 INT175106 Gene_expression of LCN1 6 0.75 4.59 0.83 99.04
51 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 99.00
52 INT22454 Regulation of Crp 213 0.62 160.67 49.24 98.96
53 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 98.96
54 INT11109 Positive_regulation of Serpina1a 5 0.68 4.97 1.12 98.88
55 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 98.84
56 INT237619 Gene_expression of Mag 34 0.63 31 5.07 98.80
57 INT106745 Localization of CRP 65 0.81 66.44 15.21 98.80
58 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7 98.76
59 INT99586 Binding of IRF6 60 0.36 27.87 13.2 98.72
60 INT216145 Transcription of IER2 4 0.51 1.52 1.25 98.64
61 INT115831 Transcription of Hmox1 16 0.66 5.31 1.14 98.48
62 INT205196 Gene_expression of Lpar2 18 0.74 12.19 3.49 98.40
63 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 98.32
64 INT2774 Binding of Crp 241 0.48 195.89 44.39 98.32
65 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 98.28
66 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 98.28
67 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 98.28
68 INT6480 Positive_regulation of IL1RN 59 0.69 33.7 16.66 98.28
69 INT148291 Positive_regulation of CSF3 9 0.61 6.37 0.7 98.28
70 INT284257 Positive_regulation of Gene_expression of Mir155 13 0.57 3.34 1.08 98.24
71 INT284287 Regulation of Adrb3 1 0.00 0.82 0.28 98.24
72 INT279572 Gene_expression of MBL2 27 0.64 20.88 1.51 98.12
73 INT306468 Positive_regulation of Gene_expression of MBL2 7 0.47 4.3 0.17 98.12
74 INT2432 Positive_regulation of Cp 41 0.67 31.1 16.68 98.08
75 INT284265 Gene_expression of Mir155 29 0.64 10.7 2.84 97.92
76 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 97.70
77 INT51028 Regulation of Il1b 28 0.60 21.15 12.47 97.68
78 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 97.64
79 INT121663 Gene_expression of CXCR3 76 0.77 50.96 30.62 97.64
80 INT64716 Regulation of Positive_regulation of Il6 7 0.54 2.83 5.34 97.64
81 INT284266 Negative_regulation of Mir155 8 0.42 2.44 0.65 97.44
82 INT284282 Regulation of Mir155 1 0.32 1.25 0.32 97.44
83 INT136424 Gene_expression of DUSP1 9 0.67 4.48 2.64 97.12
84 INT9649 Positive_regulation of LPA 105 0.69 74.75 13.89 97.08
85 INT7561 Positive_regulation of gr 70 0.57 31.92 20.22 96.92
86 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 96.92
87 INT98310 Regulation of gr 21 0.39 15.04 6.68 96.92
88 INT2921 Positive_regulation of F8 53 0.59 41.56 8.56 96.76
89 INT251659 Positive_regulation of Prdx6 2 0.11 2.07 0.36 96.64
90 INT174491 Positive_regulation of Regulation of CRP 2 0.22 0.9 0.04 96.60
91 INT86437 Binding of IL6 154 0.48 121.22 29.3 96.50
92 INT11385 Gene_expression of RAE1 5 0.49 4.16 1.76 96.32
93 INT100593 Gene_expression of UBAP1 8 0.65 13.81 5.74 96.04
94 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84 95.92
95 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65 95.72
96 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54 95.72
97 INT89941 Positive_regulation of Il1r2 4 0.49 1.92 2.43 95.72
98 INT329705 Positive_regulation of Il10rb 1 0.07 0.89 0.21 95.72
99 INT129207 Gene_expression of Cxcl1 114 0.75 68.54 30.82 95.72
100 INT204124 Transcription of CRP 14 0.69 20.79 2.71 95.72
101 INT23257 Regulation of CRP 127 0.62 100.05 21.87 95.56
102 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 95.56
103 INT174816 Binding of IL6R 14 0.09 11.26 3.63 95.36
104 INT220893 Gene_expression of C4bp 1 0.74 3.37 0.29 95.08
105 INT51474 Binding of Il6 55 0.48 44.99 20.52 94.76
106 INT894 Binding of Avp 84 0.48 29.16 29.63 94.76
107 INT59148 Negative_regulation of DCD 4 0.20 7.21 0.61 94.56
108 INT269045 Positive_regulation of Binding of Il11ra1 1 0.19 0.72 0.22 94.40
109 INT163912 Binding of Il11ra1 5 0.33 5.06 2.22 94.16
110 INT53491 Negative_regulation of Jun 28 0.57 14.2 6.9 94.12
111 INT19511 Localization of Il6 212 0.81 118.17 67.67 93.96
112 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 93.92
113 INT15385 Negative_regulation of Negative_regulation of CD79A 2 0.41 3.05 0.17 93.84
114 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 93.76
115 INT234 Binding of Alb 151 0.48 52.34 32.97 93.76
116 INT35380 Binding of Fn1 8 0.35 4.84 2.23 93.76
117 INT91372 Negative_regulation of Positive_regulation of STAT3 8 0.40 2 0.5 93.76
118 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 93.60
119 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 93.60
120 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 93.60
121 INT15386 Positive_regulation of Negative_regulation of CD79A 2 0.49 0.91 0.08 93.60
122 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 93.56
123 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 93.56
124 INT64815 Binding of Jun 49 0.48 21.47 8.59 93.52
125 INT176524 Binding of Mapk14 19 0.43 12.54 5.21 93.52
126 INT36923 Binding of Mdk 7 0.35 3.81 2.58 93.52
127 INT284269 Positive_regulation of Negative_regulation of Adrb3 1 0.01 2.42 1.06 93.44
128 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08 93.32
129 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 93.28
130 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13 93.28
131 INT158508 Negative_regulation of Gene_expression of STAT3 2 0.43 1.74 0.15 93.28
132 INT119048 Negative_regulation of Gene_expression of HIF1A 10 0.57 9.23 1.5 93.28
133 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 93.28
134 INT144039 Negative_regulation of Negative_regulation of STAT3 2 0.55 0.85 0.07 93.28
135 INT477 Localization of Avp 813 0.81 131.58 300.4 93.24
136 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18 93.20
137 INT10969 Positive_regulation of PLEK 33 0.67 16.96 8.35 93.12
138 INT78363 Negative_regulation of Adrb3 2 0.19 3.32 1.38 93.08
139 INT70816 Negative_regulation of Fos 32 0.58 13 11.18 92.92
140 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04 92.76
141 INT93684 Gene_expression of STAT3 66 0.78 34.42 5.94 92.72
142 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 92.64
143 INT11071 Positive_regulation of PPBP 43 0.68 26.85 13.43 92.60
144 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 92.56
145 INT135319 Positive_regulation of Positive_regulation of CRP 20 0.50 26.45 5.61 92.56
146 INT6481 Binding of TNF 624 0.48 510.2 214.82 92.56
147 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79 92.56
148 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 92.52
149 INT74262 Negative_regulation of Egr1 15 0.57 7.51 2.41 92.40
150 INT13995 Gene_expression of gr 96 0.74 48.21 26.54 92.32
151 INT204852 Gene_expression of Cd83 7 0.48 3.15 0.76 92.32
152 INT152682 Negative_regulation of Gene_expression of H2-Ab1 4 0.34 3.3 0.46 92.32
153 INT204840 Gene_expression of Tnfsf9 1 0.52 0.99 0.4 92.32
154 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 92.20
155 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 92.20
156 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 92.20
157 INT35174 Positive_regulation of Localization of IL18 7 0.69 5.22 1.08 92.20
158 INT35175 Localization of IL18 18 0.80 12.96 3.83 92.20
159 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 92.20
160 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 92.20
161 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 92.16
162 INT247102 Binding of MBL2 16 0.38 14.18 1.54 92.16
163 INT8685 Negative_regulation of RRBP1 1 0.13 0.54 0.08 92.16
164 INT22481 Gene_expression of CADM1 28 0.65 30.26 8.5 92.12
165 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 91.76
166 INT94744 Regulation of Transcription of Il1b 3 0.44 2.83 1.26 91.60
167 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 91.48
168 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 91.36
169 INT47540 Binding of Cp 20 0.41 15.54 7.01 91.20
170 INT47538 Negative_regulation of Binding of Cp 3 0.37 1 0.47 91.20
171 INT24684 Localization of PLAT 30 0.78 26.21 13.56 91.16
172 INT23188 Localization of Serpine1 22 0.79 16.06 1.96 91.16
173 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99 91.12
174 INT9660 Regulation of TNF 363 0.62 312.94 139.99 91.08
175 INT25464 Binding of SAA1 11 0.42 6.89 3.72 91.04
176 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 90.40
177 INT215362 Positive_regulation of Gene_expression of HSPE1 1 0.44 1.82 0.71 90.36
178 INT215366 Gene_expression of HSPE1 12 0.74 6.39 1.39 90.36
179 INT212510 Binding of Apcs 26 0.48 15.2 0.72 90.32
180 INT215371 Positive_regulation of HSPE1 1 0.66 3.4 0.95 89.96
181 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24 89.96
182 INT16478 Positive_regulation of Plg 29 0.45 18.07 4.07 89.76
183 INT122165 Binding of TNFRSF1B 8 0.28 7.46 4.87 89.64
184 INT148705 Binding of TNFRSF1A 8 0.38 5.19 1.81 89.64
185 INT317880 Regulation of Gene_expression of Dusp1 2 0.42 2.98 1.94 89.48
186 INT137181 Gene_expression of CXCL9 25 0.65 13.09 9.56 89.20
187 INT6484 Binding of IL1B 122 0.47 75.84 35.07 89.04
188 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 88.84
189 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 88.72
190 INT178400 Negative_regulation of Gene_expression of Dusp1 4 0.40 3.61 0.31 88.56
191 INT284259 Positive_regulation of Negative_regulation of Csf3 2 0.48 0.79 0.54 88.44
192 INT206136 Positive_regulation of Gene_expression of STAT3 14 0.46 4.3 1.1 88.40
193 INT178339 Binding of Cxcl1 17 0.36 5.14 2.04 88.28
194 INT546 Binding of ALB 311 0.48 85.98 60.14 88.00
195 INT90372 Negative_regulation of Hrec 12 0.03 11.73 4.74 88.00
196 INT83954 Binding of Cxcr2 21 0.37 17.27 7.65 87.96
197 INT111100 Gene_expression of Dusp1 18 0.76 14.81 5.21 87.96
198 INT24926 Regulation of Csf3 17 0.52 10.41 3.04 87.88
199 INT28714 Negative_regulation of Csf3 10 0.41 6.9 1.6 87.88
200 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 87.84
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