D:Acute Cholecystitis

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Disease Term
Synonyms None
Documents 560
Hot Single Events 27
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Acute Cholecystitis. They are ordered first by their relevance to Acute Cholecystitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT209918 Positive_regulation of Nlrp3 Positive_regulation of Localization of Il1 1 0.42 1.06 0.4 5.00
2 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
3 INT296023 Positive_regulation of Apoa2 Negative_regulation of APOA1 1 0.50 0.35 0.05 5.00
4 INT296024 Apoa2 Negative_regulation of CETP 1 0.39 0.35 0.05 5.00
5 INT296025 Apoa2 Negative_regulation of APOA1 1 0.47 0.35 0.05 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Acute Cholecystitis. They are ordered first by their pain relevance and then by number of times they were reported in Acute Cholecystitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.92
2 INT236277 Positive_regulation of Gene_expression of CADPS 5 0.42 9.17 1.29 99.70
3 INT209501 Gene_expression of CADPS 15 0.65 20.7 2.22 99.70
4 INT259031 Negative_regulation of Gene_expression of CADPS 1 0.07 3.04 0.35 99.70
5 INT219022 Positive_regulation of IgM 1:10240 1 0.01 1.44 0.16 99.44
6 INT38056 Localization of Crp 71 0.78 53.14 17.03 98.72
7 INT7133 Negative_regulation of MME 85 0.59 29.22 33.1 98.60
8 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 98.00
9 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 98.00
10 INT288302 Positive_regulation of Phosphorylation of SLC17A5 1 0.49 2 0.24 98.00
11 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 98.00
12 INT288300 Positive_regulation of Phosphorylation of GGT1 1 0.49 1.94 0.21 98.00
13 INT288297 Positive_regulation of Phosphorylation of Crp 1 0.03 1.93 0.21 98.00
14 INT36479 Binding of NR0B2 2 0.36 3.5 0.21 97.52
15 INT149259 Gene_expression of RCT 38 0.67 15.73 3.87 96.64
16 INT87573 Phosphorylation of Crp 2 0.05 1.99 0.21 95.84
17 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 94.32
18 INT288301 Phosphorylation of SLC17A5 1 0.79 1.8 0.23 93.00
19 INT288303 Phosphorylation of GGT1 1 0.79 1.74 0.2 93.00
20 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 90.96
21 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 90.96
22 INT4535 Localization of PROC 106 0.73 76.24 21.1 90.60
23 INT193437 Negative_regulation of MCO 4 0.48 0.68 0 86.80
24 INT175262 Binding of SH2B2 18 0.36 22.85 3.18 86.00
25 INT96071 Localization of PIAS1 6 0.71 4.44 3.79 84.20
26 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 80.64
27 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 80.48
28 INT193439 Localization of MCO 1 0.61 0.49 0.08 78.64
29 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79 77.36
30 INT37335 Gene_expression of Nsdhl 45 0.51 24.36 4.58 76.44
31 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 66.84
32 INT209503 Positive_regulation of CADPS 3 0.42 7 1.11 65.08
33 INT193438 Binding of MCO 1 0.39 1.77 0.06 64.88
34 INT57431 Binding of PIAS1 4 0.30 4.35 1.94 64.88
35 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75 61.48
36 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 60.48
37 INT36480 Localization of NR0B2 1 0.73 0.78 0.12 57.68
38 INT16461 Negative_regulation of Gene_expression of PROC 13 0.24 4.39 2.17 57.24
39 INT1168 Binding of PROC 62 0.38 44.15 9.04 56.32
40 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 56.32
41 INT68725 Regulation of Cyp11a1 6 0.19 2.62 0.44 55.84
42 INT297020 Positive_regulation of CLTC 5 0.36 3.38 0.41 55.60
43 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 55.20
44 INT24471 Regulation of Brs3 3 0.17 1.56 2.19 51.32
45 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 50.00
46 INT193440 Positive_regulation of MCO 4 0.45 1.22 0 50.00
47 INT344613 Negative_regulation of Gene_expression of CLTC 2 0.31 1.19 0.37 49.56
48 INT192450 Gene_expression of CLTC 26 0.55 18.82 3.26 49.16
49 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 44.08
50 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 44.08
51 INT22454 Regulation of Crp 213 0.62 160.67 49.24 41.56
52 INT288 Positive_regulation of Sct 88 0.70 32.83 24.5 40.32
53 INT2367 Binding of Sct 34 0.42 8.46 8.62 40.32
54 INT190017 Localization of Scrib 6 0.10 7 0.38 34.56
55 INT322916 Negative_regulation of HTA 1 0.29 1.77 0 30.68
56 INT118217 Regulation of Cuzd1 2 0.30 2.36 0.91 30.12
57 INT322917 Negative_regulation of Negative_regulation of HTA 1 0.21 0.88 0 28.36
58 INT182810 Gene_expression of Cuzd1 5 0.44 1.49 0.53 20.32
59 INT102251 Positive_regulation of Positive_regulation of Crp 24 0.58 29.62 7.5 20.08
60 INT192448 Positive_regulation of Gene_expression of CLTC 5 0.32 3.01 0.33 16.36
61 INT97189 Gene_expression of Cd33 10 0.73 7.7 0.44 10.68
62 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 6.48
63 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 6.48
64 INT34592 Positive_regulation of Gene_expression of ALPP 51 0.67 20.62 5.68 6.48
65 INT22907 Positive_regulation of Ggt1 33 0.67 17.82 5.28 6.48
66 INT30731 Positive_regulation of Gene_expression of GGT1 8 0.49 6.55 1.15 6.48
67 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.64
68 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.64
69 INT8106 Gene_expression of GGT1 31 0.75 18.65 6.1 5.64
70 INT8107 Gene_expression of Ggt1 9 0.75 4.04 1.05 5.64
71 INT158 Localization of Prl 2431 0.81 378.96 952.2 5.00
72 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
73 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
74 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
75 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
76 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
77 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
78 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
79 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
80 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
81 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
82 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 5.00
83 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 5.00
84 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
85 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
86 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
87 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
88 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
89 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
90 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
91 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
92 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 5.00
93 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
94 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
95 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
96 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 5.00
97 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
98 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
99 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
100 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
101 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 5.00
102 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 5.00
103 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
104 INT921 Regulation of GH1 172 0.60 52.88 51.04 5.00
105 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
106 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 5.00
107 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 5.00
108 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
109 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
110 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 5.00
111 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
112 INT2429 Negative_regulation of Mpo 128 0.59 93.76 39.57 5.00
113 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
114 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
115 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
116 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
117 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
118 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
119 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 5.00
120 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 5.00
121 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
122 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
123 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
124 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42 5.00
125 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
126 INT61953 Transcription of Nos2 101 0.72 46.64 25.49 5.00
127 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 5.00
128 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
129 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
130 INT20129 Regulation of Il1 53 0.53 44.14 19.89 5.00
131 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
132 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
133 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
134 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
135 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 5.00
136 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
137 INT32203 Negative_regulation of Crp 48 0.58 32.77 11.89 5.00
138 INT1636 Gene_expression of Sct 58 0.77 16.14 11.57 5.00
139 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67 5.00
140 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11 5.00
141 INT25608 Regulation of Gene_expression of Il1 37 0.44 27.76 10.1 5.00
142 INT35707 Gene_expression of Nlrp1a 20 0.75 9.61 9.32 5.00
143 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96 5.00
144 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 5.00
145 INT62400 Positive_regulation of Localization of Il1 34 0.67 35.53 7.96 5.00
146 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 5.00
147 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 5.00
148 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 5.00
149 INT35584 Binding of ACLY 22 0.35 31.78 7.17 5.00
150 INT36960 Gene_expression of vs 33 0.43 20.77 6.97 5.00
151 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 5.00
152 INT90077 Gene_expression of Casp1 29 0.76 20.79 6.26 5.00
153 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
154 INT9683 Binding of GH1 57 0.47 21.14 5.99 5.00
155 INT193271 Gene_expression of Brs3 8 0.05 1.25 5.87 5.00
156 INT69153 Positive_regulation of Gene_expression of IL5 22 0.32 23.59 5.7 5.00
157 INT15143 Protein_catabolism of MME 16 1.00 4.56 5.54 5.00
158 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69 5.00
159 INT24910 Negative_regulation of Enpp3 20 0.57 8.23 4.67 5.00
160 INT36221 Positive_regulation of Nlrp3 25 0.68 19.7 4.5 5.00
161 INT99020 Gene_expression of Nlrp3 23 0.75 18.86 4.4 5.00
162 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.00
163 INT14930 Regulation of Gene_expression of SST 12 0.45 6.86 3.89 5.00
164 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 5.00
165 INT9854 Localization of GGT1 11 0.78 6.09 3.57 5.00
166 INT117476 Negative_regulation of Gene_expression of Mpo 10 0.43 8.25 3.33 5.00
167 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
168 INT59433 Gene_expression of PASK 24 0.68 25.13 3.21 5.00
169 INT80656 Regulation of SLC17A5 15 0.26 6.89 3.19 5.00
170 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12 5.00
171 INT27465 Positive_regulation of F12 21 0.70 8.09 3.06 5.00
172 INT61791 Positive_regulation of SH2B2 9 0.50 8.36 2.99 5.00
173 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 5.00
174 INT21269 Positive_regulation of Gene_expression of Sct 14 0.50 5.41 2.8 5.00
175 INT49759 Negative_regulation of CETP 43 0.58 52 2.68 5.00
176 INT193268 Binding of Brs3 3 0.03 1.56 2.67 5.00
177 INT21712 Positive_regulation of APOA1 32 0.67 21.64 2.64 5.00
178 INT59784 Binding of DES 22 0.47 19.48 2.27 5.00
179 INT183360 Binding of Cr2 13 0.27 7.68 2.19 5.00
180 INT11183 Negative_regulation of SH2B2 4 0.34 6.99 2.12 5.00
181 INT68243 Regulation of Gene_expression of IgG 10 0.44 4.93 2.04 5.00
182 INT24472 Positive_regulation of Brs3 5 0.28 1 1.73 5.00
183 INT22329 Gene_expression of Ptprc 36 0.66 15.84 1.59 5.00
184 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 5.00
185 INT112540 Negative_regulation of Hmgb1 2 0.26 1.98 1.51 5.00
186 INT12035 Regulation of F2 21 0.45 12.66 1.47 5.00
187 INT259036 Transcription of SH2B2 2 0.55 7.01 1.46 5.00
188 INT181868 Localization of ACLY 5 0.62 6.36 1.4 5.00
189 INT287241 Positive_regulation of BMP7 10 0.43 2.68 1.38 5.00
190 INT22558 Gene_expression of COL3A1 10 0.78 7.22 1.36 5.00
191 INT191589 Gene_expression of Msu 9 0.46 7.08 1.33 5.00
192 INT152982 Negative_regulation of ACCS 14 0.37 9.63 1.3 5.00
193 INT209915 Protein_catabolism of Il1 6 0.57 3.97 1.17 5.00
194 INT93168 Gene_expression of Ttf1 24 0.63 17.18 1.14 5.00
195 INT128412 Positive_regulation of Cand1 5 0.67 3.58 1.1 5.00
196 INT247970 Regulation of CLTC 8 0.28 5.37 1.06 5.00
197 INT209912 Gene_expression of Pycard 17 0.22 12.04 1.04 5.00
198 INT3529 Regulation of GOT1 6 0.52 2.4 1.01 5.00
199 INT190031 Binding of Scrib 19 0.36 21.9 1.01 5.00
200 INT180451 Positive_regulation of Apoa2 15 0.67 12.65 0.89 5.00
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