D:Acute Intermittent Porphyria

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pChart

Disease Term
Synonyms Acute Intermittent Porphyrias, Acute Porphyria, Acute Porphyrias, INTERMITTENT PORPHYRIA ACUTE, INTERMITTENT PORPHYRIAS ACUTE, PORPHYRIA ACUTE, Porphyrias Acute, Porphyrias Acute Intermittent
Documents 80
Hot Single Events 19
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Acute Intermittent Porphyria. They are ordered first by their relevance to Acute Intermittent Porphyria and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT158466 FECH Negative_regulation of Fech 1 0.23 0.57 0.2 84.96
2 INT282684 FECH Positive_regulation of Negative_regulation of Ssbp3 1 0.00 1.54 0.08 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Acute Intermittent Porphyria. They are ordered first by their pain relevance and then by number of times they were reported in Acute Intermittent Porphyria. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT148671 Gene_expression of Aip 26 0.63 24.32 3.91 100.00
2 INT22591 Negative_regulation of Hmbs 6 0.51 5.04 1.74 99.84
3 INT40215 Negative_regulation of Fech 9 0.57 8.39 1.85 99.84
4 INT15509 Negative_regulation of HMBS 14 0.58 13.13 2.78 99.18
5 INT24800 Negative_regulation of AMPD1 44 0.59 21.19 6.76 99.18
6 INT62690 Gene_expression of PPOX 7 0.77 3.3 0.13 97.72
7 INT62689 Negative_regulation of PPOX 7 0.58 4.66 0.28 97.32
8 INT214 Localization of AVP 370 0.81 208.51 91.09 97.08
9 INT196375 Negative_regulation of Ppox 2 0.08 2.73 0 97.08
10 INT40216 Positive_regulation of Alas1 11 0.65 6.08 1.8 96.04
11 INT62515 Regulation of Ppox 1 0.11 0.1 0.22 95.48
12 INT22592 Positive_regulation of Hmbs 2 0.48 2.27 0.87 89.92
13 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16 86.32
14 INT102747 Gene_expression of Hmbs 17 0.78 10.53 1.34 85.28
15 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 85.28
16 INT62580 Gene_expression of Cyp2e1 31 0.78 15.4 11.08 85.28
17 INT45263 Gene_expression of Alas1 3 0.29 1.39 0.24 85.28
18 INT32852 Negative_regulation of FECH 18 0.57 10.59 3.08 83.52
19 INT62514 Negative_regulation of Ppox 1 0.15 0.08 0.21 82.84
20 INT46038 Positive_regulation of ALAS1 3 0.60 0.9 1 75.00
21 INT70410 Positive_regulation of AKAP13 2 0.49 0.77 0.96 75.00
22 INT46036 Regulation of ALAS1 2 0.39 0.23 0.72 75.00
23 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39 74.12
24 INT158463 Regulation of Hmbs 7 0.31 4.87 0.4 69.72
25 INT102746 Negative_regulation of Hmbs 11 0.59 8.35 0.77 65.80
26 INT62513 Negative_regulation of Ugt1a8 1 0.06 0.06 0.18 62.76
27 INT158461 Positive_regulation of Localization of Alas1 1 0.04 1.48 0.52 62.32
28 INT158460 Localization of Alas1 1 0.06 0.74 0.26 62.00
29 INT127038 Gene_expression of Alas1 6 0.72 3.94 1.48 45.92
30 INT170444 Binding of Gopc 172 0.39 45.05 20.71 34.28
31 INT196371 Gene_expression of Ireb2 1 0.41 1.95 0 24.32
32 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
33 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
34 INT3359 Regulation of YY1 32 0.60 8.19 19.2 5.00
35 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64 5.00
36 INT541 Positive_regulation of MBP 31 0.67 28.56 12.24 5.00
37 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19 5.00
38 INT87698 Gene_expression of WAS 25 0.58 8.75 11.83 5.00
39 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 5.00
40 INT127037 Gene_expression of Ppig 26 0.65 16.08 6.84 5.00
41 INT35990 Negative_regulation of Sds 8 0.49 4.47 4.96 5.00
42 INT80486 Gene_expression of FECH 13 0.54 10.42 4.8 5.00
43 INT127039 Negative_regulation of Ppig 13 0.21 5.29 3.87 5.00
44 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69 5.00
45 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03 5.00
46 INT46650 Localization of Trf 13 0.61 4.4 2.91 5.00
47 INT196377 Gene_expression of Nrf1 4 0.68 5.97 2.63 5.00
48 INT243496 Positive_regulation of Gene_expression of FECH 4 0.40 4.02 2.34 5.00
49 INT53567 Positive_regulation of FECH 14 0.45 11.03 1.82 5.00
50 INT84130 Gene_expression of Foxo1 1 0.26 0.97 1.22 5.00
51 INT115264 Binding of FECH 9 0.41 7.93 1.1 5.00
52 INT127040 Negative_regulation of Alas1 2 0.35 0.72 0.54 5.00
53 INT68694 Positive_regulation of Gene_expression of HTT 7 0.49 4.29 0.29 5.00
54 INT254877 Positive_regulation of Gene_expression of Htt 15 0.64 6.29 0.28 5.00
55 INT196376 Positive_regulation of Gene_expression of Alas1 1 0.19 1.01 0.25 5.00
56 INT282679 Localization of FECH 1 0.12 9.57 0.23 5.00
57 INT120656 Localization of HMBS 3 0.16 2.6 0.23 5.00
58 INT196372 Positive_regulation of Alas1 1 0.19 1.91 0.22 5.00
59 INT326316 Positive_regulation of SSR1 1 0.49 0.41 0.13 5.00
60 INT158690 Negative_regulation of 3.8-1.4 2 0.07 2.77 0.13 5.00
61 INT196374 Negative_regulation of Positive_regulation of Alas1 1 0.16 0.67 0.12 5.00
62 INT282678 Negative_regulation of Ssbp3 1 0.02 1.53 0.08 5.00
63 INT282677 Gene_expression of Ssbp3 1 0.03 0.89 0 5.00
64 INT196373 Negative_regulation of Vmn2r81 1 0.02 1.96 0 5.00
65 INT239437 Transcription of PPOX 1 0.42 0.62 0 5.00
66 INT151791 Binding of Ppox 2 0.14 0.57 0 5.00
67 INT239436 Localization of PPOX 3 0.54 0.67 0 5.00
68 INT239435 Regulation of PPOX 1 0.18 0.26 0 5.00
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