D:Acute Lymphoid Leukemia

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Disease Term
Synonyms Acute Lymphatic Leukaemia, Acute Lymphatic Leukemia, ACUTE LYMPHOBLASTIC LEUKAEMIA, ACUTE LYMPHOBLASTIC LEUKAEMIA LYMPHOMA, Acute Lymphoblastic Leukaemia Precursor Cell Type, Acute Lymphoblastic Leukemia, Acute Lymphoblastic Leukemia Lymphoma, Acute Lymphoblastic Leukemia Precursor Cell Type, ACUTE LYMPHOCYTIC LEUKAEMIA, Acute Lymphocytic Leukemia, ACUTE LYMPHOGENOUS LEUKAEMIA
Documents 31
Hot Single Events 5
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Acute Lymphoid Leukemia. They are ordered first by their relevance to Acute Lymphoid Leukemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT238392 RB1 Regulation of E2F2 1 0.01 0.36 0.08 5.00
2 INT238397 EID1 Regulation of E2F2 1 0.00 0.36 0.08 5.00
3 INT238395 BAX Regulation of CDKN1A 1 0.03 0.31 0.03 5.00
4 INT238388 ELANE Positive_regulation of ELANE Positive_regulation of PPARA 1 0.02 0.46 0 5.00
5 INT238389 SRA1 Positive_regulation of Negative_regulation of MAX 1 0.03 0.43 0 5.00
6 INT238390 ELANE Positive_regulation of Gene_expression of TP53 1 0.04 0.42 0 5.00
7 INT238391 ELANE Positive_regulation of PCNA 1 0.01 0.07 0 5.00
8 INT238393 Binding of E2F2 and RB1 3 0.04 0.24 0 5.00
9 INT238394 Binding of PCNA and SRA1 1 0.00 0.07 0 5.00
10 INT238396 ELANE Regulation of PPARA 1 0.04 0.65 0 5.00
11 INT238398 ELANE Positive_regulation of Gene_expression of BAX 1 0.05 0.47 0 5.00
12 INT238399 ELANE Positive_regulation of SRA1 1 0.01 0.07 0 5.00
13 INT238400 Binding of SRA1 and Positive_regulation of Negative_regulation of MAX 1 0.03 0.43 0 5.00
14 INT238401 PPARA Positive_regulation of Gene_expression of CDKN1A 1 0.11 0.48 0 5.00
15 INT238402 ELANE Positive_regulation of Gene_expression of CDKN1A 1 0.03 0.48 0 5.00
16 INT238403 PPARA Regulation of ELANE 1 0.04 0.65 0 5.00
17 INT238405 ELANE Positive_regulation of PPARA 1 0.08 0.46 0 5.00
18 INT238406 Binding of ELANE and PPARA 1 0.07 0.43 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Acute Lymphoid Leukemia. They are ordered first by their pain relevance and then by number of times they were reported in Acute Lymphoid Leukemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT173159 Localization of PPARA 96 0.74 64.55 10.26 91.52
2 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 90.96
3 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 90.96
4 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18 81.00
5 INT238439 Positive_regulation of PDPK1 2 0.20 1.3 0.31 80.64
6 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 78.08
7 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 75.12
8 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21 74.24
9 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 73.84
10 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16 14.08
11 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 13.72
12 INT145249 Negative_regulation of Cflar 6 0.42 7.16 0.42 13.04
13 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 12.64
14 INT151983 Negative_regulation of CFLAR 13 0.57 13.51 2.05 12.56
15 INT92756 Negative_regulation of Binding of LMOD1 4 0.54 3.83 3.08 7.28
16 INT175703 Negative_regulation of E2F2 6 0.38 3.47 2.44 7.28
17 INT238433 Negative_regulation of Gene_expression of E2F2 2 0.27 1.01 1.07 7.28
18 INT238440 Negative_regulation of Binding of E2F2 3 0.27 1.09 1.07 7.28
19 INT238423 Negative_regulation of Negative_regulation of LMOD1 1 0.07 0.36 0.14 7.28
20 INT174189 Gene_expression of E2F2 19 0.49 12.58 4.71 6.72
21 INT182427 Binding of E2F2 7 0.23 2.78 1.49 6.72
22 INT86464 Binding of LMOD1 31 0.44 10.23 10.46 6.28
23 INT51030 Negative_regulation of LMOD1 9 0.44 5.83 4.58 5.52
24 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
25 INT6855 Binding of NCOR2 71 0.41 15.64 28.96 5.00
26 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
27 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
28 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
29 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
30 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
31 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
32 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
33 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 5.00
34 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
35 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22 5.00
36 INT22285 Negative_regulation of Mtx1 16 0.49 7.84 8.98 5.00
37 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 5.00
38 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 5.00
39 INT86023 Transcription of PPARA 60 0.66 25.8 5.7 5.00
40 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
41 INT10100 Binding of ELANE 22 0.47 15.32 5.19 5.00
42 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57 5.00
43 INT42581 Regulation of Gene_expression of ELANE 11 0.38 9.25 3.38 5.00
44 INT20419 Negative_regulation of Gene_expression of MYC 19 0.57 9.7 3.29 5.00
45 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 5.00
46 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12 5.00
47 INT73263 Negative_regulation of MYC 20 0.57 12.86 2.95 5.00
48 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81 5.00
49 INT222961 Negative_regulation of Binding of PPARA 22 0.41 10.76 2.72 5.00
50 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31 5.00
51 INT50558 Negative_regulation of PCNA 31 0.57 13.97 2.3 5.00
52 INT101572 Negative_regulation of Gene_expression of PCNA 24 0.53 13.87 2.21 5.00
53 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97 5.00
54 INT139459 Negative_regulation of MAX 6 0.57 0.32 1.79 5.00
55 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57 5.00
56 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26 5.00
57 INT160013 Gene_expression of CCND2 7 0.42 5.98 1.18 5.00
58 INT176594 Gene_expression of SRA1 20 0.35 9.65 1.15 5.00
59 INT19501 Gene_expression of MYCN 5 0.75 3.06 1.05 5.00
60 INT82795 Binding of MYC 16 0.47 6.1 0.9 5.00
61 INT32443 Negative_regulation of Binding of ELANE 2 0.11 0.54 0.89 5.00
62 INT238442 Regulation of Transcription of PPARA 3 0.37 2.64 0.77 5.00
63 INT117935 Negative_regulation of SRA1 6 0.11 2.63 0.66 5.00
64 INT180149 Positive_regulation of SRA1 7 0.40 2.65 0.65 5.00
65 INT194993 Binding of RB1 15 0.37 10.96 0.4 5.00
66 INT192071 Gene_expression of Carg1 10 0.13 9.4 0.36 5.00
67 INT238429 Transcription of E2F2 3 0.45 0.55 0.31 5.00
68 INT238431 Binding of SRA1 8 0.37 2.53 0.25 5.00
69 INT238438 Negative_regulation of MYB 1 0.05 1.03 0.25 5.00
70 INT154147 Gene_expression of TP73 7 0.34 3.97 0.19 5.00
71 INT199982 Positive_regulation of Gene_expression of SRA1 3 0.03 1.24 0.18 5.00
72 INT94168 Positive_regulation of Phosphorylation of RB1 12 0.60 6.6 0.15 5.00
73 INT238422 Positive_regulation of Positive_regulation of PCNA 4 0.20 2.92 0.13 5.00
74 INT238432 Negative_regulation of CCND2 2 0.08 0.9 0.1 5.00
75 INT238428 Gene_expression of CDKN2C 1 0.11 0.3 0.08 5.00
76 INT238437 Positive_regulation of Gene_expression of CDKN2C 1 0.09 0.3 0.08 5.00
77 INT154149 Positive_regulation of Gene_expression of TP73 3 0.18 0.67 0 5.00
78 INT185289 Phosphorylation of E2F2 3 0.11 1.39 0 5.00
79 INT225170 Regulation of Phosphorylation of RB1 2 0.36 1.12 0 5.00
80 INT238424 Negative_regulation of Positive_regulation of SRA1 1 0.03 0.15 0 5.00
81 INT238425 Negative_regulation of Positive_regulation of PCNA 2 0.05 1.39 0 5.00
82 INT238427 Positive_regulation of Positive_regulation of SRA1 1 0.03 0.15 0 5.00
83 INT238436 Transcription of CAPN1 1 0.01 0.17 0 5.00
84 INT238441 Positive_regulation of Binding of SRA1 1 0.03 0.21 0 5.00
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