D:Acute Monocytic Leukemia

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Disease Term
Synonyms ACUTE MONOBLASTIC LEUKEMIA, Acute Monoblastic Leukemias, Acute Monocytic Leukemias, LEUKEMIA ACUTE MONOBLASTIC, LEUKEMIA ACUTE MONOCYTIC, Leukemia Monoblastic Acute, Leukemia Myeloid Acute M5, Leukemia Myeloid Schilling Type, Leukemia Schilling Type Myeloid, Leukemias Acute Monoblastic, LEUKEMIAS ACUTE MONOCYTIC
Documents 20
Hot Single Events 26
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Acute Monocytic Leukemia. They are ordered first by their relevance to Acute Monocytic Leukemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT352385 MIR27A Regulation of Foxo1 1 0.45 0.48 0.04 63.84
2 INT352368 MIR20B Regulation of VEGFA 1 0.08 0.44 0.04 58.32
3 INT244133 DDB1 Positive_regulation of Gene_expression of IL6 1 0.01 1.91 0.99 5.00
4 INT334013 Ccl25 Positive_regulation of Gene_expression of Lrp1 1 0.07 0.98 0.56 5.00
5 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56 5.00
6 INT194595 Binding of TNFSF10 and TNFRSF10B 4 0.15 9.3 0.53 5.00
7 INT334025 Binding of CCR9 and Ccl25 1 0.40 0.96 0.4 5.00
8 INT334009 Binding of CCL25 and CCR9 1 0.40 0.96 0.4 5.00
9 INT194596 Binding of HLA-DRB4 and TNFSF10 3 0.08 6 0.38 5.00
10 INT350214 Binding of GPER and HSPG2 1 0.00 0.12 0.32 5.00
11 INT334024 Ccl25 Positive_regulation of Gene_expression of CD36 1 0.31 0.36 0.31 5.00
12 INT334023 pma Positive_regulation of Gene_expression of CD36 1 0.04 0.31 0.28 5.00
13 INT350220 Positive_regulation of HSPG2 Positive_regulation of Localization of ITPR3 1 0.05 0.09 0.09 5.00
14 INT350216 ITPR3 Regulation of Localization of TNIP3 1 0.01 0.08 0.09 5.00
15 INT350217 Positive_regulation of HSPG2 Positive_regulation of ITPR3 1 0.05 0.09 0.09 5.00
16 INT350218 Positive_regulation of HSPG2 Positive_regulation of Gene_expression of ITPR3 1 0.04 0.09 0.08 5.00
17 INT322560 Binding of TNFSF10 and DICER1 1 0.07 1.76 0.07 5.00
18 INT244130 Binding of CASP1 and RNGTT 1 0.07 0.24 0.07 5.00
19 INT244131 Binding of RNGTT and NLRP1 1 0.11 0.24 0.07 5.00
20 INT334027 Ccl25 Regulation of Gene_expression of CD36 1 0.14 0.24 0.05 5.00
21 INT350219 ITPR3 Positive_regulation of CA2 1 0.22 0 0.05 5.00
22 INT334026 pma Regulation of Gene_expression of CD36 1 0.02 0.16 0.05 5.00
23 INT322554 TFAM Negative_regulation of CDH16 1 0.00 1.6 0.04 5.00
24 INT244129 Binding of RNGTT and NOD1 1 0.11 0 0.04 5.00
25 INT244132 DDB1 Regulation of Transcription of NOD1 1 0.01 0.09 0.03 5.00
26 INT352381 Mir21 Regulation of Ephb1 1 0.02 0 0.03 5.00
27 INT322559 TNFSF10 Positive_regulation of CASP9 1 0.03 1.79 0 5.00
28 INT322558 Binding of AKT1 and TNFSF10 1 0.05 1.59 0 5.00
29 INT322561 Negative_regulation of TNFSF10 Positive_regulation of CASP9 1 0.03 1.15 0 5.00
30 INT322555 TNFSF10 Positive_regulation of MCL1 1 0.16 1.26 0 5.00
31 INT322596 Myc Negative_regulation of TNFSF10 Positive_regulation of BIRC3 1 0.12 1.38 0 5.00
32 INT322597 Myc Negative_regulation of Gene_expression of CFLAR 1 0.11 1.35 0 5.00
33 INT322553 TNFSF10 Positive_regulation of CASP8 1 0.05 1.79 0 5.00
34 INT322557 TNFSF10 Positive_regulation of BIRC3 1 0.12 1.27 0 5.00
35 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Acute Monocytic Leukemia. They are ordered first by their pain relevance and then by number of times they were reported in Acute Monocytic Leukemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT182217 Gene_expression of CCR9 8 0.75 44.81 18.15 99.60
2 INT334022 Positive_regulation of Gene_expression of CCR9 1 0.67 5.97 2.07 99.60
3 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 97.24
4 INT197969 Localization of Prdx5 1 0.72 3.39 0.96 96.40
5 INT217167 Negative_regulation of Gene_expression of MIR155 4 0.23 3.43 0.91 96.32
6 INT217186 Gene_expression of MIR155 26 0.48 29.45 7.92 95.76
7 INT15239 Regulation of Junb 13 0.62 1.14 4.1 94.52
8 INT75557 Regulation of Jund 4 0.52 0.96 0.2 94.52
9 INT119674 Localization of GLI2 6 0.52 2.84 0.99 94.24
10 INT197989 Localization of CALU 1 0.02 0.47 0.14 94.24
11 INT11292 Gene_expression of Mme 77 0.78 20.98 35.85 90.08
12 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 89.60
13 INT75311 Gene_expression of Cd79a 5 0.77 5.13 0.58 89.12
14 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 88.56
15 INT52905 Gene_expression of Cd4 84 0.78 45.68 12.75 87.92
16 INT89928 Gene_expression of CSF2RA 19 0.75 6.78 1.27 87.92
17 INT27878 Gene_expression of FCGR1B 22 0.26 20.62 2.04 87.92
18 INT352378 Positive_regulation of Negative_regulation of Mir21 1 0.08 0.64 0.04 86.52
19 INT318442 Negative_regulation of Mir21 5 0.24 4.6 0.09 86.08
20 INT48518 Gene_expression of ANPEP 51 0.78 22.88 4.18 85.68
21 INT318440 Positive_regulation of Mir21 10 0.33 5.93 0.86 85.32
22 INT68913 Gene_expression of Cd14 55 0.76 38.99 15.67 83.68
23 INT73938 Gene_expression of Cd36 20 0.76 12.27 1.35 82.56
24 INT244139 Gene_expression of DDB1 3 0.02 0.45 0 82.36
25 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 81.52
26 INT66776 Negative_regulation of Kcne2 6 0.35 2.48 0.33 80.16
27 INT197967 Gene_expression of Prdx5 62 0.74 22.34 9.32 77.80
28 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99 76.36
29 INT38479 Positive_regulation of Kcne2 4 0.40 1 0.63 75.28
30 INT153125 Negative_regulation of Protein_catabolism of PARP1 8 0.32 6.57 0.98 73.44
31 INT162721 Negative_regulation of Positive_regulation of CASP8 3 0.12 3.17 0.52 73.44
32 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 73.04
33 INT150528 Positive_regulation of Gene_expression of TNFSF10 26 0.67 30.71 5.43 73.04
34 INT155928 Positive_regulation of Gene_expression of PARP1 13 0.68 6.54 2.1 73.04
35 INT116856 Gene_expression of TNFSF10 110 0.75 115.76 21.48 71.92
36 INT113845 Protein_catabolism of PARP1 54 0.88 43.86 8.77 71.92
37 INT10992 Gene_expression of PARP1 32 0.76 22.22 3.74 71.92
38 INT120547 Positive_regulation of Prdx5 2 0.67 2.12 0.94 70.36
39 INT197982 Positive_regulation of Gene_expression of Prdx5 1 0.67 6.27 3.03 68.60
40 INT125865 Regulation of TNFSF10 12 0.44 15.75 1.81 67.20
41 INT322588 Regulation of Regulation of TNFSF10 1 0.13 0.79 0.04 67.20
42 INT334015 Regulation of CCR9 1 0.44 5.32 2.69 63.68
43 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 58.96
44 INT130926 Negative_regulation of TNFSF10 9 0.36 10.18 1.3 57.72
45 INT163397 Regulation of CCR6 4 0.44 3.15 0.32 56.96
46 INT272508 Regulation of DICER1 4 0.11 1.21 0.05 56.32
47 INT32155 Gene_expression of TNFRSF10B 36 0.67 30.32 5.74 52.48
48 INT237960 Negative_regulation of Gene_expression of TNFRSF10B 3 0.21 3.27 0.18 52.48
49 INT334016 Localization of CCR9 1 0.72 4.05 2.33 52.24
50 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 51.92
51 INT197971 Transcription of Prdx5 1 0.69 2.43 0.84 50.44
52 INT197968 Positive_regulation of Transcription of Prdx5 1 0.67 0.46 0.2 50.44
53 INT149093 Positive_regulation of TNFSF10 31 0.49 34.61 4.56 49.16
54 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81 48.72
55 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46 45.44
56 INT197985 Negative_regulation of Gene_expression of Prdx5 1 0.56 2.15 0.75 41.92
57 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 40.28
58 INT291800 Positive_regulation of NEU2 2 0.01 0.57 1.26 40.28
59 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 36.20
60 INT118870 Positive_regulation of STAT1 36 0.67 26.18 5.46 35.08
61 INT128422 Positive_regulation of Positive_regulation of STAT1 5 0.35 4.24 0.67 35.08
62 INT126047 Regulation of Phosphorylation of Mapk14 7 0.60 5.05 5.03 34.72
63 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 34.48
64 INT182322 Negative_regulation of Gene_expression of GLI2 6 0.11 2.37 0.98 34.16
65 INT64807 Positive_regulation of Positive_regulation of CA2 10 0.41 1.21 1.7 31.44
66 INT3535 Regulation of CA2 61 0.32 16.48 10.8 28.32
67 INT350224 Regulation of NEU2 1 0.00 0.25 0.35 27.20
68 INT63936 Positive_regulation of Phosphorylation of Ephb1 131 0.70 49.38 73.16 21.04
69 INT197974 Regulation of Prdx5 1 0.51 5.27 1.4 20.40
70 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66 18.72
71 INT23535 Positive_regulation of Localization of CA2 41 0.41 13.52 9.43 15.20
72 INT350222 Positive_regulation of Localization of NEU2 1 0.00 0 0.17 15.20
73 INT185501 Localization of NEU2 4 0.02 1.08 1.04 14.92
74 INT5489 Localization of CA2 172 0.80 39.46 33.56 14.52
75 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 7.04
76 INT322593 Gene_expression of RPS18 1 0.05 2.51 0.03 5.44
77 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.28
78 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.28
79 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
80 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
81 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
82 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
83 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
84 INT16194 Binding of CNR1 82 0.48 20.75 39.59 5.00
85 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 5.00
86 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 5.00
87 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
88 INT3841 Gene_expression of FCGR3B 117 0.75 58.99 28.87 5.00
89 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
90 INT81496 Gene_expression of CNR2 68 0.75 30.04 24.92 5.00
91 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27 5.00
92 INT141612 Gene_expression of Ccr1 92 0.77 72.09 24.14 5.00
93 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
94 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 5.00
95 INT17313 Positive_regulation of HSPG2 57 0.67 55.78 16.65 5.00
96 INT164366 Localization of NLRP1 26 0.71 5.9 16.54 5.00
97 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2 5.00
98 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
99 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
100 INT92354 Localization of ESR1 77 0.75 33.04 15.51 5.00
101 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
102 INT107585 Gene_expression of CCR2 35 0.71 26.44 14.75 5.00
103 INT81495 Positive_regulation of CNR2 28 0.67 14.62 14.27 5.00
104 INT142621 Positive_regulation of Gene_expression of CD36 38 0.70 15.18 13.4 5.00
105 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
106 INT83601 Binding of CNR2 30 0.47 7.79 12.37 5.00
107 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35 5.00
108 INT145425 Positive_regulation of NLRP1 19 0.47 6.93 12.09 5.00
109 INT69158 Localization of IL4 48 0.71 31.3 11.98 5.00
110 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
111 INT119700 Gene_expression of VDR 88 0.75 65.33 11.5 5.00
112 INT20603 Positive_regulation of TNFRSF10B 40 0.67 32.61 11.44 5.00
113 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67 5.00
114 INT3830 Positive_regulation of FCGR3B 27 0.67 15.18 10.49 5.00
115 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43 5.00
116 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 5.00
117 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67 5.00
118 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37 5.00
119 INT71174 Gene_expression of CASP1 44 0.75 30.3 9.37 5.00
120 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 5.00
121 INT209866 Regulation of Gene_expression of CD36 27 0.60 10.04 8.42 5.00
122 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
123 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36 5.00
124 INT75382 Negative_regulation of HSPG2 20 0.57 15.18 7.03 5.00
125 INT76120 Gene_expression of Ptprc 102 0.59 30.42 7.02 5.00
126 INT1766 Negative_regulation of PYCARD 25 0.37 6.54 6.76 5.00
127 INT117544 Regulation of CD14 24 0.45 5.85 6.66 5.00
128 INT181382 Gene_expression of Ccl25 2 0.74 10.94 6.56 5.00
129 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47 5.00
130 INT137206 Positive_regulation of TLR2 47 0.65 33.36 6.4 5.00
131 INT13406 Negative_regulation of CASP1 25 0.57 10.61 6.36 5.00
132 INT90077 Gene_expression of Casp1 29 0.76 20.79 6.26 5.00
133 INT17641 Gene_expression of NLRP1 33 0.73 8.85 6.02 5.00
134 INT26919 Gene_expression of ITPR3 47 0.42 5.86 5.79 5.00
135 INT5490 Binding of CA2 52 0.36 9.73 5.53 5.00
136 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33 5.00
137 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 5.00
138 INT26334 Localization of ITPR3 39 0.49 2.53 5.07 5.00
139 INT124375 Gene_expression of Wnt2 67 0.56 38.03 4.67 5.00
140 INT91463 Positive_regulation of NFKB2 19 0.40 17.7 4.6 5.00
141 INT149197 Negative_regulation of NFKB2 14 0.25 10.55 4.46 5.00
142 INT133231 Regulation of PYCARD 18 0.39 5.02 4.44 5.00
143 INT57338 Gene_expression of ITGAX 31 0.75 24.62 4.39 5.00
144 INT97131 Positive_regulation of CD14 25 0.67 12.03 4.21 5.00
145 INT86919 Negative_regulation of PIK3CG 40 0.57 21.16 3.97 5.00
146 INT99509 Gene_expression of CFLAR 25 0.75 22.59 3.78 5.00
147 INT15982 Positive_regulation of NLRP3 25 0.65 23.19 3.57 5.00
148 INT69155 Positive_regulation of Localization of IL4 13 0.40 10.18 3.56 5.00
149 INT120874 Regulation of CNR2 7 0.44 2.47 3.39 5.00
150 INT97138 Positive_regulation of Gene_expression of CD14 17 0.48 9.07 3.35 5.00
151 INT36286 Binding of Cd3e 33 0.36 10.11 3.21 5.00
152 INT95723 Localization of TNIP3 6 0.03 0.71 3.21 5.00
153 INT155091 Localization of PARP1 15 0.63 13.34 3.15 5.00
154 INT104930 Protein_catabolism of BID 12 0.86 10.82 3.15 5.00
155 INT105783 Protein_catabolism of IL6 7 0.48 4.72 2.95 5.00
156 INT188047 Positive_regulation of Wnt2 51 0.58 31.41 2.94 5.00
157 INT91520 Negative_regulation of Positive_regulation of CA2 7 0.30 0.99 2.92 5.00
158 INT164582 Negative_regulation of MCL1 56 0.56 67.11 2.82 5.00
159 INT162792 Gene_expression of NOD1 19 0.71 6.11 2.71 5.00
160 INT164588 Regulation of MCL1 12 0.43 14.09 2.63 5.00
161 INT93562 Negative_regulation of Localization of CA2 15 0.59 1.87 2.51 5.00
162 INT144822 Negative_regulation of Gene_expression of CD14 18 0.56 4.48 2.5 5.00
163 INT26918 Positive_regulation of Gene_expression of ITPR3 14 0.27 2.31 2.41 5.00
164 INT88225 Transcription of Ugt1a1 5 0.61 1.51 2.4 5.00
165 INT198662 Positive_regulation of CD36 14 0.68 7.73 2.36 5.00
166 INT10612 Localization of NLRP3 13 0.78 8.91 2.27 5.00
167 INT172078 Localization of Cd3e 22 0.37 9.88 2.27 5.00
168 INT269217 Gene_expression of SNAI1 81 0.76 80.49 2.26 5.00
169 INT100622 Localization of CD68 16 0.73 6.58 2.2 5.00
170 INT182230 Binding of CCR9 3 0.36 4.32 2.19 5.00
171 INT173090 Regulation of INCENP 24 0.09 9.45 2.16 5.00
172 INT161382 Localization of KRT20 25 0.61 12.97 2.13 5.00
173 INT95592 Positive_regulation of Gene_expression of CASP1 15 0.48 13.06 2.1 5.00
174 INT104931 Binding of TNFSF10 15 0.36 17.44 2.07 5.00
175 INT142056 Binding of NLRP1 7 0.47 1.7 2.02 5.00
176 INT94285 Negative_regulation of CD36 10 0.43 6.61 1.98 5.00
177 INT24453 Binding of NLRP3 18 0.48 13.7 1.93 5.00
178 INT198885 Gene_expression of Lrp1 33 0.57 10.2 1.91 5.00
179 INT125869 Regulation of Gene_expression of TNFSF10 5 0.38 8.77 1.9 5.00
180 INT153800 Positive_regulation of Protein_catabolism of PARP1 18 0.49 16.16 1.89 5.00
181 INT117221 Positive_regulation of Gene_expression of NOD2 7 0.65 4.39 1.83 5.00
182 INT244169 Localization of RNGTT 8 0.23 1.92 1.81 5.00
183 INT33845 Binding of GPER 20 0.36 5.61 1.81 5.00
184 INT122488 Protein_catabolism of CASP9 8 0.46 8.64 1.8 5.00
185 INT122487 Positive_regulation of Positive_regulation of CASP9 16 0.67 17.88 1.79 5.00
186 INT181280 Regulation of Gene_expression of INCENP 5 0.07 4 1.78 5.00
187 INT24283 Regulation of Positive_regulation of CA2 8 0.30 3.06 1.74 5.00
188 INT120505 Negative_regulation of ITPR3 6 0.27 1.46 1.68 5.00
189 INT97749 Regulation of BCL2L1 10 0.41 9.72 1.65 5.00
190 INT194896 Gene_expression of Mfi2 14 0.15 6.65 1.59 5.00
191 INT187183 Localization of CD14 6 0.54 2.69 1.57 5.00
192 INT197972 Regulation of Gene_expression of Prdx5 1 0.59 4.14 1.55 5.00
193 INT162463 Localization of BID 6 0.73 7.47 1.5 5.00
194 INT318449 Gene_expression of Mir21 18 0.37 11.92 1.46 5.00
195 INT168682 Localization of NDRG1 3 0.36 0.84 1.45 5.00
196 INT242153 Negative_regulation of Wnt2 19 0.49 11.87 1.37 5.00
197 INT334014 Regulation of Gene_expression of CCR9 1 0.59 3.07 1.36 5.00
198 INT182456 Gene_expression of Cxcr6 14 0.77 1.75 1.35 5.00
199 INT334019 Positive_regulation of CCR9 1 0.45 3 1.33 5.00
200 INT92383 Gene_expression of KRAS 38 0.65 32.94 1.32 5.00
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