D:Acute Myocarditis

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Disease Term
Synonyms Myocarditis
Documents 81
Hot Single Events 63
Hot Interactions 8

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Acute Myocarditis. They are ordered first by their relevance to Acute Myocarditis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT269504 Lta Negative_regulation of Map2k1 Negative_regulation of Nos1 1 0.17 0.49 0.03 95.52
2 INT269502 Lta Negative_regulation of Map2k1 1 0.17 0.48 0.03 91.84
3 INT285344 Il10 Negative_regulation of Gene_expression of Tnf 1 0.15 1.91 0.49 91.28
4 INT285341 Mtx1 Regulation of Gene_expression of Tnf 1 0.03 0.78 0.22 90.12
5 INT285340 Mtx1 Regulation of Tnf 1 0.03 0.78 0.22 90.12
6 INT285342 Mtx1 Regulation of Il10 1 0.03 0.78 0.22 90.12
7 INT285343 Mtx1 Regulation of Il6 1 0.04 0.78 0.22 90.12
8 INT269500 Lta Positive_regulation of Protein_catabolism of Nos1 1 0.29 0.65 0 88.04
9 INT269503 Lta Regulation of Nos1 1 0.44 1.3 0 76.32
10 INT222691 Negative_regulation of Binding of FLNA and TNF 1 0.14 1.92 0.54 68.24
11 INT222692 Binding of FLNA and TNF 1 0.12 1.92 0.53 68.24
12 INT222690 TNF Positive_regulation of Gene_expression of NPEPPS 1 0.01 1.03 0.3 64.64
13 INT329324 KNG1 Positive_regulation of Localization of ecs 1 0.00 1.16 0.17 59.84
14 INT329317 ACE Regulation of Positive_regulation of KNG1 1 0.02 1.05 0.12 54.16
15 INT329325 ACE Regulation of Negative_regulation of Agtr2 1 0.01 0.93 0.12 49.20
16 INT329323 ecs Positive_regulation of Gene_expression of Il6 1 0.00 0.52 0.21 5.00
17 INT291837 Binding of Pecam1 and Vegfa 1 0.09 1.1 0.07 5.00
18 INT269501 Nos1 Regulation of Lta 1 0.28 0.26 0.05 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Acute Myocarditis. They are ordered first by their pain relevance and then by number of times they were reported in Acute Myocarditis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT330579 Positive_regulation of Eam 1 0.01 1.32 0.07 100.00
2 INT330580 Gene_expression of Eam 1 0.01 0.95 0.08 100.00
3 INT60568 Negative_regulation of Mtx1 5 0.38 3.6 2.87 100.00
4 INT175470 Regulation of Gene_expression of Etohi3 1 0.04 0.35 0 100.00
5 INT175472 Gene_expression of Etohi3 1 0.06 0.35 0 100.00
6 INT330583 Binding of EMB 1 0.07 1.23 0.22 99.92
7 INT63957 Positive_regulation of Tnnt2 33 0.69 18.56 5.41 99.72
8 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 99.36
9 INT42138 Binding of Myo1f 5 0.10 1.49 1.03 99.32
10 INT67060 Negative_regulation of Transcription of TNF 17 0.59 12.94 5.88 98.62
11 INT285338 Negative_regulation of Transcription of Il2 1 0.08 1.97 0.48 98.62
12 INT13354 Transcription of TNF 108 0.72 85.81 42.32 98.04
13 INT85869 Transcription of Il2 5 0.23 2.49 0.95 98.04
14 INT258990 Localization of Emb 1 0.21 0.98 0.21 97.72
15 INT96523 Positive_regulation of Chka 5 0.69 3.78 0.19 96.74
16 INT258989 Binding of Emb 1 0.10 0.98 0.21 96.24
17 INT171070 Positive_regulation of Hey2 8 0.05 10.12 1.96 96.16
18 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 95.88
19 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 95.68
20 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 95.68
21 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87 95.52
22 INT36142 Negative_regulation of Hmgcr 33 0.46 15.91 3.54 95.20
23 INT86751 Negative_regulation of Il10 62 0.59 40.1 20.51 95.16
24 INT135407 Negative_regulation of Ccl2 33 0.57 32.74 9.45 95.16
25 INT26583 Positive_regulation of Cd4 40 0.54 21.96 4.83 95.08
26 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 94.56
27 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 94.56
28 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 94.56
29 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 94.40
30 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 93.28
31 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 93.28
32 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 93.28
33 INT125709 Positive_regulation of Gene_expression of Col3a1 7 0.27 5.17 0.65 93.20
34 INT22973 Gene_expression of Col3a1 22 0.42 15.85 4.32 93.20
35 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08 93.04
36 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 92.88
37 INT129423 Negative_regulation of Impdh1 2 0.11 0.62 0.11 92.56
38 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 91.56
39 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 91.36
40 INT28862 Positive_regulation of Mtx1 3 0.38 2.49 1.77 91.36
41 INT175471 Localization of Gbp1 2 0.73 1.05 0 91.04
42 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 89.96
43 INT88237 Gene_expression of Gbp1 9 0.65 5.46 0.61 89.44
44 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12 89.36
45 INT193360 Localization of LEFTY1 3 0.04 0.49 0.21 89.36
46 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 89.00
47 INT258991 Gene_expression of Emb 2 0.43 2.55 0.23 87.92
48 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 87.84
49 INT269497 Protein_catabolism of Nos1 1 0.57 0.64 0 87.56
50 INT77146 Binding of IL4 23 0.36 13.69 5.39 87.36
51 INT16964 Binding of IFNG 27 0.48 14.31 2.45 87.08
52 INT129534 Gene_expression of Nppb 19 0.58 23.68 1.6 86.92
53 INT222695 Binding of CLEC2B 1 0.03 0.89 0.23 86.80
54 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 86.68
55 INT69304 Negative_regulation of Il10 47 0.59 36.88 19.79 86.56
56 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07 86.20
57 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 85.12
58 INT243415 Positive_regulation of EMB 2 0.10 1.73 0.15 82.64
59 INT18909 Positive_regulation of Cd8a 92 0.60 56.55 7.35 81.92
60 INT108535 Positive_regulation of TNNI1 7 0.67 5.54 2.12 81.84
61 INT330581 Positive_regulation of Negative_regulation of EMB 1 0.09 0.52 0.1 81.20
62 INT330582 Negative_regulation of EMB 1 0.09 0.52 0.1 80.84
63 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 80.80
64 INT243416 Negative_regulation of Binding of PTPRC 1 0.42 0.45 0.05 78.20
65 INT74254 Binding of PTPRC 16 0.36 8.37 1.27 77.76
66 INT114025 Transcription of Nos1 20 0.70 16.48 15.63 76.72
67 INT114023 Positive_regulation of Transcription of Nos1 7 0.60 5.35 8.06 76.72
68 INT110039 Positive_regulation of Nppb 38 0.53 34.54 2.88 75.00
69 INT242986 Positive_regulation of Gene_expression of Nppb 3 0.26 2.77 0.5 75.00
70 INT110040 Binding of Nppb 9 0.18 8.91 0.19 74.96
71 INT68187 Gene_expression of TNNT2 21 0.67 10.22 1.64 74.52
72 INT336490 Regulation of jg 1 0.23 4.61 0.11 73.84
73 INT254671 Regulation of Map2k1 5 0.43 1.83 0.14 73.68
74 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 72.56
75 INT223567 Gene_expression of Lamp2 3 0.65 1.07 0.26 72.56
76 INT336487 Positive_regulation of Gene_expression of Lamp2 2 0.49 0.84 0.21 72.56
77 INT50879 Regulation of TNNT2 3 0.26 1.53 0.55 70.68
78 INT60040 Negative_regulation of Negative_regulation of Ace 6 0.43 3.64 0.38 67.76
79 INT12290 Gene_expression of Dhfr 7 0.76 2.04 1.47 67.12
80 INT285339 Negative_regulation of Gene_expression of Dhfr 1 0.11 1.93 0.65 67.12
81 INT285337 Regulation of Gene_expression of Dhfr 1 0.11 1.93 0.65 67.12
82 INT48896 Positive_regulation of Gene_expression of Il10 73 0.70 43.14 35.5 67.00
83 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 65.72
84 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 60.20
85 INT37394 Localization of ecs 9 0.34 6.41 2.11 59.84
86 INT134470 Positive_regulation of Map2k1 74 0.49 46.07 3.02 59.60
87 INT138287 Gene_expression of Map2k1 69 0.65 46.14 1.02 59.60
88 INT138282 Positive_regulation of Gene_expression of Map2k1 13 0.49 7.46 0.39 59.60
89 INT254673 Positive_regulation of Positive_regulation of Map2k1 3 0.35 1.65 0.11 59.60
90 INT336484 Binding of Ddx39b 1 0.06 1.01 0.04 57.00
91 INT21647 Negative_regulation of Positive_regulation of KNG1 11 0.43 5.54 5.73 56.00
92 INT25381 Localization of Csf2 62 0.76 47.48 9.03 54.32
93 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 54.16
94 INT140224 Localization of Ccl2 32 0.72 26.91 9.39 51.52
95 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 50.32
96 INT18007 Positive_regulation of C6orf25 23 0.66 14.98 1.95 49.60
97 INT70027 Positive_regulation of Gene_expression of C6orf25 10 0.62 7.21 0.83 49.60
98 INT257384 Positive_regulation of Positive_regulation of C6orf25 2 0.14 2.17 0 49.60
99 INT31925 Negative_regulation of Agtr2 13 0.43 7.59 2.94 49.20
100 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 48.96
101 INT11858 Localization of Tbxa2r 39 0.80 21.24 7.09 48.96
102 INT10053 Localization of Paf 15 0.80 9.14 3.64 48.96
103 INT8775 Binding of IGHE 167 0.48 102.61 23.54 47.92
104 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 47.00
105 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 46.80
106 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 46.60
107 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 45.80
108 INT99942 Positive_regulation of Fasl 37 0.68 32.61 6.92 45.80
109 INT139180 Regulation of Positive_regulation of Fas 2 0.43 2.19 0.69 45.80
110 INT347940 Regulation of Positive_regulation of Fasl 1 0.30 1.95 0.13 45.80
111 INT20205 Binding of IgG 108 0.46 66.68 8.57 43.76
112 INT59473 Negative_regulation of Col1a1 4 0.25 1.33 1.24 38.48
113 INT25958 Regulation of Ace 26 0.59 11.88 7.87 25.00
114 INT336486 Positive_regulation of jg 1 0.25 0.63 0.08 20.16
115 INT17685 Negative_regulation of Cog1 23 0.42 15.65 3.56 12.56
116 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
117 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 5.00
118 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
119 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
120 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
121 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
122 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
123 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
124 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 5.00
125 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
126 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
127 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
128 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
129 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
130 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
131 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 5.00
132 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
133 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
134 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
135 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 5.00
136 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
137 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 5.00
138 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64 5.00
139 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
140 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
141 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
142 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 5.00
143 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
144 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
145 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
146 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 5.00
147 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
148 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 5.00
149 INT234 Binding of Alb 151 0.48 52.34 32.97 5.00
150 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 5.00
151 INT35406 Localization of Tnf 94 0.81 64.63 31.65 5.00
152 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75 5.00
153 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
154 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
155 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
156 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 5.00
157 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45 5.00
158 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 5.00
159 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 5.00
160 INT49172 Regulation of Nos1 43 0.52 27.53 23.66 5.00
161 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 5.00
162 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62 5.00
163 INT7994 Gene_expression of Lta 113 0.67 69.81 19.59 5.00
164 INT11803 Positive_regulation of Il2 62 0.70 31.44 18.93 5.00
165 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
166 INT93948 Negative_regulation of Gene_expression of Il12a 48 0.55 27.77 16.87 5.00
167 INT103757 Negative_regulation of Il12a 37 0.55 21.62 16.38 5.00
168 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
169 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
170 INT93620 Positive_regulation of Gene_expression of Fasl 51 0.66 59.45 12.04 5.00
171 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
172 INT13499 Gene_expression of Agtr2 68 0.76 35.64 10.59 5.00
173 INT86361 Positive_regulation of Positive_regulation of NOS1 39 0.53 18.93 10.42 5.00
174 INT7995 Positive_regulation of Lta 28 0.66 14.98 9.8 5.00
175 INT11859 Positive_regulation of Tbxa2r 44 0.61 22.62 9.61 5.00
176 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55 5.00
177 INT18145 Positive_regulation of Gene_expression of Tbxa2r 30 0.66 18.91 9.52 5.00
178 INT97439 Positive_regulation of Il5 46 0.60 25.6 9.47 5.00
179 INT85966 Gene_expression of Cd40lg 50 0.73 30.9 9.11 5.00
180 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86 5.00
181 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79 5.00
182 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66 5.00
183 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
184 INT25392 Positive_regulation of Gene_expression of Csf2 41 0.49 34.28 8.36 5.00
185 INT177759 Negative_regulation of IFN1@ 51 0.57 31.81 7.76 5.00
186 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71 5.00
187 INT65246 Negative_regulation of Nos3 36 0.50 25.65 7.62 5.00
188 INT112986 Positive_regulation of S100b 19 0.70 17.61 6.86 5.00
189 INT16720 Negative_regulation of Xdh 35 0.59 14 6.67 5.00
190 INT86805 Localization of HGF 49 0.71 28.48 6.35 5.00
191 INT173974 Positive_regulation of Localization of Il10 25 0.68 16.81 5.87 5.00
192 INT32389 Regulation of ecs 11 0.49 7.23 5.43 5.00
193 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81 5.00
194 INT81628 Positive_regulation of Gene_expression of Fas 32 0.67 38.13 4.23 5.00
195 INT26239 Positive_regulation of Gene_expression of Lta 12 0.36 8.86 4.22 5.00
196 INT1149 Binding of ecs 19 0.37 13.67 3.9 5.00
197 INT22223 Positive_regulation of Xdh 18 0.67 5.87 3.84 5.00
198 INT144231 Gene_expression of Il12b 18 0.75 12.93 3.65 5.00
199 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 5.00
200 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16 5.00
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