D:Addisons Disease

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Disease Term
Synonyms Addison Disease, Addison S Disease, Addisonian, ADRENAL CORTICAL HYPOFUNCTION, ADRENAL INSUFFICIENCY PRIMARY, Adrenocortical Insufficiencies Primary, Adrenocortical Insufficiency Primary, Chronic Adrenocortical Insufficiency, Cortisol Deficiency, Disease Addison, HYPOADRENALISM PRIMARY
Documents 64
Hot Single Events 14
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Addisons Disease. They are ordered first by their relevance to Addisons Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT251469 INS Negative_regulation of Gene_expression of SHBG 2 0.11 4.11 0.08 74.84
2 INT350121 INS Negative_regulation of Positive_regulation of SHBG 1 0.09 1.48 0.04 74.84
3 INT350118 INS Negative_regulation of SHBG 1 0.09 1.42 0.04 74.84
4 INT45780 GNRH1 Positive_regulation of PLOD1 3 0.07 1.02 0.63 5.00
5 INT54584 GNRH1 Positive_regulation of FSHR 3 0.48 2.02 0.54 5.00
6 INT179237 Binding of SERPINA6 and POMC 1 0.03 1.15 0.49 5.00
7 INT179233 IRF6 Negative_regulation of Binding of GSR 1 0.03 0.83 0.25 5.00
8 INT179230 Binding of MAPK14 and GSR 1 0.03 0.5 0.23 5.00
9 INT179229 Binding of GSR and NR3C2 1 0.03 0.37 0.23 5.00
10 INT179234 Binding of SERPINA6 and ELANE 1 0.01 0.22 0.12 5.00
11 INT284891 FSHR Positive_regulation of Gene_expression of PLOD1 2 0.03 1.32 0.11 5.00
12 INT179232 Binding of CREM and GSR 1 0.00 0 0.06 5.00
13 INT334918 GNRH1 Positive_regulation of Gene_expression of FSHR 2 0.11 1.27 0.03 5.00
14 INT350119 Positive_regulation of GNRH1 Positive_regulation of PLOD1 1 0.04 0.86 0.03 5.00
15 INT350114 Positive_regulation of GNRH1 Positive_regulation of FSHR 1 0.05 0.86 0.03 5.00
16 INT350120 FSHR Regulation of CYP19A1 1 0.01 3.02 0 5.00
17 INT350115 GNRH1 Negative_regulation of Localization of PLOD1 1 0.04 0.99 0 5.00
18 INT350117 GNRHR Negative_regulation of Localization of FSHR 1 0.01 1.06 0 5.00
19 INT350116 FSHR Positive_regulation of Gene_expression of CGA 1 0.01 1.28 0 5.00
20 INT350113 GNRHR Negative_regulation of Localization of PLOD1 1 0.01 1.06 0 5.00
21 INT350122 GNRH1 Negative_regulation of Localization of FSHR 1 0.05 0.99 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Addisons Disease. They are ordered first by their pain relevance and then by number of times they were reported in Addisons Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 98.72
2 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 97.98
3 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 97.98
4 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 95.52
5 INT21254 Regulation of Positive_regulation of POMC 12 0.61 3.64 4.67 95.52
6 INT1977 Negative_regulation of Positive_regulation of Prl 98 0.59 17.06 47.88 90.60
7 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 88.56
8 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 87.44
9 INT443 Localization of POMC 1020 0.81 284.52 443.17 84.64
10 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34 84.64
11 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 83.08
12 INT153130 Binding of Nr0b1 1 0.26 0.49 0.08 81.68
13 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 80.84
14 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 80.52
15 INT1180 Gene_expression of Ren 63 0.77 27.33 10.51 79.88
16 INT162 Regulation of Prl 794 0.62 165.01 322.24 74.88
17 INT1530 Regulation of Gh 382 0.61 115.96 112.47 74.56
18 INT99034 Negative_regulation of CYP11A1 2 0.41 0.92 0.1 73.88
19 INT179255 Negative_regulation of Localization of CYP11A1 1 0.04 0.84 0.1 73.88
20 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 73.84
21 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 73.84
22 INT179252 Localization of CYP11A1 1 0.07 0.83 0.1 72.64
23 INT921 Regulation of GH1 172 0.60 52.88 51.04 72.36
24 INT738 Regulation of POMC 459 0.62 111.19 243.74 71.68
25 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 66.56
26 INT5454 Localization of CRH 124 0.79 79.18 41.53 65.96
27 INT109242 Gene_expression of Igis1 1 0.01 1.54 0.2 60.88
28 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 54.20
29 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 37.04
30 INT170886 Gene_expression of AIRE 2 0.49 4.63 0.19 37.04
31 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 34.40
32 INT812 Localization of INS 1026 0.81 515.6 145.31 31.44
33 INT546 Binding of ALB 311 0.48 85.98 60.14 31.32
34 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 25.00
35 INT2981 Negative_regulation of Gene_expression of CGA 14 0.42 3.41 1.05 25.00
36 INT92826 Gene_expression of Esrrb 3 0.75 1.58 1.18 24.72
37 INT92827 Negative_regulation of Gene_expression of Esrrb 1 0.01 0.16 0.18 24.72
38 INT34058 Gene_expression of FMR1 5 0.75 5.11 0.26 18.64
39 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14 18.00
40 INT180359 Localization of AIRE 3 0.54 3.94 0.03 10.48
41 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
42 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
43 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
44 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
45 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
46 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
47 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
48 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
49 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
50 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
51 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
52 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
53 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
54 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
55 INT920 Localization of PLOD1 223 0.81 42.25 78.7 5.00
56 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
57 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
58 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02 5.00
59 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 5.00
60 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 5.00
61 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
62 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
63 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
64 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 5.00
65 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58 5.00
66 INT22045 Gene_expression of IRF6 158 0.75 58.07 27.81 5.00
67 INT2609 Localization of ELANE 111 0.81 50.22 26.63 5.00
68 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61 5.00
69 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2 5.00
70 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94 5.00
71 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 5.00
72 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
73 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 5.00
74 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
75 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
76 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
77 INT3118 Negative_regulation of Positive_regulation of POMC 33 0.59 9.42 18.07 5.00
78 INT912 Localization of FSHR 91 0.79 23.61 15.58 5.00
79 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 5.00
80 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 5.00
81 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 5.00
82 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
83 INT11288 Negative_regulation of CRH 44 0.00 16.69 12.37 5.00
84 INT69158 Localization of IL4 48 0.71 31.3 11.98 5.00
85 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
86 INT66606 Gene_expression of CXCR1 34 0.75 27.79 11.36 5.00
87 INT3845 Gene_expression of GSR 79 0.76 44.69 11.19 5.00
88 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
89 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37 5.00
90 INT52924 Negative_regulation of GSR 49 0.58 28.08 9.28 5.00
91 INT44550 Positive_regulation of Gene_expression of AVP 38 0.70 22.27 8.62 5.00
92 INT132822 Localization of IL13 26 0.67 22.85 6.66 5.00
93 INT76096 Positive_regulation of Gene_expression of IRF6 37 0.49 14.24 6.39 5.00
94 INT38686 Binding of NR3C1 20 0.48 9.25 5.99 5.00
95 INT57502 Positive_regulation of Gene_expression of CRH 30 0.70 23.37 5.7 5.00
96 INT105538 Negative_regulation of Tnfrsf1a 16 0.56 12.51 5.61 5.00
97 INT124976 Positive_regulation of Tnfrsf1b 15 0.67 14.92 5.15 5.00
98 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 5.00
99 INT52818 Localization of NR3C1 13 0.69 7.65 4.57 5.00
100 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.00
101 INT29138 Positive_regulation of Localization of IL2 25 0.50 10.06 3.89 5.00
102 INT179261 Gene_expression of SERPINA6 12 0.14 3.53 3.82 5.00
103 INT26233 Binding of GSR 45 0.46 18.22 3.74 5.00
104 INT69155 Positive_regulation of Localization of IL4 13 0.40 10.18 3.56 5.00
105 INT63534 Binding of CRH 23 0.47 6.84 3.43 5.00
106 INT91070 Regulation of GSR 27 0.59 16.64 3.42 5.00
107 INT15609 Positive_regulation of Gene_expression of GNRH1 17 0.49 5.15 3.34 5.00
108 INT140107 Negative_regulation of Tnfrsf1b 6 0.36 6.11 3.2 5.00
109 INT83351 Positive_regulation of Gene_expression of GSR 15 0.64 12.03 2.97 5.00
110 INT173179 Binding of MAPK14 13 0.29 4.51 2.92 5.00
111 INT79658 Transcription of GSR 8 0.68 3.59 2.19 5.00
112 INT179256 Positive_regulation of Localization of IL13 7 0.42 7.04 2.14 5.00
113 INT2982 Positive_regulation of Gene_expression of CGA 17 0.59 9.08 1.99 5.00
114 INT42497 Regulation of Negative_regulation of POMC 4 0.44 0.63 1.99 5.00
115 INT7972 Positive_regulation of Gene_expression of PLOD1 15 0.42 5.73 1.96 5.00
116 INT45711 Localization of Pgr 7 0.61 1.27 1.56 5.00
117 INT115963 Negative_regulation of Gene_expression of CRH 9 0.59 4.53 1.48 5.00
118 INT14727 Regulation of FN1 13 0.45 5.95 1.26 5.00
119 INT179257 Binding of SERPINA6 5 0.10 2.09 1.24 5.00
120 INT177629 Negative_regulation of SERPINA6 5 0.57 2.1 1.22 5.00
121 INT110582 Localization of GSR 10 0.79 4.03 1.19 5.00
122 INT179262 Localization of SERPINA6 4 0.16 1.29 1.1 5.00
123 INT15040 Gene_expression of NKX2-1 8 0.65 3.95 1.02 5.00
124 INT76757 Positive_regulation of SERPINA6 3 0.59 1.19 0.97 5.00
125 INT160056 Positive_regulation of AKT2 3 0.48 1.43 0.88 5.00
126 INT125627 Gene_expression of TTF1 11 0.78 12.68 0.78 5.00
127 INT83353 Negative_regulation of Binding of NR3C1 3 0.24 1.09 0.57 5.00
128 INT179248 Positive_regulation of Positive_regulation of GSR 3 0.40 4.65 0.56 5.00
129 INT83349 Negative_regulation of Binding of GSR 3 0.39 1.48 0.49 5.00
130 INT7067 Negative_regulation of Gene_expression of SHBG 7 0.41 5.08 0.48 5.00
131 INT177628 Protein_catabolism of SERPINA6 2 0.96 1.2 0.42 5.00
132 INT268804 Gene_expression of ma 2 0.16 11.97 0.38 5.00
133 INT149140 Gene_expression of Skap2 8 0.64 1.3 0.32 5.00
134 INT179227 Positive_regulation of Crisp1 3 0.45 1.15 0.3 5.00
135 INT60645 Regulation of COL4A4 1 0.22 0.51 0.27 5.00
136 INT179228 Localization of Crisp1 2 0.73 0.9 0.2 5.00
137 INT213275 Positive_regulation of Gene_expression of SHBG 6 0.46 4.24 0.19 5.00
138 INT179250 Negative_regulation of Transcription of GSR 2 0.56 1.7 0.18 5.00
139 INT179247 Negative_regulation of Localization of GSR 1 0.24 0.65 0.18 5.00
140 INT179260 Binding of AKT2 2 0.27 1.8 0.15 5.00
141 INT179259 Negative_regulation of Localization of SERPINA6 1 0.08 0.5 0.13 5.00
142 INT179253 Regulation of SERPINA6 1 0.06 0.57 0.12 5.00
143 INT284568 Negative_regulation of Ods 1 0.05 2.51 0.11 5.00
144 INT268803 Binding of ma 2 0.08 3.55 0 5.00
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