D:Adenosquamous Carcinoma

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Disease Term
Synonyms Adenosquamous Carcinomas, Carcinomas Adenosquamous
Documents 65
Hot Single Events 8
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Adenosquamous Carcinoma. They are ordered first by their relevance to Adenosquamous Carcinoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT244452 CS Positive_regulation of Phosphorylation of EIF2S2 1 0.21 2.07 0.09 5.00
2 INT244449 CS Regulation of Gene_expression of ATF4 1 0.15 0.83 0.08 5.00
3 INT244461 CS Positive_regulation of ESR1 1 0.06 1.15 0.05 5.00
4 INT244464 EIF2AK3 Positive_regulation of Positive_regulation of EIF2S2 1 0.17 0.37 0.04 5.00
5 INT244463 EIF2AK3 Regulation of Phosphorylation of EIF2S2 1 0.09 0.37 0.04 5.00
6 INT244474 CS Regulation of XBP1 1 0.20 0.15 0 5.00
7 INT244480 CS Negative_regulation of Gene_expression of XBP1 1 0.16 0.11 0 5.00
8 INT244462 XBP1 Regulation of Gene_expression of DNAJB11 1 0.11 0 0 5.00
9 INT199365 Igf2 Positive_regulation of Phosphorylation of Macf1 1 0.13 1.84 0 5.00
10 INT199359 Igf2 Regulation of Macf1 1 0.11 3.11 0 5.00
11 INT244454 Binding of EIF2AK3 and SIL1 1 0.05 0.41 0 5.00
12 INT199361 Regulation of Igf2 Regulation of Macf1 1 0.11 1.59 0 5.00
13 INT199367 DST Regulation of Igf2 1 0.03 1.03 0 5.00
14 INT244476 CS Positive_regulation of ATF3 1 0.13 0.13 0 5.00
15 INT244469 CS Positive_regulation of PPP1R15A 1 0.08 0.12 0 5.00
16 INT244457 CS Positive_regulation of Gene_expression of ESR1 1 0.07 0.67 0 5.00
17 INT244458 CS Positive_regulation of ERN1 1 0.17 0.71 0 5.00
18 INT244475 Binding of CS and Positive_regulation of EIF2S2 1 0.11 0.07 0 5.00
19 INT244473 ATF6 Regulation of Gene_expression of DNAJB11 1 0.10 0 0 5.00
20 INT199368 DST Positive_regulation of Gene_expression of Igf2 1 0.04 1.51 0 5.00
21 INT244459 ERN1 Regulation of Positive_regulation of MAPK8 1 0.03 0.47 0 5.00
22 INT244450 TMBIM6 Negative_regulation of Gene_expression of ESR1 1 0.04 0.68 0 5.00
23 INT199371 DST Regulation of Transcription of Igf2 1 0.05 1.47 0 5.00
24 INT199366 DST Positive_regulation of Macf1 1 0.01 1.14 0 5.00
25 INT199360 Igf2 Regulation of Gene_expression of Lyve1 1 0.30 1.13 0 5.00
26 INT199363 Igf2 Regulation of Gopc 1 0.15 1.61 0 5.00
27 INT199370 DST Regulation of Gene_expression of Igf2 1 0.02 1.07 0 5.00
28 INT244477 CS Regulation of Gene_expression of ATF6 1 0.18 0.07 0 5.00
29 INT199369 DST Regulation of Igf1 1 0.02 0.8 0 5.00
30 INT244453 CS Positive_regulation of Gene_expression of TMBIM6 1 0.07 1.3 0 5.00
31 INT244479 CS Positive_regulation of ATF6 1 0.17 1.02 0 5.00
32 INT244481 Binding of ERN1 and ATF6 1 0.17 0.69 0 5.00
33 INT244471 TMBIM6 Negative_regulation of ESR1 1 0.04 0.68 0 5.00
34 INT244460 Binding of CS and Positive_regulation of Positive_regulation of EIF2S2 1 0.13 0.06 0 5.00
35 INT244470 ATF6 Regulation of XBP1 1 0.22 0.69 0 5.00
36 INT244466 EIF2AK3 Positive_regulation of Localization of SIL1 1 0.06 0.47 0 5.00
37 INT244468 CS Positive_regulation of EIF2S2 1 0.16 0.43 0 5.00
38 INT244467 Negative_regulation of CS Positive_regulation of EIF2S2 1 0.11 0.14 0 5.00
39 INT244455 ATF6 Regulation of SIL1 1 0.06 0.69 0 5.00
40 INT244478 Regulation of CS Regulation of XBP1 1 0.20 0.06 0 5.00
41 INT244482 CS Positive_regulation of Transcription of ATF3 1 0.13 0.13 0 5.00
42 INT244472 CS Negative_regulation of Binding of XBP1 1 0.19 1.07 0 5.00
43 INT244451 TMBIM6 Negative_regulation of Gene_expression of XBP1 1 0.13 0.68 0 5.00
44 INT244465 Binding of EIF2AK3 and ATF6 1 0.14 0.69 0 5.00
45 INT199362 Igf2 Positive_regulation of Macf1 1 0.11 1.67 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Adenosquamous Carcinoma. They are ordered first by their pain relevance and then by number of times they were reported in Adenosquamous Carcinoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT114824 Binding of PTHLH 12 0.42 9.5 0.9 99.66
2 INT126726 Binding of Pthlh 1 0.03 1.05 0.09 98.58
3 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 90.24
4 INT244563 Positive_regulation of EIF2S2 1 0.41 7.67 0.13 89.36
5 INT62360 Positive_regulation of PTHLH 31 0.70 28.23 3.46 82.92
6 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13 81.28
7 INT9899 Gene_expression of Vwf 91 0.74 45.06 9.13 81.28
8 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 81.04
9 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 79.20
10 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 79.20
11 INT67379 Positive_regulation of Cd34 38 0.58 26.18 3.28 79.20
12 INT81574 Positive_regulation of SIL1 21 0.67 10.85 0.31 79.20
13 INT82684 Positive_regulation of Pecam1 27 0.49 25.67 11.47 78.72
14 INT82685 Gene_expression of Pecam1 36 0.76 27.95 9.01 78.72
15 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 78.60
16 INT356395 Gene_expression of Ascc1 1 0.02 1.72 0 75.76
17 INT86184 Negative_regulation of Acsl1 10 0.34 20.45 2.23 75.60
18 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 72.96
19 INT244568 Positive_regulation of Gene_expression of EIF2S2 1 0.41 12.82 0 70.28
20 INT244562 Gene_expression of EIF2S2 1 0.46 23.74 0 69.88
21 INT244524 Phosphorylation of EIF2S2 1 0.49 11.33 0.2 69.04
22 INT229306 Positive_regulation of BAS 4 0.23 2 0.84 66.72
23 INT81575 Gene_expression of SIL1 29 0.25 19.76 1.24 65.24
24 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01 64.56
25 INT81576 Positive_regulation of Gene_expression of SIL1 5 0.23 7.03 0.27 59.80
26 INT283506 Gene_expression of SLC4A2 7 0.47 4 1.4 59.44
27 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 58.80
28 INT62509 Gene_expression of MCS 58 0.67 21.46 6.57 54.64
29 INT167070 Positive_regulation of Gene_expression of MCS 3 0.30 3.75 1.48 54.64
30 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 50.00
31 INT199340 Localization of Igf2 4 0.75 4.47 0.39 49.84
32 INT6884 Negative_regulation of pr 20 0.42 13.18 7.97 43.60
33 INT48219 Gene_expression of SLC4A1 34 0.75 33.18 2.84 40.00
34 INT105782 Positive_regulation of Krt20 9 0.20 9.62 0.53 35.76
35 INT115982 Positive_regulation of KRT7 18 0.50 19.81 1.14 35.04
36 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 28.48
37 INT175520 Gene_expression of Igf2 43 0.78 48.93 1.21 23.48
38 INT244553 Positive_regulation of Gene_expression of CS 6 0.22 3.07 0.09 23.48
39 INT125573 Gene_expression of CS 26 0.41 8 0.98 23.04
40 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 22.52
41 INT199358 Negative_regulation of Gene_expression of Igf2 3 0.43 4.48 0.3 21.48
42 INT175512 Positive_regulation of Gene_expression of Igf2 16 0.70 22.75 0.08 19.36
43 INT244490 Gene_expression of HSP90B1 4 0.33 41.16 10.37 8.00
44 INT244512 Positive_regulation of Gene_expression of HSP90B1 2 0.30 12.08 3.12 8.00
45 INT26364 Positive_regulation of CS 12 0.30 4.99 1.89 7.56
46 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
47 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
48 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 5.00
49 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 5.00
50 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
51 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 5.00
52 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
53 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
54 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
55 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
56 INT61949 Regulation of Nos2 74 0.58 34.08 16.7 5.00
57 INT20611 Gene_expression of Asap1 55 0.65 23.71 14.62 5.00
58 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
59 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8 5.00
60 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
61 INT94784 Binding of ROS1 113 0.40 71.57 10.26 5.00
62 INT67101 Gene_expression of DST 47 0.54 25.92 9.59 5.00
63 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
64 INT38644 Positive_regulation of DST 30 0.53 12.48 6.59 5.00
65 INT87470 Gene_expression of SDC1 27 0.78 24.86 5.81 5.00
66 INT73608 Localization of Nos2 21 0.75 9.58 5.05 5.00
67 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57 5.00
68 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 5.00
69 INT124622 Positive_regulation of ATF3 26 0.70 21.6 4.03 5.00
70 INT88867 Localization of MCS 19 0.62 28.31 3.88 5.00
71 INT93110 Regulation of CDCP1 16 0.03 7.98 3.83 5.00
72 INT218955 Protein_catabolism of ESR1 9 0.92 3.95 3.74 5.00
73 INT102076 Regulation of DST 15 0.22 10 3.5 5.00
74 INT5286 Gene_expression of ANTXR2 46 0.75 21.06 3.41 5.00
75 INT178631 Phosphorylation of ESR1 21 0.75 9.16 3.36 5.00
76 INT57222 Gene_expression of ATF3 22 0.78 54.71 3.28 5.00
77 INT162372 Positive_regulation of SFTPD 15 0.67 11.8 3.21 5.00
78 INT134795 Positive_regulation of Scrib 30 0.22 36.91 2.81 5.00
79 INT145328 Negative_regulation of Scrib 25 0.16 26.79 2.66 5.00
80 INT103282 Positive_regulation of ATF4 12 0.66 7.28 2.65 5.00
81 INT15695 Positive_regulation of EIF2AK3 12 0.67 7.01 2.56 5.00
82 INT87287 Phosphorylation of CDCP1 20 0.04 5.62 2.43 5.00
83 INT26363 Negative_regulation of CS 8 0.26 2.49 2.36 5.00
84 INT99157 Binding of SIL1 8 0.35 2.66 2.33 5.00
85 INT18570 Gene_expression of HERPUD1 3 0.57 0.45 2.15 5.00
86 INT26606 Gene_expression of RNASE1 19 0.65 7.18 1.46 5.00
87 INT130704 Gene_expression of ATF4 9 0.78 5.29 1.45 5.00
88 INT130343 Gene_expression of CTNND2 5 0.75 6.98 1.38 5.00
89 INT90491 Binding of Igf1 25 0.44 9.75 1.36 5.00
90 INT162467 Gene_expression of ERN1 10 0.56 5.11 1.26 5.00
91 INT127900 Phosphorylation of EIF2AK3 14 0.80 7.99 1.22 5.00
92 INT157765 Negative_regulation of CDH1 32 0.53 35.72 1.15 5.00
93 INT162471 Positive_regulation of ERN1 7 0.34 3.02 1.08 5.00
94 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95 5.00
95 INT156641 Positive_regulation of CNOT4 4 0.07 3.19 0.9 5.00
96 INT199345 Gene_expression of Lyve1 11 0.50 8.44 0.89 5.00
97 INT129192 Transcription of ATF3 5 0.53 1.81 0.86 5.00
98 INT127059 Positive_regulation of SF3A3 4 0.02 2.08 0.82 5.00
99 INT9368 Regulation of CS 6 0.17 1.67 0.8 5.00
100 INT127899 Gene_expression of EIF2AK3 8 0.75 2.89 0.8 5.00
101 INT127898 Positive_regulation of Phosphorylation of EIF2AK3 3 0.49 2.03 0.67 5.00
102 INT52910 Localization of SIL1 2 0.19 1.03 0.66 5.00
103 INT90362 Negative_regulation of Gene_expression of SDC1 3 0.59 2.88 0.59 5.00
104 INT130711 Positive_regulation of DNAJB11 2 0.16 0.79 0.55 5.00
105 INT165682 Phosphorylation of NFE2L2 4 0.78 1.53 0.51 5.00
106 INT199342 Regulation of Igfbp2 5 0.60 3.3 0.5 5.00
107 INT199332 Binding of Igfbp2 2 0.36 1.46 0.41 5.00
108 INT244505 Regulation of Transcription of HSP90B1 2 0.19 1.47 0.41 5.00
109 INT244495 Transcription of HSP90B1 2 0.28 1.47 0.4 5.00
110 INT137415 Regulation of Gene_expression of SDC1 2 0.02 2.53 0.4 5.00
111 INT156643 Positive_regulation of Positive_regulation of CNOT4 2 0.05 1.64 0.39 5.00
112 INT183634 Positive_regulation of Macf1 2 0.13 6.25 0.38 5.00
113 INT215359 Regulation of Gene_expression of SIL1 2 0.14 1.11 0.37 5.00
114 INT140617 Positive_regulation of ATF6 4 0.64 4.11 0.35 5.00
115 INT176586 Positive_regulation of Binding of ESR1 11 0.41 4.64 0.33 5.00
116 INT244571 Positive_regulation of HERPUD1 2 0.32 0.39 0.33 5.00
117 INT140619 Gene_expression of ATF6 3 0.62 3.29 0.3 5.00
118 INT199343 Positive_regulation of Igfbp2 8 0.67 7.85 0.28 5.00
119 INT199354 Gene_expression of Pck1 13 0.72 5.57 0.26 5.00
120 INT117878 Positive_regulation of Regulation of Nos2 3 0.41 1.35 0.25 5.00
121 INT244537 Regulation of ERN1 3 0.26 1.32 0.25 5.00
122 INT205532 Binding of CS 7 0.14 1.27 0.22 5.00
123 INT199333 Gene_expression of Igfbp2 8 0.65 9.3 0.21 5.00
124 INT215365 Gene_expression of SCAP 4 0.01 1.93 0.19 5.00
125 INT183631 Gene_expression of Macf1 2 0.13 5.64 0.18 5.00
126 INT199349 Regulation of Gene_expression of Igf2 4 0.50 4.56 0.15 5.00
127 INT244569 Phosphorylation of CS 1 0.31 2.96 0.15 5.00
128 INT215885 Transcription of DDIT3 3 0.69 2.57 0.13 5.00
129 INT118235 Positive_regulation of Igf2 9 0.70 10.05 0.12 5.00
130 INT244559 Negative_regulation of Phosphorylation of EIF2S2 1 0.35 1.56 0.12 5.00
131 INT244487 Regulation of Positive_regulation of CS 1 0.10 0.18 0.12 5.00
132 INT130699 Gene_expression of DNAJB9 2 0.49 0.56 0.11 5.00
133 INT244502 Binding of XBP1 5 0.33 2.43 0.11 5.00
134 INT130706 Gene_expression of DNAJB11 2 0.40 0.56 0.11 5.00
135 INT244566 Positive_regulation of Phosphorylation of EIF2S2 1 0.41 2.69 0.09 5.00
136 INT199357 Negative_regulation of Igf2 1 0.38 1.91 0.09 5.00
137 INT199348 Negative_regulation of Igfbp2 1 0.41 0.2 0.09 5.00
138 INT199337 Binding of Igf2 1 0.37 1.55 0.09 5.00
139 INT244534 Negative_regulation of ERN1 2 0.25 1.08 0.09 5.00
140 INT140615 Transcription of ATF6 2 0.55 0.73 0.08 5.00
141 INT244544 Positive_regulation of Positive_regulation of EIF2S2 1 0.28 0.67 0.07 5.00
142 INT224299 Positive_regulation of Protein_catabolism of ESR1 3 0.64 1.43 0.07 5.00
143 INT205533 Localization of CS 4 0.28 0.69 0.06 5.00
144 INT199335 Negative_regulation of Macf1 1 0.11 9.66 0.06 5.00
145 INT244536 Negative_regulation of Gene_expression of CS 3 0.31 0.88 0.04 5.00
146 INT336900 Positive_regulation of Sftpd 1 0.01 1.39 0.03 5.00
147 INT244535 Negative_regulation of Positive_regulation of EIF2S2 1 0.35 0.54 0.03 5.00
148 INT244519 Positive_regulation of Gene_expression of SCAP 2 0.01 0.76 0.03 5.00
149 INT244561 Positive_regulation of Positive_regulation of ATF4 1 0.31 0.42 0.03 5.00
150 INT244556 Regulation of Positive_regulation of EIF2S2 1 0.27 0.59 0.03 5.00
151 INT244518 Positive_regulation of Localization of CS 2 0.19 0.37 0.03 5.00
152 INT199356 Positive_regulation of Gene_expression of Igfbp2 1 0.48 2.86 0 5.00
153 INT199351 Phosphorylation of Macf1 1 0.18 3.61 0 5.00
154 INT244545 Positive_regulation of Transcription of HGFAC 1 0.01 0.52 0 5.00
155 INT244492 Positive_regulation of Gene_expression of HERPUD1 1 0.32 0 0 5.00
156 INT244488 Positive_regulation of Gene_expression of TMBIM6 1 0.21 1.27 0 5.00
157 INT244540 Gene_expression of TMBIM6 1 0.24 2.58 0 5.00
158 INT244530 Regulation of Binding of CS 1 0.17 0.06 0 5.00
159 INT199344 Negative_regulation of Positive_regulation of Igfbp2 1 0.41 0.87 0 5.00
160 INT269127 Protein_catabolism of HPV6AI1 1 0.01 0.78 0 5.00
161 INT244498 Negative_regulation of XBP1 1 0.38 0.36 0 5.00
162 INT244548 Negative_regulation of ATF6 1 0.34 0.97 0 5.00
163 INT244500 Regulation of XBP1 1 0.40 0.37 0 5.00
164 INT244485 Gene_expression of EDEM1 1 0.20 0 0 5.00
165 INT199347 Transcription of Igf2 1 0.72 1.41 0 5.00
166 INT199338 Localization of Macf1 1 0.14 1.98 0 5.00
167 INT244533 Negative_regulation of Phosphorylation of EIF2AK3 1 0.20 0.39 0 5.00
168 INT244554 Gene_expression of PPP1R15A 2 0.24 1.17 0 5.00
169 INT244543 Positive_regulation of Positive_regulation of ATF6 1 0.40 0.09 0 5.00
170 INT244504 Phosphorylation of ERN1 1 0.47 0.97 0 5.00
171 INT244539 Negative_regulation of Gene_expression of SCAP 1 0.01 0.75 0 5.00
172 INT242321 Negative_regulation of Gene_expression of Asap1 1 0.20 1.96 0 5.00
173 INT244508 Positive_regulation of SERP1 1 0.10 0 0 5.00
174 INT244532 Protein_catabolism of ATF6 1 0.52 0.84 0 5.00
175 INT244494 Regulation of Transcription of SIL1 1 0.11 0.15 0 5.00
176 INT356397 Negative_regulation of SDC1 1 0.01 2.75 0 5.00
177 INT244541 Negative_regulation of EIF2S2 1 0.25 0 0 5.00
178 INT244491 Gene_expression of SYVN1 1 0.22 0 0 5.00
179 INT244516 Protein_catabolism of NUP50 1 0.04 0.08 0 5.00
180 INT199339 Negative_regulation of Positive_regulation of Macf1 1 0.09 1.4 0 5.00
181 INT244555 Transcription of HGFAC 1 0.01 0.52 0 5.00
182 INT199350 Positive_regulation of Negative_regulation of Macf1 1 0.10 3.9 0 5.00
183 INT244558 Negative_regulation of Gene_expression of ERN1 1 0.24 0.71 0 5.00
184 INT244549 Gene_expression of DNAJC3 1 0.24 0 0 5.00
185 INT244529 Localization of ATF6 1 0.64 0.06 0 5.00
186 INT244509 Regulation of Gene_expression of EIF2S2 1 0.27 1.14 0 5.00
187 INT244511 Regulation of EIF2S2 1 0.37 4.46 0 5.00
188 INT199330 Regulation of Pck1 3 0.57 3.12 0 5.00
189 INT199353 Positive_regulation of Positive_regulation of Igf2 1 0.50 1.35 0 5.00
190 INT244542 Positive_regulation of EDEM1 1 0.16 0 0 5.00
191 INT244497 Negative_regulation of Gene_expression of RNASE1 1 0.05 0.7 0 5.00
192 INT244489 Gene_expression of SERP1 1 0.26 0 0 5.00
193 INT244550 Transcription of SIL1 1 0.16 0.15 0 5.00
194 INT181035 Binding of Macf1 2 0.26 1.61 0 5.00
195 INT244538 Transcription of XBP1 1 0.61 0.15 0 5.00
196 INT244525 Gene_expression of XBP1 10 0.69 4.47 0 5.00
197 INT244514 Regulation of Positive_regulation of ATF6 1 0.36 0.15 0 5.00
198 INT199331 Positive_regulation of Positive_regulation of Macf1 1 0.10 1.69 0 5.00
199 INT199346 Negative_regulation of Negative_regulation of Macf1 1 0.08 1.92 0 5.00
200 INT244531 Negative_regulation of Gene_expression of XBP1 1 0.38 0.88 0 5.00
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