D:Adrenal Insufficiency

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Disease Term
Synonyms ADRENAL GLAND HYPOFUNCTION, Adrenal Insufficiencies, HYPOADRENALISM, Hypofunction Adrenal Gland
Documents 248
Hot Single Events 104
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Adrenal Insufficiency. They are ordered first by their relevance to Adrenal Insufficiency and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT280820 S100a8 Positive_regulation of Gene_expression of Crh 1 0.01 0.65 0.19 81.52
2 INT177958 IGHE Positive_regulation of TNF 1 0.03 2.23 0 76.80
3 INT177959 Positive_regulation of IGHE Positive_regulation of TNF 1 0.03 2.23 0 76.80
4 INT92205 Crh Positive_regulation of Localization of SST 1 0.30 0.87 0.21 62.56
5 INT179237 Binding of SERPINA6 and POMC 1 0.03 1.15 0.49 60.20
6 INT281005 Hdlcl1 Regulation of OTOR 1 0.00 1.62 0.26 59.88
7 INT253774 THBD Regulation of F2 1 0.00 0.61 0.08 55.84
8 INT341043 Avp Regulation of Camp 1 0.10 0.47 0.03 55.12
9 INT280816 Crh Positive_regulation of Gene_expression of Pomc 1 0.15 0.28 0.06 53.24
10 INT280810 Avp Negative_regulation of Gene_expression of Pomc 1 0.02 0.22 0.06 50.08
11 INT253776 Binding of THBD and F2 1 0.00 1.15 0.18 49.92
12 INT234802 Binding of AQP2 and AVPR2 2 0.15 0.84 0.07 47.08
13 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69 43.28
14 INT280826 Il6 Positive_regulation of Localization of Avp 1 0.01 0.64 0.47 23.40
15 INT60626 Crh Positive_regulation of Localization of Pomc 7 0.54 2.3 1.99 20.20
16 INT280821 Son Regulation of Gene_expression of gr 1 0.01 0.18 0.08 10.96
17 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65 5.00
18 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03 5.00
19 INT302309 Hps4 Positive_regulation of Cia1 1 0.01 1.34 0.95 5.00
20 INT122191 Binding of Crh and Ucn 4 0.36 0.79 0.82 5.00
21 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77 5.00
22 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69 5.00
23 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69 5.00
24 INT122190 Binding of Crhr1 and Ucn 4 0.49 0.65 0.67 5.00
25 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66 5.00
26 INT339794 Sstr2 Positive_regulation of Gene_expression of Sstr5 1 0.08 0.25 0.64 5.00
27 INT220145 HPSE Negative_regulation of Gene_expression of CRH 1 0.01 0.92 0.64 5.00
28 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58 5.00
29 INT93063 Binding of gr and Jun 3 0.14 0.79 0.57 5.00
30 INT149473 Avp Positive_regulation of Localization of Pomc 4 0.48 2.64 0.56 5.00
31 INT316546 Binding of GH1 and SST 2 0.03 0.55 0.54 5.00
32 INT215101 Hmgb1 Positive_regulation of Localization of Il6 4 0.16 1.18 0.54 5.00
33 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52 5.00
34 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49 5.00
35 INT132792 IL4 Positive_regulation of IL6 4 0.28 1.81 0.47 5.00
36 INT222284 Negative_regulation of Casp1 Negative_regulation of Il18 1 0.01 0.79 0.46 5.00
37 INT222283 Negative_regulation of Casp1 Negative_regulation of Il1a 1 0.00 0.78 0.46 5.00
38 INT122188 Binding of Crh and Ucn2 2 0.22 0.29 0.38 5.00
39 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37 5.00
40 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37 5.00
41 INT122189 Binding of Crhr1 and Ucn2 2 0.08 0.27 0.36 5.00
42 INT182126 IRF6 Positive_regulation of Gene_expression of SELE 1 0.03 0.86 0.34 5.00
43 INT280808 Prkcg Positive_regulation of Transcription of Fos 1 0.02 0.06 0.33 5.00
44 INT280838 Binding of Crh and gr 1 0.06 0 0.33 5.00
45 INT280814 Positive_regulation of Mapk1 Positive_regulation of Transcription of Fos 1 0.02 0.06 0.33 5.00
46 INT253766 Binding of Apex1 and Tlr4 1 0.03 0.53 0.32 5.00
47 INT253762 Binding of Apex1 and Hmgb1 1 0.09 1.29 0.32 5.00
48 INT280827 Positive_regulation of Fos Positive_regulation of Avp 1 0.02 0.08 0.28 5.00
49 INT280825 Mapk1 Positive_regulation of Avp 1 0.01 0.08 0.28 5.00
50 INT280807 Mapk1 Positive_regulation of Positive_regulation of Prkcg 1 0.01 0.08 0.28 5.00
51 INT280832 Binding of Crh and Ucn3 1 0.16 0.07 0.27 5.00
52 INT280850 Binding of Crh and Ucn Positive_regulation of Negative_regulation of Crh 1 0.26 0.06 0.27 5.00
53 INT280822 Jun Regulation of Regulation of Crh 1 0.20 0.08 0.27 5.00
54 INT280805 Positive_regulation of Prkcg Positive_regulation of Avp 1 0.01 0.16 0.26 5.00
55 INT177961 Binding of CCR3 and CCL11 1 0.04 0.73 0.26 5.00
56 INT132801 IL4 Positive_regulation of Localization of IL6 2 0.26 1.47 0.26 5.00
57 INT179233 IRF6 Negative_regulation of Binding of GSR 1 0.03 0.83 0.25 5.00
58 INT280811 Binding of Crhr1 and Ucn3 1 0.08 0.05 0.25 5.00
59 INT177957 CCL11 Regulation of Binding of IL5 and CCL11 1 0.01 0.71 0.25 5.00
60 INT177960 Binding of IL5 and CCL11 1 0.03 0.71 0.25 5.00
61 INT253765 Apex1 Positive_regulation of Hmgb1 1 0.09 1.27 0.24 5.00
62 INT253771 Gopc Positive_regulation of Hmgb1 1 0.03 1.27 0.24 5.00
63 INT253773 TNF Positive_regulation of Hmgb1 1 0.09 1.21 0.23 5.00
64 INT179230 Binding of MAPK14 and GSR 1 0.03 0.5 0.23 5.00
65 INT179229 Binding of GSR and NR3C2 1 0.03 0.37 0.23 5.00
66 INT121050 Crh Regulation of Localization of Pomc 4 0.43 0.6 0.22 5.00
67 INT177962 IL4 Positive_regulation of VCAM1 1 0.02 0.97 0.2 5.00
68 INT220146 Binding of IGF1 and IGFBP1 2 0.10 1.57 0.19 5.00
69 INT280839 Il6 Positive_regulation of Gene_expression of Crh 1 0.09 0.1 0.19 5.00
70 INT280833 Il1 Positive_regulation of Gene_expression of Crh 1 0.05 0.09 0.17 5.00
71 INT353041 IL4 Positive_regulation of Localization of IL1B 1 0.02 0.99 0.16 5.00
72 INT280846 Crh Positive_regulation of Localization of POMC 1 0.03 0.37 0.16 5.00
73 INT353036 IL4 Positive_regulation of Localization of IL10 1 0.03 0.99 0.16 5.00
74 INT353040 IL4 Positive_regulation of IL8 1 0.02 0.99 0.16 5.00
75 INT353037 IL4 Positive_regulation of IL2 1 0.02 0.99 0.16 5.00
76 INT353038 IL4 Positive_regulation of Localization of IL2 1 0.02 0.99 0.16 5.00
77 INT353039 IL4 Positive_regulation of Localization of IL8 1 0.02 0.99 0.16 5.00
78 INT280813 Binding of Avp and S100a8 1 0.00 0.28 0.15 5.00
79 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
80 INT284570 Binding of Avp and Il6 1 0.04 2.17 0.13 5.00
81 INT220147 IGFBP3 Positive_regulation of IGF1 1 0.10 0.53 0.13 5.00
82 INT280819 Binding of Creb1 and gr 1 0.01 0 0.13 5.00
83 INT280809 Binding of gr and Rela 1 0.00 0 0.13 5.00
84 INT179234 Binding of SERPINA6 and ELANE 1 0.01 0.22 0.12 5.00
85 INT253761 Hmgb1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.73 0.12 5.00
86 INT253772 Binding of THBD and Hmgb1 1 0.05 0.95 0.12 5.00
87 INT253775 Negative_regulation of Binding of THBD and Hmgb1 1 0.06 0.69 0.12 5.00
88 INT220149 Binding of IGF1 and IGFALS 2 0.39 0.44 0.1 5.00
89 INT280836 Gene_expression of Fos Positive_regulation of Crh 1 0.09 0.17 0.1 5.00
90 INT280841 Jun Positive_regulation of Gene_expression of Crh 1 0.35 0.16 0.1 5.00
91 INT316543 GH1 Regulation of Gene_expression of IGF1 1 0.03 1.32 0.09 5.00
92 INT316552 Binding of SST and Sst1 1 0.03 0.53 0.09 5.00
93 INT250730 Hmgb1 Positive_regulation of Localization of TNF 1 0.08 0.92 0.09 5.00
94 INT250729 Crlf1 Positive_regulation of Localization of TNF 1 0.02 0.92 0.09 5.00
95 INT253764 Atp9a Positive_regulation of Apex1 1 0.00 0.39 0.08 5.00
96 INT193564 Binding of STMN1 and MRI1 1 0.07 0.06 0.07 5.00
97 INT179232 Binding of CREM and GSR 1 0.00 0 0.06 5.00
98 INT280818 Jun Positive_regulation of Avp 1 0.06 0.23 0.06 5.00
99 INT280834 Negative_regulation of Jun Positive_regulation of Avp 1 0.05 0.23 0.06 5.00
100 INT323043 Binding of CYP21A1P and HLA-DOA 1 0.04 1.48 0.06 5.00
101 INT323042 Binding of CYP21A2 and HLA-DOA 1 0.04 1.49 0.06 5.00
102 INT222295 Binding of CPP and Cebpz 1 0.00 0.73 0.05 5.00
103 INT280843 Binding of Crem and Crh 1 0.03 0.22 0.04 5.00
104 INT280817 Binding of Cdx1 and Crh 1 0.02 0.21 0.04 5.00
105 INT280849 REST Negative_regulation of Gene_expression of Avp 1 0.09 0.09 0 5.00
106 INT354097 Timp1 Negative_regulation of Localization of NFKB2 1 0.04 0.94 0 5.00
107 INT280823 Positive_regulation of Prkaca Positive_regulation of Gene_expression of Crh 1 0.08 0.11 0 5.00
108 INT280840 Avp Regulation of Localization of Pomc 1 0.02 0.16 0 5.00
109 INT280845 Binding of ELANE and Avp 1 0.06 0 0 5.00
110 INT253769 Binding of Hmgb1 and Il1 1 0.01 0.27 0 5.00
111 INT280844 Binding of Avp and Tcf12 1 0.00 0.52 0 5.00
112 INT280806 Avpr1b Positive_regulation of Localization of Pomc 1 0.19 0.17 0 5.00
113 INT280835 Usf1 Positive_regulation of Gene_expression of Avp 1 0.03 1.06 0 5.00
114 INT280830 Binding of Avp and Usf2 1 0.02 0.53 0 5.00
115 INT280812 Usf2 Positive_regulation of Gene_expression of Avp 1 0.03 0.52 0 5.00
116 INT280831 Prkaca Positive_regulation of Gene_expression of Crh 1 0.08 0 0 5.00
117 INT280815 Vmn1r66 Negative_regulation of Gene_expression of Avp 1 0.00 0.09 0 5.00
118 INT327198 DBT Positive_regulation of Gene_expression of ESRRA 1 0.00 0.42 0 5.00
119 INT280824 Binding of Avp and Crh 1 0.05 0.55 0 5.00
120 INT280848 Binding of REST and Rest 1 0.02 0.09 0 5.00
121 INT280847 Avp Regulation of Binding of ELANE 1 0.07 0 0 5.00
122 INT280828 Binding of Avp and Avpr2 2 0.15 0.28 0 5.00
123 INT354096 Timp1 Negative_regulation of Positive_regulation of NFKB2 1 0.04 0.94 0 5.00
124 INT280829 Binding of Tcf12 and Usf2 1 0.00 0.53 0 5.00
125 INT214886 Binding of Atcay and FIP1L1 1 0.08 4.06 0 5.00
126 INT280851 Binding of Avp and Usf2 Positive_regulation of Gene_expression of Avp 1 0.00 0.53 0 5.00
127 INT214885 Binding of PDGFRA and Atcay 1 0.08 4.05 0 5.00
128 INT280837 Binding of Rest and Negative_regulation of Gene_expression of Avp 1 0.00 0.09 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Adrenal Insufficiency. They are ordered first by their pain relevance and then by number of times they were reported in Adrenal Insufficiency. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6129 Positive_regulation of Localization of AVP 63 0.70 30.44 16.64 100.00
2 INT149140 Gene_expression of Skap2 8 0.64 1.3 0.32 100.00
3 INT255580 Positive_regulation of Gene_expression of NR0B1 3 0.42 1.15 0.28 99.90
4 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38 99.90
5 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97 99.82
6 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 99.82
7 INT84598 Regulation of Aqp2 13 0.45 4.28 0.86 99.82
8 INT14184 Positive_regulation of CPB1 23 0.55 14.38 1.73 99.74
9 INT16314 Gene_expression of NR0B1 25 0.65 7.99 1.71 99.72
10 INT214 Localization of AVP 370 0.81 208.51 91.09 99.48
11 INT11303 Gene_expression of Avp 116 0.78 39.23 23.88 99.36
12 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 99.32
13 INT11288 Negative_regulation of CRH 44 0.00 16.69 12.37 99.24
14 INT21179 Negative_regulation of Crh 22 0.58 8.03 7.87 99.24
15 INT14185 Regulation of CPB1 9 0.35 5.88 0.93 99.12
16 INT95415 Gene_expression of Abcd1 2 0.52 1.95 0.39 99.00
17 INT44816 Regulation of Serpina6 16 0.62 3.63 8.02 98.96
18 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 98.92
19 INT21379 Transcription of Crh 65 0.72 15.64 27.92 98.82
20 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 98.68
21 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 98.58
22 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 98.58
23 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 98.56
24 INT76757 Positive_regulation of SERPINA6 3 0.59 1.19 0.97 98.44
25 INT1166 Negative_regulation of Dbh 56 0.59 12.54 28.26 98.40
26 INT115963 Negative_regulation of Gene_expression of CRH 9 0.59 4.53 1.48 98.36
27 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79 98.28
28 INT45673 Gene_expression of Serpina6 10 0.53 3.47 3 98.00
29 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 97.76
30 INT28573 Positive_regulation of Rit1 5 0.33 3.46 0.4 97.76
31 INT84595 Negative_regulation of Aqp2 11 0.58 4.88 1.78 97.34
32 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 97.32
33 INT389 Gene_expression of Ace 21 0.67 10.31 8.1 97.28
34 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 96.80
35 INT684 Binding of AVP 38 0.48 13.9 8.85 96.60
36 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 96.56
37 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58 96.20
38 INT477 Localization of Avp 813 0.81 131.58 300.4 95.72
39 INT6127 Regulation of Localization of AVP 60 0.62 15.12 20.84 95.68
40 INT6278 Negative_regulation of Gene_expression of Pomc 35 0.59 11.07 14.8 95.20
41 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 94.88
42 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 94.64
43 INT69160 Positive_regulation of IL5 41 0.65 36.04 7.75 94.64
44 INT255571 Gene_expression of Gk 15 0.26 15.42 0.38 94.64
45 INT255568 Positive_regulation of Gene_expression of Gk 4 0.17 8.23 0.11 94.64
46 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 94.48
47 INT546 Binding of ALB 311 0.48 85.98 60.14 94.28
48 INT5454 Localization of CRH 124 0.79 79.18 41.53 94.28
49 INT21032 Gene_expression of Adh1 23 0.78 22.1 6.14 93.96
50 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34 93.92
51 INT255576 Transcription of NR0B1 2 0.58 1.38 0.13 93.60
52 INT255582 Positive_regulation of Transcription of NR0B1 1 0.42 0.18 0 93.60
53 INT255581 Negative_regulation of Transcription of NR0B1 1 0.36 0.18 0 93.60
54 INT443 Localization of POMC 1020 0.81 284.52 443.17 93.56
55 INT19805 Negative_regulation of Avp 18 0.59 4.57 5.87 93.32
56 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 93.20
57 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14 92.92
58 INT10369 Positive_regulation of Spic 4 0.03 1.99 1.54 92.92
59 INT15347 Positive_regulation of Localization of Pomc 81 0.70 28.1 31.01 92.36
60 INT1438 Localization of Pomc 360 0.81 101.26 116.47 91.88
61 INT64123 Gene_expression of PIP 16 0.70 5.77 0.86 91.76
62 INT84599 Gene_expression of Aqp2 31 0.77 22.58 2.54 91.64
63 INT149238 Positive_regulation of Gene_expression of Aqp2 5 0.66 3.07 0.73 91.64
64 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 91.12
65 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 91.12
66 INT9660 Regulation of TNF 363 0.62 312.94 139.99 90.64
67 INT1721 Negative_regulation of HP 148 0.42 86.82 16.89 90.64
68 INT83745 Gene_expression of SULT2A1 34 0.59 15.96 6.66 90.60
69 INT170181 Regulation of SULT2A1 4 0.26 5.15 1.56 90.28
70 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 89.88
71 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 89.68
72 INT229618 Gene_expression of SCGB2A2 3 0.54 3.09 0.22 89.60
73 INT1295 Binding of Pomc 85 0.48 12.92 42.8 89.56
74 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02 88.40
75 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 88.40
76 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 88.16
77 INT2586 Positive_regulation of Gcg 35 0.70 9.25 11.75 87.60
78 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 87.40
79 INT24420 Transcription of Pomc 13 0.69 3.32 4.54 87.16
80 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 86.52
81 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 86.28
82 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 86.12
83 INT255569 Negative_regulation of Gk 7 0.14 4.56 0.07 85.44
84 INT85655 Gene_expression of Crhr1 17 0.68 9.34 6.31 85.40
85 INT35209 Positive_regulation of Negative_regulation of Gnrhr 5 0.48 1.38 1.53 85.32
86 INT619 Positive_regulation of Positive_regulation of Prl 116 0.70 22.69 45.06 85.32
87 INT56385 Positive_regulation of Gk 11 0.22 15.07 1.28 85.12
88 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 85.00
89 INT695 Binding of POMC 304 0.48 56.66 126.85 84.92
90 INT63534 Binding of CRH 23 0.47 6.84 3.43 84.92
91 INT738 Regulation of POMC 459 0.62 111.19 243.74 83.00
92 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 83.00
93 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 83.00
94 INT10848 Negative_regulation of Gene_expression of AVP 13 0.59 6.76 2.71 82.92
95 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 82.24
96 INT57502 Positive_regulation of Gene_expression of CRH 30 0.70 23.37 5.7 82.24
97 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 82.24
98 INT74020 Negative_regulation of XRCC1 16 0.35 17.18 1.06 81.84
99 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 81.68
100 INT7584 Gene_expression of Crh 112 0.78 39.15 25.33 81.52
101 INT148717 Binding of NR0B1 6 0.34 5.4 0.25 81.48
102 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 80.68
103 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58 80.40
104 INT28572 Regulation of Rit1 4 0.30 3.63 0.48 80.32
105 INT3118 Negative_regulation of Positive_regulation of POMC 33 0.59 9.42 18.07 78.40
106 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 78.32
107 INT10879 Positive_regulation of Avp 39 0.65 14.01 8.76 78.16
108 INT252 Localization of GH1 529 0.80 227.4 122.05 78.04
109 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 78.04
110 INT255577 Negative_regulation of Negative_regulation of NR0B1 1 0.36 0.15 0 78.00
111 INT34777 Localization of IGF1 82 0.80 42.68 8.62 77.92
112 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 77.68
113 INT158 Localization of Prl 2431 0.81 378.96 952.2 77.68
114 INT109242 Gene_expression of Igis1 1 0.01 1.54 0.2 77.68
115 INT320068 Gene_expression of AVPR2 1 0.65 0.91 0.19 77.32
116 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 77.20
117 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 76.80
118 INT61734 Regulation of HPSE 16 0.60 13.05 3.5 76.64
119 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 76.56
120 INT16915 Negative_regulation of NR0B1 6 0.36 2.32 0.17 76.24
121 INT180379 Gene_expression of Olr1 31 0.36 36.46 4.84 75.72
122 INT212988 Positive_regulation of Gene_expression of Olr1 8 0.24 6.64 1.2 75.72
123 INT122285 Gene_expression of Cog1 10 0.14 5.95 0.98 75.72
124 INT170185 Localization of SULT2A1 4 0.47 4.65 2 75.56
125 INT170184 Negative_regulation of Localization of SULT2A1 1 0.25 1.56 0.54 75.56
126 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 75.04
127 INT75846 Positive_regulation of MC4R 7 0.70 5.73 1.05 75.00
128 INT75847 Regulation of Positive_regulation of MC4R 1 0.35 0.83 0.18 75.00
129 INT2290 Protein_catabolism of POMC 41 0.99 4.86 23.36 75.00
130 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 74.96
131 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 74.80
132 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 74.80
133 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 74.44
134 INT175389 Positive_regulation of Ugcg 9 0.32 8.79 1.09 74.24
135 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 73.44
136 INT4146 Binding of SHBG 49 0.47 31 4.71 73.40
137 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 72.76
138 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 72.12
139 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 70.88
140 INT320067 Localization of AVPR1A 1 0.73 1.78 0.27 70.84
141 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 69.52
142 INT7565 Transcription of Pomc 69 0.72 14.46 27.41 69.52
143 INT5511 Negative_regulation of Gene_expression of Pomc 47 0.59 12.08 23.02 69.52
144 INT22337 Negative_regulation of Transcription of Pomc 12 0.59 2.17 4.32 69.52
145 INT63441 Regulation of Transcription of Crh 9 0.60 4.51 3.9 69.44
146 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 69.04
147 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 69.04
148 INT234 Binding of Alb 151 0.48 52.34 32.97 68.72
149 INT14480 Positive_regulation of RIT1 5 0.67 1.95 1 67.68
150 INT11300 Positive_regulation of Gene_expression of Avp 24 0.50 10.18 2.69 67.24
151 INT241783 Positive_regulation of AVPR1A 2 0.67 1.34 0.14 66.88
152 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 66.40
153 INT1893 Localization of Gh 1041 0.79 340.23 256.58 66.32
154 INT44550 Positive_regulation of Gene_expression of AVP 38 0.70 22.27 8.62 66.28
155 INT21177 Positive_regulation of Crh 39 0.70 17.5 15.28 65.84
156 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 65.56
157 INT89661 Gene_expression of Hrec 102 0.21 69.91 39.57 65.04
158 INT237902 Regulation of Gene_expression of Hrec 7 0.04 6.74 2.36 65.04
159 INT1279 Negative_regulation of Cox6c 10 0.30 3.1 2.82 64.88
160 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 63.28
161 INT153130 Binding of Nr0b1 1 0.26 0.49 0.08 63.16
162 INT112424 Gene_expression of AVPR1B 6 0.65 1.35 0.16 62.52
163 INT397 Localization of SST 232 0.81 58.05 101.19 61.96
164 INT797 Regulation of Penk 812 0.62 111.13 542.24 60.88
165 INT18710 Regulation of Regulation of Crh 6 0.60 0.79 1.6 60.88
166 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 60.84
167 INT77000 Protein_catabolism of Fgg 5 0.04 3.57 0.64 60.84
168 INT24643 Gene_expression of Hdlcl1 30 0.73 26.83 1.9 59.88
169 INT1586 Regulation of Binding of POMC 7 0.45 1.14 2.61 59.68
170 INT35584 Binding of ACLY 22 0.35 31.78 7.17 58.76
171 INT82929 Gene_expression of Plat 58 0.78 26.96 13.85 58.16
172 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61 57.84
173 INT72676 Gene_expression of APOA1 34 0.75 34.15 1.67 57.76
174 INT179257 Binding of SERPINA6 5 0.10 2.09 1.24 57.48
175 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 57.36
176 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53 57.36
177 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 57.28
178 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 56.96
179 INT1898 Regulation of Crh 220 0.62 61.33 102.64 56.88
180 INT238858 Gene_expression of GK 4 0.08 2.18 0.14 56.88
181 INT179261 Gene_expression of SERPINA6 12 0.14 3.53 3.82 56.28
182 INT17493 Binding of Ar 14 0.48 3.62 0.6 56.24
183 INT320070 Localization of AVPR2 1 0.72 1.07 0.15 55.92
184 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 55.84
185 INT235853 Regulation of Gene_expression of Crh 7 0.51 1.98 2.66 55.28
186 INT155992 Gene_expression of THBD 16 0.66 17 1.24 54.44
187 INT341036 Regulation of Camp 1 0.44 0.42 0.03 54.12
188 INT163259 Positive_regulation of Tpo 1 0.14 1.16 0.17 53.28
189 INT16879 Binding of Crh 72 0.48 21.65 28.43 52.92
190 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09 52.32
191 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 52.00
192 INT157836 Regulation of Gene_expression of Aqp2 9 0.57 8.37 0.37 50.84
193 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 50.44
194 INT26181 Positive_regulation of Negative_regulation of POMC 12 0.70 1.03 6.14 50.08
195 INT255579 Negative_regulation of GK 1 0.03 0.65 0 50.08
196 INT255578 Negative_regulation of Binding of NR0B1 1 0.32 0.65 0 50.08
197 INT60339 Gene_expression of CYP21A2 8 0.66 4.04 2.77 50.04
198 INT9950 Gene_expression of OTOR 11 0.65 10.05 2.23 49.88
199 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 48.96
200 INT255583 Binding of GK 1 0.03 0.54 0 48.56
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