D:Adrenocortical Hyperfunction

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Disease Term
Synonyms ADRENAL GLAND HYPERFUNCTION, HYPERADRENALISM, Hyperadrenocorticism, Hypercorticism, Hyperfunction Adrenal Gland, Hyperfunction Adrenocortical
Documents 36
Hot Single Events 19
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Adrenocortical Hyperfunction. They are ordered first by their relevance to Adrenocortical Hyperfunction and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
2 INT306795 Binding of LEP and SFTPD 1 0.08 1.13 0.23 5.00
3 INT199436 Binding of Capns1 and Cysltr1 1 0.00 0.79 0.1 5.00
4 INT306794 Binding of LEP and COPD 1 0.15 3.94 0.09 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Adrenocortical Hyperfunction. They are ordered first by their pain relevance and then by number of times they were reported in Adrenocortical Hyperfunction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT28572 Regulation of Rit1 4 0.30 3.63 0.48 99.84
2 INT695 Binding of POMC 304 0.48 56.66 126.85 99.48
3 INT89467 Gene_expression of Lhcgr 9 0.36 1.59 1.62 99.22
4 INT15357 Positive_regulation of STH 7 0.49 4.55 1.6 99.08
5 INT5868 Positive_regulation of GNRH1 122 0.69 20.96 32.8 98.80
6 INT106498 Positive_regulation of Lhcgr 2 0.08 0.41 0.12 98.80
7 INT89465 Positive_regulation of Gene_expression of Lhcgr 4 0.24 1.03 0.41 97.76
8 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 97.60
9 INT18345 Positive_regulation of Positive_regulation of Gnrhr 16 0.42 4.99 4.91 96.92
10 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64 96.00
11 INT14480 Positive_regulation of RIT1 5 0.67 1.95 1 95.48
12 INT28573 Positive_regulation of Rit1 5 0.33 3.46 0.4 93.68
13 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 93.44
14 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26 90.64
15 INT251 Regulation of INS 398 0.62 232.47 55.04 85.04
16 INT5100 Positive_regulation of Ghrh 100 0.64 24.2 30.21 83.76
17 INT11604 Regulation of Positive_regulation of Ghrh 4 0.42 0.62 2.05 83.76
18 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 80.80
19 INT693 Negative_regulation of Localization of SST 46 0.59 8.57 21.75 80.20
20 INT397 Localization of SST 232 0.81 58.05 101.19 79.72
21 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 78.88
22 INT252 Localization of GH1 529 0.80 227.4 122.05 78.68
23 INT1893 Localization of Gh 1041 0.79 340.23 256.58 78.24
24 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 78.24
25 INT45201 Negative_regulation of ABCA4 6 0.42 4.02 0.51 76.92
26 INT249 Localization of GHRH 215 0.80 78.02 51.87 74.48
27 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 73.64
28 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23 62.08
29 INT16879 Binding of Crh 72 0.48 21.65 28.43 58.84
30 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 47.08
31 INT5502 Positive_regulation of Gene_expression of Crh 69 0.70 43.06 42.23 47.08
32 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 46.72
33 INT5498 Positive_regulation of Positive_regulation of Crh 19 0.70 9.82 7.97 46.72
34 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 35.76
35 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 35.12
36 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 32.88
37 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 24.28
38 INT6110 Negative_regulation of Gene_expression of Ins1 83 0.56 60.59 16.07 21.56
39 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 21.00
40 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 11.68
41 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
42 INT3439 Localization of Abat 1017 0.78 112.39 727.06 5.00
43 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
44 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
45 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
46 INT2365 Positive_regulation of Cck 354 0.70 87.8 277.41 5.00
47 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
48 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
49 INT1902 Gene_expression of Cck 348 0.78 70.33 241.92 5.00
50 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
51 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
52 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
53 INT2366 Binding of Cck 192 0.48 30.64 163.46 5.00
54 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
55 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
56 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
57 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
58 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
59 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
60 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
61 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
62 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
63 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
64 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
65 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
66 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
67 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28 5.00
68 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
69 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
70 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
71 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
72 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
73 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
74 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
75 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
76 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
77 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
78 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
79 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
80 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 5.00
81 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 5.00
82 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
83 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
84 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
85 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 5.00
86 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41 5.00
87 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
88 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29 5.00
89 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
90 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 5.00
91 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
92 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 5.00
93 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
94 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 5.00
95 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 5.00
96 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
97 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
98 INT70970 Binding of COPD 144 0.42 180.34 18.29 5.00
99 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
100 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 5.00
101 INT75908 Regulation of LEP 77 0.60 60.16 15.19 5.00
102 INT33358 Gene_expression of Cysltr1 46 0.62 24.18 13.36 5.00
103 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
104 INT22030 Negative_regulation of Cysltr1 31 0.39 21.83 12.49 5.00
105 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
106 INT21467 Negative_regulation of Binding of Cck 18 0.57 2.84 11.91 5.00
107 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17 5.00
108 INT987 Localization of TRH 37 0.78 10.53 11.1 5.00
109 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 5.00
110 INT18088 Binding of Tspo 26 0.48 9.12 10.2 5.00
111 INT87863 Positive_regulation of IL18 40 0.69 34.08 9.53 5.00
112 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37 5.00
113 INT34777 Localization of IGF1 82 0.80 42.68 8.62 5.00
114 INT75907 Binding of LEP 53 0.46 46.65 8.44 5.00
115 INT156827 Localization of MRI1 25 0.65 16.06 8.33 5.00
116 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19 5.00
117 INT13539 Gene_expression of LTA 39 0.62 22.55 8.07 5.00
118 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 5.00
119 INT178198 Gene_expression of C3 62 0.78 39.5 7.69 5.00
120 INT147793 Localization of COPD 70 0.64 89.01 7.3 5.00
121 INT5822 Gene_expression of Ltb4r1 51 0.76 37.43 7.2 5.00
122 INT10505 Gene_expression of Ptafr 18 0.62 10.7 6.83 5.00
123 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 5.00
124 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2 5.00
125 INT9683 Binding of GH1 57 0.47 21.14 5.99 5.00
126 INT22630 Positive_regulation of Binding of Cck 4 0.48 2.27 5.92 5.00
127 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61 5.00
128 INT65356 Localization of LEP 46 0.79 41.17 5.43 5.00
129 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15 5.00
130 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74 5.00
131 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 5.00
132 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61 5.00
133 INT236335 Gene_expression of SFTPD 26 0.75 15.92 4.59 5.00
134 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26 5.00
135 INT37907 Positive_regulation of Capns1 9 0.41 3.55 4.1 5.00
136 INT156416 Gene_expression of Lipg 38 0.67 18.35 4.07 5.00
137 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 5.00
138 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67 5.00
139 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 5.00
140 INT48726 Gene_expression of IGFBP1 27 0.67 9.45 3.36 5.00
141 INT52899 Positive_regulation of TNFRSF1A 16 0.46 19.04 3.34 5.00
142 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09 5.00
143 INT16130 Binding of IGF1 67 0.48 27.43 2.95 5.00
144 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91 5.00
145 INT49653 Gene_expression of NFKB2 12 0.61 9.51 2.73 5.00
146 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64 5.00
147 INT105694 Binding of SFTPD 11 0.46 8.47 2.45 5.00
148 INT15607 Localization of GNRHR 14 0.62 7.56 2.3 5.00
149 INT58469 Negative_regulation of Positive_regulation of IL6 16 0.42 8.1 2.14 5.00
150 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 5.00
151 INT245577 Localization of SFTPD 7 0.63 10.43 1.84 5.00
152 INT13544 Localization of LTA 9 0.78 6.34 1.8 5.00
153 INT57018 Gene_expression of GANAB 9 0.08 3.76 1.79 5.00
154 INT78938 Binding of IGFBP3 40 0.45 27.95 1.73 5.00
155 INT108078 Regulation of Regulation of Abat 2 0.30 0.95 1.64 5.00
156 INT212048 Negative_regulation of SFTPD 3 0.42 5.45 1.61 5.00
157 INT48616 Positive_regulation of IGFBP1 14 0.43 5.62 1.56 5.00
158 INT182037 Localization of C3 10 0.68 6.69 1.54 5.00
159 INT109104 Positive_regulation of Protein_catabolism of INS 4 0.50 4.44 1.24 5.00
160 INT3486 Positive_regulation of Regulation of INS 9 0.47 5.65 1.15 5.00
161 INT213277 Positive_regulation of Gene_expression of ADIPOQ 14 0.50 17.7 1.14 5.00
162 INT168374 Negative_regulation of Capns1 2 0.50 5.09 1.1 5.00
163 INT100892 Positive_regulation of GCLC 8 0.68 3.44 1.08 5.00
164 INT13545 Negative_regulation of Gene_expression of LTA 5 0.34 3.23 0.86 5.00
165 INT172360 Binding of POU6F1 1 0.35 1.75 0.83 5.00
166 INT192300 Positive_regulation of Gene_expression of IGFBP1 6 0.60 2.85 0.81 5.00
167 INT221384 Positive_regulation of Localization of COPD 6 0.29 9.13 0.75 5.00
168 INT199430 Regulation of LTA 4 0.11 2.48 0.75 5.00
169 INT199433 Negative_regulation of LTA 5 0.17 3.84 0.74 5.00
170 INT306800 Positive_regulation of Localization of SFTPD 1 0.16 2.1 0.68 5.00
171 INT158836 Positive_regulation of Localization of TRH 7 0.49 2.61 0.67 5.00
172 INT145384 Binding of LTA 10 0.32 4.4 0.66 5.00
173 INT178752 Binding of IGFBP1 8 0.15 4.58 0.61 5.00
174 INT187050 Localization of RENBP 8 0.35 6.92 0.61 5.00
175 INT199424 Negative_regulation of Gene_expression of Cysltr1 2 0.35 0.71 0.59 5.00
176 INT306798 Protein_catabolism of LEP 1 0.65 2.45 0.58 5.00
177 INT55047 Gene_expression of GNRHR 8 0.78 5.2 0.53 5.00
178 INT128363 Negative_regulation of Gene_expression of Ltb4r1 5 0.50 2.53 0.52 5.00
179 INT192653 Binding of Capns1 8 0.26 9.94 0.51 5.00
180 INT126683 Localization of Lipg 7 0.70 3.87 0.46 5.00
181 INT147960 Negative_regulation of GCLC 8 0.28 4.4 0.45 5.00
182 INT196594 Localization of CFD 4 0.65 4.36 0.39 5.00
183 INT21349 Binding of Ltb4r1 4 0.07 2.9 0.34 5.00
184 INT199434 Negative_regulation of Cysltr2 1 0.04 0.52 0.26 5.00
185 INT12531 Localization of GANAB 3 0.09 2.79 0.26 5.00
186 INT199432 Regulation of Localization of LTA 1 0.03 0.79 0.24 5.00
187 INT192652 Regulation of Capns1 2 0.32 1.3 0.18 5.00
188 INT172368 Negative_regulation of Binding of IGF1 3 0.42 1.57 0.18 5.00
189 INT101819 Positive_regulation of Positive_regulation of GCLC 2 0.59 1.47 0.15 5.00
190 INT239095 Negative_regulation of PTTG1 2 0.32 8.24 0.09 5.00
191 INT232566 Gene_expression of FHIT 1 0.58 2.97 0.08 5.00
192 INT239094 Negative_regulation of Binding of GH1 2 0.34 1.61 0.06 5.00
193 INT239092 Positive_regulation of Binding of IGFBP1 1 0.04 0.6 0.04 5.00
194 INT231433 Positive_regulation of Binding of IGFBP3 2 0.34 0.6 0.04 5.00
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