D:African Trypanosomiasis

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Disease Term
Synonyms African Sleeping Sickness, AFRICAN TRYPANOSOMIASES, NAGANA, Sleeping Sickness African, Trypanosomiases African, TRYPANOSOMIASIS AFRICAN
Documents 48
Hot Single Events 55
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for African Trypanosomiasis. They are ordered first by their relevance to African Trypanosomiasis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT297589 Binding of HAT1 and Il10 1 0.00 1.14 0.08 100.00
2 INT297559 Binding of IL6 and HAT1 1 0.00 1.13 0.08 100.00
3 INT297558 Binding of APOL1 and SRA1 1 0.22 0.56 0 97.20
4 INT297563 Binding of HSD11B1 and TBPL1 1 0.01 0.41 0 20.40
5 INT296114 Il4 Regulation of Gene_expression of Arg1 1 0.00 0.65 0.46 9.36
6 INT297562 TNF Positive_regulation of IFNA1 1 0.00 0.62 0.06 5.00
7 INT296113 Fig4 Negative_regulation of Gene_expression of Csf2 1 0.01 0.91 0.04 5.00
8 INT296115 Fig4 Negative_regulation of Csf2 1 0.01 0.91 0.04 5.00
9 INT297560 Binding of HSD11B1 and APOL1 1 0.04 0.88 0 5.00
10 INT318683 ARPP21 Negative_regulation of SET 1 0.00 0.1 0 5.00
11 INT304270 Binding of Apoa1 and Scarb1 1 0.00 0.39 0 5.00
12 INT279131 LTF Positive_regulation of CALR 1 0.03 2.39 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for African Trypanosomiasis. They are ordered first by their pain relevance and then by number of times they were reported in African Trypanosomiasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT172625 Regulation of HAT1 9 0.35 9.21 0.28 100.00
2 INT172617 Positive_regulation of HAT1 7 0.33 5.47 0.54 100.00
3 INT192563 Gene_expression of HAT1 8 0.38 4.47 1.71 100.00
4 INT341511 Regulation of Regulation of HAT1 1 0.15 1.63 0 100.00
5 INT351707 Localization of HAT1 1 0.06 0.67 0 100.00
6 INT203688 Positive_regulation of Hmgcr 10 0.17 6.08 0.52 100.00
7 INT192564 Binding of HAT1 5 0.15 2.77 0.96 100.00
8 INT200037 Regulation of TMPRSS11D 1 0.44 0.44 0.03 100.00
9 INT151123 Negative_regulation of Gene_expression of Csf2 21 0.53 21.76 3.22 99.84
10 INT127710 Negative_regulation of Gene_expression of Hcrt 2 0.39 0.34 0.37 99.84
11 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 99.40
12 INT297583 Regulation of APOL1 1 0.40 0.57 0 99.12
13 INT127709 Positive_regulation of Gene_expression of Hcrt 3 0.45 0.55 0.84 99.08
14 INT81153 Gene_expression of Hcrt 31 0.77 6.04 8.16 98.68
15 INT173090 Regulation of INCENP 24 0.09 9.45 2.16 98.40
16 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 98.00
17 INT142162 Binding of IL10 30 0.37 21.9 4.84 98.00
18 INT100603 Gene_expression of DCSTAMP 7 0.22 3.05 2.25 97.76
19 INT127244 Binding of APOL1 1 0.33 3.29 0.09 97.20
20 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58 96.60
21 INT238431 Binding of SRA1 8 0.37 2.53 0.25 96.32
22 INT13354 Transcription of TNF 108 0.72 85.81 42.32 96.24
23 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 96.12
24 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 95.88
25 INT176594 Gene_expression of SRA1 20 0.35 9.65 1.15 95.80
26 INT201005 Gene_expression of APOL1 9 0.75 4.66 0.53 95.80
27 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 95.80
28 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 95.52
29 INT192565 Binding of DCSTAMP 1 0.12 0.46 0.03 95.44
30 INT61949 Regulation of Nos2 74 0.58 34.08 16.7 95.32
31 INT188755 Positive_regulation of Binding of CSF2 6 0.44 8.79 0.35 94.48
32 INT14301 Binding of CSF2 82 0.48 67.95 8.98 94.48
33 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 93.52
34 INT114862 Gene_expression of BEST1 16 0.65 12.14 1.53 93.48
35 INT152223 Binding of BEST1 10 0.29 6.67 1.46 92.76
36 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 92.44
37 INT59792 Gene_expression of STH 14 0.75 15.2 0.61 91.52
38 INT159128 Localization of Nps 12 0.69 5.18 1.74 91.40
39 INT58365 Gene_expression of LTF 51 0.78 44.14 7.25 91.36
40 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 91.20
41 INT97436 Positive_regulation of Transcription of Il4 3 0.51 1.8 0.38 91.20
42 INT97438 Transcription of Il4 17 0.67 9.17 3.4 90.80
43 INT147113 Binding of LTF 14 0.29 18.24 0.98 90.20
44 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 89.44
45 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 89.24
46 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 88.80
47 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 88.48
48 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 88.36
49 INT25381 Localization of Csf2 62 0.76 47.48 9.03 87.84
50 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 87.04
51 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 84.16
52 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25 82.80
53 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 82.76
54 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 82.72
55 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 82.52
56 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 79.24
57 INT86713 Positive_regulation of Mip 10 0.67 6.44 2.63 79.08
58 INT23588 Positive_regulation of CCR1 6 0.67 4.44 2.24 79.08
59 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11 76.28
60 INT162801 Localization of CALR 7 0.73 8.69 0.6 75.68
61 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 75.00
62 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 75.00
63 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 75.00
64 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 75.00
65 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 73.40
66 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 72.08
67 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71 70.20
68 INT38268 Positive_regulation of BEST1 16 0.17 14.54 1.93 59.00
69 INT36177 Binding of Alms1 70 0.31 35.47 13.81 55.00
70 INT95414 Positive_regulation of Alms1 40 0.41 20.3 8.1 54.96
71 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 54.16
72 INT132377 Negative_regulation of Binding of Nos2 5 0.29 0.75 0.28 53.44
73 INT296111 Negative_regulation of Binding of Arg1 1 0.04 0.12 0.04 53.44
74 INT304273 Regulation of PBCA 1 0.03 0.32 0 52.48
75 INT3477 Regulation of Npc1 6 0.45 1.87 0.47 52.24
76 INT126223 Binding of Nos2 17 0.37 6 3.22 50.40
77 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 50.00
78 INT97596 Localization of S100a8 94 0.78 90.69 40.41 50.00
79 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 50.00
80 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 50.00
81 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 50.00
82 INT101105 Positive_regulation of FUT1 62 0.30 55.96 9.28 50.00
83 INT76120 Gene_expression of Ptprc 102 0.59 30.42 7.02 50.00
84 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47 50.00
85 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 50.00
86 INT21406 Negative_regulation of Gene_expression of IgG 20 0.41 9.36 3.58 50.00
87 INT91890 Positive_regulation of Kit 36 0.50 25.44 3.06 50.00
88 INT28815 Gene_expression of Ighd 18 0.65 11.02 2.48 50.00
89 INT132903 Gene_expression of Cd34 65 0.72 33.95 2.2 50.00
90 INT73674 Regulation of Gene_expression of Vcam1 9 0.33 11.23 1.64 50.00
91 INT206528 Negative_regulation of Gene_expression of Ptprc 8 0.34 3.91 1.61 50.00
92 INT129231 Gene_expression of Ddx41 29 0.63 9.73 1.52 50.00
93 INT181809 Gene_expression of Atxn1 81 0.77 28.66 1.42 50.00
94 INT62031 Gene_expression of Cd19 27 0.65 10.39 0.93 50.00
95 INT326427 Gene_expression of Eif2ak2 2 0.36 1.32 0.83 50.00
96 INT189438 Regulation of Gene_expression of Kit 10 0.45 4.94 0.61 50.00
97 INT237075 Gene_expression of Spn 5 0.42 5.18 0.56 50.00
98 INT315712 Positive_regulation of Gene_expression of Ddx41 3 0.31 2.24 0.46 50.00
99 INT326428 Positive_regulation of Gene_expression of Eif2ak2 2 0.32 0.75 0.43 50.00
100 INT237834 Regulation of Il7 4 0.26 0.95 0.4 50.00
101 INT181806 Positive_regulation of Gene_expression of Atxn1 6 0.41 2.85 0.21 50.00
102 INT229573 Positive_regulation of Positive_regulation of Kit 3 0.39 1.46 0.09 50.00
103 INT199124 Transcription of Kit 6 0.67 1.49 0.09 50.00
104 INT201346 Negative_regulation of Gene_expression of Cd19 3 0.32 2.1 0.05 50.00
105 INT326411 Gene_expression of H2afy 1 0.05 0.8 0.03 50.00
106 INT326426 Negative_regulation of Ddx41 1 0.04 0.32 0 50.00
107 INT326413 Positive_regulation of H2afy 1 0.03 0.11 0 50.00
108 INT326412 Positive_regulation of Gene_expression of H2afy 1 0.03 0.67 0 50.00
109 INT326414 Gene_expression of PRAC 1 0.01 0.26 0 50.00
110 INT296110 Binding of Arg1 1 0.03 0.07 0.04 48.88
111 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 47.24
112 INT6849 Localization of IL1B 229 0.81 112.56 69.63 46.56
113 INT177759 Negative_regulation of IFN1@ 51 0.57 31.81 7.76 46.20
114 INT61951 Regulation of Negative_regulation of Nos2 5 0.58 3.08 1.39 41.68
115 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78 40.16
116 INT156727 Gene_expression of Arg1 4 0.44 2.1 0.97 38.36
117 INT145809 Gene_expression of stm 9 0.65 3.66 1.4 37.24
118 INT93658 Transcription of Nos1 16 0.72 6.85 6.16 36.80
119 INT120320 Positive_regulation of Transcription of Nos1 3 0.46 0.58 0.29 36.80
120 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05 33.84
121 INT79835 Regulation of Il10 28 0.61 21.22 11.29 31.36
122 INT71768 Regulation of Gene_expression of Il10 27 0.62 19.17 10.4 31.36
123 INT79693 Regulation of Il4 30 0.51 21.96 8.6 31.36
124 INT186270 Regulation of Il13 13 0.43 11.58 4.19 31.36
125 INT187817 Regulation of Gene_expression of Il13 6 0.22 6.5 2.92 31.36
126 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 29.84
127 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 28.48
128 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 24.48
129 INT191765 Regulation of CALM1 15 0.52 9.52 8.56 21.68
130 INT4740 Gene_expression of Th 298 0.78 61.27 154.03 20.32
131 INT334558 Positive_regulation of Ism1 1 0.43 0.18 0.04 20.00
132 INT221097 Negative_regulation of Atp8a1 15 0.57 10.52 2.65 18.52
133 INT17086 Binding of HSD11B1 84 0.47 122.28 6.16 18.40
134 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95 17.24
135 INT159127 Gene_expression of Nps 49 0.75 16.91 12.06 15.44
136 INT334560 Transcription of Ism1 1 0.59 0.18 0.04 10.48
137 INT297578 Regulation of Gene_expression of TBPL1 1 0.09 0.45 0 6.80
138 INT297579 Gene_expression of TBPL1 1 0.16 0.45 0 6.64
139 INT197674 Positive_regulation of Gene_expression of Arg1 2 0.33 0.63 0.44 5.84
140 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 5.00
141 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
142 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
143 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
144 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
145 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
146 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
147 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
148 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
149 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
150 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
151 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
152 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
153 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
154 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
155 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 5.00
156 INT33567 Gene_expression of CALM1 139 0.67 48.85 56.14 5.00
157 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
158 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
159 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
160 INT81251 Gene_expression of Trpv2 78 0.78 28.27 41.76 5.00
161 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
162 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
163 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
164 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
165 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
166 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 5.00
167 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
168 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 5.00
169 INT35406 Localization of Tnf 94 0.81 64.63 31.65 5.00
170 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75 5.00
171 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
172 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
173 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 5.00
174 INT48766 Regulation of NOS1 73 0.61 37.01 24.59 5.00
175 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 5.00
176 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 5.00
177 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 5.00
178 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 5.00
179 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62 5.00
180 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
181 INT93948 Negative_regulation of Gene_expression of Il12a 48 0.55 27.77 16.87 5.00
182 INT103757 Negative_regulation of Il12a 37 0.55 21.62 16.38 5.00
183 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
184 INT10000 Regulation of Gene_expression of IL2 56 0.45 15.33 16.2 5.00
185 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
186 INT24798 Negative_regulation of Glul 52 0.55 27.25 15.17 5.00
187 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
188 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 5.00
189 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34 5.00
190 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 5.00
191 INT62441 Gene_expression of ABCC1 56 0.78 21.01 12.93 5.00
192 INT93620 Positive_regulation of Gene_expression of Fasl 51 0.66 59.45 12.04 5.00
193 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
194 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 5.00
195 INT121796 Gene_expression of NeuN 92 0.78 23.18 10.53 5.00
196 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 5.00
197 INT85966 Gene_expression of Cd40lg 50 0.73 30.9 9.11 5.00
198 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
199 INT25392 Positive_regulation of Gene_expression of Csf2 41 0.49 34.28 8.36 5.00
200 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71 5.00
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