D:Age-related Macular Degeneration

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Disease Term
Synonyms Age Related Macular Degeneration, AGE RELATED MACULOPATHIES, Age Related Maculopathy, Amd, Armd, Atrophic Macular Degeneration, Choroidal Neovascularisation, Choroidal Neovascularization, Degeneration Macular, DEGENERATIONS MACULAR, DRY AGE RELATED MACULAR DEGENERATION
Documents 483
Hot Single Events 200
Hot Interactions 51

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Age-related Macular Degeneration. They are ordered first by their relevance to Age-related Macular Degeneration and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT229977 Binding of amd and Cfb 1 0.03 2.78 0.06 100.00
2 INT229985 Binding of C2 and amd 1 0.01 1.89 0.06 100.00
3 INT243119 Binding of amd and Sod2 1 0.29 3.25 0.06 100.00
4 INT353106 Binding of amd and C3 1 0.09 1.69 0 100.00
5 INT277112 Binding of AMD1 and CFH 1 0.16 2.45 0.18 100.00
6 INT229982 Binding of C3 and amd 1 0.02 1.14 0.06 100.00
7 INT339585 Binding of AMD1 and MDM1 1 0.06 2.02 0 100.00
8 INT339582 AMD1 Regulation of C1QTNF5 1 0.07 2 0 100.00
9 INT353104 Binding of amd and Gtf3a 1 0.01 1.53 0.03 100.00
10 INT243120 Binding of amd and Rpe 1 0.26 1.18 0 100.00
11 INT243118 amd Regulation of Rpe 1 0.20 1.16 0 100.00
12 INT346947 Binding of VEGFA and amd 1 0.01 0.1 0 100.00
13 INT229981 Binding of ABCA1 and Cdca3 1 0.00 0.74 0 99.76
14 INT229923 Binding of ABCA1 and C9 1 0.00 0.74 0 99.76
15 INT300446 VEGFA Positive_regulation of Flt1 1 0.09 2.62 0.07 99.72
16 INT300445 VEGFA Positive_regulation of Vegfa 1 0.03 1.33 0.03 99.72
17 INT262620 Renbp Positive_regulation of Ager Positive_regulation of Rpe 1 0.00 0.81 0 99.08
18 INT235800 Twist1 Positive_regulation of VEGFA 1 0.02 0.62 0.03 98.60
19 INT273770 VEGFA Negative_regulation of Localization of Twist1 1 0.07 0.58 0 98.60
20 INT262617 Ager Positive_regulation of Rpe 1 0.00 0.81 0 98.48
21 INT149844 Negative_regulation of Cxcl12 Negative_regulation of C19orf10 1 0.16 0.45 1.26 98.28
22 INT342355 Arrd1 Positive_regulation of Osbpl1a 1 0.01 0.8 0.04 98.08
23 INT342359 Arrd1 Positive_regulation of Scd1 1 0.01 0.8 0.04 98.08
24 INT342356 Arrd1 Positive_regulation of Negative_regulation of Ppara 1 0.01 0.81 0.04 98.08
25 INT229931 Negative_regulation of Binding of C3 and CFH 1 0.08 1.35 0.17 97.84
26 INT152024 Ptgs1 Regulation of Fgf2 1 0.04 0.9 0.17 97.76
27 INT229984 Binding of CD59 and Cdca3 1 0.03 0.73 0 97.72
28 INT229922 Binding of C9 and CD59 1 0.08 0.72 0 97.72
29 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69 97.32
30 INT229928 Binding of C3 and CFH 1 0.07 1.35 0.17 97.32
31 INT149845 Cxcl12 Negative_regulation of C19orf10 1 0.16 0.45 1.24 96.16
32 INT339587 Positive_regulation of Binding of ABCA1 and RPE 1 0.04 1.38 0.05 95.88
33 INT339583 Binding of ABCA1 and RPE 1 0.03 1.38 0.05 95.52
34 INT245823 Binding of Plg and Plg 1 0.03 1.41 0 93.72
35 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16 92.96
36 INT353110 Binding of VEGFA and Eo 1 0.00 0.67 0 90.00
37 INT300449 VEGFA Positive_regulation of Protein_catabolism of Ppp2r2b 1 0.00 1.51 0.05 89.16
38 INT339581 Binding of TIMP1 and TIMP3 1 0.30 0.54 0 88.24
39 INT229983 Binding of CFH and Crp 2 0.14 1.48 0 88.12
40 INT340505 Binding of Twist1 and Mgat4b 1 0.01 0.45 0.08 87.96
41 INT233904 NLRP3 Positive_regulation of AGT 1 0.06 0.81 0.17 87.04
42 INT233929 PPARA Negative_regulation of ras 1 0.02 2.39 0.22 86.88
43 INT245833 Plg Negative_regulation of VEGFA 1 0.05 2.21 0.04 85.00
44 INT245827 Plg Negative_regulation of Vegfa 1 0.14 1.3 0 85.00
45 INT279534 Binding of CFH and PTPN11 1 0.02 2.54 0 83.08
46 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73 82.96
47 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73 82.96
48 INT260529 Twist1 Positive_regulation of Gene_expression of Vegfa 1 0.04 0.54 0 82.72
49 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 82.40
50 INT298635 PPARA Negative_regulation of Localization of ZDHHC2 1 0.01 0.21 0.05 80.36
51 INT287381 Cxcl2 Regulation of Gene_expression of VEGFA 1 0.42 1.1 0.1 80.16
52 INT353108 Binding of VEGFA and Pgf 1 0.02 2.17 0 78.28
53 INT353107 Binding of VEGFA and Vegfb 1 0.02 1.08 0 78.28
54 INT339580 TIMP3 Positive_regulation of ABCA1 1 0.16 0.73 0 74.40
55 INT339586 TIMP3 Positive_regulation of RPE 1 0.16 0.72 0 72.72
56 INT245835 Plg Negative_regulation of Gene_expression of VEGFA 1 0.05 3.51 0 70.56
57 INT298637 ZDHHC2 Negative_regulation of Gene_expression of VEGFA 1 0.01 0.27 0.04 70.40
58 INT209580 Twist1 Positive_regulation of Localization of VEGFA 1 0.05 0.53 0 69.68
59 INT274099 Binding of FANCB and VEGFA 1 0.10 0.33 0 69.08
60 INT268710 Binding of RHO and ERLEC1 1 0.00 0.71 0.03 64.80
61 INT245832 VEGFA Positive_regulation of Phosphorylation of Ocln 1 0.04 1.61 0 55.20
62 INT245830 VEGFA Regulation of Ocln 1 0.02 0.83 0 55.20
63 INT233397 Binding of ABCA4 and COL2A1 1 0.38 3.59 0.03 54.72
64 INT279537 ICAM3 Positive_regulation of C3 1 0.06 0.85 0 53.08
65 INT230760 VEGFA Positive_regulation of Flt1 1 0.03 0.96 0.12 52.04
66 INT230761 VEGFA Positive_regulation of Kdr 2 0.02 2.16 0.12 52.04
67 INT245821 Binding of Ppp2r2b and Ocln 1 0.00 0.81 0 50.24
68 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21 44.56
69 INT308328 Hif1a Regulation of Positive_regulation of Trib3 1 0.02 0.89 0.05 42.96
70 INT282630 Binding of CISH and UGT2B17 1 0.04 0 0 35.72
71 INT300512 Binding of Plau and Vtn 1 0.06 2.28 0.13 33.92
72 INT300511 Binding of Plaur and Vtn 1 0.10 2.28 0.13 33.92
73 INT300513 Binding of Serpine1 and Vtn 1 0.17 2.27 0.13 33.92
74 INT256072 Serpina3k Negative_regulation of Positive_regulation of Ros1 1 0.04 0.49 0 30.68
75 INT262618 Binding of SOAT1 and Kras 1 0.00 0.81 0.12 29.84
76 INT324663 Negative_regulation of Flt1 Positive_regulation of Vash1 1 0.44 0.55 0 27.52
77 INT324662 Negative_regulation of Kdr Positive_regulation of Vash1 1 0.51 0.55 0 27.52
78 INT324669 VEGFA Positive_regulation of Vash1 1 0.46 0.49 0 25.12
79 INT353105 Binding of Aes and Rgs9bp 1 0.01 0.35 0.05 24.96
80 INT262619 Gopc Regulation of Gene_expression of ROS1 1 0.01 0.51 0 23.88
81 INT339570 Gene_expression of Positive_regulation of Gene_expression of CYP4A11 1 0.00 0.5 0.23 22.88
82 INT321967 Binding of PDR and PVR 1 0.01 2.32 0 22.08
83 INT245826 Plg Regulation of Gene_expression of Serpinf1 1 0.09 1.57 0.04 19.68
84 INT245831 Phosphorylation of Mapk3 Positive_regulation of Gene_expression of VEGFA 1 0.05 0.58 0 18.60
85 INT339535 FGF2 Positive_regulation of Gene_expression of CYP4A11 1 0.00 0.55 0.22 17.20
86 INT245820 Binding of Sp1 and Tfap2a 1 0.03 0.64 0 13.68
87 INT245829 Binding of VEGFA and Sp1 1 0.04 0.65 0 13.68
88 INT245828 Binding of VEGFA and Tfap2a 1 0.01 0.64 0 13.48
89 INT198595 Binding of CFH and CFHR1 3 0.41 1.36 0.03 10.32
90 INT245822 Plg Negative_regulation of Phosphorylation of Mapk3 1 0.10 2.09 0 10.00
91 INT182819 Binding of CD63 and PECAM1 1 0.00 1.63 0.61 9.00
92 INT182815 Binding of CD63 and ICAM1 1 0.00 1.63 0.61 9.00
93 INT229930 C3AR1 Positive_regulation of C3 1 0.00 0 0 8.88
94 INT229932 C4B Positive_regulation of C3 1 0.07 0 0 8.88
95 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 8.56
96 INT170127 Binding of ITGAL and PECAM1 2 0.01 2.71 0.75 8.56
97 INT324660 Vash1 Regulation of Gene_expression of Fgf1 1 0.14 0.44 0 8.40
98 INT182814 Binding of ICAM1 and PECAM1 2 0.02 3.32 0.77 8.16
99 INT345158 Lpar1 Positive_regulation of Gene_expression of Sele 1 0.02 0.21 0 7.68
100 INT345148 Lpar1 Positive_regulation of Gene_expression of Vcam1 1 0.07 0.21 0 6.48
101 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35 5.00
102 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9 5.00
103 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 5.00
104 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
105 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27 5.00
106 INT260833 Binding of NRP2 and Flt1 1 0.00 3.61 1.22 5.00
107 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18 5.00
108 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16 5.00
109 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 5.00
110 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98 5.00
111 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93 5.00
112 INT289461 IRF6 Positive_regulation of ICAM1 1 0.08 0.61 0.91 5.00
113 INT260842 Binding of NRP2 and Kdr 1 0.00 2.28 0.85 5.00
114 INT282129 Il10 Positive_regulation of Icam1 1 0.56 3.12 0.82 5.00
115 INT260832 Binding of NRP2 and Nrp1 1 0.00 2.32 0.7 5.00
116 INT153289 Binding of Lpar1 and Gpr87 2 0.29 1.19 0.67 5.00
117 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63 5.00
118 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61 5.00
119 INT345180 Binding of Lpar4 and Gpr87 1 0.06 0.69 0.59 5.00
120 INT345192 Binding of Gpr87 and Lpar5 1 0.07 0.69 0.59 5.00
121 INT260821 NRP2 Positive_regulation of Gene_expression of TNF 1 0.01 1.48 0.56 5.00
122 INT260830 Binding of NRP2 and Flt1 Positive_regulation of Gene_expression of TNF 1 0.01 1.5 0.56 5.00
123 INT260845 Binding of Flt1 and Positive_regulation of Gene_expression of TNF 1 0.36 1.5 0.56 5.00
124 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56 5.00
125 INT339532 FGF2 Positive_regulation of YWHAZ 1 0.00 1.26 0.54 5.00
126 INT182813 EEF1A2 Negative_regulation of ITGAL 1 0.10 1.53 0.51 5.00
127 INT289464 Negative_regulation of IRF6 Positive_regulation of ICAM1 1 0.07 0.31 0.5 5.00
128 INT260836 Il18 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.48 5.00
129 INT289462 Negative_regulation of IRF6 Positive_regulation of IL1B 2 0.04 0.31 0.48 5.00
130 INT289463 IRF6 Positive_regulation of Localization of IL1B 1 0.05 0.52 0.48 5.00
131 INT292814 Binding of VEGFA and Kdr 8 0.18 3.63 0.48 5.00
132 INT115186 IL6 Positive_regulation of Phosphorylation of STAT3 2 0.19 0.35 0.48 5.00
133 INT260843 Il6 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47 5.00
134 INT260838 Il17a Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47 5.00
135 INT260839 Hivep3 Positive_regulation of Gene_expression of TNF 1 0.01 1.21 0.47 5.00
136 INT288350 IFNA1 Positive_regulation of Localization of Il6 1 0.01 1.49 0.46 5.00
137 INT353109 Binding of VEGFA and Aes 1 0.02 3.93 0.43 5.00
138 INT321860 Timp1 Negative_regulation of Icam1 1 0.22 1.13 0.39 5.00
139 INT191493 Binding of AGTR1 and NLRP3 2 0.03 2.35 0.39 5.00
140 INT153288 Binding of Lpar1 and Lpar6 2 0.31 0.78 0.36 5.00
141 INT172213 Binding of BAX and BCL2L1 3 0.22 4.02 0.35 5.00
142 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34 5.00
143 INT287380 Binding of VEGFA and Kdr 12 0.18 11.97 0.34 5.00
144 INT353362 amd Negative_regulation of Cxcr4 1 0.04 0.52 0.33 5.00
145 INT312803 F2 Positive_regulation of NPEPPS 1 0.01 1.32 0.32 5.00
146 INT312802 F2 Positive_regulation of Binding of NPEPPS 1 0.01 1.33 0.32 5.00
147 INT260841 Il6 Positive_regulation of Localization of NRP2 1 0.00 0.7 0.29 5.00
148 INT260831 Pgf Positive_regulation of TNF 1 0.60 0.75 0.29 5.00
149 INT182499 Binding of AGTR1 and AGTR2 3 0.20 2.79 0.28 5.00
150 INT260828 Pgf Positive_regulation of Gene_expression of Gtf3a 1 0.01 0.73 0.28 5.00
151 INT260837 NRP2 Negative_regulation of Negative_regulation of Bcl2 1 0.00 0.9 0.28 5.00
152 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28 5.00
153 INT282128 Gene_expression of Il10 Positive_regulation of Positive_regulation of Icam1 1 0.37 1.12 0.28 5.00
154 INT333246 Binding of Cxcr4 and Cxcl12 3 0.34 0.99 0.27 5.00
155 INT302169 PTGER2 Positive_regulation of DYNC1LI1 1 0.02 1.51 0.25 5.00
156 INT260840 NRP2 Positive_regulation of Gene_expression of Bcl2 1 0.00 0.85 0.24 5.00
157 INT260835 NRP2 Positive_regulation of Eif2ak3 1 0.00 0.73 0.23 5.00
158 INT302170 PTGER2 Positive_regulation of Gene_expression of BCL2 1 0.04 3.76 0.23 5.00
159 INT230748 Agtr2 Positive_regulation of Gene_expression of Ros1 2 0.05 1.04 0.23 5.00
160 INT279503 Binding of C1s and C1ra 1 0.03 0.58 0.22 5.00
161 INT289998 CNTF Negative_regulation of Casp3 1 0.04 0.99 0.22 5.00
162 INT289981 Cntf Negative_regulation of Casp3 1 0.02 1.01 0.22 5.00
163 INT289997 CNTF Negative_regulation of Binding of CNTF and Casp3 1 0.05 0.99 0.22 5.00
164 INT289999 Binding of CNTF and Casp3 1 0.04 0.99 0.22 5.00
165 INT260844 NRP2 Positive_regulation of Akt1 1 0.00 0.73 0.22 5.00
166 INT339903 Binding of SCN5A and ZGLP1 1 0.01 0.18 0.22 5.00
167 INT182816 EEF1A2 Negative_regulation of CRP 1 0.28 1.84 0.21 5.00
168 INT345196 Lpar2 Positive_regulation of Gene_expression of VEGFA 1 0.08 2.14 0.2 5.00
169 INT345186 Lpar2 Positive_regulation of Gene_expression of Plau 1 0.05 2.2 0.2 5.00
170 INT260827 Binding of Flt1 and Pgf 1 0.27 0.6 0.2 5.00
171 INT339901 Binding of INS and SCN5A 1 0.01 0.18 0.2 5.00
172 INT304882 Agtr2 Positive_regulation of Mapk1 1 0.07 0.95 0.2 5.00
173 INT282864 Bpifa2 Positive_regulation of Gene_expression of Serpinf1 1 0.15 1.16 0.2 5.00
174 INT282866 Bpifa2 Negative_regulation of Gene_expression of VEGFA 1 0.11 1.14 0.19 5.00
175 INT265048 INCENP Positive_regulation of Positive_regulation of Nfasc 1 0.00 0.69 0.19 5.00
176 INT345172 Lpar1 Positive_regulation of S1pr1 1 0.21 0.19 0.19 5.00
177 INT282863 Bpifa2 Positive_regulation of Gene_expression of Aggf1 1 0.01 1.07 0.19 5.00
178 INT279507 Serping1 Negative_regulation of Gene_expression of C3 1 0.03 1.12 0.19 5.00
179 INT206089 Negative_regulation of FOSB Negative_regulation of Gene_expression of PTGS2 1 0.00 0.97 0.19 5.00
180 INT279965 STAT3 Regulation of Transcription of BCL2L1 1 0.10 2.31 0.19 5.00
181 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 5.00
182 INT279500 Serping1 Negative_regulation of Transcription of C3 1 0.03 1.12 0.19 5.00
183 INT193214 Binding of PTGER2 and PTGER4 2 0.08 2.51 0.18 5.00
184 INT192333 PDGFA Positive_regulation of Gene_expression of FN1 2 0.11 1.26 0.18 5.00
185 INT288349 TNF Positive_regulation of Gene_expression of Mcpt1 1 0.02 1.1 0.18 5.00
186 INT330514 Vegfa Positive_regulation of VEGFA 1 0.18 0.5 0.18 5.00
187 INT288351 Mcpt1 Positive_regulation of Gene_expression of TNF 1 0.02 1.1 0.18 5.00
188 INT282858 Bpifa2 Negative_regulation of Akt1 1 0.05 0.91 0.17 5.00
189 INT282859 Bpifa2 Negative_regulation of Mapk1 1 0.01 0.91 0.17 5.00
190 INT282861 Bpifa2 Negative_regulation of Phosphorylation of Akt1 1 0.05 0.91 0.17 5.00
191 INT206081 IL6ST Negative_regulation of IL6 1 0.11 0.81 0.17 5.00
192 INT353361 Positive_regulation of Binding of Cxcr4 and Cxcl12 1 0.46 0 0.17 5.00
193 INT298641 PPARA Regulation of STAT3 1 0.23 0.98 0.16 5.00
194 INT206059 IL6 Positive_regulation of INS 1 0.02 1.16 0.16 5.00
195 INT345176 Lpar1 Positive_regulation of Gene_expression of Car2 1 0.03 0.11 0.16 5.00
196 INT251349 Ifnar1 Positive_regulation of Rock1 1 0.01 1.27 0.16 5.00
197 INT251347 Binding of Bmpr2 and Limk1 1 0.18 1.51 0.16 5.00
198 INT206070 ANG Positive_regulation of Transcription of IL6 1 0.05 1.5 0.15 5.00
199 INT345157 Lpar1 Positive_regulation of Gene_expression of Gtf3a 1 0.00 0.89 0.15 5.00
200 INT288026 PROC Positive_regulation of Gene_expression of VEGFA 1 0.01 0.5 0.15 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Age-related Macular Degeneration. They are ordered first by their pain relevance and then by number of times they were reported in Age-related Macular Degeneration. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT139863 Binding of amd 27 0.41 41.3 0.91 100.00
2 INT229940 Positive_regulation of amd 10 0.49 27.97 0.15 100.00
3 INT228770 Gene_expression of amd 16 0.57 21.49 1.05 100.00
4 INT260525 Gene_expression of AMD1 25 0.66 24.58 1.32 100.00
5 INT202940 Binding of AMD1 13 0.41 16.43 0.56 100.00
6 INT139862 Negative_regulation of amd 8 0.35 10.15 0.6 100.00
7 INT215454 Regulation of amd 4 0.38 8.07 0.29 100.00
8 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 100.00
9 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 100.00
10 INT260527 Negative_regulation of AMD1 6 0.37 5 0.05 100.00
11 INT242922 Positive_regulation of Gene_expression of amd 2 0.43 5.99 0.1 100.00
12 INT147818 Localization of amd 3 0.60 4.04 0.14 100.00
13 INT269748 Positive_regulation of AMD1 4 0.43 3.56 0.28 100.00
14 INT70744 Regulation of CFH 12 0.41 7.38 0.8 100.00
15 INT202939 Regulation of AMD1 4 0.38 2.68 0 100.00
16 INT269750 Localization of AMD1 2 0.64 2.82 0.13 100.00
17 INT235796 Positive_regulation of Binding of amd 2 0.21 2.76 0.04 100.00
18 INT282403 Negative_regulation of Gene_expression of FANCG 1 0.06 0.97 0 100.00
19 INT139470 Positive_regulation of Htra1 2 0.48 1.58 0.03 100.00
20 INT353097 Positive_regulation of Plekha1 1 0.34 1.47 0.03 100.00
21 INT353103 Positive_regulation of ARMS2 1 0.05 1.47 0.03 100.00
22 INT353098 Phosphorylation of amd 1 0.65 1.26 0 100.00
23 INT353100 Negative_regulation of Localization of amd 1 0.34 1.38 0 100.00
24 INT269746 Positive_regulation of Localization of AMD1 1 0.43 2.54 0 100.00
25 INT260524 Phosphorylation of AMD1 1 0.16 1.16 0.04 100.00
26 INT269749 Transcription of AMD1 1 0.59 1.04 0.05 100.00
27 INT265417 Positive_regulation of Positive_regulation of TLR3 2 0.16 1.1 0 100.00
28 INT233908 Protein_catabolism of amd 1 0.08 1.73 0.04 100.00
29 INT260526 Negative_regulation of Gene_expression of AMD1 2 0.36 0.71 0.09 100.00
30 INT94028 Regulation of Twist1 37 0.44 22.41 5.33 100.00
31 INT341863 Negative_regulation of Localization of RPE 1 0.03 7.39 0.9 100.00
32 INT274026 Positive_regulation of Gene_expression of AMD1 1 0.16 0.41 0.07 100.00
33 INT322621 Regulation of Positive_regulation of TLR3 1 0.04 0.41 0 100.00
34 INT155130 Gene_expression of IMPACT 14 0.58 3.43 1.61 100.00
35 INT109904 Localization of RPE 5 0.73 4.9 0.56 100.00
36 INT346946 Regulation of Negative_regulation of amd 1 0.05 0.57 0.3 100.00
37 INT205525 Negative_regulation of Binding of amd 1 0.15 0.97 0 100.00
38 INT109124 Positive_regulation of TIMP3 8 0.61 5.57 5.72 99.96
39 INT161027 Negative_regulation of RPE 7 0.37 4.34 0.38 99.94
40 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 99.92
41 INT274183 Negative_regulation of Gene_expression of ELN 3 0.30 3.29 0 99.92
42 INT18670 Negative_regulation of ABCA1 16 0.54 5.8 3.39 99.92
43 INT339591 Positive_regulation of Gene_expression of FBLN1 1 0.08 1.31 0 99.92
44 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.90
45 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 99.90
46 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 99.90
47 INT186810 Positive_regulation of TLR3 13 0.65 6.37 1.37 99.90
48 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 99.88
49 INT200754 Gene_expression of Rpe 35 0.51 6.3 0.58 99.88
50 INT308300 Positive_regulation of Localization of CD34 3 0.44 1.82 0.05 99.88
51 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 99.84
52 INT109925 Gene_expression of RPE 11 0.65 12.46 0.68 99.84
53 INT116540 Binding of Twist1 35 0.48 16.32 2.85 99.84
54 INT339592 Regulation of ARMS2 2 0.26 2.27 0 99.84
55 INT24224 Positive_regulation of Rere 3 0.67 1.15 1.17 99.84
56 INT186637 Regulation of ABCA4 3 0.37 2.02 0.07 99.84
57 INT262591 Transcription of Renbp 1 0.02 0.8 0 99.84
58 INT159060 Localization of PDR 8 0.65 10.45 0.96 99.80
59 INT135885 Negative_regulation of PDR 5 0.46 2.66 0.19 99.80
60 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 99.78
61 INT290491 Positive_regulation of Fcgrt 1 0.39 2.73 0.24 99.78
62 INT339590 Negative_regulation of Gene_expression of FBLN1 1 0.10 2.61 0 99.76
63 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 99.76
64 INT102428 Binding of C2 17 0.32 5.12 1.58 99.76
65 INT282404 Gene_expression of FANCG 1 0.10 0.96 0 99.76
66 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 99.76
67 INT219579 Negative_regulation of Gene_expression of Twist1 12 0.43 9.07 1.36 99.74
68 INT56219 Gene_expression of KDM5D 16 0.53 5.59 1.23 99.72
69 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 99.72
70 INT134753 Gene_expression of TIMP3 19 0.68 15.24 0.88 99.68
71 INT99608 Transcription of MMP9 18 0.65 9.67 4.11 99.68
72 INT87819 Localization of CD34 21 0.81 7.69 0.47 99.66
73 INT16389 Gene_expression of Plg 80 0.67 36.88 6.74 99.62
74 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 99.60
75 INT184378 Binding of Cfb 54 0.20 12.49 2.36 99.60
76 INT339593 Gene_expression of FBLN1 2 0.14 3.01 0.24 99.60
77 INT261186 Positive_regulation of Niacr1 6 0.49 5.28 1.81 99.60
78 INT260172 Localization of Rpe 11 0.49 3.53 0.12 99.56
79 INT290490 Positive_regulation of Gene_expression of Fcgrt 1 0.39 1.16 0.11 99.56
80 INT43931 Binding of CFH 49 0.48 31.85 3.96 99.52
81 INT233921 Binding of PDR 6 0.14 7.03 0.75 99.52
82 INT77490 Positive_regulation of Tnnc1 85 0.68 43.54 9.07 99.52
83 INT125534 Regulation of Tg(CAG-EGFP)D4Nagy 31 0.39 13.88 5.58 99.50
84 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 99.44
85 INT10130 Positive_regulation of Serpinf1 10 0.53 5.62 0.7 99.28
86 INT22871 Gene_expression of ELN 30 0.68 14.86 1.33 99.26
87 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 99.24
88 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 99.24
89 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 99.24
90 INT109536 Negative_regulation of Vegfa 15 0.46 10.35 1.39 99.22
91 INT290493 Gene_expression of Fcgrt 1 0.43 3.11 0.3 99.20
92 INT27446 Negative_regulation of CTSA 11 0.57 5.58 3.08 99.20
93 INT94173 Positive_regulation of CTSA 3 0.53 3.22 0.4 99.20
94 INT174868 Regulation of Negative_regulation of VEGFA 4 0.43 4.51 0.63 99.16
95 INT2393 Positive_regulation of Mb 174 0.69 93.59 26.79 99.16
96 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15 99.12
97 INT247568 Negative_regulation of Negative_regulation of VEGFA 5 0.41 5.35 0.43 99.06
98 INT228771 Localization of C3ar1 2 0.03 2.71 0.38 99.04
99 INT10873 Localization of Twist1 21 0.74 10.43 1.37 99.00
100 INT50080 Binding of APOE 38 0.45 29.61 2.67 99.00
101 INT243112 Regulation of Rpe 5 0.40 3.14 0.1 99.00
102 INT157378 Gene_expression of PDR 14 0.53 11.46 0.64 98.96
103 INT73602 Positive_regulation of Ager 35 0.69 30.66 3.74 98.92
104 INT19449 Binding of FANCB 22 0.47 7.4 4.27 98.86
105 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 98.84
106 INT161436 Transcription of F2 2 0.69 1.21 0.36 98.84
107 INT197512 Gene_expression of ABCA4 19 0.75 7.08 0.57 98.80
108 INT213395 Positive_regulation of Gene_expression of ABCA4 2 0.41 1.22 0 98.80
109 INT353102 Gene_expression of Htra1 1 0.46 1.29 0 98.76
110 INT168642 Gene_expression of Cx3cr1 15 0.77 21.73 8.1 98.76
111 INT168637 Negative_regulation of Cx3cr1 6 0.58 11.67 2.41 98.76
112 INT109930 Positive_regulation of RPE 4 0.49 5.88 0.15 98.72
113 INT11476 Positive_regulation of H2-K1 17 0.26 9.48 2.23 98.72
114 INT342320 Positive_regulation of Irf6 1 0.44 1.08 0.13 98.72
115 INT342327 Positive_regulation of Erap1 1 0.43 1.1 0.13 98.72
116 INT261192 Gene_expression of Niacr1 57 0.67 24.37 1.89 98.68
117 INT100861 Binding of CRP 179 0.48 175.2 26.45 98.68
118 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 98.68
119 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 98.64
120 INT71768 Regulation of Gene_expression of Il10 27 0.62 19.17 10.4 98.64
121 INT243843 Negative_regulation of FMT 3 0.07 1.4 0.32 98.60
122 INT251332 Negative_regulation of Limk1 1 0.59 16.43 4.66 98.60
123 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 98.48
124 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 98.32
125 INT229964 Positive_regulation of C3AR1 1 0.02 0.82 0 98.32
126 INT90792 Localization of Il10 144 0.80 87.88 30.03 98.32
127 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 98.32
128 INT339599 Negative_regulation of CFHR3 1 0.33 1.05 0 98.32
129 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 98.32
130 INT149843 Negative_regulation of C19orf10 1 0.41 0.45 1.25 98.28
131 INT154018 Binding of Lhb 5 0.31 1.39 1.13 98.28
132 INT233924 Negative_regulation of Gene_expression of PDR 1 0.08 1.3 0.17 98.24
133 INT45722 Negative_regulation of CFHR1 6 0.56 1.43 0.78 98.16
134 INT85616 Negative_regulation of Positive_regulation of P9Ehs1 8 0.37 4.17 8.11 98.08
135 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17 98.06
136 INT10171 Binding of Gtf3a 33 0.36 19.84 5.1 98.00
137 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 97.88
138 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 97.88
139 INT43723 Regulation of Vegfa 9 0.34 4.96 2.28 97.88
140 INT23122 Gene_expression of Ptger3 31 0.72 11.94 11.37 97.84
141 INT87436 Regulation of Fgf2 6 0.45 3.95 2.03 97.76
142 INT20457 Regulation of Ptgs1 23 0.48 11.63 11.56 97.76
143 INT152023 Regulation of Vegfa 4 0.52 3.99 0.41 97.76
144 INT282127 Regulation of Regulation of Best1 1 0.15 1.67 0.18 97.68
145 INT114504 Positive_regulation of Scd1 10 0.48 3.77 0.8 97.60
146 INT342335 Positive_regulation of Osbpl1a 1 0.42 0.8 0.04 97.60
147 INT122041 Binding of Ppara 308 0.48 189.17 51.48 97.60
148 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 97.52
149 INT6748 Regulation of Dio1 15 0.45 2.63 11.18 97.40
150 INT274104 Regulation of PLXNA2 2 0.33 2.66 0.25 97.32
151 INT211972 Regulation of Best1 18 0.33 12.04 0.67 97.28
152 INT189629 Negative_regulation of TIMP3 14 0.48 7.63 3.91 97.18
153 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 97.16
154 INT227759 Gene_expression of Best1 26 0.42 20.36 1.73 97.12
155 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 97.08
156 INT7872 Positive_regulation of P9Ehs1 74 0.50 18.54 66.16 96.96
157 INT255233 Negative_regulation of MCDR1 1 0.07 2.07 0 96.92
158 INT228772 Positive_regulation of Localization of Ccl2 3 0.48 4.23 1.21 96.92
159 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 96.92
160 INT26167 Positive_regulation of Hrasls 18 0.23 8.67 4.87 96.84
161 INT126999 Positive_regulation of Gene_expression of Cfb 4 0.28 2.37 0.29 96.80
162 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 96.76
163 INT2384 Regulation of CTSA 4 0.44 2.22 0.69 96.76
164 INT35975 Regulation of Cpox 109 0.39 57.88 49.69 96.72
165 INT210228 Positive_regulation of Rpe 15 0.52 8.78 0.26 96.68
166 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 96.64
167 INT216512 Gene_expression of C3AR1 13 0.70 8.44 1.31 96.60
168 INT140224 Localization of Ccl2 32 0.72 26.91 9.39 96.48
169 INT12339 Localization of IL8 437 0.81 251.87 117.39 96.48
170 INT102891 Positive_regulation of AGTR1 31 0.67 30.57 5.29 96.32
171 INT45004 Gene_expression of Cfb 28 0.37 15.06 1.99 96.32
172 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 96.28
173 INT158863 Negative_regulation of Ros1 84 0.35 40.3 10.14 96.24
174 INT229966 Binding of C9 3 0.47 2.22 0 96.12
175 INT173100 Binding of KDR 39 0.39 22.48 0.81 95.84
176 INT206683 Negative_regulation of Binding of KDR 3 0.34 2.54 0.08 95.84
177 INT144322 Regulation of RPE 1 0.24 1.9 0.08 95.64
178 INT21546 Regulation of ABCA1 16 0.40 4.21 1.04 95.64
179 INT43415 Gene_expression of CYP4A11 11 0.56 7.65 5.94 95.64
180 INT115385 Negative_regulation of Ppara 154 0.58 129.05 27.58 95.64
181 INT160235 Positive_regulation of Gene_expression of FIGF 4 0.20 5.53 1 95.60
182 INT112110 Positive_regulation of FIGF 3 0.18 5.28 0.37 95.60
183 INT200555 Negative_regulation of Gene_expression of Kdr 8 0.38 3.78 0.19 95.48
184 INT112109 Gene_expression of FIGF 13 0.31 8.31 1.44 95.24
185 INT108252 Positive_regulation of Renbp 16 0.24 11.66 1.68 95.24
186 INT127914 Gene_expression of AGTR2 23 0.68 26.87 4.69 95.20
187 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47 95.20
188 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 95.20
189 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 95.12
190 INT89116 Regulation of Positive_regulation of VEGFA 8 0.43 6.62 1.5 95.12
191 INT255662 Regulation of Positive_regulation of Flt1 1 0.29 2.57 0.4 95.12
192 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 95.08
193 INT339598 Gene_expression of ARMS2 1 0.65 1.03 0 95.08
194 INT2774 Binding of Crp 241 0.48 195.89 44.39 95.04
195 INT32579 Binding of C4B 14 0.36 14.99 7.79 95.04
196 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 95.00
197 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 94.96
198 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09 94.68
199 INT211968 Localization of Best1 11 0.40 9.33 0.38 94.44
200 INT72947 Binding of CHM 9 0.42 5.86 0.06 94.24
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