D:Agranulocytosis

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Disease Term
Synonyms Agranulocytoses, Granulocytopenia, GRANULOCYTOPENIAS
Documents 337
Hot Single Events 46
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Agranulocytosis. They are ordered first by their relevance to Agranulocytosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT179903 Binding of ELANE and SRI 1 0.17 1.07 0.03 87.32
2 INT179905 Positive_regulation of ELANE Positive_regulation of SRI 1 0.19 0.92 0 77.00
3 INT179904 Positive_regulation of ELANE Positive_regulation of NYS3 1 0.10 0.92 0 76.68
4 INT37547 Binding of GP1BA and F8 1 0.03 0.15 0.07 44.56
5 INT170121 ITGAL Regulation of CD44 1 0.07 1.07 0 20.40
6 INT170118 PECAM1 Regulation of CD44 1 0.01 1.07 0 20.40
7 INT170116 ITGAM Regulation of CD44 1 0.07 1.07 0 20.40
8 INT81716 ITGAL Regulation of ITGB2 2 0.30 1.24 0.78 19.68
9 INT170124 ITGAM Regulation of ITGB2 1 0.04 1.07 0 19.68
10 INT170126 PECAM1 Regulation of ITGB2 1 0.01 1.07 0 19.68
11 INT170120 PECAM1 Regulation of ITGAM 1 0.00 1.07 0 19.20
12 INT170125 ITGAM Regulation of Positive_regulation of PECAM1 1 0.01 1.07 0 19.20
13 INT170114 ITGAM Regulation of Positive_regulation of ITGAL 1 0.04 1.07 0 19.20
14 INT170119 PECAM1 Regulation of Positive_regulation of ITGAL 1 0.01 1.07 0 18.64
15 INT170123 ITGAL Regulation of Positive_regulation of PECAM1 1 0.01 1.07 0 18.64
16 INT170115 PECAM1 Regulation of ITGAL 1 0.00 1.07 0 18.64
17 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
18 INT170127 Binding of ITGAL and PECAM1 2 0.01 2.71 0.75 5.00
19 INT210878 Binding of FLT1 and HBM 1 0.06 0.83 0.5 5.00
20 INT170128 Binding of ITGAL and ITGB2 2 0.04 1.6 0.28 5.00
21 INT193695 Il2 Positive_regulation of Ctla4 1 0.01 1.63 0.18 5.00
22 INT193693 Binding of Myd88 and Pain1 1 0.14 0.82 0.13 5.00
23 INT193697 Apaf1 Positive_regulation of CASP9 1 0.02 1.84 0.12 5.00
24 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09 5.00
25 INT193691 Positive_regulation of Positive_regulation of Bcr 1 0.01 0.07 0.08 5.00
26 INT193692 IgG2a Positive_regulation of Bcr 1 0.02 0.07 0.08 5.00
27 INT193694 IgG2a Positive_regulation of Tlr9 1 0.05 0.07 0.08 5.00
28 INT295003 Binding of Tnfrsf11b and Tnfsf11 3 0.22 1.85 0.08 5.00
29 INT268679 Binding of HDAC1 and NCOR2 3 0.17 2.8 0.07 5.00
30 INT321891 Dkk1 Negative_regulation of Wnt2 1 0.12 0.94 0.05 5.00
31 INT295006 Binding of TNFRSF11A and Tnfrsf11b 2 0.10 1.6 0.04 5.00
32 INT321890 Slc3a2 Regulation of Dkk1 1 0.01 0.93 0.04 5.00
33 INT284916 IL1RN Negative_regulation of HDAC4 1 0.00 1.66 0.03 5.00
34 INT223067 IFI27 Negative_regulation of CCND1 1 0.05 0.65 0.03 5.00
35 INT223066 CDKN1A Negative_regulation of CCND1 1 0.04 0.66 0.03 5.00
36 INT193696 Binding of CD8A and Trav6-3 1 0.00 0.85 0 5.00
37 INT241500 Binding of Kit and Kitl 1 0.08 0.92 0 5.00
38 INT284919 XRCC6 Negative_regulation of BAX 1 0.01 0.64 0 5.00
39 INT284920 Binding of HDAC1 and NCOR1 1 0.03 0.13 0 5.00
40 INT284918 RUNX1T1 Regulation of DNMT1 1 0.21 1.09 0 5.00
41 INT284917 RUNX1T1 Regulation of HDAC9 1 0.19 1.09 0 5.00
42 INT284914 Binding of HDAC1 and NCK1 1 0.00 0.13 0 5.00
43 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0 5.00
44 INT284915 Binding of CDKN2B and HIST2H3C 1 0.05 0.43 0 5.00
45 INT315889 Binding of B4GALNT1 and IKBKAP 1 0.00 0.68 0 5.00
46 INT284995 Binding of HDAC1 and Sin3a 1 0.00 0.13 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Agranulocytosis. They are ordered first by their pain relevance and then by number of times they were reported in Agranulocytosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT211098 Negative_regulation of Msra 1 0.01 1.36 0.16 99.84
2 INT232405 Binding of DFP 1 0.27 2.4 0.03 99.54
3 INT45473 Positive_regulation of LIPC 3 0.20 5.49 0.2 99.52
4 INT2607 Negative_regulation of Localization of NEU1 3 0.30 1.52 0.88 99.40
5 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 99.20
6 INT42176 Gene_expression of DFP 2 0.39 3.71 1.03 98.84
7 INT2610 Positive_regulation of Localization of NEU1 2 0.12 0.7 0.44 98.60
8 INT70201 Negative_regulation of ESCO2 4 0.37 1.46 1.01 98.32
9 INT2606 Localization of NEU1 10 0.41 4.6 1.82 98.28
10 INT24715 Regulation of CSF3 3 0.38 0.9 0.16 98.24
11 INT2608 Localization of GPI 7 0.73 4.53 0.85 97.60
12 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 97.52
13 INT2605 Regulation of ELANE 39 0.61 18.22 7.11 97.52
14 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 97.32
15 INT46109 Binding of SERPINF2 6 0.37 1.08 2.06 96.96
16 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 96.92
17 INT74421 Positive_regulation of Gene_expression of SPHAR 2 0.06 0.99 0.81 96.60
18 INT74425 Gene_expression of SPHAR 8 0.08 7.81 2.15 96.32
19 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12 96.04
20 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 96.00
21 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 92.76
22 INT2512 Negative_regulation of Cp 27 0.51 10.15 8.37 92.12
23 INT3286 Positive_regulation of Gpt 90 0.69 45.08 28.34 91.76
24 INT31572 Negative_regulation of FLT1 21 0.48 16.49 1.18 91.72
25 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 91.28
26 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 90.84
27 INT20633 Positive_regulation of Gene_expression of LDHA 15 0.49 15.94 1.42 90.84
28 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 90.48
29 INT22823 Positive_regulation of Positive_regulation of ELANE 12 0.45 6.89 3.35 90.16
30 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 89.60
31 INT42581 Regulation of Gene_expression of ELANE 11 0.38 9.25 3.38 87.20
32 INT51646 Binding of IL3 3 0.37 3.26 0.56 85.84
33 INT128160 Regulation of DDIT3 3 0.57 2.45 1.29 85.32
34 INT14184 Positive_regulation of CPB1 23 0.55 14.38 1.73 85.28
35 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 85.04
36 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 85.04
37 INT14688 Gene_expression of CSF3R 7 0.46 3.93 0.06 85.04
38 INT179907 Positive_regulation of Gene_expression of CSF3R 1 0.22 1.02 0 85.04
39 INT48626 Positive_regulation of Csf3 33 0.66 29.79 7.34 84.44
40 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 83.28
41 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 83.28
42 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 83.28
43 INT11803 Positive_regulation of Il2 62 0.70 31.44 18.93 83.28
44 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 83.28
45 INT97439 Positive_regulation of Il5 46 0.60 25.6 9.47 83.28
46 INT26583 Positive_regulation of Cd4 40 0.54 21.96 4.83 81.44
47 INT23257 Regulation of CRP 127 0.62 100.05 21.87 79.88
48 INT546 Binding of ALB 311 0.48 85.98 60.14 79.76
49 INT12010 Gene_expression of Cp 38 0.65 20.55 7.84 79.72
50 INT18478 Protein_catabolism of CSF2 6 0.88 1.75 1.26 79.56
51 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 78.28
52 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 77.56
53 INT62127 Localization of SRI 12 0.45 10.21 1.54 77.00
54 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 76.80
55 INT348064 Localization of LAT2 1 0.31 1.03 0.09 76.72
56 INT179906 Localization of NYS3 1 0.16 0.91 0 76.68
57 INT3823 Positive_regulation of ALPI 27 0.69 19.49 2.15 76.24
58 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36 76.20
59 INT32034 Binding of LOH19CR1 9 0.23 6.55 0.62 75.60
60 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 75.36
61 INT14689 Localization of CSF3R 5 0.56 3.85 1.02 74.76
62 INT232406 Positive_regulation of DFP 1 0.28 1.29 0.06 74.64
63 INT232407 Negative_regulation of Gene_expression of DFP 1 0.24 0.53 0 74.64
64 INT68576 Positive_regulation of Positive_regulation of CSF2 8 0.40 8.1 2.83 74.40
65 INT39269 Positive_regulation of Negative_regulation of CSF2 3 0.28 1.28 0.88 74.40
66 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 74.00
67 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 73.84
68 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 73.00
69 INT14690 Localization of CSF2 124 0.80 85.17 27.26 72.72
70 INT194380 Negative_regulation of Gene_expression of IL5 22 0.42 15.78 4.1 72.40
71 INT171021 Negative_regulation of IL5 18 0.41 14.74 3.39 72.40
72 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 71.88
73 INT2609 Localization of ELANE 111 0.81 50.22 26.63 70.84
74 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 67.32
75 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 65.56
76 INT33327 Positive_regulation of Gene_expression of Gabrg1 39 0.69 9.68 18.82 65.56
77 INT2611 Negative_regulation of AQP1 17 0.39 10.04 2.15 65.44
78 INT19775 Localization of Il1 183 0.78 145.5 50.91 65.24
79 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 65.20
80 INT154057 Gene_expression of Ear1 14 0.41 9.72 1.12 64.56
81 INT161779 Positive_regulation of Gene_expression of Ear1 3 0.27 1.91 0.22 64.56
82 INT197157 Gene_expression of CAPN7 19 0.51 11.33 0.4 64.04
83 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 62.56
84 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 62.56
85 INT68589 Gene_expression of Cacna1c 14 0.58 6.36 0.69 62.56
86 INT14502 Gene_expression of BCHE 40 0.67 18.52 4.6 62.40
87 INT5652 Negative_regulation of Positive_regulation of ELANE 7 0.37 2.46 1.21 61.60
88 INT267577 Localization of ERC1 1 0.78 3.84 2.71 61.36
89 INT78478 Negative_regulation of TOP1 3 0.21 1.75 0.06 53.68
90 INT263054 Positive_regulation of ERC1 2 0.49 0.78 0.49 50.12
91 INT38831 Regulation of SELL 9 0.20 5.82 1.56 48.80
92 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 48.64
93 INT73524 Positive_regulation of Ear1 7 0.27 4.82 0.54 48.20
94 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04 46.24
95 INT23264 Negative_regulation of Positive_regulation of Ptgs1 16 0.39 8.47 8.9 46.24
96 INT175597 Regulation of IGKV2D-19 3 0.01 3.11 0.58 46.04
97 INT19606 Negative_regulation of Ear1 3 0.22 3.25 0.61 45.36
98 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 44.56
99 INT284953 Protein_catabolism of CDA 1 0.07 1.18 0.1 43.12
100 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 43.04
101 INT19286 Negative_regulation of Cacna1c 11 0.46 5.12 2.22 43.04
102 INT59969 Positive_regulation of Htr1a 12 0.67 5.07 5.73 42.32
103 INT13139 Negative_regulation of Cd4 27 0.47 17.49 6.61 42.08
104 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 40.88
105 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 38.68
106 INT216262 Gene_expression of CYGB 2 0.43 2.18 0.03 38.24
107 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 37.36
108 INT2216 Gene_expression of SELL 92 0.77 59.29 17.71 34.96
109 INT62945 Negative_regulation of Gene_expression of SELL 12 0.58 12.86 3.23 34.96
110 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 34.28
111 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 34.24
112 INT30777 Negative_regulation of SELL 20 0.56 18.05 7.32 34.08
113 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 32.32
114 INT68675 Regulation of APCS 10 0.62 7.61 3.01 30.12
115 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 28.56
116 INT63348 Regulation of PECAM1 14 0.40 16.05 0.97 28.48
117 INT7207 Regulation of HBG1 27 0.60 22.1 1.12 26.88
118 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 25.00
119 INT9079 Gene_expression of PPBP 52 0.75 31.2 21.52 25.00
120 INT16460 Negative_regulation of PPBP 21 0.57 13.86 8.54 25.00
121 INT11390 Gene_expression of PF4 5 0.65 3.09 2.07 25.00
122 INT23359 Negative_regulation of PF4 6 0.58 3.54 0.97 25.00
123 INT36269 Negative_regulation of Gene_expression of PF4 1 0.25 0.59 0.07 25.00
124 INT216261 Regulation of Gene_expression of Cacna1c 3 0.25 1.12 0.15 23.52
125 INT216263 Regulation of Gene_expression of BCHE 1 0.44 0.6 0.04 23.52
126 INT91430 Positive_regulation of CD44 25 0.69 15.43 1.76 20.40
127 INT63356 Regulation of CD44 6 0.23 6.29 0.61 20.40
128 INT10919 Positive_regulation of ITGB2 25 0.67 13.75 5.45 19.68
129 INT20992 Regulation of ITGB2 11 0.37 9.04 1.73 19.68
130 INT10917 Positive_regulation of ITGAM 31 0.67 16.39 6.69 19.20
131 INT20991 Regulation of ITGAM 9 0.45 5.46 2.27 19.20
132 INT61418 Positive_regulation of ITGAL 24 0.14 12.86 2.3 18.64
133 INT12942 Regulation of ITGAL 8 0.35 3.29 1.57 18.64
134 INT9954 Negative_regulation of Hrh1 16 0.52 13.04 11.76 17.36
135 INT82354 Positive_regulation of PECAM1 25 0.34 22.93 4.69 17.36
136 INT39463 Positive_regulation of Tg 15 0.69 11.49 2.46 12.80
137 INT3530 Regulation of BCHE 18 0.60 5.47 4.12 7.52
138 INT246089 Negative_regulation of Negative_regulation of MAOA 2 0.41 2.42 1.92 6.96
139 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05 5.76
140 INT246088 Negative_regulation of Negative_regulation of COMT 2 0.37 2.01 1 5.76
141 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
142 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 5.00
143 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
144 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
145 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
146 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
147 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
148 INT738 Regulation of POMC 459 0.62 111.19 243.74 5.00
149 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 5.00
150 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
151 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
152 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
153 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
154 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
155 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
156 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
157 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
158 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
159 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
160 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
161 INT214 Localization of AVP 370 0.81 208.51 91.09 5.00
162 INT10166 Localization of Tnf 237 0.81 153.95 88.64 5.00
163 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
164 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
165 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 5.00
166 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
167 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
168 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
169 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
170 INT24989 Positive_regulation of Cfp 125 0.61 29.55 64.9 5.00
171 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
172 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 5.00
173 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
174 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
175 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28 5.00
176 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
177 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
178 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 5.00
179 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
180 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 5.00
181 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32 5.00
182 INT1726 Positive_regulation of Kitl 65 0.70 38.81 44.85 5.00
183 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
184 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 5.00
185 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
186 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49 5.00
187 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
188 INT6357 Positive_regulation of Localization of Gabrg1 53 0.41 7.03 39.21 5.00
189 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
190 INT17736 Gene_expression of Cfp 111 0.65 40.68 36.61 5.00
191 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
192 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
193 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 5.00
194 INT234 Binding of Alb 151 0.48 52.34 32.97 5.00
195 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
196 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
197 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 5.00
198 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
199 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
200 INT6594 Gene_expression of HTR1D 60 0.75 10.15 27.13 5.00
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