D:Airway Obstruction

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Disease Term
Synonyms Airway Obstructions, Choking, OBSTRUCTION AIRWAY, Obstructions Airway
Documents 1231
Hot Single Events 171
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Airway Obstruction. They are ordered first by their relevance to Airway Obstruction and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT292363 Rbmy1a1 Positive_regulation of Bhr1 1 0.05 1.04 0.12 99.80
2 INT250804 Binding of CCL4L1 and AP5M1 1 0.01 1.48 0.08 95.80
3 INT250801 Binding of AP5M1 and MAPKAP1 1 0.00 1.48 0.08 95.80
4 INT250802 Binding of IL6 and AP5M1 1 0.01 1.47 0.05 95.80
5 INT271478 Tacr1 Regulation of Binding of Mthfd1 1 0.09 0.48 0.13 85.60
6 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48 69.56
7 INT261841 Mastl Positive_regulation of Trpa1 1 0.00 0.82 1.3 66.32
8 INT180447 Binding of Rhoa and Car2 1 0.17 0.56 0.13 65.12
9 INT223088 Binding of ELF3 and NAGLU 1 0.14 0.84 0.09 56.20
10 INT223089 Binding of IDS and NAGLU 1 0.26 0.72 0.09 54.88
11 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 50.16
12 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 49.48
13 INT310695 Binding of Btk and Pla2g6 1 0.18 0.16 0.12 46.92
14 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71 46.08
15 INT310696 Tlr4 Positive_regulation of Positive_regulation of Cftr 1 0.16 0.74 0.28 45.72
16 INT327162 Binding of SERPING1 and F12 1 0.05 0.29 0.04 42.80
17 INT325222 Il13 Regulation of Ahr 1 0.21 0.58 0.11 42.24
18 INT325223 Il13 Regulation of Hrh4 1 0.38 0.58 0.11 41.68
19 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42 40.92
20 INT337535 HLA-DRB1 Positive_regulation of Trav6-3 1 0.00 1.14 0.04 32.28
21 INT349668 Binding of HRH1 and PYCARD 1 0.00 0.37 0.21 31.96
22 INT327382 Oxt Positive_regulation of Positive_regulation of Oxtr 1 0.30 0.41 0.2 31.28
23 INT261832 Trpv1 Negative_regulation of Trpa1 1 0.10 0.58 0.64 29.48
24 INT261830 Hspg2 Negative_regulation of Trpa1 1 0.01 0.58 0.63 29.20
25 INT189127 Mch Positive_regulation of Ahr 1 0.18 0.29 0 23.00
26 INT170729 NGF Positive_regulation of Gene_expression of IFNA1 1 0.04 0.15 0.2 8.48
27 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91 5.00
28 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85 5.00
29 INT267133 Binding of ICAM1 and VCAM1 25 0.32 25.43 1.83 5.00
30 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54 5.00
31 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07 5.00
32 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03 5.00
33 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9 5.00
34 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78 5.00
35 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76 5.00
36 INT275554 Binding of CXCL10 and Cxcr3 1 0.03 2.18 0.71 5.00
37 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66 5.00
38 INT274167 Il13 Regulation of Il5 2 0.09 2.05 0.59 5.00
39 INT275552 Tlr4 Positive_regulation of Gene_expression of Il1 1 0.00 1.28 0.59 5.00
40 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58 5.00
41 INT244232 Binding of Ccr5 and Ccl4 3 0.17 1.48 0.55 5.00
42 INT310767 Tlr4 Regulation of Gene_expression of S100a8 1 0.02 0.7 0.54 5.00
43 INT267707 Binding of Tnf and ARID1B 2 0.20 8.2 0.54 5.00
44 INT193480 Binding of ABCA1 and IRF6 1 0.00 1.08 0.46 5.00
45 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46 5.00
46 INT310769 Pam Regulation of Tlr4 1 0.01 0.69 0.46 5.00
47 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46 5.00
48 INT261839 Binding of Car2 and Trpv1 1 0.03 0 0.45 5.00
49 INT327386 TNF Regulation of Gene_expression of Oxtr 1 0.20 0.98 0.45 5.00
50 INT228732 Il13 Regulation of Gene_expression of Il5 1 0.15 0.44 0.44 5.00
51 INT352972 IL4 Negative_regulation of Gene_expression of IL8 1 0.07 1.01 0.43 5.00
52 INT352986 IL10 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43 5.00
53 INT352985 IL4 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43 5.00
54 INT259637 Binding of Mmp12 and COPD 2 0.02 1.71 0.4 5.00
55 INT352970 IL4 Negative_regulation of Positive_regulation of TH1L 1 0.01 0.91 0.4 5.00
56 INT186758 Il13 Regulation of Ccl5 2 0.17 0.17 0.39 5.00
57 INT186757 Il13 Regulation of Ccl11 2 0.21 0.17 0.39 5.00
58 INT273617 Gene_expression of Slc6a4 Positive_regulation of Pah 1 0.02 0.93 0.38 5.00
59 INT310697 Tlr4 Positive_regulation of Gene_expression of Ptger2 2 0.03 1.34 0.38 5.00
60 INT180442 Acot1 Positive_regulation of Rhoa 1 0.08 1.03 0.38 5.00
61 INT169507 Oxt Regulation of Gene_expression of Oxtr 2 0.20 0.84 0.38 5.00
62 INT275557 Negative_regulation of Binding of CXCL10 and Cxcr3 1 0.04 1.09 0.35 5.00
63 INT327381 Il13 Regulation of Gene_expression of Oxtr 1 0.37 0.88 0.35 5.00
64 INT288537 Binding of Ccr3 and Ccl11 1 0.17 2.92 0.35 5.00
65 INT310765 Binding of Pam and Tlr2 1 0.01 0.57 0.35 5.00
66 INT310934 Positive_regulation of Tgm2 Positive_regulation of Binding of IGHE 1 0.14 1.33 0.34 5.00
67 INT325221 Il13 Regulation of Ccl3 1 0.08 0.17 0.32 5.00
68 INT349664 PYCARD Negative_regulation of Localization of AR 1 0.05 0 0.32 5.00
69 INT259639 MAPK14 Regulation of Gene_expression of IL8 1 0.02 1.2 0.32 5.00
70 INT349662 Binding of PYCARD and Negative_regulation of Localization of AR 1 0.05 0 0.32 5.00
71 INT327380 Il13 Positive_regulation of Oxt 1 0.29 0.13 0.32 5.00
72 INT325220 Il13 Negative_regulation of Ccl11 1 0.29 0.65 0.3 5.00
73 INT272925 Ccl2 Positive_regulation of Gene_expression of Col7a1 1 0.00 0.72 0.3 5.00
74 INT275555 Binding of Ltb4r1 and COPD 1 0.01 1.02 0.3 5.00
75 INT272932 Binding of Mmp9 and COPD 1 0.01 0.78 0.29 5.00
76 INT190826 ELANE Positive_regulation of Localization of MUC1 1 0.07 0 0.29 5.00
77 INT272930 Positive_regulation of Binding of Mmp1a and COPD 1 0.01 0.79 0.29 5.00
78 INT327379 S100a8 Regulation of Oxt 1 0.00 0.95 0.29 5.00
79 INT272933 Binding of Mmp1a and COPD 1 0.01 0.78 0.29 5.00
80 INT272929 Positive_regulation of Binding of Mmp9 and COPD 1 0.01 0.79 0.29 5.00
81 INT272928 Positive_regulation of Binding of Mmp12 and COPD 1 0.01 0.79 0.29 5.00
82 INT275548 Il10 Regulation of Mmp9 1 0.00 0.86 0.28 5.00
83 INT275556 Il10 Positive_regulation of Gene_expression of TIMP1 1 0.00 0.85 0.28 5.00
84 INT193479 TLR2 Regulation of Binding of IRF6 1 0.04 0.75 0.28 5.00
85 INT275509 IL8 Positive_regulation of Gene_expression of TIMP1 1 0.00 0.85 0.28 5.00
86 INT310771 Pam Positive_regulation of TNF 1 0.02 0.29 0.27 5.00
87 INT310768 Pam Positive_regulation of Cxcl2 1 0.01 0.29 0.26 5.00
88 INT310766 Tlr4 Positive_regulation of Cxcl2 1 0.29 0.28 0.26 5.00
89 INT275553 Negative_regulation of Binding of Ccr5 and Ccl3 1 0.05 0.73 0.26 5.00
90 INT327387 TNF Positive_regulation of Oxtr 1 0.15 0.28 0.25 5.00
91 INT180718 Binding of SARS and ACE2 3 0.12 7.76 0.25 5.00
92 INT327383 Il13 Positive_regulation of Gene_expression of Cd38 1 0.19 0 0.25 5.00
93 INT261842 Pla2g6 Positive_regulation of Trpm8 1 0.03 0 0.23 5.00
94 INT259623 Binding of Eln and Elane 1 0.02 1.38 0.23 5.00
95 INT190827 KCNA1 Regulation of Localization of MUC1 1 0.05 0.08 0.22 5.00
96 INT319971 App Regulation of Enpp1 1 0.02 0.72 0.21 5.00
97 INT180450 Positive_regulation of Acot1 Positive_regulation of Acot1 Positive_regulation of Rhoa 1 0.01 0.44 0.2 5.00
98 INT175464 Hand2 Positive_regulation of Gene_expression of Sftpd 1 0.19 1.05 0.2 5.00
99 INT180441 Acot1 Positive_regulation of Gopc 1 0.03 0.43 0.19 5.00
100 INT180435 Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19 5.00
101 INT180444 Positive_regulation of Acot1 Positive_regulation of Rhoa 1 0.08 0.43 0.19 5.00
102 INT179683 Binding of Col7a1 and Eln 2 0.00 3.02 0.19 5.00
103 INT180437 Positive_regulation of Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19 5.00
104 INT180440 Positive_regulation of Acot1 Positive_regulation of Gopc 1 0.03 0.43 0.19 5.00
105 INT327385 Binding of TNF and Il13 1 0.09 0.6 0.18 5.00
106 INT326464 KNG1 Positive_regulation of SERPING1 1 0.19 1.53 0.18 5.00
107 INT272931 Binding of IL8 and Cxcr1 1 0.07 0.65 0.18 5.00
108 INT259634 Elane Positive_regulation of Gene_expression of COPD 1 0.01 0.92 0.17 5.00
109 INT310932 Binding of Tgm2 and Serpinb1a 1 0.04 0.87 0.17 5.00
110 INT259633 Mmp9 Positive_regulation of Gene_expression of COPD 1 0.01 0.92 0.17 5.00
111 INT349659 PYCARD Positive_regulation of ADRB2 1 0.06 0.19 0.17 5.00
112 INT319974 App Negative_regulation of Enpp1 1 0.02 0.58 0.16 5.00
113 INT267138 Binding of CDH5 and PECAM1 2 0.16 2.69 0.16 5.00
114 INT259628 Cxcl10 Positive_regulation of Protein_catabolism of Ecm1 1 0.00 0.64 0.15 5.00
115 INT319972 App Negative_regulation of Gene_expression of Enpp1 1 0.02 1.87 0.15 5.00
116 INT259627 Cxcl10 Positive_regulation of Gene_expression of Mmp12 1 0.02 0.64 0.15 5.00
117 INT286901 Binding of HBM and VEGFA 1 0.05 1.08 0.14 5.00
118 INT286900 Binding of HBM and PDGFA 1 0.04 1.08 0.14 5.00
119 INT286898 Binding of HBM and IL6 1 0.01 1.09 0.14 5.00
120 INT272927 Mapk14 Positive_regulation of Gene_expression of TNF 1 0.16 0.53 0.14 5.00
121 INT307627 Binding of BMP1 and CSF2 1 0.01 0.33 0.12 5.00
122 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11 5.00
123 INT259629 Binding of Adam17 and Timp3 1 0.01 0.19 0.11 5.00
124 INT269013 Binding of CSRP1 and COPD 1 0.08 1.3 0.11 5.00
125 INT180715 Binding of SARS and CLEC4M 2 0.12 2.92 0.11 5.00
126 INT175463 Sftpd Negative_regulation of Gene_expression of Hand2 1 0.17 0.96 0.11 5.00
127 INT259636 Binding of Tbce and COPD 1 0.04 1 0.11 5.00
128 INT347647 Inpp5d Negative_regulation of Pik3r1 1 0.31 0.37 0.1 5.00
129 INT327384 S100a8 Regulation of Gene_expression of Oxtr 1 0.00 0.1 0.1 5.00
130 INT180449 Rhoa Regulation of Positive_regulation of Car2 1 0.13 0 0.09 5.00
131 INT267684 Binding of INS and ARID1B 3 0.10 6.08 0.09 5.00
132 INT337536 Binding of Klrk1 and COPD 1 0.03 3.09 0.09 5.00
133 INT349660 Binding of INSR and PYCARD 1 0.01 0 0.09 5.00
134 INT277890 Binding of Ids and Tas2r111-ps2 1 0.08 0.5 0.09 5.00
135 INT277889 Regulation of Binding of Ids and Tas2r111-ps2 1 0.09 0.5 0.09 5.00
136 INT180443 Rhoa Regulation of Negative_regulation of Mlc1 1 0.04 0 0.09 5.00
137 INT259622 Elane Positive_regulation of Protein_catabolism of Ecm1 1 0.00 0.38 0.08 5.00
138 INT286899 Binding of IL6 and CCL2 1 0.03 0.92 0.08 5.00
139 INT232917 Binding of KRT8 and KRT19 2 0.16 1.04 0.08 5.00
140 INT279767 Binding of IGHG3 and KRT19 1 0.01 0.84 0.07 5.00
141 INT273616 PVR Positive_regulation of Pah 1 0.10 0.86 0.07 5.00
142 INT240484 Ctsk Positive_regulation of Protein_catabolism of Col7a1 1 0.12 0.42 0.07 5.00
143 INT310933 Il6 Positive_regulation of Tgm2 1 0.00 0.55 0.07 5.00
144 INT267137 ICAM1 Regulation of ITGAL 2 0.12 0.57 0.07 5.00
145 INT251645 Binding of SERPING1 and CD79A 1 0.10 1.31 0.06 5.00
146 INT320160 Binding of FCER2 and IGHG3 1 0.00 0.35 0.06 5.00
147 INT259635 Plau Positive_regulation of PLG 1 0.13 0.22 0.06 5.00
148 INT320161 Binding of IGHE and IGHG3 1 0.02 0.35 0.06 5.00
149 INT259638 COPD Positive_regulation of NFE2L2 1 0.03 1.31 0.05 5.00
150 INT349665 Positive_regulation of Binding of AR and TFPI 1 0.02 0 0.05 5.00
151 INT224150 Binding of TREM1 and COPD 1 0.07 0.7 0.05 5.00
152 INT349667 Binding of AR and TFPI 1 0.02 0 0.05 5.00
153 INT349663 Binding of TFPI and PYCARD 1 0.04 0 0.04 5.00
154 INT279763 Binding of IGHG3 and KRT18 1 0.00 0.43 0.04 5.00
155 INT319973 App Regulation of Gene_expression of Mapk12 1 0.02 0.98 0.04 5.00
156 INT181168 Binding of CD79A and TAPBP 1 0.10 0.7 0.04 5.00
157 INT279764 Binding of IGHG3 and BTG3 1 0.00 0.3 0.04 5.00
158 INT267685 Binding of CENPJ and ARID1B 1 0.09 0.58 0.04 5.00
159 INT279766 Binding of IGHG3 and TGM1 1 0.01 0.3 0.04 5.00
160 INT279765 Binding of IGHG3 and KRT8 1 0.01 0.42 0.04 5.00
161 INT250803 Binding of SARS and MBL3P 1 0.09 1.7 0.04 5.00
162 INT279762 Binding of KRT18 and KRT19 1 0.01 0.43 0.04 5.00
163 INT288538 Il2 Positive_regulation of Gene_expression of Bcl2 1 0.04 1.96 0.03 5.00
164 INT180438 Positive_regulation of Rhoa Positive_regulation of Car2 1 0.22 0.48 0.03 5.00
165 INT259621 Serpinc1 Regulation of Gene_expression of Mmp12 1 0.01 0.89 0.03 5.00
166 INT349661 PYCARD Positive_regulation of AR 1 0.08 0 0.03 5.00
167 INT267686 Binding of RYBP and CENPJ 1 0.01 0.12 0.03 5.00
168 INT310694 Tlr4 Positive_regulation of Cftr 1 0.16 0.34 0.03 5.00
169 INT277892 IDS Regulation of Ids 1 0.18 0.41 0 5.00
170 INT352175 USE1 Regulation of NAGA 1 0.01 0.33 0 5.00
171 INT181169 TAPBP Negative_regulation of MALT1 1 0.00 0.48 0 5.00
172 INT181167 TAPBP Negative_regulation of CD79A 1 0.11 0.48 0 5.00
173 INT180446 Rhoa Regulation of Gene_expression of Car2 1 0.21 0.17 0 5.00
174 INT349666 Binding of AR and PYCARD 1 0.06 0 0 5.00
175 INT272867 Binding of NLRP1 and COPD 1 0.00 1.07 0 5.00
176 INT221910 Binding of SRI and COPD 1 0.01 1.27 0 5.00
177 INT259670 CSE Positive_regulation of Hmox1 1 0.06 0.97 0 5.00
178 INT261833 Binding of Add3 and Trpv4 1 0.00 0.12 0 5.00
179 INT261838 Lyn Regulation of Trpv4 1 0.03 0.19 0 5.00
180 INT181165 TAPBP Regulation of Gene_expression of CD79A 1 0.07 0.35 0 5.00
181 INT267136 Binding of CD44 and FN1 2 0.04 0.56 0 5.00
182 INT261840 Binding of Mtap7 and Trpv4 1 0.05 0.12 0 5.00
183 INT261843 Lyn Regulation of Regulation of Trpv4 1 0.03 0.19 0 5.00
184 INT269014 Binding of EGR1 and COPD 1 0.12 0.96 0 5.00
185 INT277891 Binding of TPBG and M6pr-ps 1 0.02 0.06 0 5.00
186 INT261844 Lyn Positive_regulation of Lyn Regulation of Trpv4 1 0.01 0.19 0 5.00
187 INT277766 EGFR Regulation of Gene_expression of VEGFA 1 0.54 0.14 0 5.00
188 INT337537 Binding of MICA and Positive_regulation of Klrk1 1 0.07 0.68 0 5.00
189 INT307774 Binding of ARMC9 and RCT 1 0.01 1.27 0 5.00
190 INT286902 Binding of PDGFA and VEGFA 1 0.24 1.1 0 5.00
191 INT180439 Rhoa Regulation of Gene_expression of Acot1 1 0.07 0.17 0 5.00
192 INT277772 Binding of EGFR and fc 1 0.01 0.57 0 5.00
193 INT353619 Positive_regulation of Mapk8 Positive_regulation of Gene_expression of Muc5ac 1 0.51 0.3 0 5.00
194 INT281402 Binding of AGRP and RAPGEFL1 1 0.05 0.29 0 5.00
195 INT261837 Binding of Aqp5 and Trpv4 1 0.05 0.17 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Airway Obstruction. They are ordered first by their pain relevance and then by number of times they were reported in Airway Obstruction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT229744 Gene_expression of AOC2 7 0.34 3.87 1.29 100.00
2 INT10918 Gene_expression of ITGB2 93 0.76 71.8 16.34 100.00
3 INT229739 Positive_regulation of Gene_expression of AOC2 1 0.05 1.19 0.4 100.00
4 INT229740 Negative_regulation of Gene_expression of AOC2 1 0.05 0.67 0.03 100.00
5 INT229745 Transcription of AOC2 1 0.08 0.53 0.14 100.00
6 INT229743 Negative_regulation of AOC2 2 0.42 2.03 0.21 100.00
7 INT229741 Phosphorylation of AOC2 1 0.09 0.57 0.07 100.00
8 INT229742 Positive_regulation of AOC2 1 0.05 0.4 0.17 100.00
9 INT229738 Regulation of AOC2 1 0.06 0.18 0.25 100.00
10 INT92838 Positive_regulation of Col4a1 8 0.36 3.48 0.6 99.96
11 INT161574 Localization of CENPJ 7 0.73 6.11 1.54 99.92
12 INT4395 Positive_regulation of CSH1 20 0.50 6.27 1.52 99.88
13 INT175442 Gene_expression of Cel 22 0.34 21.36 3.33 99.80
14 INT104395 Gene_expression of Cxcl9 83 0.76 73.1 19.79 99.80
15 INT147572 Gene_expression of Ahr 73 0.75 38.99 3.15 99.68
16 INT22965 Positive_regulation of Pah 42 0.61 41.41 8.84 99.60
17 INT36978 Localization of Pah 9 0.73 7.43 0.82 99.60
18 INT19563 Gene_expression of CHRM3 6 0.58 2.68 0.66 99.54
19 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 99.52
20 INT177643 Binding of CENPJ 12 0.36 8.59 0.22 99.36
21 INT34864 Binding of Cp 23 0.47 5.17 1.78 99.20
22 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 98.96
23 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 98.96
24 INT147793 Localization of COPD 70 0.64 89.01 7.3 98.92
25 INT74272 Localization of CPOX 39 0.63 25.12 10.53 98.88
26 INT35349 Gene_expression of CENPJ 52 0.57 25.36 2.54 98.72
27 INT175455 Gene_expression of Hspb8 54 0.76 59.87 3.9 98.52
28 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 98.52
29 INT136688 Binding of Cenpj 1 0.30 0.1 0.42 98.48
30 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 98.38
31 INT112970 Regulation of Ccr1 8 0.29 7.77 1.93 98.38
32 INT1893 Localization of Gh 1041 0.79 340.23 256.58 98.36
33 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 98.20
34 INT61784 Positive_regulation of CENPJ 27 0.51 11.46 2.28 98.12
35 INT244344 Gene_expression of Rbmy1a1 12 0.14 6.72 0.42 98.08
36 INT57338 Gene_expression of ITGAX 31 0.75 24.62 4.39 98.04
37 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 98.00
38 INT150867 Regulation of COPD 54 0.48 71.38 8.8 97.96
39 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 97.92
40 INT175444 Gene_expression of Tchol1 1 0.02 2.18 0.08 97.92
41 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 97.92
42 INT7620 Localization of TPO 4 0.26 5.35 0.88 97.90
43 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 97.84
44 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 97.78
45 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 97.78
46 INT574 Negative_regulation of C1S 9 0.47 11.25 1.41 97.52
47 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 97.04
48 INT33466 Negative_regulation of C4B 14 0.43 9.06 4.64 97.04
49 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24 96.96
50 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 96.96
51 INT289312 Phosphorylation of Ahr 1 0.03 0.86 0.15 96.96
52 INT55671 Gene_expression of Ik 151 0.27 80.1 48.49 96.96
53 INT73416 Binding of Mch 4 0.28 1.99 0.5 96.84
54 INT277882 Gene_expression of Ids 5 0.71 1.6 0.26 96.76
55 INT1353 Negative_regulation of Localization of Acot1 153 0.53 15.05 75.17 96.68
56 INT36461 Regulation of Col4a1 10 0.26 5.43 1.17 96.52
57 INT3880 Negative_regulation of Serping1 54 0.58 37.19 4.75 96.00
58 INT1352 Localization of Acot1 728 0.80 73.01 296.01 95.60
59 INT17370 Negative_regulation of Negative_regulation of Ptgs1 16 0.22 6.5 6.12 95.40
60 INT224151 Positive_regulation of Gene_expression of TREM1 14 0.52 13.04 1.36 95.20
61 INT224154 Positive_regulation of TREM1 14 0.56 22.65 2.71 95.20
62 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 94.96
63 INT48993 Positive_regulation of Cftr 17 0.57 6.02 4.12 94.72
64 INT298739 Regulation of USE1 3 0.20 1.58 0.04 94.72
65 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 94.48
66 INT219695 Positive_regulation of Gene_expression of COPD 24 0.40 33.04 3.42 94.48
67 INT13145 Positive_regulation of Car1 60 0.70 16.32 23.23 94.48
68 INT6869 Positive_regulation of Car3 34 0.61 5.15 14.21 94.48
69 INT70970 Binding of COPD 144 0.42 180.34 18.29 94.28
70 INT90603 Positive_regulation of Ahr 103 0.69 58.65 7.73 94.16
71 INT164189 Gene_expression of TREM1 82 0.62 60.77 5.85 94.16
72 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24 94.04
73 INT12082 Localization of IL6 365 0.81 241.78 105.78 93.92
74 INT3188 Regulation of Localization of Acot1 84 0.59 8.94 38.56 93.84
75 INT224156 Negative_regulation of Gene_expression of TREM1 7 0.32 4.93 0.9 93.64
76 INT16618 Negative_regulation of SERPING1 81 0.59 86.28 7.17 93.60
77 INT4808 Gene_expression of LTC4S 37 0.73 18.36 9.62 93.60
78 INT1682 Negative_regulation of Rem1 28 0.37 7.38 8.4 93.60
79 INT8775 Binding of IGHE 167 0.48 102.61 23.54 93.56
80 INT5871 Binding of IFNA2 38 0.48 20.35 6.46 93.56
81 INT168153 Localization of CCL4L1 2 0.26 1.58 0.37 93.56
82 INT289310 Protein_catabolism of Serpinb1b 1 0.52 0.7 0.07 93.36
83 INT117601 Positive_regulation of Trpa1 174 0.70 72.41 71.9 93.28
84 INT13543 Positive_regulation of LTC4S 5 0.58 2.26 0.88 93.00
85 INT197250 Localization of Muc5ac 7 0.71 4.83 0.55 92.80
86 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79 92.44
87 INT76339 Positive_regulation of Ltb4r1 23 0.45 22.78 3.58 92.24
88 INT4587 Negative_regulation of Serping1 32 0.47 19.11 5.92 92.24
89 INT37864 Regulation of Negative_regulation of Serping1 1 0.10 0.69 0.09 92.24
90 INT214921 Localization of MAPKAP1 3 0.09 2.5 0.08 92.16
91 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 92.04
92 INT20131 Negative_regulation of Mthfs 18 0.57 7.93 10.54 91.92
93 INT5904 Localization of MPO 62 0.81 36.37 14.64 91.64
94 INT154048 Negative_regulation of Gene_expression of Mapk8 5 0.43 4.43 1.22 91.20
95 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 91.20
96 INT250814 Positive_regulation of Gene_expression of MAPKAP1 2 0.49 2.78 0.25 91.20
97 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 91.12
98 INT97308 Gene_expression of TPO 15 0.65 13.26 2.12 90.96
99 INT76468 Regulation of Positive_regulation of Car2 13 0.29 4.54 3.46 90.96
100 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 90.84
101 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 90.84
102 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 90.84
103 INT70322 Gene_expression of MAPKAP1 10 0.65 6.06 1.7 90.84
104 INT108156 Positive_regulation of MAPKAP1 4 0.08 1.91 1.14 90.84
105 INT250810 Regulation of Gene_expression of MAPKAP1 1 0.06 1.42 0.08 90.84
106 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02 90.80
107 INT99444 Positive_regulation of Proc 15 0.45 9.18 1.75 90.80
108 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65 90.68
109 INT131717 Positive_regulation of Gene_expression of Mapk8 18 0.55 14.25 5.02 90.60
110 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 90.32
111 INT22557 Gene_expression of BMP1 3 0.59 20.18 4.73 90.16
112 INT117316 Positive_regulation of GZMA 3 0.59 3.11 0.15 90.04
113 INT105993 Gene_expression of IDS 26 0.78 10.83 2.41 89.68
114 INT267698 Gene_expression of ARID1B 18 0.63 20.47 0.47 89.36
115 INT6107 Localization of Npy 180 0.81 26.76 81.67 88.72
116 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 88.40
117 INT69158 Localization of IL4 48 0.71 31.3 11.98 88.04
118 INT132822 Localization of IL13 26 0.67 22.85 6.66 88.04
119 INT263095 Transcription of COPD 3 0.53 2.78 0.33 87.64
120 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 87.60
121 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 87.52
122 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31 87.04
123 INT174197 Negative_regulation of Gene_expression of RB1 4 0.47 4.25 0 87.04
124 INT174188 Positive_regulation of Gene_expression of RB1 9 0.45 6.22 0.94 87.04
125 INT184386 Binding of DNAI1 5 0.36 3.77 0.82 86.92
126 INT325356 Regulation of Binding of DNAI1 1 0.44 1.12 0.04 86.92
127 INT103842 Gene_expression of Cftr 53 0.78 59.59 21.82 86.84
128 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 86.76
129 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 86.60
130 INT134651 Binding of TLR4 89 0.48 66.96 23.19 86.60
131 INT270441 Negative_regulation of Negative_regulation of COPD 3 0.36 4.18 0.23 86.40
132 INT289306 Positive_regulation of Serpinb1b 6 0.41 2.83 0.48 86.24
133 INT14092 Gene_expression of Serpinb1b 3 0.40 2.26 1.77 85.88
134 INT69134 Positive_regulation of MPEG1 9 0.26 5.95 0.97 85.84
135 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 85.36
136 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 85.32
137 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 85.12
138 INT103469 Positive_regulation of Gene_expression of BDNF 59 0.67 24.39 18.36 85.12
139 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26 84.72
140 INT188591 Positive_regulation of Binding of Mthfd1 3 0.26 0.9 0.69 84.36
141 INT48141 Binding of Csf3 18 0.39 9.93 1.71 84.32
142 INT206820 Gene_expression of Muc1 17 0.60 13.48 0.36 84.16
143 INT58449 Binding of Mthfd1 47 0.47 22.02 10.29 84.04
144 INT272885 Positive_regulation of Gene_expression of Gmcl1 1 0.08 0.76 0.15 83.88
145 INT209537 Gene_expression of Muc4 16 0.74 6.54 0.31 83.80
146 INT153492 Gene_expression of Gmcl1 44 0.65 15.77 2.56 83.60
147 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 83.44
148 INT175447 Positive_regulation of Positive_regulation of IgG2a 2 0.28 1.69 0.04 83.44
149 INT56364 Regulation of Gene_expression of ITGAM 19 0.61 9.82 5.09 83.36
150 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 82.60
151 INT68235 Positive_regulation of IgG2a 39 0.49 30.96 2.75 82.60
152 INT173504 Positive_regulation of Gene_expression of Ighg1 16 0.47 7.2 2.36 82.60
153 INT173507 Positive_regulation of Gene_expression of IgG2a 12 0.26 5.97 0.65 82.60
154 INT20991 Regulation of ITGAM 9 0.45 5.46 2.27 82.48
155 INT101891 Negative_regulation of Cftr 25 0.58 24.09 9.55 82.48
156 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 81.76
157 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 81.60
158 INT11591 Gene_expression of IgG2a 53 0.65 23.14 6.73 81.40
159 INT277576 Regulation of HRCT1 1 0.03 0.9 0.03 81.40
160 INT310680 Gene_expression of ARSB 1 0.64 6.28 0.12 80.96
161 INT152552 Gene_expression of Muc5ac 24 0.73 19.44 4 80.92
162 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 80.56
163 INT103683 Gene_expression of Muc2 18 0.73 12.47 2.43 80.48
164 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 80.40
165 INT122376 Localization of Pla2g4a 12 0.73 7.18 2.58 80.36
166 INT294726 Positive_regulation of Lts1 5 0.49 4.06 0.87 80.36
167 INT58527 Gene_expression of Prtn3 20 0.71 15.99 2.9 80.28
168 INT69142 Positive_regulation of Atxn3 3 0.50 1.52 0.53 80.24
169 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15 80.20
170 INT61417 Gene_expression of ITGAL 36 0.75 29.62 6.15 80.04
171 INT159989 Positive_regulation of Ctsk 17 0.69 10.51 2.25 80.04
172 INT3127 Gene_expression of SRI 38 0.68 26.29 3.82 79.76
173 INT2216 Gene_expression of SELL 92 0.77 59.29 17.71 79.64
174 INT82942 Binding of Crot 2 0.05 0.64 0 79.52
175 INT22429 Positive_regulation of PDAP1 34 0.61 22.58 2.91 79.48
176 INT103638 Negative_regulation of MEFV 7 0.39 5.88 0.54 79.36
177 INT701 Localization of IGHE 87 0.80 40.5 10.62 79.12
178 INT3816 Gene_expression of Ahr 13 0.65 7.51 1.31 79.12
179 INT224155 Regulation of Gene_expression of TREM1 4 0.36 3.06 0.52 79.12
180 INT153731 Positive_regulation of Gene_expression of Ahr 2 0.32 2 0.28 79.12
181 INT289311 Negative_regulation of Gene_expression of Ahr 1 0.02 1 0.09 79.12
182 INT96480 Negative_regulation of Positive_regulation of Mthfd1 5 0.30 0.99 0.83 79.00
183 INT289309 Positive_regulation of Gene_expression of Serpinb1b 1 0.30 0.65 0.26 78.88
184 INT17997 Positive_regulation of Mch 23 0.49 12.71 6.67 78.04
185 INT157816 Positive_regulation of Positive_regulation of Mthfd1 5 0.33 3.73 1.93 77.84
186 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35 77.52
187 INT22081 Regulation of Ceacam1 8 0.23 4.11 0.95 77.52
188 INT218776 Negative_regulation of Ccdc80 2 0.02 0.97 0.99 77.40
189 INT261817 Protein_catabolism of Ccdc80 1 0.02 0.86 0.45 77.40
190 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 77.36
191 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 77.36
192 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 77.12
193 INT310764 Positive_regulation of Pam 1 0.02 0.5 0.12 77.12
194 INT193428 Gene_expression of Muc5b 20 0.75 8.15 1.13 77.08
195 INT175460 Gene_expression of Sle1 2 0.08 3.5 0.09 77.04
196 INT17998 Gene_expression of Mch 29 0.58 7.76 1.37 76.72
197 INT104389 Positive_regulation of Gene_expression of Cxcl9 15 0.49 17.42 4.59 76.64
198 INT6097 Negative_regulation of NEUROD1 30 0.57 9.71 6.24 76.44
199 INT119892 Gene_expression of Cftr 54 0.77 23.76 9.73 76.32
200 INT12339 Localization of IL8 437 0.81 251.87 117.39 76.32
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