D:Alcohol Addiction

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Disease Term
Synonyms Abuse Alcohol, Alchoholism, ALCOHOL ABUSE, Alcohol Dependence, Alcohol Dependence Disorder, Alcohol Dependence Syndrome, ALCOHOL DEPENDENCY, ALCOHOL DRINKING BEHAVIOR, Alcohol Drinking Behaviour, Alcohol Intoxication, ALCOHOL PROBLEM DRINKING
Documents 3077
Hot Single Events 200
Hot Interactions 33

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Alcohol Addiction. They are ordered first by their relevance to Alcohol Addiction and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77 99.48
2 INT172205 Binding of Maoa and ADHD1 1 0.03 0.82 0.05 97.76
3 INT97594 Penk Regulation of Gene_expression of Drd2 1 0.15 0.1 0.28 97.24
4 INT97595 Penk Regulation of Gene_expression of Drd1a 1 0.25 0.1 0.28 97.24
5 INT312692 CCR6 Regulation of CCL20 1 0.29 2.42 0.73 96.44
6 INT172203 Binding of Comt and Maoa 1 0.31 0.98 1.43 95.84
7 INT6931 Binding of Oprk1 and Pdyn 2 0.24 0.92 1.92 93.84
8 INT205030 Crh Positive_regulation of Crhr1 2 0.54 1.33 0.51 93.60
9 INT69556 Slc7a11 Regulation of Cpe 2 0.06 0.46 1.95 93.44
10 INT10844 Ghrh Regulation of Gh 13 0.13 4.77 4.71 93.24
11 INT58243 Ghrh Regulation of Prl 1 0.04 0.18 0.21 92.96
12 INT89332 Binding of SP1 and SP3 1 0.30 0.76 0.39 92.32
13 INT17726 Positive_regulation of Binding of AKR1A1 and Aldh2 1 0.11 0.35 0.41 91.84
14 INT172206 Binding of Slc6a3 and ADHD1 2 0.03 2.76 1.61 91.60
15 INT17725 Binding of AKR1A1 and Aldh2 1 0.08 0.35 0.4 91.00
16 INT356317 Crhr1 Regulation of Gene_expression of Cea 1 0.18 0.65 1.33 89.12
17 INT356326 Crhr1 Regulation of Gene_expression of Helt 1 0.01 0.65 1.32 89.12
18 INT79094 PDYN Positive_regulation of PRL 1 0.35 0.09 1.07 88.24
19 INT271888 Binding of DRD2 and DNAJC7 1 0.14 0.36 0.55 87.52
20 INT109958 Binding of CRH and HPSE 1 0.10 0.72 1.46 87.32
21 INT125389 Regulation of Flvcr2 Positive_regulation of Fbxo23 1 0.03 0.27 0.44 87.24
22 INT125388 Flvcr2 Positive_regulation of Fbxo23 1 0.05 0.27 0.42 87.24
23 INT271889 Binding of DRD2 and ANKK1 1 0.23 0.36 0.55 87.04
24 INT356321 Positive_regulation of Crhr1 Positive_regulation of Cea 1 0.19 0.37 0.56 85.52
25 INT32482 Ghrh Positive_regulation of Prl 3 0.18 0.26 1.62 84.36
26 INT164362 Binding of NLRP1 and VTA1 1 0.15 2.37 4.67 84.16
27 INT164365 Positive_regulation of Binding of NLRP1 and VTA1 1 0.14 0.6 1.21 84.16
28 INT312686 CP Positive_regulation of CP Positive_regulation of CCL20 1 0.03 10.97 2.94 83.56
29 INT312690 CP Positive_regulation of CCL20 1 0.11 8.23 2.2 83.56
30 INT77689 Binding of Ace and Tenc1 1 0.28 0.65 0.7 82.28
31 INT312691 CCR6 Regulation of PCA 1 0.20 2.76 0.74 81.44
32 INT60626 Crh Positive_regulation of Localization of Pomc 7 0.54 2.3 1.99 81.36
33 INT60627 Crh Positive_regulation of Localization of Mc2r 2 0.11 0.44 0.53 81.36
34 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62 79.36
35 INT60628 Crh Positive_regulation of Pomc 1 0.52 0.17 0.32 79.16
36 INT225083 Binding of ETF1 and fc 1 0.00 2.13 0.57 79.12
37 INT185997 Binding of FANCB and fc 2 0.01 2.51 0.63 79.12
38 INT225082 Binding of IGHG3 and fc 6 0.01 3.6 0.55 79.12
39 INT225067 Binding of ETF1 and IGHG3 1 0.03 4.52 1.17 78.88
40 INT83422 Binding of FANCB and IGHG3 3 0.12 5.09 1.22 78.88
41 INT356328 Crh Positive_regulation of Cea 1 0.26 0.28 0.6 78.84
42 INT225065 Binding of ETF1 and FANCB 1 0.01 2.07 0.59 78.56
43 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91 75.76
44 INT271902 Binding of KCNK1 and Jun 1 0.12 0.08 0.53 75.20
45 INT261629 Binding of CPD and TRPC5 1 0.04 0.52 0.32 73.68
46 INT201512 Binding of PRSS1 and hcp 1 0.09 1.9 0.57 67.88
47 INT312688 PCA Regulation of Localization of CCR6 1 0.20 2.67 0.67 67.64
48 INT312694 PCA Regulation of Localization of CP 1 0.05 2.65 0.66 66.68
49 INT21607 ACE Positive_regulation of ANGPT2 1 0.03 0.13 0.61 66.32
50 INT356329 Crhr1 Regulation of Cea 1 0.09 0.31 0.64 66.20
51 INT164363 Regulation of Binding of NLRP1 and VTA1 1 0.14 0.45 0.86 56.12
52 INT356320 ORF61 Positive_regulation of Positive_regulation of Prkaca 1 0.01 0.05 0.57 53.68
53 INT263230 Prkcg Regulation of Trpv1 1 0.05 0.95 0.56 52.60
54 INT310402 Binding of CALM1 and Grin1 1 0.00 0 0.26 50.00
55 INT263232 Prkcg Positive_regulation of Trpv4 1 0.12 1.1 1.02 48.08
56 INT292873 Binding of Fas and Fasl 5 0.26 15.74 0.49 43.60
57 INT292871 Binding of Fas and Tg(MMTV-Notch4)3Rnc 1 0.05 1.25 0.03 43.40
58 INT292872 Binding of Fasl and Tg(MMTV-Notch4)3Rnc 1 0.05 1.25 0.03 43.24
59 INT250632 Binding of MCPH1 and Fbxo23 1 0.01 0 0.11 40.88
60 INT356315 Crh Regulation of Cea 1 0.16 0.08 0.58 40.16
61 INT356311 Crh Regulation of Gabrg1 1 0.08 0.08 0.57 40.16
62 INT258768 Drd2 Regulation of ADHD1 1 0.14 0.79 0.07 35.04
63 INT356314 Binding of Crhr1 and ORF61 1 0.00 0 0.63 34.16
64 INT356323 Binding of ac and Crhr1 1 0.01 0 0.32 34.16
65 INT356312 Binding of ac and ORF61 1 0.00 0 0.32 34.16
66 INT186989 Binding of Akt1 and Tert 1 0.00 0.61 0 33.72
67 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2 33.28
68 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2 32.32
69 INT72917 Binding of Crh and Crhr1 4 0.32 0.73 0.91 29.68
70 INT342466 Binding of FFAR1 and MAFD1 1 0.03 0.87 0.05 28.12
71 INT104126 STAT3 Regulation of Phospho1 1 0.00 0.06 0.86 27.68
72 INT129919 IFNA2 Positive_regulation of Gene_expression of SLC6A4 1 0.02 0.38 0.69 25.00
73 INT129921 IL4 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.38 0.68 25.00
74 INT129920 IFNA2 Regulation of ADO 1 0.00 0.64 0.64 25.00
75 INT349083 Binding of Lep and Rtn1 1 0.09 1.68 0.57 24.96
76 INT179346 Pdgfa Positive_regulation of Positive_regulation of Mapk3 1 0.05 0.71 0.07 23.48
77 INT179345 Pdgfa Positive_regulation of Mapk3 1 0.05 0.71 0.07 23.48
78 INT250553 Binding of RS1 and SUGT1 3 0.00 3.36 0.22 22.24
79 INT326941 Nts Regulation of Nalcn 1 0.04 0.24 0.23 20.80
80 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31 20.52
81 INT352521 Cnn1 Positive_regulation of Cp 1 0.00 1.45 0.5 19.60
82 INT261631 Binding of CYP2A6 and CYP2B6 1 0.18 0.32 0.18 19.04
83 INT312794 Hdl1 Regulation of Pon1 1 0.02 1.63 0.15 15.76
84 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78 15.52
85 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28 11.80
86 INT177478 Gnrhr Positive_regulation of Localization of IGF1 1 0.04 1.01 0.28 11.80
87 INT258757 Binding of Drd2 and Rends1 1 0.00 1.26 0.25 11.56
88 INT326940 Chrm3 Positive_regulation of Nalcn 1 0.06 0.21 0.19 11.36
89 INT330425 Gene_expression of Aldh2 Negative_regulation of Zmat3 1 0.00 0.64 0.04 10.92
90 INT212824 WAS Positive_regulation of Cnr1 1 0.21 0.62 1.16 10.00
91 INT300199 PCSK9 Regulation of Gene_expression of LDLR 1 0.13 0.88 0 10.00
92 INT202573 Binding of DIO2 and DRD4 1 0.07 0.09 0.03 9.68
93 INT212815 WAS Positive_regulation of CNR1 1 0.01 0.62 1.16 9.52
94 INT330426 Pcyt2 Regulation of Gene_expression of Aldh2 1 0.09 0.46 0.03 5.60
95 INT186999 Binding of KIT and Gtf3a 1 0.00 0.25 0 5.20
96 INT95730 Binding of CP and SPINK1 2 0.19 5.65 4.02 5.00
97 INT198958 Cnr1 Positive_regulation of Kcnj9 1 0.00 0.15 2.24 5.00
98 INT356313 Crh Positive_regulation of Localization of Helt 1 0.02 0 2.11 5.00
99 INT356327 Crh Positive_regulation of Localization of Gabrg1 1 0.17 0 1.58 5.00
100 INT208991 Binding of CALM1 and Ca2 10 0.06 1.34 1.55 5.00
101 INT69031 IL12A Positive_regulation of IFNA1 9 0.13 4.23 1.52 5.00
102 INT198957 Binding of Cnr1 and Mastl 1 0.00 0 1.31 5.00
103 INT70226 Binding of TAC1 and B3GAT1 4 0.24 4.5 1.26 5.00
104 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21 5.00
105 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16 5.00
106 INT235709 Binding of NA and SSR1 1 0.07 0.72 1.08 5.00
107 INT356316 Crh Positive_regulation of Localization of Cea 1 0.34 0 1.06 5.00
108 INT263227 Positive_regulation of Prkcg Regulation of Trpv4 1 0.07 0.95 1 5.00
109 INT310348 Binding of Tspo and Gabrd 1 0.00 0.43 0.88 5.00
110 INT272039 Ddc Positive_regulation of Gene_expression of Aanat 1 0.00 0.26 0.87 5.00
111 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 5.00
112 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 5.00
113 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82 5.00
114 INT356324 ORF61 Regulation of Localization of Gabrg1 1 0.00 0.19 0.76 5.00
115 INT292598 CNR1 Regulation of ABAT 1 0.08 0.32 0.75 5.00
116 INT292599 CNR1 Regulation of Localization of ABAT 1 0.08 0.32 0.75 5.00
117 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73 5.00
118 INT263236 DAG1 Positive_regulation of Prkcg 2 0.01 0.31 0.7 5.00
119 INT33561 Crh Positive_regulation of POMC 3 0.45 1.19 0.64 5.00
120 INT264775 Binding of Gabbr1 and Abat 1 0.03 0 0.64 5.00
121 INT181491 Tryptase Positive_regulation of HTR1A 1 0.02 0.93 0.61 5.00
122 INT327167 RETNLB Regulation of IL6 1 0.00 2.26 0.6 5.00
123 INT327164 RETNLB Regulation of TNF 1 0.00 2.27 0.6 5.00
124 INT327165 RETNLB Regulation of Gene_expression of CRP 1 0.01 2.25 0.59 5.00
125 INT327166 RETNLB Regulation of IL36RN 1 0.00 2.25 0.59 5.00
126 INT175323 Tlr4 Positive_regulation of Gene_expression of TLR2 1 0.02 0.31 0.56 5.00
127 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55 5.00
128 INT263231 Positive_regulation of Trpv1 Positive_regulation of Prkcg 1 0.08 0.57 0.55 5.00
129 INT223556 Churc1 Regulation of Cnr2 1 0.00 0.8 0.54 5.00
130 INT356322 Positive_regulation of Crhr1 Positive_regulation of ORF61 1 0.00 0 0.54 5.00
131 INT263229 Trpv1 Positive_regulation of Prkcg 1 0.08 0.57 0.54 5.00
132 INT184878 Binding of Lmo1 and ADHD1 2 0.04 2.33 0.53 5.00
133 INT312693 Binding of CCR6 and CCL20 2 0.34 2.33 0.53 5.00
134 INT223558 Dpcr1 Regulation of Cms1 1 0.00 0.79 0.51 5.00
135 INT263228 Prkcg Regulation of Trpv4 1 0.07 0.36 0.5 5.00
136 INT263235 Trpv4 Regulation of Trpv1 1 0.17 0.7 0.5 5.00
137 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49 5.00
138 INT175326 SERPINH1 Regulation of Pnlip 1 0.00 0.53 0.49 5.00
139 INT172207 Binding of Drd4 and ADHD1 2 0.03 1.56 0.48 5.00
140 INT189859 Binding of SLC6A3 and ADHD1 2 0.32 0.68 0.48 5.00
141 INT229127 SPINK1 Positive_regulation of PRSS1 1 0.53 1.59 0.48 5.00
142 INT229128 Binding of CP and PRSS1 1 0.14 0.77 0.47 5.00
143 INT213027 Binding of Apoa1 and Scarb1 6 0.09 7.52 0.43 5.00
144 INT138384 Binding of Htr1b and ADHD1 2 0.07 1.46 0.42 5.00
145 INT326942 Unc79 Regulation of Nalcn 1 0.20 0.08 0.41 5.00
146 INT322995 Binding of ABCC1 and SSD 1 0.00 0.42 0.41 5.00
147 INT209130 Binding of Riok3 and Sugt1 1 0.00 0.44 0.4 5.00
148 INT209133 Binding of Bcl2a1a and Riok3 1 0.00 0.44 0.4 5.00
149 INT356330 ORF61 Regulation of ORF61 Regulation of Crh 1 0.00 0.1 0.38 5.00
150 INT310600 Tbxa2r Positive_regulation of PLEK 1 0.53 0.45 0.38 5.00
151 INT356319 ORF61 Regulation of Crh 1 0.00 0.1 0.38 5.00
152 INT263226 Prkcg Negative_regulation of Positive_regulation of Ca2 1 0.01 0.58 0.36 5.00
153 INT258762 Binding of Dbh and ADHD1 1 0.08 1.61 0.34 5.00
154 INT175319 Negative_regulation of Nos2 Negative_regulation of Positive_regulation of Pnlip 1 0.01 0.83 0.34 5.00
155 INT236955 Binding of Cxcr5 and Cxcl13 1 0.28 2.26 0.34 5.00
156 INT353128 Negative_regulation of Binding of TAC1 and B3GAT1 1 0.29 1.95 0.33 5.00
157 INT318323 Binding of GRB2 and HSPA5 1 0.34 0.28 0.31 5.00
158 INT258763 Binding of Drd5 and ADHD1 1 0.07 1.11 0.31 5.00
159 INT258764 Binding of Drd4 and ADHD1 1 0.08 1.11 0.31 5.00
160 INT239344 Nr1h2 Positive_regulation of Gene_expression of Srebf1 1 0.26 0.84 0.29 5.00
161 INT239324 Nr1h2 Positive_regulation of Hltf 1 0.04 0.78 0.29 5.00
162 INT239347 Nr1h2 Positive_regulation of Srebf1 1 0.26 0.78 0.29 5.00
163 INT239329 Nr1h2 Positive_regulation of Gene_expression of Hltf 1 0.04 0.84 0.29 5.00
164 INT326438 Binding of HFE and TAPVR1 1 0.01 0.48 0.29 5.00
165 INT239336 Nr1h2 Positive_regulation of Gene_expression of Fas 1 0.07 0.84 0.29 5.00
166 INT293900 TYRP1 Regulation of IGKC 1 0.01 0.11 0.27 5.00
167 INT258766 Binding of Csf2 and ADHD1 1 0.01 0.69 0.27 5.00
168 INT257577 CALCA Positive_regulation of DMD 1 0.01 0.57 0.26 5.00
169 INT312768 Pon1 Negative_regulation of Gene_expression of Ccl2 1 0.06 1.42 0.26 5.00
170 INT177961 Binding of CCR3 and CCL11 1 0.04 0.73 0.26 5.00
171 INT239335 Eef1a2 Positive_regulation of Ppara 1 0.27 0.57 0.26 5.00
172 INT175321 IL6 Positive_regulation of Localization of Oxt 1 0.01 0.7 0.25 5.00
173 INT175322 Oxt Positive_regulation of Gene_expression of PTGER2 1 0.00 0.09 0.25 5.00
174 INT177957 CCL11 Regulation of Binding of IL5 and CCL11 1 0.01 0.71 0.25 5.00
175 INT177960 Binding of IL5 and CCL11 1 0.03 0.71 0.25 5.00
176 INT229129 SPINK1 Negative_regulation of PRSS1 1 0.49 0.79 0.24 5.00
177 INT239337 Abca1 Positive_regulation of RCT 1 0.07 3.11 0.24 5.00
178 INT175324 Hsp90b1 Positive_regulation of TLR2 1 0.00 0.65 0.23 5.00
179 INT175317 Hsp90b1 Positive_regulation of Tlr4 1 0.02 0.66 0.23 5.00
180 INT312689 Binding of PCA and CCL20 1 0.15 1.27 0.22 5.00
181 INT177477 Crh Positive_regulation of Crh Regulation of POMC 1 0.02 0.86 0.22 5.00
182 INT264776 Abat Positive_regulation of Gabbr1 1 0.03 0.06 0.22 5.00
183 INT306178 Rhoa Positive_regulation of Rock2 2 0.40 1.04 0.21 5.00
184 INT264778 Binding of CA2 and Gabbr1 1 0.02 0 0.21 5.00
185 INT175320 Tlr4 Positive_regulation of Gene_expression of Mmp9 1 0.01 0.54 0.21 5.00
186 INT257397 Binding of FGD1 and INS 1 0.07 0.27 0.21 5.00
187 INT317394 Binding of Stk11 and Amp1 1 0.04 0.89 0.21 5.00
188 INT177479 Negative_regulation of Crh Regulation of POMC 1 0.05 0.84 0.21 5.00
189 INT257398 Binding of FGD1 and GHRH 1 0.03 0.27 0.2 5.00
190 INT177962 IL4 Positive_regulation of VCAM1 1 0.02 0.97 0.2 5.00
191 INT239328 Hdl1 Regulation of Gene_expression of Kitl 1 0.08 1.86 0.2 5.00
192 INT265048 INCENP Positive_regulation of Positive_regulation of Nfasc 1 0.00 0.69 0.19 5.00
193 INT291788 ALDOA Positive_regulation of Gnat3 2 0.02 0.52 0.18 5.00
194 INT300193 Binding of APOA1 and INSL4 1 0.01 2.17 0.18 5.00
195 INT280052 Negative_regulation of Dpp4 Positive_regulation of Zglp1 1 0.03 0.72 0.18 5.00
196 INT239316 Nr1h2 Positive_regulation of Transcription of Abca1 1 0.15 0.67 0.18 5.00
197 INT214380 Binding of IL1A and PRTN3 1 0.00 0.94 0.18 5.00
198 INT318324 Binding of AKT1 and PRKCA 1 0.03 0.63 0.18 5.00
199 INT261628 Binding of CHRNA3 and MAOA 1 0.22 1.61 0.17 5.00
200 INT252646 Binding of C6orf25 and SYT16 1 0.00 0.51 0.17 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Alcohol Addiction. They are ordered first by their pain relevance and then by number of times they were reported in Alcohol Addiction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 100.00
2 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46 100.00
3 INT255 Regulation of Localization of GH1 89 0.62 18.71 35.3 100.00
4 INT9782 Binding of HTR1B 43 0.47 12.08 19.83 100.00
5 INT102999 Binding of DCAF7 1 0.05 0.69 0.41 100.00
6 INT9389 Regulation of Cpe 14 0.61 2.23 7.79 100.00
7 INT5704 Binding of Slc3a1 78 0.43 8.52 51.78 100.00
8 INT20336 Positive_regulation of CYP2E1 48 0.70 19.26 15.66 99.98
9 INT9387 Positive_regulation of Cpe 27 0.70 3.99 8.87 99.98
10 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93 99.98
11 INT199173 Gene_expression of Aldh2 25 0.77 14.1 2.12 99.96
12 INT330414 Positive_regulation of Gene_expression of Aldh2 11 0.69 8.58 1.09 99.96
13 INT199179 Negative_regulation of Gene_expression of Aldh2 6 0.43 3.55 0.97 99.96
14 INT158340 Negative_regulation of ALDH2 13 0.58 2.76 1.64 99.92
15 INT104226 Localization of Oprk1 12 0.75 3.22 5.41 99.92
16 INT8351 Positive_regulation of LOC360919 11 0.57 10.6 1.24 99.92
17 INT12597 Gene_expression of LOC360919 6 0.54 4.67 1.4 99.92
18 INT7585 Regulation of Crh 24 0.58 9.88 12.97 99.88
19 INT93792 Binding of Crhr1 4 0.48 1.32 1.49 99.84
20 INT19777 Binding of Crh 16 0.40 6.65 4.36 99.84
21 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28 99.84
22 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 99.82
23 INT30731 Positive_regulation of Gene_expression of GGT1 8 0.49 6.55 1.15 99.82
24 INT6179 Binding of Oprk1 37 0.48 9.24 24.83 99.80
25 INT75418 Negative_regulation of Cnr1 41 0.59 14.65 27.28 99.80
26 INT34132 Binding of Oprk1 6 0.48 2.15 4.78 99.80
27 INT356308 Binding of Adcy7 1 0.24 0.37 0.63 99.80
28 INT989 Negative_regulation of Trh 90 0.59 15.45 43.63 99.80
29 INT12484 Binding of Drd2 45 0.48 15.17 24.72 99.76
30 INT127123 Positive_regulation of Snca 35 0.70 14.76 10.1 99.76
31 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 99.76
32 INT30245 Binding of Pdyn 26 0.37 2.31 17 99.76
33 INT120253 Binding of Gabra2 1 0.36 0.75 0.85 99.76
34 INT22145 Binding of Sugt1 16 0.13 8.31 4.37 99.76
35 INT2432 Positive_regulation of Cp 41 0.67 31.1 16.68 99.76
36 INT180497 Binding of MRI1 45 0.42 28.35 14.77 99.74
37 INT49774 Binding of DRD2 48 0.48 17.42 20.73 99.68
38 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49 99.68
39 INT254 Regulation of Localization of GHRH 30 0.60 5.17 11.46 99.66
40 INT8106 Gene_expression of GGT1 31 0.75 18.65 6.1 99.64
41 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 99.60
42 INT167556 Binding of MECP2 7 0.27 4.57 2.6 99.58
43 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93 99.56
44 INT18621 Binding of ABAT 28 0.36 9.88 18.04 99.54
45 INT113415 Positive_regulation of gp 8 0.28 1.62 2.07 99.52
46 INT3002 Binding of SUGT1 62 0.24 55.9 14.91 99.48
47 INT9821 Binding of Bcl2a1a 9 0.33 4.32 3.47 99.48
48 INT114773 Negative_regulation of GABBR1 4 0.43 0.55 2.33 99.48
49 INT93424 Binding of SLC45A2 3 0.36 0.58 0.95 99.48
50 INT242104 Transcription of CFP 2 0.44 0.86 0.32 99.48
51 INT242109 Transcription of OFC1 1 0.33 0.61 0.28 99.48
52 INT6270 Binding of HTR1D 55 0.47 9.54 22.86 99.46
53 INT18644 Binding of OXT 6 0.31 1.22 0.55 99.44
54 INT7057 Binding of FAIM3 19 0.48 4.02 13.78 99.42
55 INT13501 Binding of Drd2 65 0.48 23.76 35.6 99.40
56 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96 99.38
57 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 99.36
58 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28 99.32
59 INT249 Localization of GHRH 215 0.80 78.02 51.87 99.30
60 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 99.28
61 INT2364 Localization of Sct 134 0.80 26.21 41.47 99.28
62 INT7674 Regulation of ENG 42 0.30 11.41 14.44 99.28
63 INT7845 Regulation of OPRK1 44 0.62 4.54 30.49 99.28
64 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 99.28
65 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1 99.24
66 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36 99.24
67 INT116970 Gene_expression of CCL20 50 0.78 70.54 15.78 99.20
68 INT66004 Binding of Cnr2 35 0.48 12.82 18.63 99.20
69 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 99.18
70 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38 99.16
71 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 99.16
72 INT11673 Positive_regulation of ECT 43 0.59 13.93 11.25 99.16
73 INT252 Localization of GH1 529 0.80 227.4 122.05 99.12
74 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63 99.12
75 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1 99.12
76 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 99.12
77 INT71933 Positive_regulation of Gene_expression of F2 19 0.56 14.24 2.53 99.12
78 INT254420 Positive_regulation of SLC25A24 1 0.45 2.27 0.2 99.12
79 INT254422 Positive_regulation of Gene_expression of SLC25A24 1 0.49 2.29 0.2 99.12
80 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 99.04
81 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08 99.04
82 INT152207 Positive_regulation of ARL6IP5 1 0.30 0.18 0.64 99.04
83 INT5957 Positive_regulation of Cpe 65 0.69 21.07 51.22 99.02
84 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47 99.00
85 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 99.00
86 INT122812 Gene_expression of SNRNP70 130 0.75 67 12.5 98.96
87 INT39587 Gene_expression of CP 42 0.65 31.48 11.87 98.96
88 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 98.92
89 INT288766 Negative_regulation of Aldh1l1 1 0.13 0.27 0.05 98.92
90 INT183560 Binding of GABRB3 12 0.23 2.59 3.77 98.88
91 INT91913 Regulation of GRIN3B 16 0.61 11.48 14.44 98.84
92 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41 98.76
93 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 98.76
94 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24 98.72
95 INT72474 Positive_regulation of PNOC 9 0.68 1.76 4.84 98.72
96 INT254421 Negative_regulation of SLC25A24 1 0.42 2.37 0.2 98.70
97 INT254419 Gene_expression of SLC25A24 1 0.65 2.28 0.2 98.70
98 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 98.68
99 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 98.60
100 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 98.56
101 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 98.56
102 INT18630 Transcription of CCK 9 0.71 3 3.73 98.54
103 INT12388 Negative_regulation of Crhr1 17 0.59 9.47 3.33 98.54
104 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 98.52
105 INT20845 Positive_regulation of Negative_regulation of Oprd1 7 0.70 1.81 7.33 98.52
106 INT4398 Regulation of LGALS1 7 0.44 2.16 2.31 98.48
107 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 98.44
108 INT121347 Binding of GNAS 8 0.13 3.99 1.47 98.36
109 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68 98.36
110 INT103469 Positive_regulation of Gene_expression of BDNF 59 0.67 24.39 18.36 98.34
111 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 98.34
112 INT12097 Regulation of GGT1 8 0.44 5.76 1.95 98.32
113 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 98.30
114 INT8798 Positive_regulation of Csrp1 61 0.69 63.86 14.14 98.30
115 INT69528 Regulation of Gene_expression of Oprk1 10 0.45 4.27 8.84 98.28
116 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93 98.28
117 INT90 Localization of Gast 400 0.81 137.67 113 98.28
118 INT91 Positive_regulation of Localization of Gast 96 0.70 23.22 29.36 98.28
119 INT94650 Gene_expression of Grm5 32 0.77 11.26 14.82 98.26
120 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97 98.24
121 INT28188 Regulation of CYP2E1 11 0.62 0.48 2.03 98.24
122 INT334927 Negative_regulation of MEHMO 1 0.01 3.46 0.1 98.16
123 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 98.16
124 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 98.10
125 INT49802 Localization of MUC1 75 0.81 44.74 8.87 98.08
126 INT104039 Positive_regulation of Crhr1 15 0.70 8.34 10.99 98.04
127 INT132663 Negative_regulation of GRINA 1 0.27 0.55 0.53 98.04
128 INT356301 Negative_regulation of Positive_regulation of Crhr1 1 0.19 0.44 0.5 98.04
129 INT74444 Phosphorylation of Cp 1 0.19 1.46 0.48 98.04
130 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 98.02
131 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35 98.00
132 INT5039 Positive_regulation of Gal 67 0.68 27.97 37.36 98.00
133 INT10916 Positive_regulation of BDNF-AS 39 0.49 25.88 5.28 98.00
134 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 97.98
135 INT921 Regulation of GH1 172 0.60 52.88 51.04 97.96
136 INT288 Positive_regulation of Sct 88 0.70 32.83 24.5 97.96
137 INT17698 Positive_regulation of Regulation of GH1 6 0.46 0.9 0.65 97.96
138 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 97.92
139 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8 97.92
140 INT1168 Binding of PROC 62 0.38 44.15 9.04 97.86
141 INT1652 Regulation of Pomc 387 0.62 61.01 186.51 97.84
142 INT738 Regulation of POMC 459 0.62 111.19 243.74 97.84
143 INT12608 Regulation of CNR1 62 0.60 24.36 36.02 97.84
144 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67 97.80
145 INT1156 Binding of CCK 27 0.48 8.71 20.58 97.76
146 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57 97.76
147 INT33612 Binding of NTS 16 0.46 4.65 6 97.76
148 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 97.76
149 INT2482 Regulation of Positive_regulation of REN 4 0.59 2.62 0.91 97.74
150 INT110208 Binding of ABR 2 0.35 10.49 0.81 97.72
151 INT127124 Regulation of Gene_expression of Snca 2 0.62 0.17 2.03 97.72
152 INT113659 Gene_expression of ABR 19 0.65 8.49 1.45 97.72
153 INT8959 Binding of Gnb5 17 0.40 31.38 5.1 97.68
154 INT101120 Gene_expression of Comt 63 0.77 34.75 26.13 97.68
155 INT172197 Positive_regulation of Gene_expression of Comt 12 0.69 7.61 4.06 97.68
156 INT7032 Positive_regulation of Pdyn 94 0.66 26.51 58.83 97.64
157 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 97.60
158 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 97.60
159 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 97.60
160 INT12010 Gene_expression of Cp 38 0.65 20.55 7.84 97.60
161 INT150698 Regulation of PTPRB 1 0.45 1.52 0.89 97.60
162 INT332757 Regulation of Binding of ADHD1 1 0.34 1.71 0.13 97.60
163 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 97.56
164 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 97.56
165 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 97.52
166 INT15643 Positive_regulation of Positive_regulation of Pomc 30 0.65 4.59 15.34 97.44
167 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 97.40
168 INT72924 Negative_regulation of MCRS1 27 0.19 33.59 10.29 97.40
169 INT6870 Positive_regulation of Oprk1 14 0.70 4 10.91 97.36
170 INT79361 Negative_regulation of Prdm6 5 0.51 3.79 1.4 97.32
171 INT48006 Negative_regulation of Oprk1 27 0.58 10.14 19.11 97.28
172 INT81895 Regulation of Positive_regulation of HTR1A 2 0.44 1.37 1.04 97.28
173 INT18451 Positive_regulation of Binding of HTR1A 3 0.67 1.97 0.81 97.28
174 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38 97.28
175 INT123593 Gene_expression of Snca 58 0.78 35.76 12.87 97.28
176 INT48882 Binding of GRIN3B 9 0.46 5.12 7.66 97.24
177 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 97.20
178 INT26973 Gene_expression of Tenc1 59 0.66 27.19 12 97.20
179 INT74695 Gene_expression of Ace 41 0.73 53.33 2.33 97.20
180 INT77688 Transcription of Mme 2 0.53 4.01 0.45 97.20
181 INT77686 Transcription of Ace 2 0.65 2.65 0.37 97.20
182 INT212818 Binding of Chrm5 5 0.35 1.34 1.15 97.20
183 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 97.20
184 INT171514 Binding of EP300 13 0.32 4.32 2.01 97.16
185 INT117460 Negative_regulation of Positive_regulation of Hmgb2 1 0.20 0.47 0.72 97.16
186 INT162 Regulation of Prl 794 0.62 165.01 322.24 97.12
187 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69 97.08
188 INT57881 Binding of Tead1 2 0.25 1.63 0.7 97.08
189 INT120478 Binding of Sugt1 1 0.01 0.26 0.75 97.04
190 INT160280 Positive_regulation of ipv 14 0.44 15.73 1.02 96.94
191 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 96.92
192 INT5573 Negative_regulation of Gene_expression of Penk 113 0.59 21.83 64.66 96.92
193 INT443 Localization of POMC 1020 0.81 284.52 443.17 96.88
194 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 96.84
195 INT4015 Positive_regulation of SCTR 5 0.37 6.45 1.62 96.84
196 INT4014 Positive_regulation of Positive_regulation of SCTR 1 0.37 0.82 0.42 96.84
197 INT13790 Binding of HTR1A 52 0.47 18.83 17.59 96.80
198 INT89337 Negative_regulation of Gene_expression of CCK 4 0.58 3.14 3.21 96.64
199 INT60635 Regulation of C12orf57 1 0.44 0.1 0.51 96.60
200 INT1166 Negative_regulation of Dbh 56 0.59 12.54 28.26 96.56
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