D:Alcoholic Hepatitis

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Disease Term
Synonyms Alcoholic Hepatitis Chronic, CHRONIC ALCOHOLIC HEPATITIDES, Chronic Alcoholic Hepatitis, HEPATITIS ALCOHOLIC, HEPATITIS ALCOHOLIC CHRONIC
Documents 65
Hot Single Events 27
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Alcoholic Hepatitis. They are ordered first by their relevance to Alcoholic Hepatitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT220289 MARS Regulation of CEBPZ 1 0.02 0.93 0.11 70.64
2 INT220288 MARS Regulation of AFM 1 0.06 1.14 0.08 11.28
3 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68 5.00
4 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61 5.00
5 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73 5.00
6 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52 5.00
7 INT331602 Binding of SSRP1 and Tlr4 1 0.03 0.9 0.21 5.00
8 INT331600 Il18 Regulation of IFN1@ 1 0.00 1.05 0.16 5.00
9 INT331601 Il10 Regulation of IFN1@ 1 0.00 1.05 0.16 5.00
10 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
11 INT294742 Lep Positive_regulation of Localization of Icam1 1 0.15 0.48 0.11 5.00
12 INT331576 IFN1@ Positive_regulation of TNFSF10 1 0.00 0.27 0.08 5.00
13 INT331575 Negative_regulation of IFN1@ Positive_regulation of TNFSF10 1 0.00 0.27 0.08 5.00
14 INT294743 Lep Positive_regulation of Transcription of Il6 1 0.18 0.42 0.07 5.00
15 INT294740 Lep Positive_regulation of Transcription of Ccl2 1 0.08 0.42 0.07 5.00
16 INT220290 Binding of AFM and MARS 1 0.05 1.09 0.07 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Alcoholic Hepatitis. They are ordered first by their pain relevance and then by number of times they were reported in Alcoholic Hepatitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT101105 Positive_regulation of FUT1 62 0.30 55.96 9.28 99.76
2 INT1922 Positive_regulation of CEACAM7 32 0.70 33.31 2.72 99.46
3 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 98.56
4 INT220296 Negative_regulation of MARS 3 0.29 1.43 0.2 98.40
5 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 98.16
6 INT80657 Gene_expression of SLC17A5 50 0.75 39.98 5.44 98.16
7 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 97.88
8 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 97.88
9 INT35584 Binding of ACLY 22 0.35 31.78 7.17 97.76
10 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 96.40
11 INT135029 Positive_regulation of Gene_expression of Cd14 11 0.66 6.4 1.75 96.40
12 INT233975 Positive_regulation of Gene_expression of Myd88 7 0.66 4.17 1.65 96.40
13 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 95.76
14 INT135022 Gene_expression of Cd14 79 0.76 36.37 10.63 95.76
15 INT197491 Gene_expression of Myd88 32 0.74 14.59 5.29 95.76
16 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 94.32
17 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 91.88
18 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04 91.88
19 INT11937 Localization of Il6 228 0.81 139.83 64.39 88.84
20 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25 88.84
21 INT66758 Binding of Nfkb1 97 0.48 50.65 23.65 88.80
22 INT35740 Regulation of GGT2 1 0.02 0.88 0.13 87.12
23 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 85.12
24 INT39549 Gene_expression of Pdk1 1 0.01 0.23 0.17 82.32
25 INT3287 Gene_expression of Gpt 50 0.75 23.69 8.57 82.32
26 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 80.40
27 INT175260 Negative_regulation of Gene_expression of SH2B2 2 0.25 4.41 0.21 80.40
28 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12 78.24
29 INT319472 Phosphorylation of Abcd1 1 0.02 3.12 0.31 77.36
30 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 75.00
31 INT4421 Positive_regulation of LAP 12 0.44 11.06 1.74 75.00
32 INT27585 Positive_regulation of smc 9 0.58 3.2 1.47 75.00
33 INT27587 Positive_regulation of STAR 7 0.46 6.37 0.99 75.00
34 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95 71.28
35 INT82082 Localization of Lep 63 0.81 26.41 8.56 66.24
36 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76 63.96
37 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 63.32
38 INT2271 Gene_expression of F2 51 0.76 30.21 7.97 63.32
39 INT157622 Positive_regulation of Localization of Tlr4 34 0.48 22.63 5.09 63.24
40 INT78057 Localization of Tlr4 140 0.77 67.75 21.72 62.80
41 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 56.32
42 INT259032 Binding of PEX1 2 0.01 4.67 0.15 55.36
43 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27 51.04
44 INT20336 Positive_regulation of CYP2E1 48 0.70 19.26 15.66 50.24
45 INT259036 Transcription of SH2B2 2 0.55 7.01 1.46 47.92
46 INT39265 Positive_regulation of Tapbp 2 0.17 2.28 0.08 44.04
47 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 40.72
48 INT84170 Positive_regulation of Gene_expression of Ccl2 58 0.69 48.79 32.43 40.72
49 INT48407 Positive_regulation of Gene_expression of Icam1 61 0.70 57.91 21.54 40.72
50 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6 39.32
51 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 38.24
52 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35 38.24
53 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 38.24
54 INT9660 Regulation of TNF 363 0.62 312.94 139.99 34.96
55 INT9210 Regulation of IL6 166 0.62 125.61 49.95 34.24
56 INT23257 Regulation of CRP 127 0.62 100.05 21.87 33.76
57 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41 28.08
58 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 27.68
59 INT28042 Gene_expression of Tsc22d3 14 0.77 6.54 6.4 25.00
60 INT28191 Positive_regulation of Positive_regulation of CYP2E1 5 0.49 3.5 2.25 25.00
61 INT117499 Negative_regulation of Adipoq 28 0.56 24.15 5.07 23.52
62 INT233645 Transcription of Tsc22d3 11 0.71 5.83 7.97 18.40
63 INT209501 Gene_expression of CADPS 15 0.65 20.7 2.22 15.00
64 INT236277 Positive_regulation of Gene_expression of CADPS 5 0.42 9.17 1.29 15.00
65 INT259031 Negative_regulation of Gene_expression of CADPS 1 0.07 3.04 0.35 15.00
66 INT60571 Positive_regulation of Gsta4 8 0.45 3.76 1.44 13.44
67 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 13.36
68 INT233620 Positive_regulation of Gene_expression of Tsc22d3 3 0.69 1.46 1.17 12.96
69 INT9904 Gene_expression of CYP2E1 64 0.78 13.11 14.65 10.96
70 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
71 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
72 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
73 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
74 INT1308 Localization of Pomc 457 0.81 66.83 217.5 5.00
75 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 5.00
76 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
77 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
78 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
79 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
80 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
81 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
82 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
83 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
84 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
85 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
86 INT82883 Positive_regulation of Ccl2 105 0.69 84.96 42.27 5.00
87 INT47939 Gene_expression of Selp 171 0.76 87.54 39.03 5.00
88 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
89 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95 5.00
90 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49 5.00
91 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
92 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36 5.00
93 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
94 INT82882 Localization of Ccl2 61 0.80 41.96 28 5.00
95 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
96 INT114362 Localization of Hmgb1 127 0.78 120.28 23.26 5.00
97 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
98 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 5.00
99 INT69877 Positive_regulation of Positive_regulation of Nfkb1 53 0.68 31.44 20.7 5.00
100 INT86751 Negative_regulation of Il10 62 0.59 40.1 20.51 5.00
101 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98 5.00
102 INT20305 Gene_expression of Cyp2e1 53 0.78 19.75 19.54 5.00
103 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
104 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
105 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58 5.00
106 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
107 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49 5.00
108 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
109 INT36262 Positive_regulation of Tbce 35 0.49 28.79 14.33 5.00
110 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
111 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 5.00
112 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62 5.00
113 INT141014 Positive_regulation of Gene_expression of Il18 46 0.68 47.63 13.3 5.00
114 INT174838 Localization of INCENP 80 0.64 19.05 12.89 5.00
115 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
116 INT73641 Regulation of Lep 45 0.62 26.2 12.59 5.00
117 INT28458 Localization of Slc6a3 31 0.76 2.33 12.49 5.00
118 INT39553 Gene_expression of Hmgb1 50 0.75 51.18 12.21 5.00
119 INT50933 Transcription of Il6 38 0.72 24.31 11.58 5.00
120 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
121 INT82079 Positive_regulation of Lep 79 0.70 40 11.07 5.00
122 INT17826 Positive_regulation of Pla2g1b 39 0.70 11.35 10.97 5.00
123 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 5.00
124 INT106200 Binding of Ccl2 22 0.42 16.7 9.75 5.00
125 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 5.00
126 INT107087 Positive_regulation of Gene_expression of Cyp2e1 20 0.70 8.89 9.04 5.00
127 INT87650 Positive_regulation of EPHB2 49 0.67 22.77 8.25 5.00
128 INT114363 Positive_regulation of Hmgb1 50 0.67 48.92 8.15 5.00
129 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11 5.00
130 INT17686 Negative_regulation of Hdl1 72 0.36 81.85 7.74 5.00
131 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 5.00
132 INT212758 Binding of Hmgb1 40 0.44 35.6 7.41 5.00
133 INT10863 Positive_regulation of Ldlr 45 0.68 31.06 7.05 5.00
134 INT125143 Gene_expression of EPHB2 40 0.71 13.27 6.97 5.00
135 INT207892 Binding of Tlr9 35 0.46 26.66 6.61 5.00
136 INT155780 Gene_expression of Mmp8 19 0.77 15.85 6.33 5.00
137 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
138 INT71727 Negative_regulation of Icam1 25 0.45 17.76 5.73 5.00
139 INT190520 Negative_regulation of Hmgb1 24 0.53 20.08 5.6 5.00
140 INT174688 Binding of Tlr2 45 0.42 36.65 5.25 5.00
141 INT36030 Gene_expression of Il1r1 16 0.68 11.42 4.87 5.00
142 INT105923 Binding of FUT1 34 0.14 17.81 4.79 5.00
143 INT104549 Localization of Il18 16 0.78 13.01 4.64 5.00
144 INT149093 Positive_regulation of TNFSF10 31 0.49 34.61 4.56 5.00
145 INT183681 Positive_regulation of Tlr3 20 0.62 16.25 4.54 5.00
146 INT59041 Negative_regulation of CYP2E1 17 0.59 5.47 4.51 5.00
147 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48 5.00
148 INT97391 Binding of Lep 18 0.48 8.97 4.47 5.00
149 INT142752 Positive_regulation of Myd88 26 0.66 12.07 4.4 5.00
150 INT215085 Positive_regulation of Gene_expression of Hmgb1 17 0.63 16.81 4.13 5.00
151 INT158596 Binding of Tlr3 24 0.47 11.66 3.69 5.00
152 INT117518 Transcription of Ccl2 12 0.68 11.12 3.61 5.00
153 INT82077 Positive_regulation of Gene_expression of Lep 32 0.70 17.9 3.5 5.00
154 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
155 INT80656 Regulation of SLC17A5 15 0.26 6.89 3.19 5.00
156 INT175262 Binding of SH2B2 18 0.36 22.85 3.18 5.00
157 INT109095 Binding of Drd4 7 0.40 3.6 3.18 5.00
158 INT17562 Negative_regulation of Lipg 32 0.51 16.91 3.17 5.00
159 INT35143 Negative_regulation of ANGPTL5 28 0.54 18.59 3.14 5.00
160 INT61791 Positive_regulation of SH2B2 9 0.50 8.36 2.99 5.00
161 INT260424 Negative_regulation of Tlr9 8 0.41 8.19 2.92 5.00
162 INT114181 Negative_regulation of Positive_regulation of Il12a 7 0.34 3.65 2.82 5.00
163 INT184257 Positive_regulation of Gene_expression of Mmp8 7 0.49 6.32 2.74 5.00
164 INT153221 Positive_regulation of Rela 5 0.16 2.16 2.72 5.00
165 INT135470 Transcription of Icam1 10 0.63 12.04 2.41 5.00
166 INT76094 Localization of NOS2 8 0.72 2.76 2.34 5.00
167 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26 5.00
168 INT72865 Localization of Icam1 12 0.68 8.18 2.24 5.00
169 INT204775 Regulation of Tlr2 21 0.41 13.6 2.18 5.00
170 INT11183 Negative_regulation of SH2B2 4 0.34 6.99 2.12 5.00
171 INT134633 Localization of Adipoq 9 0.60 6.39 2.03 5.00
172 INT447 Localization of Comt 4 0.75 0.76 1.8 5.00
173 INT82083 Negative_regulation of Gene_expression of Lep 12 0.56 8.07 1.75 5.00
174 INT209366 Negative_regulation of GSX1 1 0.42 0.92 1.72 5.00
175 INT12035 Regulation of F2 21 0.45 12.66 1.47 5.00
176 INT147788 Regulation of FUT1 11 0.12 7.72 1.44 5.00
177 INT83464 Positive_regulation of Localization of Icam1 3 0.46 3.71 1.4 5.00
178 INT181868 Localization of ACLY 5 0.62 6.36 1.4 5.00
179 INT224501 Positive_regulation of Gene_expression of EPHB2 9 0.49 4.29 1.39 5.00
180 INT187411 Gene_expression of Cd320 23 0.75 12.1 1.39 5.00
181 INT31403 Positive_regulation of AFM 3 0.29 5.57 1.38 5.00
182 INT38964 Negative_regulation of Lsd 3 0.37 0.52 1.32 5.00
183 INT55599 Gene_expression of GSX1 3 0.65 3.72 1.23 5.00
184 INT79927 Localization of GSTK1 5 0.40 1.29 1.21 5.00
185 INT47839 Localization of Slc6a4 4 0.79 0.96 1.14 5.00
186 INT209503 Positive_regulation of CADPS 3 0.42 7 1.11 5.00
187 INT294735 Positive_regulation of Binding of Ccl2 2 0.34 0.69 1.11 5.00
188 INT82084 Positive_regulation of Localization of Lep 11 0.70 4.65 1.11 5.00
189 INT108997 Localization of Htt 28 0.77 3.76 1.07 5.00
190 INT134260 Negative_regulation of Transcription of Il6 2 0.25 1.39 0.99 5.00
191 INT199009 Negative_regulation of Transcription of Icam1 4 0.38 3.81 0.95 5.00
192 INT250645 Gene_expression of Samsn1 6 0.33 9.95 0.86 5.00
193 INT208511 Positive_regulation of Use1 24 0.13 11.51 0.8 5.00
194 INT63109 Gene_expression of Chol1 12 0.75 5.04 0.78 5.00
195 INT209367 Binding of GSX1 1 0.47 0.56 0.76 5.00
196 INT331594 Localization of Tlr9 1 0.41 1.66 0.71 5.00
197 INT331595 Positive_regulation of Localization of Tlr9 1 0.28 1.66 0.71 5.00
198 INT209368 Positive_regulation of GSX1 1 0.49 0.51 0.67 5.00
199 INT52740 Binding of ACLS 5 0.31 3 0.54 5.00
200 INT259035 Localization of SH2B2 3 0.43 1.77 0.42 5.00
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