D:Alcoholic Liver Cirrhosis

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Disease Term
Synonyms Alcoholic Cirrhosis, ALCOHOLIC HEPATIC CIRRHOSIS, HEPATIC CIRRHOSIS ALCOHOLIC
Documents 150
Hot Single Events 40
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Alcoholic Liver Cirrhosis. They are ordered first by their relevance to Alcoholic Liver Cirrhosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT339676 CSF2 Positive_regulation of HGF 1 0.08 0.46 0 96.96
2 INT186672 IL8 Positive_regulation of Transcription of PTH 1 0.01 1.83 0.85 41.36
3 INT186673 IL8 Positive_regulation of Positive_regulation of PTH 1 0.01 0.92 0.42 41.36
4 INT326585 Binding of GYPA and SLC6A3 1 0.13 0.86 2.64 5.00
5 INT186674 Binding of BGLAP and CYP27A1 1 0.01 1.91 0.71 5.00
6 INT326586 SLC18A2 Negative_regulation of DDC 1 0.28 0.91 0.66 5.00
7 INT254761 Igh-Dex Positive_regulation of Apoe 1 0.00 0.08 0.52 5.00
8 INT254768 DNMT1 Positive_regulation of Gene_expression of Apoe 1 0.02 0.05 0.49 5.00
9 INT254760 Igh-Dex Positive_regulation of Gene_expression of Apoe 1 0.00 0 0.42 5.00
10 INT326587 GYPA Regulation of DDC 1 0.08 0.83 0.33 5.00
11 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31 5.00
12 INT254759 Igh-Dex Positive_regulation of Localization of Apoe 1 0.00 0.32 0.28 5.00
13 INT254769 Binding of LDLR and Apoe 1 0.03 0 0.28 5.00
14 INT254772 DNMT1 Positive_regulation of Apoe 1 0.02 0 0.25 5.00
15 INT254773 PPARA Positive_regulation of Gene_expression of Apoe 1 0.01 0.07 0.24 5.00
16 INT254774 DNMT1 Positive_regulation of Localization of Apoe 1 0.01 0.31 0.23 5.00
17 INT346455 IFNA1 Regulation of HCC 1 0.02 1.64 0.23 5.00
18 INT254770 Regulation of Binding of DNMT1 and Igh-Dex 1 0.00 0 0.22 5.00
19 INT326583 GYPA Negative_regulation of Binding of GYPA and SLC6A3 1 0.03 0.22 0.22 5.00
20 INT346458 ROS1 Regulation of Localization of TGFB1 1 0.00 1.71 0.21 5.00
21 INT327112 HCCS Positive_regulation of Gene_expression of SLCO1B3 1 0.03 0.65 0.19 5.00
22 INT254771 Binding of DNMT1 and Igh-Dex 1 0.00 0 0.19 5.00
23 INT346459 Binding of RNASE1 and ROS1 1 0.06 1.42 0.18 5.00
24 INT350363 Gatm Negative_regulation of NOS1 1 0.00 0.31 0.17 5.00
25 INT346451 Positive_regulation of Binding of IFNA1 and DDX58 1 0.01 0.54 0.15 5.00
26 INT346450 Binding of IFNA1 and DDX58 1 0.01 0.54 0.15 5.00
27 INT329796 TICAM1 Positive_regulation of IFNA1 2 0.02 0.89 0.15 5.00
28 INT346500 TLR3 Positive_regulation of Nfkb1 1 0.01 0.49 0.13 5.00
29 INT346501 MYD88 Positive_regulation of Nfkb1 1 0.01 0.5 0.13 5.00
30 INT220289 MARS Regulation of CEBPZ 1 0.02 0.93 0.11 5.00
31 INT220288 MARS Regulation of AFM 1 0.06 1.14 0.08 5.00
32 INT220290 Binding of AFM and MARS 1 0.05 1.09 0.07 5.00
33 INT346499 Mal Positive_regulation of TICAM1 1 0.06 0.66 0.07 5.00
34 INT346452 TLR3 Positive_regulation of TBK1 1 0.03 0.45 0.06 5.00
35 INT346456 TLR3 Positive_regulation of IKBKE 1 0.02 0.45 0.06 5.00
36 INT346449 TICAM1 Positive_regulation of TBK1 1 0.01 0.45 0.06 5.00
37 INT346454 TICAM1 Positive_regulation of IKBKE 1 0.01 0.45 0.06 5.00
38 INT212440 STAT3 Regulation of Phosphorylation of SOAT1 1 0.11 1.42 0.05 5.00
39 INT346457 IRF3 Positive_regulation of IFNA1 1 0.03 0.56 0.05 5.00
40 INT212442 HGF Positive_regulation of MET 2 0.21 1.25 0.04 5.00
41 INT346453 Binding of DDX58 and IFIH1 1 0.00 1.04 0.03 5.00
42 INT339675 CSF2 Positive_regulation of Localization of FUT1 1 0.01 0.42 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Alcoholic Liver Cirrhosis. They are ordered first by their pain relevance and then by number of times they were reported in Alcoholic Liver Cirrhosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT19409 Binding of Cyp1a1 12 0.48 2.58 1.97 99.44
2 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 99.18
3 INT1869 Negative_regulation of SLC17A5 12 0.42 5.51 0.75 98.36
4 INT36329 Negative_regulation of GGCX 2 0.12 1.9 0.26 98.36
5 INT18391 Positive_regulation of GYPA 41 0.40 16.47 8.69 97.92
6 INT4075 Positive_regulation of Gene_expression of Gast 24 0.68 19.99 4.02 97.88
7 INT50895 Regulation of GYPA 10 0.60 4.05 1.95 97.56
8 INT22132 Positive_regulation of CAT 41 0.67 18.64 10.67 97.32
9 INT30 Gene_expression of Gast 158 0.78 99 41.45 97.20
10 INT87819 Localization of CD34 21 0.81 7.69 0.47 95.88
11 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 95.68
12 INT2723 Gene_expression of Salpa1 16 0.64 11.78 3.5 95.68
13 INT4422 Positive_regulation of Gene_expression of Alb 30 0.50 18.56 6.12 95.60
14 INT23199 Binding of LDLR 22 0.47 17.08 1.16 95.24
15 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 94.80
16 INT110961 Binding of GYPA 14 0.36 6.66 2.03 92.16
17 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 92.16
18 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83 90.80
19 INT14301 Binding of CSF2 82 0.48 67.95 8.98 90.32
20 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04 89.84
21 INT161248 Positive_regulation of Gene_expression of Mtor 2 0.06 6.47 0.51 89.84
22 INT220291 Binding of MARS 1 0.25 0.75 0.05 87.52
23 INT67169 Negative_regulation of GOT2 2 0.36 0.94 0.25 87.48
24 INT79140 Binding of HCC 36 0.31 46.96 1.87 87.36
25 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 87.24
26 INT70242 Localization of HCC 18 0.66 23.95 2.35 87.20
27 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 85.84
28 INT207177 Gene_expression of VAC14 4 0.42 3.49 0.46 85.84
29 INT152174 Negative_regulation of Samsn1 5 0.14 6.46 2.1 85.68
30 INT250645 Gene_expression of Samsn1 6 0.33 9.95 0.86 85.68
31 INT90 Localization of Gast 400 0.81 137.67 113 85.52
32 INT91 Positive_regulation of Localization of Gast 96 0.70 23.22 29.36 85.52
33 INT220295 Gene_expression of MARS 6 0.47 4.74 0.35 84.88
34 INT220294 Positive_regulation of Gene_expression of MARS 3 0.35 2.45 0.05 84.88
35 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 83.16
36 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 83.16
37 INT207176 Positive_regulation of VAC14 1 0.29 0.52 0 81.60
38 INT63042 Binding of Apoe 59 0.48 31.23 5.88 81.56
39 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 80.56
40 INT36293 Gene_expression of Mtor 24 0.25 14.5 2.04 80.04
41 INT326599 Positive_regulation of Binding of GYPA 1 0.14 0.88 0.03 79.92
42 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 78.88
43 INT14470 Gene_expression of HCC 83 0.67 110.55 4.61 78.12
44 INT74286 Regulation of Il10 42 0.44 28.06 19.44 75.00
45 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 75.00
46 INT69304 Negative_regulation of Il10 47 0.59 36.88 19.79 75.00
47 INT214 Localization of AVP 370 0.81 208.51 91.09 72.92
48 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 72.16
49 INT86410 Localization of PDK1 1 0.05 0.65 0.44 71.32
50 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64 70.80
51 INT142265 Regulation of Apoe 20 0.60 9.52 2.23 68.84
52 INT21487 Negative_regulation of HCC 18 0.49 29.81 1.88 66.40
53 INT39945 Binding of Dlat 27 0.32 14.95 3.88 65.68
54 INT53929 Positive_regulation of GNPTAB 12 0.32 6.66 1.4 64.40
55 INT198892 Regulation of Binding of Apoe 6 0.45 2.94 0.21 62.68
56 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 60.08
57 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 59.60
58 INT4159 Gene_expression of Hp 33 0.72 12.49 8.39 55.76
59 INT8579 Gene_expression of Apoa1 13 0.76 35.89 7.21 55.12
60 INT207178 Regulation of VAC14 1 0.28 0.9 0 49.60
61 INT319472 Phosphorylation of Abcd1 1 0.02 3.12 0.31 48.56
62 INT20129 Regulation of Il1 53 0.53 44.14 19.89 48.48
63 INT70673 Regulation of IL11 5 0.45 2.89 1.2 48.24
64 INT9660 Regulation of TNF 363 0.62 312.94 139.99 47.84
65 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 44.16
66 INT96764 Positive_regulation of Gene_expression of SOD1 36 0.61 16.55 1.99 44.16
67 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 42.24
68 INT59454 Regulation of Gene_expression of CSF2 22 0.52 19.67 2.69 42.24
69 INT20336 Positive_regulation of CYP2E1 48 0.70 19.26 15.66 40.16
70 INT327115 Binding of HCCS 1 0.07 2.44 0.14 39.68
71 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 38.36
72 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 38.08
73 INT82214 Transcription of PTH 6 0.54 3.33 1.11 37.72
74 INT14690 Localization of CSF2 124 0.80 85.17 27.26 36.84
75 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 32.68
76 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55 32.36
77 INT326600 Negative_regulation of Gene_expression of DRD2 1 0.53 0.35 0.23 32.36
78 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8 31.88
79 INT53210 Gene_expression of AKR1A1 2 0.45 0.36 0.4 28.32
80 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 25.28
81 INT37588 Gene_expression of FAM20B 4 0.63 1.35 1.58 25.00
82 INT45713 Negative_regulation of Gene_expression of FAM20B 3 0.35 1.18 1.33 25.00
83 INT58922 Positive_regulation of OR51E1 1 0.00 0.93 0.31 25.00
84 INT58923 Positive_regulation of Positive_regulation of OR51E1 1 0.00 0.46 0.15 25.00
85 INT73080 Positive_regulation of TTF1 4 0.38 2.37 0.14 25.00
86 INT97787 Positive_regulation of Transcription of TTF1 1 0.16 0.15 0 25.00
87 INT97788 Transcription of TTF1 1 0.16 0.15 0 25.00
88 INT224924 Binding of TARM1 4 0.18 3.42 0.39 23.80
89 INT49567 Regulation of DRD1 5 0.35 1.02 1.54 22.76
90 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 18.64
91 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27 12.00
92 INT38964 Negative_regulation of Lsd 3 0.37 0.52 1.32 10.84
93 INT6129 Positive_regulation of Localization of AVP 63 0.70 30.44 16.64 10.00
94 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 5.00
95 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
96 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
97 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 5.00
98 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 5.00
99 INT287 Localization of Cck 518 0.81 86.84 364.04 5.00
100 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
101 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
102 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
103 INT1308 Localization of Pomc 457 0.81 66.83 217.5 5.00
104 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
105 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
106 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
107 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
108 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
109 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
110 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
111 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
112 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
113 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
114 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49 5.00
115 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
116 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7 5.00
117 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
118 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
119 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 5.00
120 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
121 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 5.00
122 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
123 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
124 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 5.00
125 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34 5.00
126 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
127 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 5.00
128 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 5.00
129 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
130 INT76620 Gene_expression of Cnr2 93 0.78 34.7 50.14 5.00
131 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
132 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
133 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
134 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
135 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 5.00
136 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
137 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
138 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
139 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92 5.00
140 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08 5.00
141 INT12608 Regulation of CNR1 62 0.60 24.36 36.02 5.00
142 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
143 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
144 INT65055 Negative_regulation of Nfkb1 83 0.58 44.85 34.94 5.00
145 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05 5.00
146 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
147 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
148 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
149 INT99610 Localization of MMP9 126 0.79 48.46 32.67 5.00
150 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49 5.00
151 INT14823 Gene_expression of MET 103 0.75 51.92 32.48 5.00
152 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
153 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 5.00
154 INT1158 Regulation of Agt 106 0.61 29.4 30.29 5.00
155 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27 5.00
156 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11 5.00
157 INT3286 Positive_regulation of Gpt 90 0.69 45.08 28.34 5.00
158 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
159 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
160 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
161 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 5.00
162 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
163 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 5.00
164 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
165 INT74377 Regulation of Cnr1 38 0.59 16.93 24.77 5.00
166 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
167 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39 5.00
168 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
169 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 5.00
170 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
171 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
172 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
173 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
174 INT49774 Binding of DRD2 48 0.48 17.42 20.73 5.00
175 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
176 INT20305 Gene_expression of Cyp2e1 53 0.78 19.75 19.54 5.00
177 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
178 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
179 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99 5.00
180 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
181 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
182 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
183 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04 5.00
184 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97 5.00
185 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71 5.00
186 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
187 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
188 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
189 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
190 INT69769 Positive_regulation of Pscs 61 0.56 39.32 15.93 5.00
191 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
192 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 5.00
193 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
194 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
195 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 5.00
196 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 5.00
197 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 5.00
198 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
199 INT10173 Binding of Tnf 45 0.48 35.6 14.32 5.00
200 INT5806 Regulation of Edn1 63 0.62 23.46 13.88 5.00
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