D:Alkalosis

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Disease Term
Synonyms Alkaloses, HYPOKALAEMIC METABOLIC ALKALOSIS, Hypokalemic Metabolic Alkalosis
Documents 114
Hot Single Events 46
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Alkalosis. They are ordered first by their relevance to Alkalosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT240724 Atp2b2 Positive_regulation of Ca2 1 0.11 0.54 0 98.00
2 INT154834 Stim1 Regulation of Regulation of Ca2 1 0.13 0.9 0.28 96.40
3 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55 5.00
4 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98 5.00
5 INT198652 F2 Positive_regulation of Gene_expression of CD36 1 0.03 1.32 0.37 5.00
6 INT198647 TNF Positive_regulation of HIF1A 1 0.03 2.97 0.34 5.00
7 INT198642 GPI Positive_regulation of TNF 1 0.03 0.98 0.33 5.00
8 INT198640 TNF Positive_regulation of ISYNA1 1 0.04 1.07 0.29 5.00
9 INT198648 VCAM1 Positive_regulation of CADM1 1 0.00 1.1 0.25 5.00
10 INT198644 TNF Positive_regulation of CADM1 1 0.02 1.07 0.24 5.00
11 INT198643 CD36 Positive_regulation of CADM1 1 0.01 1.07 0.24 5.00
12 INT198649 Binding of HIF1A and MIF 1 0.01 1.53 0.18 5.00
13 INT198638 GPI Positive_regulation of Gene_expression of TNF 1 0.03 1.44 0.15 5.00
14 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 0.00 1.37 0.13 5.00
15 INT240726 Binding of Esr1 and Ca2 1 0.02 0.57 0.05 5.00
16 INT198639 S100A12 Positive_regulation of TNF 1 0.15 1.49 0.04 5.00
17 INT198646 S100A12 Positive_regulation of IL1B 1 0.01 1.49 0.04 5.00
18 INT198651 Positive_regulation of S100A12 Positive_regulation of TNF 1 0.15 1.5 0.04 5.00
19 INT198650 Positive_regulation of S100A12 Positive_regulation of IL1B 1 0.01 1.5 0.04 5.00
20 INT292680 Negative_regulation of TXK Negative_regulation of ABL1 1 0.00 0.26 0 5.00
21 INT292679 GOPC Positive_regulation of HSP90AA1 1 0.01 0.1 0 5.00
22 INT240722 Cd38 Positive_regulation of Localization of Ca2 1 0.04 0.79 0 5.00
23 INT292727 GSK Positive_regulation of Negative_regulation of Hsf1 1 0.21 0 0 5.00
24 INT292723 Akt1 Positive_regulation of Localization of Hsf1 1 0.05 0.36 0 5.00
25 INT240723 Atp2b2 Positive_regulation of Localization of Ca2 1 0.11 0.43 0 5.00
26 INT292722 Akt1 Regulation of Localization of Hsf1 1 0.06 0 0 5.00
27 INT292721 Mapk1 Negative_regulation of Phosphorylation of Hsf1 1 0.02 0.06 0 5.00
28 INT292725 GOPC Positive_regulation of Protein_catabolism of Akt1 1 0.01 0.1 0 5.00
29 INT240725 Esr1 Positive_regulation of Localization of Ca2 1 0.03 0.72 0 5.00
30 INT292726 ABL1 Positive_regulation of Mapk1 1 0.01 0.15 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Alkalosis. They are ordered first by their pain relevance and then by number of times they were reported in Alkalosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT218593 Regulation of Gene_expression of Ecm1 1 0.04 1.49 0.1 100.00
2 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 99.98
3 INT132187 Gene_expression of Ecm1 14 0.21 8.12 3.52 99.82
4 INT11761 Negative_regulation of DST 13 0.42 7.66 3.65 99.80
5 INT58766 Gene_expression of ANGPT2 41 0.67 21.65 4.82 98.76
6 INT21610 Positive_regulation of ANGPT2 23 0.41 13.28 3.03 98.76
7 INT58765 Positive_regulation of Gene_expression of ANGPT2 11 0.38 8.2 0.81 98.76
8 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08 98.64
9 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 98.44
10 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 98.44
11 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 98.44
12 INT661 Gene_expression of REN 100 0.78 48.21 11.36 97.80
13 INT27989 Positive_regulation of Gene_expression of REN 18 0.55 12.69 2.11 97.80
14 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 97.44
15 INT48120 Positive_regulation of Cacna1h 5 0.34 1.2 2.22 96.92
16 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71 96.68
17 INT19366 Negative_regulation of Localization of Ca2 33 0.50 6.51 6.61 96.68
18 INT1032 Regulation of Ca2 202 0.52 54.91 53.03 96.40
19 INT4822 Localization of Ca2 417 0.80 99.57 96.45 96.12
20 INT154832 Negative_regulation of Plekhh3 1 0.01 0.97 0.4 96.08
21 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 94.48
22 INT192806 Binding of SSRP1 11 0.27 9.12 0.37 94.04
23 INT218587 Gene_expression of Btg2 16 0.11 7.4 0.51 93.96
24 INT158820 Positive_regulation of COX3 1 0.04 1.25 0.16 93.68
25 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 93.64
26 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 93.64
27 INT73429 Negative_regulation of Atp2a2 20 0.20 9.05 0.74 90.88
28 INT53282 Negative_regulation of Atp2b2 4 0.15 2.6 0.45 90.40
29 INT218600 Regulation of Gene_expression of Btg2 1 0.02 1.69 0.06 89.32
30 INT154833 Regulation of Stim1 3 0.27 1.56 0.88 89.24
31 INT154830 Binding of Stim1 1 0.48 1.48 0.56 89.24
32 INT5806 Regulation of Edn1 63 0.62 23.46 13.88 89.24
33 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 88.88
34 INT88182 Gene_expression of Atp2a2 40 0.78 22.91 4.26 88.88
35 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 88.84
36 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 88.52
37 INT98645 Gene_expression of FGF23 9 0.78 10.07 0.8 87.52
38 INT130802 Localization of FGF23 2 0.17 1.78 0.2 87.52
39 INT62195 Positive_regulation of Hsf1 17 0.70 11.51 0.95 87.12
40 INT130797 Gene_expression of Fgf23 6 0.66 4.73 0.77 86.36
41 INT130799 Localization of Fgf23 2 0.63 1.94 0.28 86.36
42 INT49536 Regulation of Regulation of Ca2 6 0.38 3.89 1.13 85.00
43 INT5460 Positive_regulation of EDAR 10 0.23 8.18 2.71 84.48
44 INT11225 Positive_regulation of SLC12A2 3 0.45 1.1 0.6 82.80
45 INT17916 Gene_expression of LOC308670 4 0.02 1.62 0.81 80.64
46 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 80.40
47 INT35975 Regulation of Cpox 109 0.39 57.88 49.69 77.36
48 INT130798 Positive_regulation of Gene_expression of Fgf23 2 0.59 1.12 0.2 76.88
49 INT218589 Positive_regulation of Gene_expression of Btg2 1 0.06 0.89 0.1 75.56
50 INT15775 Positive_regulation of Ren1 50 0.69 22.38 6.19 75.32
51 INT70253 Negative_regulation of Gene_expression of Ca2 29 0.49 16.31 2.69 74.64
52 INT99426 Negative_regulation of Gene_expression of Atp2a2 19 0.59 13.7 1.96 74.64
53 INT56972 Regulation of ANGPT2 6 0.44 3.48 0.86 74.04
54 INT28733 Regulation of EDAR 4 0.12 2.11 0.89 72.32
55 INT327508 Localization of CYBRD1 1 0.01 0.24 0 71.12
56 INT60683 Regulation of VIPR1 3 0.07 1.53 1.27 69.44
57 INT49978 Localization of Hbb 4 0.39 1.11 1.29 67.76
58 INT130800 Localization of Mepe 1 0.30 0.46 0 66.92
59 INT130801 Localization of SFRP4 4 0.28 2.41 0.49 66.52
60 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 65.80
61 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 65.44
62 INT240720 Transcription of Atp2a2 2 0.20 1.26 0 65.04
63 INT94181 Gene_expression of VIPR1 7 0.58 0.55 1.79 64.72
64 INT94180 Positive_regulation of Gene_expression of VIPR1 3 0.10 0.61 0.96 64.72
65 INT119936 Transcription of Ca2 13 0.59 1.71 1.47 64.24
66 INT59278 Regulation of H19 1 0.60 0.19 0.95 63.68
67 INT5743 Localization of NA 104 0.59 14.35 35.29 61.64
68 INT144646 Positive_regulation of Rela 53 0.67 27.78 13.2 61.12
69 INT218583 Regulation of Positive_regulation of Rela 1 0.05 1.51 0.21 61.12
70 INT38249 Positive_regulation of VIPR1 9 0.40 2.58 3.96 56.48
71 INT16395 Gene_expression of CEBPZ 30 0.57 11.02 6.66 54.00
72 INT129933 Negative_regulation of SLC12A3 2 0.38 3.67 0.08 48.40
73 INT88183 Localization of Atp2a2 6 0.63 2.1 2.22 48.00
74 INT134512 Negative_regulation of Dct 4 0.22 2.31 0.22 42.48
75 INT339 Regulation of Trh 156 0.62 39.27 83.55 40.16
76 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 36.80
77 INT5490 Binding of CA2 52 0.36 9.73 5.53 36.40
78 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 33.56
79 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 28.80
80 INT73599 Negative_regulation of Gene_expression of Cpox 47 0.55 19.89 17.26 28.80
81 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 27.52
82 INT218598 Localization of Amigo2 2 0.15 2.15 0.35 27.04
83 INT1562 Localization of Crh 499 0.81 126.74 236.68 26.96
84 INT2982 Positive_regulation of Gene_expression of CGA 17 0.59 9.08 1.99 26.52
85 INT216932 Positive_regulation of Negative_regulation of Il6 3 0.38 4.88 1.55 25.88
86 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 25.40
87 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 25.00
88 INT44271 Localization of TSHB 3 0.31 3.34 0.13 25.00
89 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58 23.60
90 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 19.12
91 INT104441 Binding of NOVA2 72 0.42 16.41 10.51 18.48
92 INT481 Regulation of Localization of Ren 37 0.62 5.95 11.61 15.16
93 INT46 Localization of Ren 233 0.81 46.15 62.44 14.76
94 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 13.60
95 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 13.60
96 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 12.08
97 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 8.84
98 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
99 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
100 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
101 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
102 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
103 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
104 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
105 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
106 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
107 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
108 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
109 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
110 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
111 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
112 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 5.00
113 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
114 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 5.00
115 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
116 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 5.00
117 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
118 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
119 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
120 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
121 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
122 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 5.00
123 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
124 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
125 INT214 Localization of AVP 370 0.81 208.51 91.09 5.00
126 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
127 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
128 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
129 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
130 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
131 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
132 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
133 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
134 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
135 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
136 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
137 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
138 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
139 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57 5.00
140 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
141 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
142 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 5.00
143 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
144 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
145 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
146 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
147 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29 5.00
148 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37 5.00
149 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
150 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 5.00
151 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
152 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
153 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
154 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 5.00
155 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
156 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18 5.00
157 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
158 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69 5.00
159 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 5.00
160 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 5.00
161 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84 5.00
162 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
163 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 5.00
164 INT70504 Regulation of Gene_expression of NOS1 30 0.51 21.72 21.72 5.00
165 INT171820 Localization of Fig4 144 0.65 27.38 20.88 5.00
166 INT440 Regulation of Gene_expression of Crh 44 0.62 17.71 20.73 5.00
167 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
168 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 5.00
169 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
170 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 5.00
171 INT14546 Positive_regulation of Localization of Ca2 93 0.67 31.09 18.72 5.00
172 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
173 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71 5.00
174 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 5.00
175 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 5.00
176 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79 5.00
177 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31 5.00
178 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
179 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
180 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 5.00
181 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11 5.00
182 INT113625 Positive_regulation of Gene_expression of Ca2 47 0.50 9.82 14.07 5.00
183 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68 5.00
184 INT2038 Localization of Esr1 104 0.79 40.12 13.27 5.00
185 INT19799 Binding of Ca2 71 0.48 13.69 12.92 5.00
186 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8 5.00
187 INT2385 Gene_expression of MIF 57 0.68 40.74 12.78 5.00
188 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
189 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25 5.00
190 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
191 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92 5.00
192 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 5.00
193 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 5.00
194 INT94784 Binding of ROS1 113 0.40 71.57 10.26 5.00
195 INT33094 Regulation of Localization of Ca2 28 0.38 8.65 9.96 5.00
196 INT17741 Gene_expression of MBP 67 0.78 23.67 9.65 5.00
197 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
198 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 5.00
199 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
200 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
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