D:Alpha-1-antitrypsin Deficiency

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pChart

Disease Term
Synonyms A1at, Alpha 1 Antitrypsin Deficiencies, Alpha 1 Antitrypsin Deficiency, Deficiencies Alpha 1 Antitrypsin, Deficiency Alpha 1 Antitrypsin
Documents 17
Hot Single Events 57
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Alpha-1-antitrypsin Deficiency. They are ordered first by their relevance to Alpha-1-antitrypsin Deficiency and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT125595 Binding of SERPINA1 and PRTN3 1 0.18 1.58 0.1 100.00
2 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9 5.00
3 INT259637 Binding of Mmp12 and COPD 2 0.02 1.71 0.4 5.00
4 INT272925 Ccl2 Positive_regulation of Gene_expression of Col7a1 1 0.00 0.72 0.3 5.00
5 INT272932 Binding of Mmp9 and COPD 1 0.01 0.78 0.29 5.00
6 INT272930 Positive_regulation of Binding of Mmp1a and COPD 1 0.01 0.79 0.29 5.00
7 INT272933 Binding of Mmp1a and COPD 1 0.01 0.78 0.29 5.00
8 INT272929 Positive_regulation of Binding of Mmp9 and COPD 1 0.01 0.79 0.29 5.00
9 INT272928 Positive_regulation of Binding of Mmp12 and COPD 1 0.01 0.79 0.29 5.00
10 INT272931 Binding of IL8 and Cxcr1 1 0.07 0.65 0.18 5.00
11 INT272927 Mapk14 Positive_regulation of Gene_expression of TNF 1 0.16 0.53 0.14 5.00
12 INT272867 Binding of NLRP1 and COPD 1 0.00 1.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Alpha-1-antitrypsin Deficiency. They are ordered first by their pain relevance and then by number of times they were reported in Alpha-1-antitrypsin Deficiency. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7 100.00
2 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93 100.00
3 INT100427 Binding of SERPINA1 9 0.36 9.63 2.51 100.00
4 INT51312 Positive_regulation of Gene_expression of SERPINA1 4 0.46 9.41 3.84 100.00
5 INT10048 Positive_regulation of SERPINA1 11 0.68 8.59 2.43 100.00
6 INT51313 Positive_regulation of Positive_regulation of SERPINA1 1 0.49 1.73 0.33 100.00
7 INT100426 Regulation of Binding of SERPINA1 1 0.39 0.98 0.45 100.00
8 INT83911 Negative_regulation of Gene_expression of SERPINA1 3 0.43 5.2 2.07 100.00
9 INT279125 Binding of COL9A2 2 0.32 2.59 0.36 100.00
10 INT341659 Protein_catabolism of COL9A2 1 0.62 2.21 0.35 100.00
11 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 100.00
12 INT104305 Binding of COL3A1 2 0.35 3.45 0.68 100.00
13 INT11890 Protein_catabolism of COL3A1 2 0.77 2.41 0.64 100.00
14 INT84561 Binding of COL1A2 18 0.47 11.76 5.09 100.00
15 INT49238 Protein_catabolism of COL1A2 30 0.97 15.64 3.45 100.00
16 INT10047 Positive_regulation of Negative_regulation of SERPINA1 4 0.47 2.27 0.83 100.00
17 INT324332 Binding of UMOD 7 0.41 7.07 0.35 100.00
18 INT341657 Binding of FGB 1 0.30 1.29 0.21 100.00
19 INT341652 Protein_catabolism of FGB 1 0.71 1.29 0.21 100.00
20 INT341653 Binding of FGA 1 0.31 1.15 0.18 100.00
21 INT341661 Protein_catabolism of FGA 1 0.74 1.15 0.18 100.00
22 INT81229 Binding of COL1A1 24 0.35 12.07 3.3 100.00
23 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3 100.00
24 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 100.00
25 INT341655 Gene_expression of FGA 1 0.56 4.48 1.07 99.96
26 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 99.84
27 INT341662 Gene_expression of FGB 1 0.48 3.06 0.6 99.78
28 INT353148 Positive_regulation of Binding of SERPINA1 1 0.13 1.87 0.89 98.88
29 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 98.80
30 INT119229 Positive_regulation of Protein_catabolism of Eln 2 0.24 1.8 0.32 98.50
31 INT92988 Protein_catabolism of Eln 6 0.47 5.48 1.03 98.10
32 INT59884 Gene_expression of UMOD 4 0.78 2.32 0.82 96.12
33 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 93.32
34 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 93.32
35 INT114709 Gene_expression of Fga 5 0.58 0.92 0.22 93.20
36 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 93.00
37 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 92.80
38 INT159044 Gene_expression of Hpt 2 0.57 2.01 1.82 92.36
39 INT17086 Binding of HSD11B1 84 0.47 122.28 6.16 92.32
40 INT159048 Gene_expression of ACTG1P1 1 0.00 0.19 0 91.92
41 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 91.60
42 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 91.60
43 INT3647 Positive_regulation of Gene_expression of F13A1 20 0.41 15.71 5.02 91.60
44 INT135722 Positive_regulation of Gene_expression of ANGPTL5 5 0.39 4.52 1.05 91.60
45 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 91.20
46 INT68091 Localization of COL1A1 19 0.66 9.13 2.56 90.60
47 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 90.60
48 INT341656 Localization of MOV10 1 0.00 2.21 0.57 89.52
49 INT341654 Localization of UMOD 1 0.73 2.2 0.57 89.04
50 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 88.96
51 INT9243 Gene_expression of FOXG1 14 0.53 7.52 1.02 88.96
52 INT341660 Localization of FAS-AS1 1 0.37 2.2 0.57 88.68
53 INT353146 Gene_expression of ITSN1 1 0.04 1.35 0.82 88.32
54 INT23191 Gene_expression of HDLCQ1 13 0.60 14.39 1.58 87.56
55 INT157637 Positive_regulation of Fga 2 0.28 0.65 0.08 83.44
56 INT114081 Positive_regulation of Hpt 4 0.18 1.41 0.09 83.00
57 INT159047 Positive_regulation of ACTG1P1 1 0.00 0.3 0 83.00
58 INT25153 Binding of RNASE1 3 0.36 1.8 0.32 75.12
59 INT25151 Binding of Rnase1 1 0.05 0.8 0.09 75.12
60 INT353154 Localization of FGG 1 0.01 1.34 0.81 74.32
61 INT91122 Localization of CAT 6 0.78 4.13 1.19 72.96
62 INT33243 Localization of HP 17 0.12 9.7 2.2 72.24
63 INT353151 Localization of ITSN1 1 0.05 1.34 0.79 72.24
64 INT353149 Localization of MACF1 1 0.17 1.33 0.78 72.24
65 INT353152 Localization of PRKACA 1 0.01 1.15 0.66 72.24
66 INT353147 Localization of SHANK2 1 0.07 1.13 0.65 72.24
67 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 65.00
68 INT353131 Gene_expression of Eno1 1 0.02 2.14 1.43 63.64
69 INT9995 Localization of C6orf25 13 0.69 6.48 2.29 50.12
70 INT9994 Negative_regulation of Localization of C6orf25 3 0.09 1.54 0.13 50.12
71 INT291968 Localization of CA1 5 0.73 4.21 1.6 47.76
72 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 47.64
73 INT111081 Gene_expression of CA1 19 0.75 51.09 26.64 40.40
74 INT2073 Regulation of CA1 5 0.26 4.9 3.86 38.96
75 INT311552 Positive_regulation of Gene_expression of CA1 3 0.67 21.83 11.2 32.28
76 INT96164 Positive_regulation of CA1 8 0.67 10.99 6.23 31.12
77 INT353145 Negative_regulation of Gene_expression of CA1 1 0.42 1.01 0.65 24.68
78 INT212006 Transcription of CA1 2 0.66 1.14 0.76 12.96
79 INT99610 Localization of MMP9 126 0.79 48.46 32.67 10.80
80 INT78901 Localization of CCL5 67 0.78 40.79 20.59 10.80
81 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 10.80
82 INT35175 Localization of IL18 18 0.80 12.96 3.83 10.80
83 INT59719 Localization of SELP 12 0.78 8.4 2.95 10.80
84 INT31162 Localization of SELL 10 0.78 7.38 1.94 10.80
85 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
86 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
87 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
88 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
89 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
90 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
91 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
92 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
93 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
94 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
95 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
96 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
97 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
98 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
99 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
100 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
101 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
102 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
103 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 5.00
104 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
105 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
106 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
107 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
108 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 5.00
109 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
110 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
111 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
112 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 5.00
113 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
114 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
115 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 5.00
116 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
117 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
118 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
119 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
120 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
121 INT30169 Negative_regulation of Pde4a 107 0.58 81 36.23 5.00
122 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
123 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
124 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 5.00
125 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
126 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
127 INT129207 Gene_expression of Cxcl1 114 0.75 68.54 30.82 5.00
128 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
129 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 5.00
130 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
131 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 5.00
132 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
133 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
134 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25 5.00
135 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 5.00
136 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 5.00
137 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
138 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 5.00
139 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
140 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 5.00
141 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
142 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36 5.00
143 INT52106 Negative_regulation of Localization of IL8 57 0.52 22.81 20.8 5.00
144 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 5.00
145 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
146 INT102545 Gene_expression of Ccr2 42 0.78 61.43 19.81 5.00
147 INT138696 Positive_regulation of Ccl2 57 0.67 59.57 19.58 5.00
148 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46 5.00
149 INT70970 Binding of COPD 144 0.42 180.34 18.29 5.00
150 INT61257 Gene_expression of Sele 79 0.77 70.97 17.78 5.00
151 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
152 INT2216 Gene_expression of SELL 92 0.77 59.29 17.71 5.00
153 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 5.00
154 INT38056 Localization of Crp 71 0.78 53.14 17.03 5.00
155 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
156 INT62546 Positive_regulation of Gene_expression of Icam1 60 0.70 59.52 16.9 5.00
157 INT10834 Binding of IL8 65 0.48 41.66 16.53 5.00
158 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
159 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33 5.00
160 INT56447 Positive_regulation of Icam1 64 0.64 64.14 16.16 5.00
161 INT615 Regulation of Alb 66 0.62 33.43 15.33 5.00
162 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 5.00
163 INT79227 Negative_regulation of Gene_expression of Icam1 45 0.59 41.65 14.97 5.00
164 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
165 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01 5.00
166 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
167 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 5.00
168 INT116433 Gene_expression of CYBB 93 0.70 50.44 11.91 5.00
169 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
170 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 5.00
171 INT89282 Regulation of MMP9 39 0.60 25.45 10.34 5.00
172 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11 5.00
173 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09 5.00
174 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79 5.00
175 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 5.00
176 INT25381 Localization of Csf2 62 0.76 47.48 9.03 5.00
177 INT161222 Positive_regulation of Ccr2 13 0.55 13.77 8.89 5.00
178 INT49802 Localization of MUC1 75 0.81 44.74 8.87 5.00
179 INT150867 Regulation of COPD 54 0.48 71.38 8.8 5.00
180 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62 5.00
181 INT81444 Positive_regulation of Gene_expression of Vcam1 40 0.70 46.38 8.58 5.00
182 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 5.00
183 INT83954 Binding of Cxcr2 21 0.37 17.27 7.65 5.00
184 INT30777 Negative_regulation of SELL 20 0.56 18.05 7.32 5.00
185 INT89309 Negative_regulation of Pde4b 21 0.53 12.81 7.32 5.00
186 INT147793 Localization of COPD 70 0.64 89.01 7.3 5.00
187 INT83951 Gene_expression of Cxcr2 31 0.71 19.36 7.24 5.00
188 INT102548 Negative_regulation of Ccr2 14 0.59 19.84 7.22 5.00
189 INT2605 Regulation of ELANE 39 0.61 18.22 7.11 5.00
190 INT81880 Positive_regulation of Gene_expression of Sele 30 0.48 27.54 7.05 5.00
191 INT23782 Positive_regulation of Spna1 58 0.50 35.41 6.94 5.00
192 INT21579 Negative_regulation of Gene_expression of TIMP1 25 0.57 12.41 6.94 5.00
193 INT61258 Transcription of Nfkb1 24 0.67 10.89 6.32 5.00
194 INT9695 Negative_regulation of Csf2 41 0.57 31.65 6.28 5.00
195 INT91657 Negative_regulation of IL18 20 0.48 15.97 6.12 5.00
196 INT34232 Regulation of TIMP1 37 0.61 18.76 6.05 5.00
197 INT116420 Localization of Elane 16 0.14 7.8 6 5.00
198 INT74109 Positive_regulation of Sele 26 0.48 22.32 5.84 5.00
199 INT179810 Protein_catabolism of Ecm1 30 0.11 18.28 5.75 5.00
200 INT150853 Negative_regulation of Cxcl1 22 0.49 12.61 5.72 5.00
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