D:Alport Syndrome

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pChart

Disease Term
Synonyms ALPORT S SYNDROME, Alport Syndrome Autosomal Dominant, Alport Syndrome Autosomal Recessive, ALPORT SYNDROME LIKE FAMILIAL NEPHRITIS, ALPORT SYNDROME LIKE HEREDITARY NEPHRITIS, Alport Syndrome X Linked, Familial Nephritides, Familial Nephritis, Familial Nephritis Nerve Deafness, Familial Nephropathy Deafness, Hereditary Nephritides
Documents 14
Hot Single Events 11
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Alport Syndrome. They are ordered first by their relevance to Alport Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT139538 Binding of CD34 and KIT 2 0.39 2.73 0.14 91.76
2 INT239406 Binding of MTTP and TAOK1 1 0.02 0.51 0 5.00
3 INT239407 Binding of MTTP and PADI1 1 0.23 0.5 0 5.00
4 INT239408 Binding of PADI1 and TAOK1 1 0.01 0.51 0 5.00
5 INT283061 Binding of ERCC8 and LDLR 1 0.00 0.44 0 5.00
6 INT283062 ERCC8 Positive_regulation of CFH 1 0.02 1.88 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Alport Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Alport Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT334577 Binding of KCNE1L 1 0.27 1.33 0 98.32
2 INT113641 Negative_regulation of Gene_expression of GP1BA 4 0.57 2.2 0.44 94.16
3 INT99615 Gene_expression of GP1BA 12 0.75 2.98 0.5 93.76
4 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17 91.76
5 INT21681 Positive_regulation of CD34 54 0.66 33.95 4.14 90.96
6 INT60766 Gene_expression of COL4A4 10 0.77 13.46 1.14 90.92
7 INT213649 Positive_regulation of AGPS 1 0.08 1.35 0 90.04
8 INT213650 Gene_expression of AGPS 1 0.11 1.35 0 90.04
9 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 88.16
10 INT99095 Binding of COL4A4 7 0.37 3.51 0.29 86.20
11 INT178513 Binding of COL4A3 3 0.35 0.8 0.04 86.20
12 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 67.12
13 INT221858 Localization of TNKS 2 0.78 1.67 0.37 52.16
14 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 34.32
15 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 33.44
16 INT193687 Gene_expression of TIMM8A 2 0.49 1.27 0.04 22.56
17 INT219498 Gene_expression of TBL1X 2 0.49 1.03 0 21.92
18 INT119827 Gene_expression of PTPN11 31 0.75 24.21 1.22 21.36
19 INT32107 Gene_expression of PTPLA 14 0.47 8.06 6.76 20.72
20 INT239412 Binding of ABL1 8 0.28 5.39 0.18 7.48
21 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 5.00
22 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
23 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 5.00
24 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 5.00
25 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 5.00
26 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67 5.00
27 INT11957 Negative_regulation of LPA 52 0.59 39.09 6.84 5.00
28 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 5.00
29 INT27118 Regulation of Binding of OPRM1 10 0.62 1.18 5.97 5.00
30 INT28673 Gene_expression of APOB 51 0.73 34.02 3.95 5.00
31 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 5.00
32 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 5.00
33 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
34 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
35 INT550 Negative_regulation of LDLR 66 0.43 44.71 3.04 5.00
36 INT50080 Binding of APOE 38 0.45 29.61 2.67 5.00
37 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 5.00
38 INT95898 Gene_expression of CAPG 14 0.39 10.51 2.33 5.00
39 INT81154 Gene_expression of HCRT 10 0.75 5.32 2.22 5.00
40 INT88701 Gene_expression of MMD 15 0.44 6.04 1.94 5.00
41 INT40877 Positive_regulation of APOB 35 0.68 32.47 1.86 5.00
42 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 5.00
43 INT9466 Binding of APOB 27 0.41 19.36 1.56 5.00
44 INT103799 Positive_regulation of CAPG 8 0.34 5.16 1.52 5.00
45 INT57425 Binding of MYH14 12 0.11 2.33 1.26 5.00
46 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 5.00
47 INT23199 Binding of LDLR 22 0.47 17.08 1.16 5.00
48 INT46044 Positive_regulation of Gene_expression of C3 23 0.53 20.07 1.06 5.00
49 INT82702 Positive_regulation of Positive_regulation of LDLR 4 0.45 1.08 0.95 5.00
50 INT150165 Gene_expression of MTTP 21 0.75 10.1 0.73 5.00
51 INT23146 Negative_regulation of Aprt 8 0.56 7.53 0.71 5.00
52 INT238245 Gene_expression of Atp5s 4 0.75 7.57 0.6 5.00
53 INT213651 Binding of HCRT 2 0.36 1.08 0.56 5.00
54 INT89217 Negative_regulation of ADAMTS13 8 0.50 12.32 0.51 5.00
55 INT73731 Binding of RAPH1 9 0.33 14.58 0.5 5.00
56 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39 5.00
57 INT213648 Phosphorylation of S100A6 2 0.30 1.43 0.36 5.00
58 INT239084 Localization of KAT2B 4 0.73 3.08 0.36 5.00
59 INT95446 Gene_expression of PHC2 2 0.32 1.59 0.3 5.00
60 INT187422 Negative_regulation of MTTP 23 0.57 11.75 0.24 5.00
61 INT161702 Gene_expression of GJB2 3 0.65 2.19 0.14 5.00
62 INT163461 Regulation of ABL1 8 0.32 5.98 0.14 5.00
63 INT187656 Positive_regulation of RAPH1 1 0.31 1.73 0.14 5.00
64 INT57557 Negative_regulation of VLDLR 2 0.19 1.23 0.08 5.00
65 INT239409 Transcription of APOB 3 0.65 1.86 0.06 5.00
66 INT109594 Positive_regulation of ABL1 10 0.49 7.19 0.05 5.00
67 INT239411 Localization of APOB 10 0.76 5.71 0.04 5.00
68 INT223606 Negative_regulation of Gene_expression of MTTP 2 0.41 0.97 0.03 5.00
69 INT213647 Gene_expression of F9 10 0.65 6.48 0 5.00
70 INT239410 Regulation of Localization of APOB 1 0.25 0.52 0 5.00
71 INT239413 Binding of PADI1 6 0.24 0.97 0 5.00
72 INT256366 Gene_expression of GJB6 2 0.50 0.8 0 5.00
73 INT283060 Positive_regulation of Atp5s 1 0.20 1.81 0 5.00
74 INT334578 Binding of SLC26A4 1 0.21 0.83 0 5.00
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