D:Altitude Sickness

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Disease Term
Synonyms ACUTE MOUNTAIN SICKNESS, Alpine Sickness, Altitude Anoxia, Altitude Sicknesses, Andes Disease, Anoxia Due To High Altitude, Chronic Mountain Sickness, Effects Of High Altitude, Hace, Hape, High Altitude Cerebral Edema
Documents 181
Hot Single Events 34
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Altitude Sickness. They are ordered first by their relevance to Altitude Sickness and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT344238 MCRS1 Regulation of TREX1 1 0.08 1.02 0.34 5.00
2 INT317071 KCNC4 Regulation of SCNN1G 1 0.03 0.17 0.13 5.00
3 INT213207 Negative_regulation of ASAP2 Negative_regulation of PVR 1 0.01 0.45 0.04 5.00
4 INT317072 SCNN1G Regulation of NA 1 0.00 0.08 0.04 5.00
5 INT213206 ASAP2 Negative_regulation of PVR 1 0.01 0.44 0.04 5.00
6 INT317073 NA Regulation of Localization of CA2 1 0.01 0.1 0.03 5.00
7 INT317070 DNAH8 Regulation of Localization of CA2 1 0.01 0.1 0.03 5.00
8 INT317075 Binding of NA and SCNN1G 1 0.00 0 0 5.00
9 INT317074 CA2 Regulation of SCNN1G 1 0.01 0.08 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Altitude Sickness. They are ordered first by their pain relevance and then by number of times they were reported in Altitude Sickness. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT327852 Positive_regulation of HACE1 1 0.10 2.62 0 100.00
2 INT120135 Negative_regulation of Hace1 1 0.37 1.12 0 100.00
3 INT22117 Positive_regulation of Negative_regulation of Cms1 1 0.39 1.31 0.19 100.00
4 INT22118 Negative_regulation of Cms1 6 0.38 4.02 0.78 100.00
5 INT9110 Binding of PAH 32 0.41 42.1 3.1 99.92
6 INT175554 Binding of MCRS1 21 0.23 25.2 8.59 99.88
7 INT2074 Negative_regulation of CA1 6 0.58 4.44 1.68 99.84
8 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 99.84
9 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36 99.56
10 INT3738 Regulation of Epo 25 0.61 13.73 6.18 99.44
11 INT22030 Negative_regulation of Cysltr1 31 0.39 21.83 12.49 99.28
12 INT25585 Positive_regulation of DNAH8 39 0.70 17.96 7.85 97.36
13 INT156723 Regulation of Localization of S100B 2 0.44 2.61 0.34 97.08
14 INT26462 Gene_expression of DNAH8 44 0.78 19.36 7.31 96.76
15 INT17742 Localization of S100B 44 0.80 17.14 4.65 96.32
16 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 96.16
17 INT184894 Localization of MCRS1 9 0.47 10.04 3.31 96.12
18 INT17399 Positive_regulation of Positive_regulation of REN 13 0.69 7.05 1.9 95.68
19 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 95.68
20 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 95.56
21 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 94.44
22 INT70877 Gene_expression of PPIG 72 0.75 22.39 10.93 94.32
23 INT2649 Regulation of Calca 433 0.62 146.05 330.95 93.72
24 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 93.04
25 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 93.04
26 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 92.68
27 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 92.28
28 INT114011 Negative_regulation of ATP1A2 5 0.45 6.12 2.41 91.44
29 INT27345 Positive_regulation of ANIB1 9 0.07 9.81 3.46 90.88
30 INT134356 Positive_regulation of PRB2 1 0.14 1.26 0.09 89.88
31 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35 88.24
32 INT214 Localization of AVP 370 0.81 208.51 91.09 82.32
33 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79 82.32
34 INT213221 Negative_regulation of ASAP2 1 0.01 5.83 0.46 80.68
35 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 78.84
36 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 78.48
37 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 77.64
38 INT19584 Negative_regulation of Ptafr 3 0.56 1.82 0.61 77.52
39 INT136021 Positive_regulation of Localization of EPO 2 0.23 1.63 0.14 75.68
40 INT8111 Localization of EPO 32 0.81 19.53 2.54 75.68
41 INT111032 Binding of ACOT8 1 0.36 1.51 0.18 75.36
42 INT28929 Negative_regulation of PVR 22 0.57 16.64 1.07 70.28
43 INT2393 Positive_regulation of Mb 174 0.69 93.59 26.79 66.04
44 INT184895 Gene_expression of MCRS1 46 0.42 56.03 19.44 56.76
45 INT93562 Negative_regulation of Localization of CA2 15 0.59 1.87 2.51 52.88
46 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 50.00
47 INT5489 Localization of CA2 172 0.80 39.46 33.56 49.44
48 INT35325 Regulation of Localization of CA2 10 0.32 1.13 1.69 49.44
49 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 47.76
50 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 46.24
51 INT213214 Positive_regulation of ASAP2 1 0.01 4.59 0.31 45.56
52 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 43.12
53 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 36.96
54 INT812 Localization of INS 1026 0.81 515.6 145.31 35.88
55 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 35.88
56 INT314811 Binding of Dnajb1 1 0.03 0.45 0 25.00
57 INT629 Negative_regulation of Localization of PGC 8 0.45 5.79 1.33 18.32
58 INT625 Localization of PGC 35 0.80 11.33 3.05 17.96
59 INT327851 Negative_regulation of Binding of HBM 1 0.03 0.49 0 8.60
60 INT93956 Binding of HBM 20 0.35 8.86 1.48 8.12
61 INT1352 Localization of Acot1 728 0.80 73.01 296.01 5.00
62 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
63 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
64 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 5.00
65 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
66 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71 5.00
67 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
68 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 5.00
69 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
70 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 5.00
71 INT1032 Regulation of Ca2 202 0.52 54.91 53.03 5.00
72 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
73 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
74 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
75 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
76 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 5.00
77 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 5.00
78 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
79 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
80 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 5.00
81 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 5.00
82 INT1558 Positive_regulation of Dnahc8 30 0.69 5.78 22.19 5.00
83 INT1561 Negative_regulation of Dnahc8 59 0.59 18.12 20.99 5.00
84 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
85 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 5.00
86 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 5.00
87 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
88 INT6791 Binding of NA 55 0.46 5.36 17.59 5.00
89 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
90 INT52591 Gene_expression of KCNMA1 78 0.76 13.95 15.55 5.00
91 INT5536 Regulation of NA 74 0.59 16.61 15.36 5.00
92 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
93 INT113625 Positive_regulation of Gene_expression of Ca2 47 0.50 9.82 14.07 5.00
94 INT19799 Binding of Ca2 71 0.48 13.69 12.92 5.00
95 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
96 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17 5.00
97 INT3535 Regulation of CA2 61 0.32 16.48 10.8 5.00
98 INT178306 Negative_regulation of Gene_expression of Gopc 71 0.37 26.43 9.74 5.00
99 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 5.00
100 INT23535 Positive_regulation of Localization of CA2 41 0.41 13.52 9.43 5.00
101 INT23094 Positive_regulation of Positive_regulation of Ca2 29 0.49 6.8 9.35 5.00
102 INT130731 Protein_catabolism of COL2A1 47 0.96 21.86 9.28 5.00
103 INT34777 Localization of IGF1 82 0.80 42.68 8.62 5.00
104 INT12924 Negative_regulation of Gene_expression of NA 25 0.30 6.59 6.71 5.00
105 INT195145 Positive_regulation of Gene_expression of CA2 25 0.37 7.2 6.59 5.00
106 INT21545 Regulation of DNAH8 22 0.59 8.67 6.48 5.00
107 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 5.00
108 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81 5.00
109 INT11064 Positive_regulation of NPR1 24 0.49 14.63 4.78 5.00
110 INT8786 Negative_regulation of ALDH7A1 27 0.52 12.81 4.76 5.00
111 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 5.00
112 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23 5.00
113 INT38249 Positive_regulation of VIPR1 9 0.40 2.58 3.96 5.00
114 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88 5.00
115 INT61680 Positive_regulation of PVR 23 0.60 23.27 3.86 5.00
116 INT136266 Gene_expression of KCNQ1 23 0.64 8.34 3.11 5.00
117 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05 5.00
118 INT16130 Binding of IGF1 67 0.48 27.43 2.95 5.00
119 INT216365 Gene_expression of CASP2 8 0.65 3.27 2.75 5.00
120 INT92877 Gene_expression of PDE5A 35 0.76 17.1 2.7 5.00
121 INT70253 Negative_regulation of Gene_expression of Ca2 29 0.49 16.31 2.69 5.00
122 INT25706 Phosphorylation of NA 7 0.54 2.3 2.55 5.00
123 INT12485 Binding of DNAH8 17 0.48 4.24 2.54 5.00
124 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53 5.00
125 INT81314 Regulation of Gene_expression of NA 10 0.27 4.53 2.45 5.00
126 INT3798 Negative_regulation of GNS 5 0.26 3.18 2.21 5.00
127 INT222088 Gene_expression of Dnajb1 11 0.65 3.37 2.18 5.00
128 INT192295 Protein_catabolism of MMP7 10 0.86 2.68 1.86 5.00
129 INT45167 Positive_regulation of ASAP1 32 0.60 17.09 1.84 5.00
130 INT94181 Gene_expression of VIPR1 7 0.58 0.55 1.79 5.00
131 INT44888 Phosphorylation of EIF2S1 12 0.80 5.7 1.7 5.00
132 INT73180 Positive_regulation of Hspa8 7 0.37 3.41 1.37 5.00
133 INT196687 Positive_regulation of SCNN1G 6 0.06 3.85 1.32 5.00
134 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 5.00
135 INT60683 Regulation of VIPR1 3 0.07 1.53 1.27 5.00
136 INT120696 Gene_expression of SCNN1G 9 0.43 5.46 1.03 5.00
137 INT217744 Positive_regulation of GNS 4 0.24 1.39 1 5.00
138 INT305620 Regulation of Positive_regulation of MCRS1 1 0.17 2.48 0.99 5.00
139 INT129971 Regulation of PVR 5 0.60 3.96 0.97 5.00
140 INT94180 Positive_regulation of Gene_expression of VIPR1 3 0.10 0.61 0.96 5.00
141 INT120697 Negative_regulation of SCNN1G 6 0.32 3.53 0.92 5.00
142 INT181177 Gene_expression of CYLD 5 0.69 24.96 0.89 5.00
143 INT71614 Localization of GNS 3 0.78 1.49 0.84 5.00
144 INT11786 Regulation of Regulation of NA 3 0.43 0.79 0.76 5.00
145 INT183672 Gene_expression of EPAS1 37 0.35 28.68 0.72 5.00
146 INT217743 Gene_expression of GNS 3 0.32 1.37 0.65 5.00
147 INT14570 Regulation of Positive_regulation of INS 8 0.45 4.97 0.62 5.00
148 INT44899 Positive_regulation of EIF2S1 3 0.45 1.67 0.51 5.00
149 INT127460 Positive_regulation of Gene_expression of PAH 5 0.43 4.3 0.5 5.00
150 INT331973 Gene_expression of MYOT 4 0.64 3.83 0.4 5.00
151 INT79599 Protein_catabolism of PDE5A 7 1.00 3.16 0.39 5.00
152 INT217745 Positive_regulation of Protein_catabolism of GNS 1 0.01 0.34 0.33 5.00
153 INT217741 Positive_regulation of Localization of GNS 1 0.01 0.34 0.33 5.00
154 INT217740 Protein_catabolism of GNS 1 0.01 0.34 0.32 5.00
155 INT213215 Gene_expression of SS18L1 2 0.58 3.71 0.29 5.00
156 INT127462 Regulation of PAH 5 0.39 3.35 0.29 5.00
157 INT203636 Positive_regulation of CD2AP 4 0.13 1.27 0.28 5.00
158 INT192302 Negative_regulation of Protein_catabolism of MMP7 2 0.01 0.21 0.26 5.00
159 INT213219 Protein_catabolism of ALDH7A1 1 0.14 0.7 0.23 5.00
160 INT120694 Negative_regulation of Gene_expression of SCNN1G 3 0.32 2.08 0.19 5.00
161 INT135433 Regulation of Dnajb1 2 0.04 1 0.19 5.00
162 INT213217 Negative_regulation of Binding of PAH 2 0.32 2.03 0.19 5.00
163 INT317078 Regulation of SCNN1G 1 0.04 0.58 0.18 5.00
164 INT222078 Positive_regulation of Gene_expression of Dnajb1 5 0.10 0.77 0.18 5.00
165 INT213222 Negative_regulation of Protein_catabolism of PDE5A 1 0.24 0.65 0.16 5.00
166 INT195573 Localization of Dnajb1 2 0.07 1.16 0.15 5.00
167 INT314806 Localization of Dnaja2 1 0.26 0.1 0.15 5.00
168 INT213220 Regulation of ASAP2 1 0.01 1.73 0.15 5.00
169 INT213218 Negative_regulation of USP33 1 0.01 0.92 0.15 5.00
170 INT314810 Localization of Hspa8 1 0.17 0.1 0.15 5.00
171 INT213212 Localization of ASAP2 1 0.01 0.78 0.13 5.00
172 INT196671 Positive_regulation of Positive_regulation of SCNN1G 2 0.04 1.04 0.13 5.00
173 INT211827 Localization of PVR 3 0.61 1.33 0.13 5.00
174 INT213211 Regulation of Localization of PVR 1 0.23 0.78 0.13 5.00
175 INT277191 Regulation of BPIFA1 2 0.26 1.46 0.12 5.00
176 INT196692 Positive_regulation of Gene_expression of SCNN1G 2 0.06 0.35 0.09 5.00
177 INT5532 Regulation of FHL1 2 0.07 0.24 0.09 5.00
178 INT44901 Gene_expression of EIF2S1 3 0.40 0.55 0.09 5.00
179 INT206463 Positive_regulation of Positive_regulation of ASAP1 4 0.41 1.28 0.07 5.00
180 INT213213 Protein_catabolism of PAH 1 0.76 1.5 0.07 5.00
181 INT185437 Negative_regulation of Gene_expression of CYLD 3 0.52 2.41 0.05 5.00
182 INT213216 Positive_regulation of Gene_expression of PDE5A 2 0.37 2.08 0.04 5.00
183 INT314807 Positive_regulation of Hspa8 1 0.09 0.71 0.04 5.00
184 INT256851 Regulation of Hspa8 4 0.19 3.71 0.03 5.00
185 INT317082 Positive_regulation of Negative_regulation of SCNN1G 1 0.04 0 0.03 5.00
186 INT217732 Localization of MTOR 11 0.56 3.19 0.03 5.00
187 INT203637 Binding of CD2AP 1 0.04 0.57 0.03 5.00
188 INT123547 Positive_regulation of HPV6AI1 1 0.09 1.28 0 5.00
189 INT314808 Binding of Hspa8 1 0.11 0.3 0 5.00
190 INT351437 Positive_regulation of Gene_expression of MYOT 1 0.12 0.31 0 5.00
191 INT351440 Positive_regulation of HIF1AN 1 0.04 0.29 0 5.00
192 INT351438 Regulation of Gene_expression of FHL1 1 0.07 0.24 0 5.00
193 INT338603 Gene_expression of FHL1 3 0.22 0.74 0 5.00
194 INT317079 Negative_regulation of Binding of SCNN1G 1 0.04 0 0 5.00
195 INT317081 Regulation of Phosphorylation of NA 1 0.03 0 0 5.00
196 INT351439 Positive_regulation of MYOT 1 0.12 0.31 0 5.00
197 INT317080 Binding of SCNN1G 1 0.03 0 0 5.00
198 INT314809 Negative_regulation of Binding of Hspa8 1 0.13 0.24 0 5.00
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