D:Alveolar Bone Loss

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Disease Term
Synonyms ALVEOLAR BONE LOSSES, ALVEOLAR RESORPTION, Alveolar Resorptions, Bone Loss Alveolar, Bone Loss Periodontal, Bone Losses Alveolar, Bone Losses Periodontal, Loss Alveolar Bone, Loss Periodontal Bone, Losses Alveolar Bone, Losses Periodontal Bone
Documents 60
Hot Single Events 21
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Alveolar Bone Loss. They are ordered first by their relevance to Alveolar Bone Loss and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT128644 Binding of Icam1 and Selp 2 0.39 0.57 0.25 5.00
2 INT349475 Regulation of Bax Regulation of Bcl2 1 0.07 1.35 0.17 5.00
3 INT349476 Bax Regulation of Bcl2 1 0.07 1.33 0.15 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Alveolar Bone Loss. They are ordered first by their pain relevance and then by number of times they were reported in Alveolar Bone Loss. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 100.00
2 INT125247 Negative_regulation of Mmp9 42 0.43 23.68 9.37 100.00
3 INT235200 Positive_regulation of Negative_regulation of ELANE 3 0.38 1.68 0.46 100.00
4 INT251907 Negative_regulation of Positive_regulation of MMP8 1 0.00 1.23 0.26 100.00
5 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 99.04
6 INT110806 Positive_regulation of Mmp8 7 0.46 1.64 0.67 98.56
7 INT3950 Gene_expression of Ptger2 293 0.77 122.28 62.42 98.48
8 INT95632 Positive_regulation of MMP8 26 0.70 10.06 9.96 98.28
9 INT25634 Binding of Mpo 21 0.48 14.78 4.39 96.28
10 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24 95.44
11 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 93.08
12 INT135319 Positive_regulation of Positive_regulation of CRP 20 0.50 26.45 5.61 93.08
13 INT106274 Positive_regulation of Syt1 16 0.67 9.76 4.1 90.32
14 INT2429 Negative_regulation of Mpo 128 0.59 93.76 39.57 88.84
15 INT57207 Protein_catabolism of Mpo 9 1.00 3.89 1.7 88.84
16 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 84.48
17 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 82.80
18 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 82.48
19 INT28891 Localization of Selp 13 0.60 8.23 2.83 81.84
20 INT144946 Localization of Icam1 21 0.75 21.84 5.33 81.84
21 INT73608 Localization of Nos2 21 0.75 9.58 5.05 81.84
22 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 79.76
23 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 78.44
24 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 77.56
25 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 75.92
26 INT11893 Positive_regulation of Ptger2 96 0.69 31.49 21.92 75.00
27 INT3174 Negative_regulation of Ptger2 43 0.38 20.95 13.43 75.00
28 INT11897 Gene_expression of Atp7b 25 0.13 7.85 12.5 75.00
29 INT11894 Negative_regulation of Gene_expression of Ptger2 47 0.55 16.95 11.59 75.00
30 INT11896 Negative_regulation of Atp7b 15 0.11 6.01 6.09 75.00
31 INT8555 Positive_regulation of co 18 0.09 3.15 2.41 75.00
32 INT6496 Gene_expression of co 18 0.24 3.33 2.24 75.00
33 INT11895 Regulation of Gene_expression of co 2 0.03 0.61 0.27 75.00
34 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 71.32
35 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 71.32
36 INT27822 Negative_regulation of HCFC1 1 0.58 0.48 0.13 64.96
37 INT65537 Positive_regulation of Positive_regulation of Nfkb1 52 0.67 30.6 26.35 61.68
38 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73 60.84
39 INT81531 Positive_regulation of Gene_expression of Nfkb1 27 0.69 13.9 11.04 60.84
40 INT22577 Positive_regulation of Gene_expression of Syt1 6 0.50 1.49 0.65 60.84
41 INT81530 Gene_expression of Nfkb1 93 0.78 48.58 32.58 60.20
42 INT22578 Gene_expression of Syt1 43 0.77 11.02 3.66 59.96
43 INT71374 Positive_regulation of Gene_expression of Il12a 5 0.22 7.49 3.8 59.92
44 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 59.92
45 INT318710 Positive_regulation of Gene_expression of Sept3 2 0.25 3.24 0.71 59.92
46 INT140906 Negative_regulation of Gene_expression of Il12a 4 0.38 5.28 1.86 57.48
47 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 57.48
48 INT318711 Negative_regulation of Gene_expression of Sept3 1 0.14 1.31 0.35 57.48
49 INT67401 Gene_expression of Il12a 25 0.55 20.04 11.12 57.04
50 INT318712 Gene_expression of Sept3 2 0.34 2.2 0.35 57.04
51 INT85877 Positive_regulation of Il12a 6 0.43 4.87 2.11 55.80
52 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 55.80
53 INT318709 Positive_regulation of Sept3 1 0.12 1.28 0.35 55.80
54 INT104744 Negative_regulation of Gene_expression of Ugt1a1 2 0.53 0.85 0 51.04
55 INT76501 Binding of Selp 16 0.41 8.51 3.4 50.60
56 INT81537 Regulation of Gene_expression of Nfkb1 10 0.57 7.09 7.48 50.48
57 INT146045 Regulation of Gene_expression of Syt1 4 0.21 0.84 0.4 50.48
58 INT147521 Regulation of Gene_expression of Ugt1a1 2 0.23 0.39 0.26 50.48
59 INT133783 Positive_regulation of Gene_expression of Ugt1a1 5 0.46 0.94 0.44 49.92
60 INT60475 Gene_expression of Ugt1a1 17 0.77 4.26 5.62 49.16
61 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 36.48
62 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 36.48
63 INT6481 Binding of TNF 624 0.48 510.2 214.82 29.48
64 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 24.96
65 INT349470 Regulation of Binding of Nos2 1 0.35 0 0 18.76
66 INT349471 Regulation of Binding of Selp 1 0.18 0 0 18.76
67 INT349474 Regulation of Binding of Icam1 1 0.25 0 0 18.76
68 INT126223 Binding of Nos2 17 0.37 6 3.22 18.32
69 INT74216 Binding of Icam1 16 0.48 10.11 2.69 18.32
70 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 15.80
71 INT55343 Localization of Ros1 39 0.60 34.51 12.5 15.32
72 INT2431 Positive_regulation of Mpo 275 0.70 211.99 78.47 13.44
73 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 11.72
74 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 11.72
75 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 11.32
76 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 10.16
77 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 8.00
78 INT150395 Binding of MEFV 55 0.44 31.18 3.42 7.44
79 INT4460 Regulation of Mpo 44 0.62 31.16 12.11 6.28
80 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.40
81 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.40
82 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 5.36
83 INT53189 Gene_expression of VSX1 32 0.69 10.59 7.21 5.20
84 INT2116 Negative_regulation of VSX1 29 0.36 10.67 1.89 5.20
85 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
86 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
87 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
88 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
89 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
90 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
91 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
92 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
93 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
94 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
95 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 5.00
96 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
97 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
98 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
99 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 5.00
100 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 5.00
101 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 5.00
102 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 5.00
103 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
104 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
105 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
106 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
107 INT47939 Gene_expression of Selp 171 0.76 87.54 39.03 5.00
108 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55 5.00
109 INT51017 Positive_regulation of Icam1 113 0.70 81.16 35.55 5.00
110 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
111 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 5.00
112 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 5.00
113 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 5.00
114 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27 5.00
115 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48 5.00
116 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01 5.00
117 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18 5.00
118 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91 5.00
119 INT11625 Localization of App 98 0.78 55.46 20.86 5.00
120 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
121 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46 5.00
122 INT38056 Localization of Crp 71 0.78 53.14 17.03 5.00
123 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 5.00
124 INT71510 Positive_regulation of Selp 47 0.68 30.43 12.8 5.00
125 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47 5.00
126 INT56985 Gene_expression of MEFV 56 0.71 46.71 9.47 5.00
127 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28 5.00
128 INT55342 Negative_regulation of Gene_expression of Ros1 49 0.37 31.62 8.93 5.00
129 INT92822 Negative_regulation of Gene_expression of Crp 36 0.49 29.5 8.83 5.00
130 INT62400 Positive_regulation of Localization of Il1 34 0.67 35.53 7.96 5.00
131 INT62944 Regulation of Icam1 33 0.47 23.52 7.94 5.00
132 INT70252 Gene_expression of Ugt1a6 20 0.77 3.89 7.45 5.00
133 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41 5.00
134 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14 5.00
135 INT54662 Positive_regulation of Positive_regulation of Il1 21 0.43 19.33 7.14 5.00
136 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72 5.00
137 INT141751 Localization of Syt1 21 0.78 11.19 5.98 5.00
138 INT91159 Negative_regulation of Ros1 35 0.44 26.12 5.97 5.00
139 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7 5.00
140 INT87468 Negative_regulation of Mmp2 24 0.57 10.79 5.55 5.00
141 INT145929 Regulation of Bax 20 0.60 18.12 5.35 5.00
142 INT141750 Positive_regulation of Localization of Syt1 10 0.67 5.53 5.28 5.00
143 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82 5.00
144 INT12104 Positive_regulation of PLG 45 0.68 28.94 4.81 5.00
145 INT1753 Gene_expression of Ache 38 0.78 15.31 4.58 5.00
146 INT125896 Negative_regulation of Gene_expression of Mmp9 15 0.43 13.73 4.18 5.00
147 INT45975 Positive_regulation of SAA1 17 0.67 19.7 4.15 5.00
148 INT192970 Negative_regulation of Hp 7 0.22 6.99 4.06 5.00
149 INT17685 Negative_regulation of Cog1 23 0.42 15.65 3.56 5.00
150 INT73802 Regulation of Selp 17 0.60 8.72 3.51 5.00
151 INT2117 Regulation of VSX1 15 0.30 3.38 3.38 5.00
152 INT70994 Negative_regulation of Positive_regulation of Icam1 8 0.51 3.49 3.12 5.00
153 INT27918 Positive_regulation of Klk1c7 6 0.36 2.89 2.84 5.00
154 INT104474 Gene_expression of Mmp8 15 0.71 3.1 2.76 5.00
155 INT59321 Transcription of Il1 13 0.50 9.73 2.68 5.00
156 INT174687 Regulation of Positive_regulation of Il6 10 0.61 9.07 2.61 5.00
157 INT107894 Gene_expression of Nfkbib 5 0.75 1.14 2.55 5.00
158 INT156093 Negative_regulation of Positive_regulation of Ros1 8 0.23 5.17 2.03 5.00
159 INT35146 Negative_regulation of PLG 27 0.57 17.63 1.98 5.00
160 INT33393 Positive_regulation of Gene_expression of PLEK 9 0.67 7.35 1.65 5.00
161 INT74586 Negative_regulation of MMP8 6 0.27 1.68 1.64 5.00
162 INT60571 Positive_regulation of Gsta4 8 0.45 3.76 1.44 5.00
163 INT80086 Regulation of Gene_expression of PLEK 5 0.60 2.79 1.29 5.00
164 INT131395 Positive_regulation of Gene_expression of Ugt1a6 6 0.69 1.86 1.23 5.00
165 INT103834 Regulation of RETNLB 4 0.04 3.87 1.02 5.00
166 INT151115 Regulation of Regulation of Bcl2 4 0.21 4.12 0.88 5.00
167 INT192761 Positive_regulation of Gene_expression of SAA1 5 0.40 7.45 0.82 5.00
168 INT144908 Gene_expression of SEA 15 0.52 3.81 0.79 5.00
169 INT79169 Binding of PLG 10 0.47 5.88 0.72 5.00
170 INT219610 Protein_catabolism of SAA1 2 0.90 4.47 0.54 5.00
171 INT45444 Binding of VSX1 5 0.30 3.38 0.5 5.00
172 INT222884 Negative_regulation of Transcription of Il1 3 0.05 2.68 0.49 5.00
173 INT131394 Negative_regulation of Gene_expression of Ugt1a6 2 0.43 0.89 0.39 5.00
174 INT278301 Gene_expression of HDLBP 2 0.08 3.09 0.37 5.00
175 INT178773 Positive_regulation of Regulation of App 2 0.49 1.01 0.32 5.00
176 INT48254 Negative_regulation of Klk1c8 3 0.13 2.09 0.29 5.00
177 INT132377 Negative_regulation of Binding of Nos2 5 0.29 0.75 0.28 5.00
178 INT258727 Localization of Apcs 2 0.37 2.49 0.28 5.00
179 INT16180 Regulation of DSPP 6 0.53 4.63 0.28 5.00
180 INT251897 Negative_regulation of Gene_expression of Mmp8 1 0.04 0.96 0.27 5.00
181 INT167751 Gene_expression of DSPP 15 0.77 8.56 0.24 5.00
182 INT258726 Positive_regulation of Nfxl1 1 0.05 1.89 0.18 5.00
183 INT193312 Localization of DSPP 8 0.74 1.88 0.18 5.00
184 INT278594 Binding of BOP 5 0.29 2.01 0.17 5.00
185 INT349473 Negative_regulation of Positive_regulation of Selp 1 0.17 0.38 0.17 5.00
186 INT172924 Gene_expression of BOP 8 0.47 3.15 0.14 5.00
187 INT251898 Negative_regulation of Transcription of Gsta4 1 0.08 1.04 0.11 5.00
188 INT251899 Transcription of Gsta4 1 0.10 1.04 0.1 5.00
189 INT251894 Regulation of Regulation of Lama5 1 0.01 1.07 0.08 5.00
190 INT251895 Regulation of Lama5 1 0.01 1.06 0.08 5.00
191 INT251896 Negative_regulation of Lama5 1 0.01 0.82 0.03 5.00
192 INT324671 Positive_regulation of DSPP 1 0.02 0.08 0 5.00
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