D:Alzheimer's Dementia

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Disease Term
Synonyms Acute Confusional Senile Dementia, Adhd Alzheimer S Disease Migraine, Alzheimer Dementia Presenile, Alzheimer Disease, ALZHEIMER DISEASE EARLY ONSET, Alzheimer Disease Late Onset, ALZHEIMER S, Alzheimer S Dementia, ALZHEIMER S DISEASE, Alzheimer S Disease Focal Onset, Alzheimer S Parkinson S
Documents 1559
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Alzheimer's Dementia. They are ordered first by their relevance to Alzheimer's Dementia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT267216 Binding of Cryab and Hspb8 1 0.36 9.29 0 100.00
2 INT267215 Binding of Cryab and Hspb1 1 0.25 7.19 0 100.00
3 INT286476 Binding of App and Itm2b 1 0.47 5.24 0.14 100.00
4 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83 100.00
5 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65 100.00
6 INT147434 Psenen Positive_regulation of APP 1 0.01 0.58 0.32 100.00
7 INT288099 Binding of APP and App 1 0.01 1.04 0.05 100.00
8 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39 100.00
9 INT162754 Negative_regulation of Binding of APP and Slc30a2 1 0.00 1.26 0.04 100.00
10 INT162753 Binding of APP and Slc30a2 1 0.00 1.25 0.04 100.00
11 INT237085 Binding of Bnip3l and Vcp 1 0.31 3.53 0.05 100.00
12 INT70082 Binding of APP and TGM1 1 0.00 1.22 0.22 100.00
13 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39 100.00
14 INT262708 Bace1 Positive_regulation of Gene_expression of App 1 0.44 2.82 0 100.00
15 INT114244 Cpox Negative_regulation of Gene_expression of APP 1 0.00 0.7 0.25 100.00
16 INT79577 APP Negative_regulation of PENK 1 0.12 0.35 0.4 100.00
17 INT108808 Binding of IAPP and INS 1 0.32 1.36 0.23 100.00
18 INT78854 APP Positive_regulation of Localization of IL6 1 0.14 0.79 0.37 100.00
19 INT25945 Plat Regulation of App 1 0.15 0.25 0.17 100.00
20 INT25947 Plat Regulation of Transcription of App 1 0.15 0.25 0.17 100.00
21 INT124376 Prodh2 Positive_regulation of App 1 0.00 0.66 0.33 100.00
22 INT124377 Prodh2 Negative_regulation of Defb40 1 0.00 0.66 0.33 100.00
23 INT124379 Prodh2 Positive_regulation of Localization of App 1 0.00 0.66 0.33 100.00
24 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07 100.00
25 INT168528 QRFP Regulation of FSIP1 2 0.07 1.32 0.93 100.00
26 INT172825 Binding of Crp and T2dm2 1 0.00 4.5 0.62 100.00
27 INT191616 Binding of Cbln1 and Nf1 1 0.01 0.2 0.32 100.00
28 INT191620 Binding of Nf1 and Gopc 1 0.08 0.2 0.32 100.00
29 INT50104 Bche Regulation of Localization of App 1 0.43 0.2 0 100.00
30 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44 100.00
31 INT237086 Binding of Bnip3l and Itm2b 1 0.28 1.66 0.03 100.00
32 INT70084 Negative_regulation of Binding of APP and TGM1 1 0.00 0.61 0.11 100.00
33 INT70083 TGM1 Positive_regulation of Binding of APP 1 0.00 0.61 0.11 100.00
34 INT124380 Prodh2 Regulation of Wnt2 1 0.00 0.63 0.35 100.00
35 INT25946 Regulation of Binding of Penk and App 1 0.18 0.19 0.27 100.00
36 INT25944 Binding of Penk and App 1 0.15 0.19 0.27 100.00
37 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95 100.00
38 INT343853 IRF6 Positive_regulation of PECAM1 1 0.00 0.53 0.43 100.00
39 INT68977 App Positive_regulation of Localization of Mmp9 1 0.05 0.38 0.3 100.00
40 INT146687 Regulation of Binding of App and Aph1a 1 0.16 0.58 0.19 100.00
41 INT146686 Binding of App and Aph1a 1 0.14 0.58 0.19 100.00
42 INT123101 Binding of APP and Ache 1 0.07 0.32 0.11 100.00
43 INT172822 Binding of Fga and T2dm2 1 0.01 2.24 0.31 100.00
44 INT139848 Binding of Bace1 and Bace2 2 0.28 0.31 0.18 100.00
45 INT191615 Binding of Nf1 and Flna 1 0.08 0.53 0.17 100.00
46 INT191621 Binding of Drd3 and Nf1 1 0.32 0.53 0.17 100.00
47 INT107635 KNG1 Regulation of Slc25a1 1 0.00 0.1 0.13 100.00
48 INT107634 Slc25a1 Regulation of AP4B1 1 0.00 0.1 0.13 100.00
49 INT107622 KNG1 Regulation of AP4B1 1 0.19 0.1 0.13 100.00
50 INT139849 Binding of App and Bace1 7 0.41 0.85 0.13 100.00
51 INT139851 Binding of MBTPS1 and Bace2 1 0.00 0.16 0.1 100.00
52 INT139847 Binding of App and Bace2 1 0.03 0.16 0.1 100.00
53 INT139850 Binding of MBTPS1 and App 1 0.00 0.16 0.1 100.00
54 INT262702 Bace1 Positive_regulation of Aplp2 1 0.14 0.25 0.09 100.00
55 INT262701 App Positive_regulation of Aplp2 1 0.12 0.25 0.09 100.00
56 INT262705 App Positive_regulation of Aplp1 1 0.13 0.25 0.09 100.00
57 INT262704 Bace1 Positive_regulation of Aplp1 1 0.15 0.25 0.09 100.00
58 INT220903 Regulation of Binding of Crp and Cd40 1 0.05 0.37 0.05 100.00
59 INT220906 Binding of Crp and Cd40 1 0.04 0.37 0.05 100.00
60 INT308648 Binding of sps and Gopc 1 0.01 2.71 0 100.00
61 INT220901 Regulation of Binding of Saa1 and Cd40 1 0.04 0.36 0 100.00
62 INT220908 Binding of Saa1 and Cd40 1 0.04 0.36 0 100.00
63 INT134391 Slc25a35 Positive_regulation of Localization of PTGER1 1 0.00 0.68 0.86 99.88
64 INT201274 Car2 Regulation of Gene_expression of Nos1 1 0.05 1.15 0.38 99.86
65 INT237089 Binding of Bnip3l and Atp6v0a4 1 0.12 1.67 0.03 99.86
66 INT135095 Negative_regulation of CTSB Negative_regulation of APP 1 0.00 0.74 0.3 99.52
67 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83 99.52
68 INT105434 TNF Positive_regulation of CPOX 1 0.27 0.75 0.12 99.52
69 INT10739 IL3 Positive_regulation of CRP 1 0.18 1.14 0.09 99.52
70 INT237090 Binding of App and Bnip3l 1 0.18 1.66 0.03 99.40
71 INT191609 Binding of Drd3 and Flna 1 0.06 0.42 0.17 99.26
72 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62 99.24
73 INT156557 TRPV6 Positive_regulation of BACE2 1 0.00 0.23 0.58 99.20
74 INT156558 TRPV6 Negative_regulation of BACE2 1 0.00 0.23 0.58 99.20
75 INT167617 Bace2 Positive_regulation of App 1 0.06 0.87 0.44 99.18
76 INT224921 Binding of TTR and TARM1 1 0.06 1.06 0 99.12
77 INT204478 Fmr1 Regulation of Gene_expression of App 1 0.50 1.44 0.16 98.80
78 INT167621 Psenen Positive_regulation of App 1 0.02 0.86 0.44 98.72
79 INT10740 IL3 Positive_regulation of TNF 1 0.29 1.14 0.09 98.72
80 INT205135 Binding of APOE and APP 1 0.05 0.35 0.08 98.52
81 INT204497 Fmr1 Regulation of Positive_regulation of Gria1 1 0.04 1.75 0.14 98.48
82 INT352270 Tnf Positive_regulation of GZMA 1 0.13 2.43 0.55 98.42
83 INT352268 Tnf Positive_regulation of Arl6ip6 1 0.02 2.42 0.54 98.42
84 INT139873 Negative_regulation of CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41 98.40
85 INT139874 CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41 98.40
86 INT105439 IL6 Positive_regulation of CPOX 1 0.11 0.75 0.12 98.40
87 INT350835 Binding of SELS and Sels 1 0.16 1.24 0.26 98.36
88 INT249600 IFNA1 Positive_regulation of Gene_expression of Cd40 1 0.49 1.13 0.52 98.08
89 INT298996 Il18 Positive_regulation of Gene_expression of Cdk5r1 1 0.03 1.65 0.29 98.04
90 INT298995 Il18 Positive_regulation of Gene_expression of Cdk5 1 0.12 1.65 0.29 98.04
91 INT299008 Il18 Positive_regulation of Transcription of Cdk5 1 0.12 1.65 0.29 98.04
92 INT299011 Il18 Positive_regulation of Transcription of Cdk5r1 1 0.03 1.65 0.29 98.04
93 INT286337 PSENEN Regulation of Psen1 1 0.07 0.37 0 97.90
94 INT191494 IL6 Positive_regulation of Binding of CRP 1 0.02 1.65 0.65 97.80
95 INT339582 AMD1 Regulation of C1QTNF5 1 0.07 2 0 97.44
96 INT50107 Ei24 Positive_regulation of Localization of CTSB 3 0.00 0.6 0.29 96.76
97 INT204489 Fmr1 Regulation of App 1 0.50 1.71 0.13 96.44
98 INT105436 IRF6 Positive_regulation of CPOX 1 0.08 0.74 0.11 95.20
99 INT236016 ROS1 Positive_regulation of MAPK8 2 0.18 1.81 0 95.12
100 INT267217 Gene_expression of Hspb8 Negative_regulation of Positive_regulation of Casp3 1 0.14 2.8 0.04 95.12
101 INT62030 Bche Regulation of Localization of CTSB 1 0.09 0.15 0.06 94.76
102 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62 94.60
103 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62 94.60
104 INT275670 Binding of HBP1 and DEFB103A 1 0.03 0.23 0.09 94.56
105 INT189200 Binding of CA2 and ITPR3 3 0.03 1.9 0.27 94.52
106 INT201273 Nos2 Regulation of Nos1 1 0.17 0.99 0.23 94.40
107 INT217396 Binding of Abca1 and App 1 0.26 0.83 0 94.40
108 INT134168 Binding of ADRA2B and APLP1 1 0.06 0.7 0.37 94.32
109 INT281881 Binding of Aco1 and Ros1 1 0.01 1.93 0.1 94.28
110 INT236015 HIST2H2AA3 Positive_regulation of Gene_expression of APP 1 0.02 0.95 0.04 93.72
111 INT267156 Binding of VDR and SUGT1 1 0.04 3.4 0.09 93.60
112 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15 93.52
113 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76 93.52
114 INT89936 Tlr4 Positive_regulation of Il6 3 0.49 0.95 0.7 93.52
115 INT223752 Tlr4 Positive_regulation of Il1 1 0.12 0.64 0.3 93.52
116 INT139980 Negative_regulation of CTSB Negative_regulation of Gene_expression of APP 1 0.15 0.7 0.26 93.40
117 INT316054 Eif1 Positive_regulation of Il6 1 0.00 0.78 0.21 93.20
118 INT316062 Ps Positive_regulation of Il6 1 0.04 0.77 0.21 93.20
119 INT267214 Hspb8 Negative_regulation of Cryab 1 0.32 1.56 0.06 92.96
120 INT139981 CTSB Negative_regulation of Gene_expression of APP 1 0.11 0.7 0.26 92.84
121 INT316063 Ps Positive_regulation of IL8 1 0.09 1.33 0.41 92.20
122 INT316065 Eif1 Positive_regulation of IL8 1 0.01 1.34 0.41 92.20
123 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54 91.72
124 INT262825 Serpinf1 Negative_regulation of Gfap 1 0.34 0.87 0.08 90.96
125 INT191611 Nf1 Regulation of ras 1 0.26 0.18 0.3 90.16
126 INT295921 Mir761 Positive_regulation of Gene_expression of Ndufv2 1 0.00 0.64 0 90.16
127 INT295919 Mir761 Regulation of Gene_expression of Ndufv2 1 0.00 0.64 0 90.16
128 INT172829 Binding of Nfkb1 and ISYNA1 1 0.00 2.06 0.17 90.08
129 INT172820 Binding of Nfkb1 and T2dm2 1 0.00 2.14 0.17 90.08
130 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14 89.84
131 INT78123 Positive_regulation of App Positive_regulation of Binding of App and 20S 1 0.05 0.61 0.4 89.68
132 INT302979 Binding of Gnb2l1 and Smpd2 1 0.07 0.71 0.09 89.52
133 INT189203 CHGB Regulation of CA2 1 0.04 0.95 0 89.44
134 INT189201 CHGB Regulation of Localization of CA2 1 0.04 0.95 0 89.44
135 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57 89.32
136 INT329847 PPARA Regulation of Gene_expression of CREB3L3 1 0.17 0.84 0.13 89.28
137 INT247600 Tlr4 Positive_regulation of Jun 1 0.05 0.52 0.17 89.24
138 INT302977 Binding of Cav1 and Smpd2 1 0.08 0.71 0.09 89.08
139 INT262821 Serpinf1 Negative_regulation of Gene_expression of Il18 1 0.54 0.85 0.08 89.04
140 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65 88.68
141 INT79593 Binding of Reg1 and LMTK2 1 0.00 0.32 0.53 88.44
142 INT290496 Binding of FANCB and Fcgrt 1 0.22 0.17 0 88.40
143 INT198927 Lrp1 Regulation of App 1 0.14 0.42 0 88.40
144 INT78121 Positive_regulation of Binding of App and 20S 1 0.23 0.61 0.4 88.32
145 INT262826 Serpinf1 Negative_regulation of Gene_expression of TNF 1 0.29 1.83 0.28 88.24
146 INT78122 Binding of App and 20S 1 0.16 0.61 0.4 87.92
147 INT52585 RPL35AP35 Positive_regulation of Positive_regulation of Ca2 1 0.00 0.34 0.24 87.20
148 INT184458 Il17a Positive_regulation of Transcription of Adamts1 1 0.05 0.87 0.18 87.20
149 INT354896 Binding of Psen2 and Fancd2 1 0.04 0.75 0.03 87.00
150 INT188693 Regulation of St6galnac2 Positive_regulation of Stab1 1 0.00 2.64 0.61 86.64
151 INT266381 Positive_regulation of Ager Positive_regulation of Nfkb1 1 0.00 0.77 0.55 86.24
152 INT331227 Binding of Becn1 and Pink1 1 0.03 1.13 0.05 86.04
153 INT343834 Binding of CD14 and IRF6 1 0.02 2.08 0.9 85.80
154 INT343844 Binding of IRF6 and LY96 1 0.01 1.03 0.4 85.80
155 INT188702 St6galnac2 Positive_regulation of Gene_expression of Stab1 1 0.00 5.09 1.23 85.72
156 INT188695 St6galnac2 Positive_regulation of Stab1 1 0.00 2.53 0.61 85.68
157 INT217398 Binding of Psen2 and Bace1 1 0.12 1.44 0 85.64
158 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0 85.64
159 INT217397 Binding of Bace1 and Alph1 1 0.02 0.73 0 85.64
160 INT217399 Binding of Bace1 and Ncstn 1 0.05 0.72 0 85.64
161 INT217402 Binding of Bace1 and PSENEN 1 0.02 0.72 0 85.64
162 INT151558 ERLEC1 Regulation of Atp2a1 1 0.00 0.64 0.53 85.64
163 INT151557 NARG2 Regulation of Atp2a1 1 0.01 0.64 0.53 85.64
164 INT151552 NARG2 Regulation of DNAH8 1 0.00 0.64 0.5 85.64
165 INT151553 ERLEC1 Regulation of DNAH8 1 0.00 0.64 0.5 85.64
166 INT270661 Regulation of Wnk1 Regulation of Napg 1 0.04 1.13 0.04 85.60
167 INT79592 Binding of APP and Reg1 1 0.01 0.16 0.27 85.52
168 INT188705 St6galnac2 Positive_regulation of Localization of Stab1 1 0.00 1.27 0.31 85.40
169 INT327366 Binding of Fap and Ttr 1 0.33 2.9 0.28 85.24
170 INT317895 Fos Regulation of Transcription of Egr1 1 0.41 1.03 0.17 85.24
171 INT317897 Egr1 Regulation of Transcription of Fosb 1 0.34 1.08 0.17 85.24
172 INT317889 Fos Regulation of Transcription of Fosb 1 0.30 1.08 0.17 85.24
173 INT317892 Egr1 Regulation of Transcription of Fos 1 0.41 1.03 0.17 85.24
174 INT238007 Binding of Cxcr3 and Saa 1 0.14 0.95 0.11 85.00
175 INT270659 Wnk1 Regulation of Napg 1 0.04 1.12 0.04 85.00
176 INT262822 Serpinf1 Negative_regulation of Negative_regulation of 1190002H23Rik 1 0.07 1.27 0.18 84.88
177 INT243468 Binding of SSTR1 and SSTR5 1 0.05 0.99 0.1 84.80
178 INT182804 Binding of ETV3 and T2DM 1 0.10 2.62 0 84.76
179 INT172837 ROS1 Positive_regulation of Nfkb1 1 0.00 2.11 0.16 84.68
180 INT234790 B4GALNT1 Positive_regulation of AGFG1 1 0.00 0.08 0 84.52
181 INT159996 Prkcg Regulation of Gene_expression of App 1 0.42 0.32 0.92 84.48
182 INT159993 App Regulation of Gene_expression of Bace1 1 0.46 0.32 0.92 84.48
183 INT159994 App Regulation of Gene_expression of Prkcg 1 0.42 0.32 0.92 84.48
184 INT264134 Binding of IFNA1 and Tlr4 1 0.01 1.5 0.22 84.28
185 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03 84.20
186 INT329799 Binding of CD14 and LY96 2 0.04 1.02 0.39 84.20
187 INT172827 ROS1 Positive_regulation of Tnf 1 0.01 2.1 0.16 84.12
188 INT198926 Binding of Apbb1 and Lrp1 5 0.12 2.18 0.24 84.08
189 INT167618 Rho Regulation of App 1 0.17 0.88 0.55 84.08
190 INT198921 Binding of App and Lrp1 3 0.32 2.7 0.03 84.08
191 INT188707 Binding of IFNA1 and Hand1 1 0.01 0.56 0.32 84.00
192 INT159995 Prkcg Regulation of Gene_expression of Bace1 1 0.39 0.32 0.91 83.96
193 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81 83.92
194 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55 83.20
195 INT70090 TGM1 Positive_regulation of Binding of Ache 1 0.03 0.59 0.15 83.20
196 INT72029 Binding of ADM and IAPP 1 0.12 0.26 0.13 83.12
197 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48 82.92
198 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 82.88
199 INT268446 Cdk5 Positive_regulation of Cdk5r1 1 0.02 0.58 0 82.56
200 INT142955 Positive_regulation of Binding of APP and BACE1 1 0.48 0.5 0 82.28

Single Events

The table below shows the top 200 pain related interactions that have been reported for Alzheimer's Dementia. They are ordered first by their pain relevance and then by number of times they were reported in Alzheimer's Dementia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT65500 Gene_expression of App 605 0.78 429.94 98.31 100.00
2 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 100.00
3 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 100.00
4 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 100.00
5 INT335733 Positive_regulation of Tardbp 8 0.69 28.41 0.41 100.00
6 INT29743 Negative_regulation of App 91 0.59 65.56 31.26 100.00
7 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38 100.00
8 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65 100.00
9 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83 100.00
10 INT16794 Binding of App 103 0.48 64.87 19.79 100.00
11 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5 100.00
12 INT65502 Regulation of App 77 0.62 52.05 19.44 100.00
13 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15 100.00
14 INT11625 Localization of App 98 0.78 55.46 20.86 100.00
15 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68 100.00
16 INT29745 Binding of APP 47 0.48 26.49 12.4 100.00
17 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48 100.00
18 INT292763 Localization of Tardbp 6 0.80 12.51 0.91 100.00
19 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2 100.00
20 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06 100.00
21 INT54052 Gene_expression of App 33 0.78 25.08 14.7 100.00
22 INT41569 Regulation of APP 32 0.62 17.15 9.4 100.00
23 INT303284 Regulation of Gene_expression of Tardbp 2 0.45 6.82 0 100.00
24 INT99262 Gene_expression of Defb42 16 0.31 9.99 7.38 100.00
25 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36 100.00
26 INT56031 Positive_regulation of App 25 0.69 13.46 7.37 100.00
27 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 100.00
28 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48 100.00
29 INT163544 Binding of Psen1 40 0.36 15.28 2.42 100.00
30 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09 100.00
31 INT50105 Localization of CTSB 29 0.78 10.98 5.21 100.00
32 INT69570 Binding of Prnp 75 0.48 44.26 4.37 100.00
33 INT107173 Phosphorylation of App 20 0.82 12.64 5.3 100.00
34 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 100.00
35 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19 100.00
36 INT120676 Localization of Tm2d1 1 0.28 2.79 0.3 100.00
37 INT1354 Negative_regulation of Acot1 87 0.43 15.01 36.44 100.00
38 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 100.00
39 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94 100.00
40 INT8089 Binding of Gnrh1 47 0.48 10.04 13.99 100.00
41 INT58003 Localization of APP 32 0.80 13.75 4.2 100.00
42 INT212189 Gene_expression of Sned1 1 0.59 7.18 1.65 100.00
43 INT87361 Negative_regulation of TTR 25 0.57 5.74 1.51 100.00
44 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34 100.00
45 INT212510 Binding of Apcs 26 0.48 15.2 0.72 100.00
46 INT99263 Localization of Defb42 7 0.16 4.03 4.46 100.00
47 INT78116 Positive_regulation of Gene_expression of App 12 0.70 10.78 4.52 100.00
48 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 100.00
49 INT99264 Negative_regulation of Gene_expression of Defb42 7 0.23 7.04 5.09 100.00
50 INT78733 Gene_expression of Iapp 20 0.78 12.99 3.33 100.00
51 INT3002 Binding of SUGT1 62 0.24 55.9 14.91 100.00
52 INT217389 Negative_regulation of Gene_expression of Bace1 43 0.59 18.57 3.27 100.00
53 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 100.00
54 INT344997 Regulation of Gene_expression of Rnrc 1 0.02 2.09 0 100.00
55 INT70089 Negative_regulation of Binding of APP 7 0.59 6.45 3.44 100.00
56 INT39008 Localization of App 13 0.77 9.07 2.05 100.00
57 INT45975 Positive_regulation of SAA1 17 0.67 19.7 4.15 100.00
58 INT48412 Gene_expression of Apcs 26 0.54 7.16 1.53 100.00
59 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 100.00
60 INT102254 Positive_regulation of Gene_expression of Prnp 72 0.70 38.11 4.81 100.00
61 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 100.00
62 INT210539 Binding of Ide 11 0.29 6.09 0.52 100.00
63 INT43085 Negative_regulation of Ide 28 0.39 19.96 3.45 100.00
64 INT147429 Negative_regulation of Positive_regulation of App 8 0.40 8.73 2.78 100.00
65 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 100.00
66 INT178772 Transcription of App 17 0.70 10.79 2.79 100.00
67 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 100.00
68 INT124250 Binding of APOA4 3 0.18 4.83 0.53 100.00
69 INT56030 Regulation of App 8 0.62 4.06 2.32 100.00
70 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 100.00
71 INT120675 Regulation of Localization of Tm2d1 1 0.11 1.4 0.15 100.00
72 INT670 Gene_expression of B2m 31 0.66 27.32 8.49 100.00
73 INT121117 Regulation of Protein_catabolism of App 10 0.62 6.41 1.78 100.00
74 INT99261 Negative_regulation of Localization of Defb42 5 0.11 2.71 2.83 100.00
75 INT355261 Positive_regulation of Saa3 1 0.31 5.37 0.25 100.00
76 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82 100.00
77 INT50106 Positive_regulation of Localization of CTSB 9 0.33 3.15 1.69 100.00
78 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 100.00
79 INT65536 Negative_regulation of Positive_regulation of Nfkb1 77 0.59 38.86 33.33 100.00
80 INT134173 Binding of APLP1 4 0.37 2.41 0.67 100.00
81 INT107915 Regulation of Negative_regulation of App 6 0.45 4.47 1.76 100.00
82 INT60749 Localization of IAPP 17 0.78 12.57 1.69 100.00
83 INT217382 Regulation of Gene_expression of Bace1 26 0.61 17 1.76 100.00
84 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94 100.00
85 INT25943 Transcription of App 5 0.53 1.79 1.44 100.00
86 INT210533 Negative_regulation of Binding of Ide 3 0.25 1.93 0.16 100.00
87 INT172794 Localization of Iapp 2 0.72 3.18 0.48 100.00
88 INT78731 Negative_regulation of Iapp 4 0.43 3.33 1.06 100.00
89 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 100.00
90 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33 100.00
91 INT61147 Protein_catabolism of App 3 0.60 3.76 0.63 100.00
92 INT125796 Regulation of Gene_expression of APP 8 0.59 5.95 1.41 100.00
93 INT20457 Regulation of Ptgs1 23 0.48 11.63 11.56 100.00
94 INT109908 Localization of MAPK8 10 0.73 3.86 2.14 100.00
95 INT162513 Regulation of Protein_catabolism of APP 5 0.51 1.79 2.36 100.00
96 INT208511 Positive_regulation of Use1 24 0.13 11.51 0.8 100.00
97 INT99819 Negative_regulation of Positive_regulation of APP 6 0.58 4.41 3.64 100.00
98 INT78117 Positive_regulation of Positive_regulation of App 4 0.48 2.6 0.51 100.00
99 INT54055 Regulation of Gene_expression of App 7 0.62 4.04 2.93 100.00
100 INT344991 Negative_regulation of Positive_regulation of Tardbp 1 0.43 0.81 0.05 100.00
101 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34 100.00
102 INT133863 Positive_regulation of Protein_catabolism of App 12 0.59 7.53 1.52 100.00
103 INT39009 Negative_regulation of App 6 0.38 3.37 1.07 100.00
104 INT121834 Gene_expression of IAPP 24 0.66 20.96 0.26 100.00
105 INT124772 Regulation of Binding of App 6 0.45 4.92 2.09 100.00
106 INT60547 Localization of Iapp 5 0.80 9.9 0.65 100.00
107 INT147431 Regulation of Gene_expression of Psenen 1 0.11 0.75 0.45 100.00
108 INT170444 Binding of Gopc 172 0.39 45.05 20.71 100.00
109 INT220592 Negative_regulation of Positive_regulation of Bace1 6 0.42 6.22 0.35 100.00
110 INT78990 Regulation of Cpox 72 0.57 35.22 18.16 100.00
111 INT605 Regulation of Acot1 61 0.62 10.7 26.34 100.00
112 INT99375 Positive_regulation of Binding of APP 3 0.61 1.63 0.83 100.00
113 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 100.00
114 INT112208 Negative_regulation of Gene_expression of App 4 0.59 1.88 0.68 100.00
115 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 100.00
116 INT110245 Gene_expression of SNCA 11 0.77 8.29 3.36 100.00
117 INT110244 Positive_regulation of Gene_expression of SNCA 5 0.69 4.66 1.19 100.00
118 INT134174 Gene_expression of APLP1 3 0.77 1.76 0.22 100.00
119 INT103488 Positive_regulation of Localization of App 5 0.50 3.05 1.28 100.00
120 INT56027 Positive_regulation of Ncam1 12 0.69 4.96 4.1 100.00
121 INT6437 Binding of YY1 154 0.47 26.3 90.46 100.00
122 INT25942 Regulation of Transcription of App 3 0.27 0.95 0.68 100.00
123 INT47706 Negative_regulation of Positive_regulation of Egr1 9 0.41 6.11 5.1 100.00
124 INT169747 Localization of AQP4 17 0.75 16.64 2.79 100.00
125 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85 100.00
126 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36 100.00
127 INT139321 Positive_regulation of Saa2 5 0.48 6.64 0.54 100.00
128 INT169424 Gene_expression of Tm2d1 1 0.63 1.31 0.24 100.00
129 INT35271 Negative_regulation of Apcs 12 0.59 8.05 1.36 100.00
130 INT92158 Gene_expression of Tm2d1 1 0.50 1.25 0.78 100.00
131 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33 100.00
132 INT205908 Positive_regulation of Hsd17b10 3 0.35 2.74 0.33 100.00
133 INT191968 Negative_regulation of Gene_expression of Ide 9 0.39 7.14 0.47 100.00
134 INT129700 Regulation of Positive_regulation of App 3 0.43 1.86 1.41 100.00
135 INT48137 Gene_expression of Saa1 3 0.61 4.36 0.63 100.00
136 INT106745 Localization of CRP 65 0.81 66.44 15.21 100.00
137 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 100.00
138 INT15161 Positive_regulation of Localization of VIP 12 0.50 3.3 7.87 100.00
139 INT7383 Localization of VIP 53 0.81 17.7 22.65 100.00
140 INT19967 Gene_expression of C9orf3 18 0.75 26.51 4.6 100.00
141 INT115817 Protein_catabolism of MAPT 1 0.64 1.21 0.1 100.00
142 INT205904 Gene_expression of Hsd17b10 8 0.57 2.58 1.45 100.00
143 INT114205 Negative_regulation of Hsd17b10 1 0.04 0.53 0.04 100.00
144 INT38056 Localization of Crp 71 0.78 53.14 17.03 100.00
145 INT142774 Regulation of Phosphorylation of App 1 0.59 2.27 1.93 100.00
146 INT5793 Binding of CTS 110 0.48 63.91 40.62 100.00
147 INT64175 Negative_regulation of Gene_expression of CPOX 66 0.38 39.64 23.07 100.00
148 INT106317 Negative_regulation of Gene_expression of S100A4 6 0.41 2.86 2.11 100.00
149 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12 100.00
150 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 100.00
151 INT169425 Regulation of Tm2d1 1 0.37 1.23 0.23 100.00
152 INT18844 Binding of IAPP 11 0.36 11.01 1.45 100.00
153 INT25076 Negative_regulation of Gene_expression of Il1 41 0.52 30.58 13.85 100.00
154 INT91769 Gene_expression of CDC42BPA 2 0.02 1.71 0.5 100.00
155 INT147433 Gene_expression of BRCA2 7 0.62 7.02 0.79 100.00
156 INT68675 Regulation of APCS 10 0.62 7.61 3.01 100.00
157 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 100.00
158 INT21782 Negative_regulation of B2M 11 0.46 5.49 1.92 100.00
159 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69 100.00
160 INT69045 Negative_regulation of Positive_regulation of App 1 0.05 0.28 0.13 100.00
161 INT232234 Positive_regulation of Positive_regulation of Saa 2 0.41 5.59 1.28 100.00
162 INT188125 Binding of Aplp2 2 0.22 0.64 0.04 100.00
163 INT163960 Localization of Saa 4 0.49 4.28 1.75 100.00
164 INT79244 Regulation of BACE2 1 0.03 1.21 0.32 100.00
165 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09 100.00
166 INT91172 Positive_regulation of Gene_expression of Pdgfrb 4 0.38 2.83 0.68 100.00
167 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 100.00
168 INT68297 Binding of MAPT 9 0.47 4.45 0.75 100.00
169 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25 100.00
170 INT67985 Regulation of Saa 9 0.44 9.36 3 100.00
171 INT15148 Gene_expression of Vip 51 0.77 25.61 18.33 100.00
172 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 100.00
173 INT24191 Binding of VIP 14 0.40 2.16 6.2 100.00
174 INT107633 Positive_regulation of AP4B1 4 0.52 1.67 1.28 100.00
175 INT10706 Regulation of Il6 150 0.62 93.23 62.34 100.00
176 INT193878 Negative_regulation of Ps 4 0.10 8.39 2.77 100.00
177 INT2683 Binding of SGSM3 6 0.36 7.98 1.2 100.00
178 INT44612 Positive_regulation of APOE 16 0.67 5.73 0.72 100.00
179 INT265901 Regulation of Localization of CRP 1 0.30 2 0.27 100.00
180 INT194049 Positive_regulation of Binding of CRP 3 0.48 4.48 0.24 100.00
181 INT50103 Regulation of Localization of App 2 0.26 0.2 0 100.00
182 INT234255 Transcription of APP 2 0.49 0.98 0 100.00
183 INT173851 Localization of FN1 20 0.76 13.95 1.97 100.00
184 INT167614 Positive_regulation of Protein_catabolism of App 1 0.30 0.88 0.44 100.00
185 INT167610 Positive_regulation of Protein_catabolism of Bace2 1 0.22 0.88 0.44 100.00
186 INT167613 Positive_regulation of Protein_catabolism of Psenen 1 0.09 0.88 0.44 100.00
187 INT167611 Protein_catabolism of Psenen 1 0.15 0.88 0.43 100.00
188 INT167616 Protein_catabolism of Ppp2cb 1 0.02 0.87 0.42 100.00
189 INT167615 Protein_catabolism of Bace2 1 0.40 0.88 0.42 100.00
190 INT212194 Gene_expression of ZFP2 1 0.01 0.36 0 100.00
191 INT100651 Regulation of Saa2 2 0.44 1.3 0.22 100.00
192 INT180102 Regulation of Protein_catabolism of Rock1 1 0.32 0.27 0.03 100.00
193 INT151036 Positive_regulation of Lcn2 13 0.49 8.57 2 100.00
194 INT151035 Negative_regulation of Lcn2 5 0.42 1.99 0.96 100.00
195 INT142112 Regulation of Regulation of App 3 0.39 2.46 0.59 100.00
196 INT180111 Protein_catabolism of Rock1 1 0.63 0.27 0.03 100.00
197 INT181526 Positive_regulation of Apcs 13 0.49 4.09 1.3 100.00
198 INT335076 Negative_regulation of Positive_regulation of Apcs 1 0.04 0.48 0.19 100.00
199 INT270304 Localization of FMOD 3 0.15 2.15 0.73 100.00
200 INT133864 Positive_regulation of Protein_catabolism of Psenen 1 0.09 0.9 0.19 100.00
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