D:Amblyopia

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Disease Term
Synonyms Amblyopia Anisometropic, Amblyopia Developmental, AMBLYOPIA STIMULUS DEPRIVATION INDUCED, AMBLYOPIA SUPPRESSION, Amblyopias, Amblyopias Anisometropic, AMBLYOPIAS DEVELOPMENTAL, Amblyopias Stimulus Deprivation Induced, Amblyopias Suppression, Anisometropic Amblyopia, Anisometropic Amblyopias
Documents 131
Hot Single Events 15
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Amblyopia. They are ordered first by their relevance to Amblyopia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT263776 Grin1 Positive_regulation of Ltp 2 0.17 0.17 0.54 5.00
2 INT268473 Negative_regulation of CNR1 Negative_regulation of Cysltr1 1 0.00 1.02 0.48 5.00
3 INT301043 P9Ehs1 Regulation of Trpv1 1 0.00 0.06 0.1 5.00
4 INT301041 Grm6 Regulation of Trpv1 1 0.00 0.06 0.1 5.00
5 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 5.00
6 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 5.00
7 INT301044 Binding of Csn2 and Trpm1 1 0.09 2.17 0.03 5.00
8 INT301042 Binding of Csn2 and Nyx 1 0.07 0.51 0 5.00
9 INT301045 Binding of Csn2 and Grm6 1 0.02 0.51 0 5.00
10 INT301046 Binding of BCS1L and Csn2 1 0.01 0.62 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Amblyopia. They are ordered first by their pain relevance and then by number of times they were reported in Amblyopia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT112372 Positive_regulation of GPSM2 8 0.41 5.49 1.94 99.24
2 INT146355 Negative_regulation of Aes 15 0.51 7.83 4.25 98.92
3 INT112373 Negative_regulation of Positive_regulation of GPSM2 1 0.38 1.87 0.73 98.44
4 INT11795 Negative_regulation of Helt 33 0.28 6.51 14.76 94.52
5 INT157121 Gene_expression of GAD2 15 0.67 7.21 5.91 92.00
6 INT318275 Negative_regulation of Gene_expression of GAD2 1 0.37 0.5 0.1 92.00
7 INT52180 Binding of Aes 38 0.42 23.16 6.7 88.88
8 INT158070 Localization of Aes 23 0.65 19.93 10.9 88.28
9 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 88.28
10 INT275875 Negative_regulation of Localization of Aes 2 0.19 3.87 1.8 88.28
11 INT155988 Regulation of Localization of ABAT 5 0.24 2.19 6.59 86.16
12 INT19488 Localization of ABAT 56 0.69 21.51 50.56 85.76
13 INT173545 Gene_expression of LR 16 0.09 13.1 0.69 82.72
14 INT28314 Negative_regulation of Gene_expression of Gabrg1 29 0.44 12.56 13.8 81.16
15 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 80.64
16 INT71807 Negative_regulation of Cp 18 0.58 8.9 1.88 79.68
17 INT305755 Positive_regulation of Negative_regulation of Cp 1 0.07 0.17 0.1 79.68
18 INT207830 Localization of GAD2 10 0.65 0.49 1.97 79.60
19 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 77.80
20 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 77.36
21 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 77.36
22 INT67620 Negative_regulation of Gene_expression of Bdnf 53 0.59 22.45 28.5 77.36
23 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 75.96
24 INT275878 Positive_regulation of Gene_expression of Aes 4 0.23 4.54 3.39 73.44
25 INT96637 Gene_expression of Gad2 21 0.76 8.15 9.53 70.96
26 INT292992 Negative_regulation of Gene_expression of GABRB3 3 0.15 0.78 2.41 67.08
27 INT318278 Regulation of Gene_expression of GABRB3 1 0.14 0.47 0.77 67.08
28 INT21132 Gene_expression of GABRB3 36 0.33 11.32 17.61 66.68
29 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 66.64
30 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51 65.60
31 INT91754 Gene_expression of Cp 42 0.77 21.97 5.38 64.96
32 INT131116 Localization of IGKV1-5 10 0.36 2.13 1.06 64.80
33 INT301040 Positive_regulation of NYX 1 0.49 1.11 0.16 63.76
34 INT266213 Positive_regulation of Grm6 2 0.46 1.88 0.16 63.16
35 INT157186 Regulation of Cps1 4 0.22 0.54 0.67 61.76
36 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 60.16
37 INT195681 Positive_regulation of Negative_regulation of APC 5 0.47 3.9 0 60.16
38 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 60.00
39 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11 59.80
40 INT18621 Binding of ABAT 28 0.36 9.88 18.04 58.00
41 INT92188 Positive_regulation of Isg15 4 0.19 2.21 0.8 55.48
42 INT305760 Positive_regulation of Positive_regulation of Isg15 1 0.09 0.3 0.13 55.48
43 INT178548 Localization of AAAS 1 0.70 1.52 0.07 53.40
44 INT76884 Positive_regulation of Cp 22 0.69 12.84 4.6 52.28
45 INT305757 Negative_regulation of Gene_expression of Isg15 1 0.09 0.15 0.08 52.16
46 INT305756 Gene_expression of Isg15 4 0.59 0.46 1.52 51.68
47 INT224413 Positive_regulation of CIMT 25 0.68 23.61 3.14 51.20
48 INT227456 Transcription of CIMT 1 0.15 0.23 0.08 51.20
49 INT305754 Regulation of Regulation of Cp 1 0.04 0.24 0.12 46.32
50 INT228262 Regulation of Cp 4 0.38 0.88 0.44 45.68
51 INT224415 Gene_expression of CIMT 28 0.57 12.35 1.15 44.48
52 INT227457 Positive_regulation of Gene_expression of CIMT 9 0.15 3.19 0.54 44.48
53 INT183560 Binding of GABRB3 12 0.23 2.59 3.77 42.56
54 INT310681 Negative_regulation of ARSB 1 0.56 6.95 0.29 40.32
55 INT301039 Positive_regulation of Gene_expression of Trpm1 1 0.46 0.55 0.23 35.04
56 INT179810 Protein_catabolism of Ecm1 30 0.11 18.28 5.75 34.88
57 INT159614 Gene_expression of Trpm1 13 0.77 9.47 1.25 34.36
58 INT243876 Gene_expression of GPHN 8 0.75 2.63 1.49 33.76
59 INT7898 Gene_expression of Homer1 123 0.78 31.52 53.67 23.72
60 INT305761 Positive_regulation of Regulation of Cp 1 0.06 0.13 0.16 21.28
61 INT102903 Regulation of Gene_expression of Bdnf 35 0.62 20.1 17.42 17.56
62 INT133231 Regulation of PYCARD 18 0.39 5.02 4.44 17.04
63 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 16.84
64 INT301035 Localization of Trpm1 1 0.80 2.46 0.37 13.16
65 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 11.48
66 INT121788 Localization of BCS1L 11 0.73 10.16 1.14 10.00
67 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 9.76
68 INT301029 Localization of Grm6 1 0.16 1.15 0.14 9.60
69 INT22329 Gene_expression of Ptprc 36 0.66 15.84 1.59 9.32
70 INT301028 Regulation of Trpm1 1 0.27 0.76 0.22 5.52
71 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 5.20
72 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
73 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
74 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
75 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
76 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 5.00
77 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
78 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
79 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
80 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
81 INT9516 Negative_regulation of Gabrg1 149 0.53 27.83 91.02 5.00
82 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91 5.00
83 INT13036 Positive_regulation of Positive_regulation of Ltp 105 0.51 23.71 77.66 5.00
84 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 5.00
85 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 5.00
86 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
87 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
88 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
89 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
90 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
91 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52 5.00
92 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43 5.00
93 INT92515 Gene_expression of Grin2a 84 0.76 26.68 38.37 5.00
94 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 5.00
95 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76 5.00
96 INT33768 Positive_regulation of Cysltr1 87 0.46 54.66 33.52 5.00
97 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 5.00
98 INT93451 Positive_regulation of Gene_expression of Grin2b 43 0.70 29.09 31.89 5.00
99 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
100 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 5.00
101 INT106554 Positive_regulation of Gene_expression of Bdnf 73 0.70 42.58 30.77 5.00
102 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 5.00
103 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
104 INT32826 Positive_regulation of Gene_expression of Ltp 52 0.45 10.34 26.8 5.00
105 INT57192 Binding of Ltp 43 0.41 17.48 24.96 5.00
106 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27 5.00
107 INT47818 Positive_regulation of Homer1 48 0.70 11.11 24.05 5.00
108 INT76249 Gene_expression of Gria1 67 0.75 15.07 22.78 5.00
109 INT10442 Negative_regulation of CNR1 47 0.59 20.88 20.2 5.00
110 INT33327 Positive_regulation of Gene_expression of Gabrg1 39 0.69 9.68 18.82 5.00
111 INT20260 Positive_regulation of Chkb 41 0.64 21.48 18.53 5.00
112 INT99058 Regulation of PAG1 18 0.45 21.62 18.5 5.00
113 INT7439 Positive_regulation of CFP 52 0.67 19.97 17.87 5.00
114 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
115 INT10187 Gene_expression of Il2ra 91 0.78 52.67 16.66 5.00
116 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 5.00
117 INT20264 Gene_expression of Chkb 29 0.46 13.14 13.65 5.00
118 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
119 INT52905 Gene_expression of Cd4 84 0.78 45.68 12.75 5.00
120 INT22030 Negative_regulation of Cysltr1 31 0.39 21.83 12.49 5.00
121 INT100799 Negative_regulation of Grin2a 27 0.57 7.33 12.2 5.00
122 INT12444 Binding of Gabrd 26 0.48 4.7 11.23 5.00
123 INT38255 Localization of Chkb 32 0.80 10.98 11.07 5.00
124 INT64193 Regulation of Grin2a 19 0.54 2.98 10.31 5.00
125 INT77877 Regulation of P9Ehs1 13 0.38 3.31 10.04 5.00
126 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 5.00
127 INT66819 Binding of CYP2C9 41 0.48 8.23 8.76 5.00
128 INT52243 Phosphorylation of Ltp 13 0.54 2.84 8.7 5.00
129 INT46112 Regulation of GAD1 15 0.52 11.09 8.37 5.00
130 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 5.00
131 INT97516 Binding of PYCARD 46 0.36 7.06 7.85 5.00
132 INT10444 Positive_regulation of Gene_expression of CNR1 18 0.69 8.69 7.84 5.00
133 INT10261 Negative_regulation of Pd 16 0.42 5.55 7.4 5.00
134 INT110705 Positive_regulation of Positive_regulation of Grin1 11 0.69 4.7 7.33 5.00
135 INT1766 Negative_regulation of PYCARD 25 0.37 6.54 6.76 5.00
136 INT137052 Positive_regulation of PYCARD 30 0.43 4.72 6.17 5.00
137 INT141151 Regulation of PSMD1 16 0.40 8.19 5.86 5.00
138 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73 5.00
139 INT208108 Localization of Grin2a 19 0.70 1.5 5.22 5.00
140 INT25831 Gene_expression of NR4A2 20 0.74 2.73 4.92 5.00
141 INT111947 Positive_regulation of Gene_expression of Grin2a 7 0.68 1.75 4.84 5.00
142 INT142488 Positive_regulation of Gene_expression of Chkb 7 0.23 4.09 4.54 5.00
143 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03 5.00
144 INT7437 Gene_expression of CFP 21 0.65 4.93 3.89 5.00
145 INT92516 Positive_regulation of Gene_expression of Grin1 8 0.45 2.53 3.77 5.00
146 INT232667 Binding of Pd 17 0.16 20.76 3.58 5.00
147 INT318271 Gene_expression of SLC32A1 7 0.44 2.74 3.28 5.00
148 INT63132 Positive_regulation of Pd 10 0.13 5.86 3.15 5.00
149 INT261712 Regulation of GABRB3 6 0.09 3.03 3.14 5.00
150 INT10443 Regulation of Gene_expression of CNR1 10 0.50 3.96 3.06 5.00
151 INT161812 Positive_regulation of PER1 17 0.56 5.64 2.93 5.00
152 INT156896 Gene_expression of Foxp3 11 0.76 7.62 2.92 5.00
153 INT161960 Regulation of lg 5 0.26 1.18 2.84 5.00
154 INT274527 Regulation of SYNM 3 0.20 2.68 2.7 5.00
155 INT292993 Positive_regulation of Gene_expression of GABRB3 4 0.17 0.9 2.63 5.00
156 INT97452 Positive_regulation of MOCS1 20 0.39 11.4 2.59 5.00
157 INT222892 Binding of CACNA2D2 2 0.23 2.78 2.42 5.00
158 INT242107 Positive_regulation of SYNM 8 0.38 2.82 2.39 5.00
159 INT165841 Gene_expression of BPIFA4P 17 0.65 6.48 2.38 5.00
160 INT89701 Binding of CYP2A6 4 0.36 0.92 2.23 5.00
161 INT21130 Positive_regulation of GABRB3 4 0.27 1.88 2.21 5.00
162 INT17747 Regulation of Cd4 14 0.41 10.02 2.12 5.00
163 INT9906 Binding of CYP2E1 15 0.40 1.89 2.08 5.00
164 INT248325 Positive_regulation of Localization of Aes 4 0.26 1.88 2.07 5.00
165 INT187994 Binding of CIMT 20 0.47 12.97 2.04 5.00
166 INT154372 Positive_regulation of Cd163 4 0.54 1.27 1.99 5.00
167 INT40104 Binding of Cysltr1 11 0.38 4.56 1.95 5.00
168 INT15506 Localization of Cp 11 0.80 4.26 1.9 5.00
169 INT36148 Binding of GAD1 10 0.41 7.91 1.47 5.00
170 INT114080 Negative_regulation of Negative_regulation of ABAT 3 0.38 1.53 1.47 5.00
171 INT59040 Regulation of Positive_regulation of Grin1 3 0.27 1.61 1.42 5.00
172 INT183557 Localization of GABRB3 3 0.46 1.01 1.34 5.00
173 INT274526 Localization of SYNM 1 0.33 1.36 1.34 5.00
174 INT242105 Positive_regulation of Positive_regulation of CFP 5 0.49 1.93 1.32 5.00
175 INT13530 Negative_regulation of GABRB3 4 0.17 1.48 1.31 5.00
176 INT248975 Positive_regulation of Csn2 4 0.10 0.66 1.31 5.00
177 INT12148 Positive_regulation of IGKV1-5 24 0.57 3.13 1.25 5.00
178 INT267652 Negative_regulation of Gene_expression of PYCARD 6 0.37 2.35 1.22 5.00
179 INT159618 Transcription of Trpm1 8 0.69 11.42 1.21 5.00
180 INT96643 Positive_regulation of Gene_expression of Gad2 3 0.49 0.15 1.18 5.00
181 INT292991 Negative_regulation of Localization of GABRB3 2 0.13 0.44 1.18 5.00
182 INT105991 Negative_regulation of IDS 12 0.38 6.31 1.04 5.00
183 INT161968 Positive_regulation of Gene_expression of GAD2 2 0.40 0.91 1.04 5.00
184 INT158278 Positive_regulation of Myst2 2 0.41 0.89 1.02 5.00
185 INT77856 Binding of Cps1 6 0.30 2.32 0.95 5.00
186 INT157846 Gene_expression of BCS1L 13 0.50 15.89 0.83 5.00
187 INT63137 Regulation of Pd 10 0.12 4.01 0.81 5.00
188 INT280447 Negative_regulation of Positive_regulation of MOCS1 1 0.00 0.75 0.69 5.00
189 INT275877 Positive_regulation of Positive_regulation of Chkb 1 0.07 0.35 0.68 5.00
190 INT287127 Gene_expression of Omd 6 0.39 1.63 0.67 5.00
191 INT47553 Gene_expression of ARSH 11 0.42 4.93 0.65 5.00
192 INT158279 Regulation of Myst2 2 0.37 0.51 0.65 5.00
193 INT63133 Gene_expression of Pd 13 0.18 5.31 0.61 5.00
194 INT180244 Positive_regulation of Gad2 4 0.49 1.07 0.61 5.00
195 INT101577 Regulation of Klrb1a 3 0.44 1.34 0.57 5.00
196 INT268472 Negative_regulation of Aoc2 1 0.12 0.93 0.56 5.00
197 INT243864 Gene_expression of DLG4 5 0.34 0.22 0.54 5.00
198 INT275876 Binding of Chkb 1 0.04 0.54 0.46 5.00
199 INT155265 Regulation of Cd3e 7 0.17 2.62 0.46 5.00
200 INT207836 Negative_regulation of GAD2 2 0.37 0.19 0.45 5.00
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