D:Amelanotic Melanoma

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pChart

Disease Term
Synonyms Amelanotic Melanomas, Melanomas Amelanotic
Documents 20
Hot Single Events 15
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Amelanotic Melanoma. They are ordered first by their relevance to Amelanotic Melanoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15 99.10
2 INT229785 Binding of RAB7A and SPTLC1 1 0.40 1.5 0.27 26.08
3 INT110835 Binding of SPTLC2 and SPTLC1 2 0.42 1.36 0.68 5.00
4 INT110834 Binding of AGXT and SPTLC2 2 0.27 0.71 0.36 5.00
5 INT285290 TNF Positive_regulation of Gene_expression of H2-D1 1 0.01 1.41 0.06 5.00
6 INT285288 TNF Positive_regulation of Gene_expression of Icam1 1 0.17 2.83 0 5.00
7 INT285289 TNF Positive_regulation of Icam1 1 0.23 1.44 0 5.00
8 INT285291 TNF Positive_regulation of Gene_expression of Vcam1 2 0.10 3.1 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Amelanotic Melanoma. They are ordered first by their pain relevance and then by number of times they were reported in Amelanotic Melanoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT91100 Binding of SPTLC1 10 0.47 12.85 5.71 99.92
2 INT49025 Positive_regulation of TYR 14 0.69 7.15 5.84 99.84
3 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55 99.84
4 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01 99.84
5 INT27935 Binding of Vim 21 0.36 15.65 2.61 98.12
6 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 97.12
7 INT101147 Gene_expression of Uchl1 31 0.76 14.73 13.22 96.24
8 INT49020 Negative_regulation of TYR 11 0.58 1.97 2.68 84.72
9 INT49027 Gene_expression of TYRP1 35 0.75 9.81 6.06 82.56
10 INT49024 Transcription of TYRP1 3 0.66 0.96 0.9 82.56
11 INT5789 Gene_expression of PMEL 23 0.75 13.18 2.67 81.28
12 INT49022 Transcription of PMEL 1 0.46 0.41 0.28 81.28
13 INT13010 Gene_expression of TYR 38 0.65 14.81 8.84 80.56
14 INT49021 Transcription of TYR 2 0.68 0.58 0.99 80.56
15 INT49023 Regulation of Gene_expression of TYR 1 0.27 0.42 0.28 80.56
16 INT71030 Binding of Mc1r 39 0.48 10.27 12.02 74.32
17 INT18995 Binding of CEL 23 0.47 14.46 4.5 74.32
18 INT40368 Positive_regulation of LRP5 5 0.49 3.19 3.51 66.08
19 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 60.72
20 INT50932 Positive_regulation of Positive_regulation of Il6 36 0.69 24.9 16.12 60.72
21 INT62844 Binding of HEXA 2 0.36 1.45 0.23 60.32
22 INT49026 Regulation of Positive_regulation of TYR 1 0.27 0.4 0.27 57.12
23 INT31528 Regulation of TYR 6 0.44 0.83 3.63 47.40
24 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 43.60
25 INT6852 Localization of TNF 883 0.81 705.95 270.84 38.20
26 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 12.32
27 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 12.32
28 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
29 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
30 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
31 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 5.00
32 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
33 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
34 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
35 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 5.00
36 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 5.00
37 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 5.00
38 INT48960 Gene_expression of SCG2 16 0.68 4.41 4.33 5.00
39 INT229788 Negative_regulation of SPTLC1 1 0.38 4.82 3.53 5.00
40 INT96150 Gene_expression of H2-D1 44 0.27 16.23 3.4 5.00
41 INT81955 Positive_regulation of SPTLC1 12 0.70 10.25 3.12 5.00
42 INT72870 Negative_regulation of SPTLC2 7 0.57 1.82 1.73 5.00
43 INT229794 Positive_regulation of RAB7A 2 0.65 11.68 1.31 5.00
44 INT110838 Regulation of AGXT 5 0.46 2.21 1.28 5.00
45 INT229791 Gene_expression of RAB7A 2 0.73 6.48 1.21 5.00
46 INT86670 Negative_regulation of AGXT 6 0.57 2.24 1.18 5.00
47 INT229792 Negative_regulation of Positive_regulation of RAB7A 1 0.40 1.49 1.17 5.00
48 INT229793 Negative_regulation of Positive_regulation of SPTLC1 1 0.43 1.49 1.17 5.00
49 INT66043 Regulation of SPTLC2 3 0.44 1.62 1.09 5.00
50 INT229787 Gene_expression of AGXT 4 0.16 0.94 1.08 5.00
51 INT148121 Gene_expression of KRT8 35 0.65 29.07 1.05 5.00
52 INT229789 Regulation of RAB7A 4 0.42 7.09 0.72 5.00
53 INT229786 Transcription of SPTLC1 1 0.60 0.78 0.71 5.00
54 INT66042 Positive_regulation of SPTLC2 2 0.68 0.97 0.66 5.00
55 INT110837 Binding of SPTLC2 1 0.36 0.7 0.35 5.00
56 INT229790 Regulation of Gene_expression of AGXT 1 0.11 0.47 0.24 5.00
57 INT179856 Gene_expression of Sdc1 4 0.75 3.88 0.03 5.00
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