D:Amenorrhea

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Disease Term
Synonyms Absence Of Menstruation, AMENIA, Amenorrhea Postpartum, AMENORRHOEA, Cessation Of Menses, Cessation Of Menstruation, Lack Of Menses, Menses Lack Of, Postpartum Amenorrhea, Postpartum Amenorrheas
Documents 35
Hot Single Events 7
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Amenorrhea. They are ordered first by their relevance to Amenorrhea and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85 5.00
2 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14 5.00
3 INT266764 TPSD1 Positive_regulation of F2RL1 Positive_regulation of Localization of SFTPA1 1 0.00 1.55 1.76 5.00
4 INT266768 NGF Positive_regulation of Localization of SFTPA1 1 0.01 1.65 1.6 5.00
5 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59 5.00
6 INT266771 Binding of NGF and GOPC 1 0.05 3.23 1.43 5.00
7 INT266769 IL2 Positive_regulation of Localization of IL4 1 0.00 1.03 0.72 5.00
8 INT266765 IL2 Positive_regulation of Localization of IL10 1 0.01 1.03 0.72 5.00
9 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32 5.00
10 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32 5.00
11 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32 5.00
12 INT266800 Dlst Positive_regulation of Localization of VEGFA 1 0.02 0.88 0.29 5.00
13 INT266766 Binding of PGR and GOPC 1 0.00 1.08 0.29 5.00
14 INT266803 Dlst Positive_regulation of VEGFA 1 0.01 0.96 0.25 5.00
15 INT266802 Dlst Positive_regulation of CCL5 1 0.00 0.95 0.25 5.00
16 INT266801 Dlst Positive_regulation of IL8 1 0.00 0.95 0.25 5.00
17 INT287174 Binding of PGR and SHBG 1 0.18 0.11 0.08 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Amenorrhea. They are ordered first by their pain relevance and then by number of times they were reported in Amenorrhea. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 95.48
2 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 88.60
3 INT2122 Negative_regulation of Localization of Gnrh1 226 0.59 26.92 92.04 88.60
4 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 86.84
5 INT19211 Binding of Shbg 35 0.48 16.29 3.31 84.92
6 INT98153 Positive_regulation of Binding of Shbg 1 0.11 0.7 0.08 84.92
7 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 84.12
8 INT1646 Negative_regulation of Localization of FSHR 17 0.58 7.36 3.46 77.96
9 INT912 Localization of FSHR 91 0.79 23.61 15.58 77.64
10 INT185518 Gene_expression of Vms1 2 0.22 2.16 0.25 69.36
11 INT313931 Positive_regulation of Gene_expression of Vms1 1 0.16 0.93 0.03 66.32
12 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
13 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
14 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
15 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
16 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
17 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
18 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
19 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
20 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
21 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
22 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
23 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
24 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
25 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
26 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
27 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
28 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 5.00
29 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
30 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
31 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
32 INT1793 Localization of CGA 379 0.81 67.38 114.69 5.00
33 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
34 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
35 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
36 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
37 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
38 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
39 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 5.00
40 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
41 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 5.00
42 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 5.00
43 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
44 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
45 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
46 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
47 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26 5.00
48 INT9489 Gene_expression of SFTPA1 112 0.66 55.38 66.45 5.00
49 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
50 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
51 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
52 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
53 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
54 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
55 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
56 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
57 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
58 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
59 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
60 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
61 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 5.00
62 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 5.00
63 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
64 INT5454 Localization of CRH 124 0.79 79.18 41.53 5.00
65 INT8835 Localization of SFTPA1 65 0.68 32.81 38.65 5.00
66 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
67 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
68 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22 5.00
69 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
70 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
71 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
72 INT5868 Positive_regulation of GNRH1 122 0.69 20.96 32.8 5.00
73 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
74 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 5.00
75 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 5.00
76 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11 5.00
77 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
78 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
79 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
80 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12 5.00
81 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94 5.00
82 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 5.00
83 INT8836 Positive_regulation of SFTPA1 36 0.47 28.37 23.59 5.00
84 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
85 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 5.00
86 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 5.00
87 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 5.00
88 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 5.00
89 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 5.00
90 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
91 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 5.00
92 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 5.00
93 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
94 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 5.00
95 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
96 INT84924 Positive_regulation of Gene_expression of NGF 29 0.68 17.91 16.46 5.00
97 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
98 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
99 INT153776 Positive_regulation of IL17A 42 0.64 34.58 14.82 5.00
100 INT71150 Binding of NGF 22 0.46 13.67 14.81 5.00
101 INT25493 Gene_expression of TFPI 74 0.76 39.44 14.78 5.00
102 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 5.00
103 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21 5.00
104 INT17035 Positive_regulation of TFPI 55 0.61 34.88 14.18 5.00
105 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 5.00
106 INT173505 Localization of Hand2 63 0.57 45.32 13.66 5.00
107 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 5.00
108 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 5.00
109 INT46619 Gene_expression of CSF1 80 0.73 36.63 12.94 5.00
110 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
111 INT5452 Regulation of CRH 56 0.62 15.32 12.42 5.00
112 INT11288 Negative_regulation of CRH 44 0.00 16.69 12.37 5.00
113 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 5.00
114 INT69158 Localization of IL4 48 0.71 31.3 11.98 5.00
115 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
116 INT4240 Positive_regulation of CCL5 32 0.58 20.55 10.65 5.00
117 INT110110 Gene_expression of ACCS 85 0.58 75.88 10.2 5.00
118 INT78895 Regulation of CCL5 30 0.46 20.45 10.18 5.00
119 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01 5.00
120 INT80549 Binding of ICAM1 53 0.47 42.76 9.72 5.00
121 INT87495 Positive_regulation of Gene_expression of CCL5 26 0.69 13.85 9.46 5.00
122 INT48233 Negative_regulation of Gene_expression of MMP1 34 0.58 12.94 9.08 5.00
123 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 5.00
124 INT65489 Regulation of Gene_expression of Crp 28 0.59 29.17 7.56 5.00
125 INT91667 Localization of IL12A 39 0.74 25.51 7.36 5.00
126 INT115213 Regulation of SFTPA1 13 0.32 6.91 7.11 5.00
127 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11 5.00
128 INT83531 Gene_expression of KITLG 54 0.65 26 7.07 5.00
129 INT20922 Positive_regulation of Localization of CRH 18 0.67 11.12 6.79 5.00
130 INT11150 Positive_regulation of Dlst 31 0.51 9.01 6.63 5.00
131 INT63374 Regulation of Gene_expression of NGF 12 0.45 5.6 6.4 5.00
132 INT118516 Positive_regulation of Positive_regulation of F2RL1 7 0.49 4.63 6.33 5.00
133 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 5.00
134 INT61417 Gene_expression of ITGAL 36 0.75 29.62 6.15 5.00
135 INT63177 Regulation of HP 71 0.44 39.48 5.86 5.00
136 INT57502 Positive_regulation of Gene_expression of CRH 30 0.70 23.37 5.7 5.00
137 INT87468 Negative_regulation of Mmp2 24 0.57 10.79 5.55 5.00
138 INT11622 Gene_expression of Coc 26 0.57 10.56 5.52 5.00
139 INT92447 Negative_regulation of Gene_expression of SFTPA1 6 0.35 2.81 5.43 5.00
140 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37 5.00
141 INT173584 Localization of IL17A 14 0.74 10.83 5.19 5.00
142 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 5.00
143 INT94433 Negative_regulation of TIMP2 16 0.55 9.38 4.78 5.00
144 INT2725 Positive_regulation of FCER2 23 0.69 23.08 4.7 5.00
145 INT98251 Binding of IL12A 20 0.37 16.03 4.51 5.00
146 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
147 INT81231 Gene_expression of LGALS3 26 0.74 9.38 3.66 5.00
148 INT46621 Positive_regulation of Gene_expression of CSF1 17 0.47 10.53 3.59 5.00
149 INT17685 Negative_regulation of Cog1 23 0.42 15.65 3.56 5.00
150 INT69155 Positive_regulation of Localization of IL4 13 0.40 10.18 3.56 5.00
151 INT3889 Regulation of Serpinc1 13 0.61 8.6 3.46 5.00
152 INT10594 Gene_expression of Dlst 33 0.57 6 3.38 5.00
153 INT57252 Negative_regulation of PGR 22 0.43 12.95 3.33 5.00
154 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
155 INT99574 Positive_regulation of KITLG 10 0.39 6.74 2.96 5.00
156 INT209033 Positive_regulation of Localization of IFN1@ 27 0.67 12.55 2.84 5.00
157 INT53733 Positive_regulation of FGFR3 6 0.45 1.32 2.76 5.00
158 INT176892 Binding of MR1 36 0.32 15.55 2.58 5.00
159 INT50006 Regulation of HLA-E 12 0.44 8.78 2.37 5.00
160 INT44544 Gene_expression of ENOPH1 18 0.76 10.28 2.35 5.00
161 INT15607 Localization of GNRHR 14 0.62 7.56 2.3 5.00
162 INT26863 Regulation of Vms1 7 0.09 2.67 2.23 5.00
163 INT111113 Binding of CYP19A1 15 0.36 9.17 2.12 5.00
164 INT263046 Negative_regulation of Gene_expression of Mmp2 7 0.34 5.98 2.09 5.00
165 INT3797 Positive_regulation of Gene_expression of Ighm 16 0.47 9.4 2.01 5.00
166 INT57339 Negative_regulation of HLA-DRA 17 0.49 7.67 1.96 5.00
167 INT91663 Positive_regulation of Localization of IL12A 9 0.27 5.91 1.95 5.00
168 INT80798 Positive_regulation of Chd7 16 0.14 7.95 1.95 5.00
169 INT125820 Localization of TPSD1 13 0.70 2.19 1.7 5.00
170 INT95134 Binding of TH1L 6 0.47 3.67 1.68 5.00
171 INT33496 Positive_regulation of Gene_expression of FSHR 14 0.46 6.05 1.66 5.00
172 INT62430 Negative_regulation of HLA-A 5 0.32 4.3 1.63 5.00
173 INT32688 Positive_regulation of Gene_expression of Shbg 14 0.45 7.01 1.6 5.00
174 INT7033 Binding of FSHR 19 0.37 6.66 1.52 5.00
175 INT171015 Positive_regulation of Positive_regulation of CCL5 3 0.42 3.63 1.51 5.00
176 INT43479 Positive_regulation of Positive_regulation of CGA 9 0.39 4.24 1.46 5.00
177 INT26859 Negative_regulation of Vms1 10 0.29 3.05 1.37 5.00
178 INT185519 Binding of Vms1 5 0.12 4.58 1.37 5.00
179 INT100621 Localization of HLA-DRA 7 0.40 2.86 1.2 5.00
180 INT250894 Positive_regulation of Localization of IL17A 5 0.46 2.49 1.19 5.00
181 INT26860 Positive_regulation of Vms1 7 0.41 3.21 1.18 5.00
182 INT3046 Gene_expression of LGALS1 20 0.75 12.48 1.11 5.00
183 INT45675 Regulation of Gene_expression of Shbg 6 0.15 4.65 1.03 5.00
184 INT232492 Gene_expression of MROS 5 0.57 4.13 1.02 5.00
185 INT266793 Positive_regulation of IL17F 2 0.04 2.55 0.89 5.00
186 INT219184 Localization of IL17F 2 0.05 1.62 0.78 5.00
187 INT203682 Negative_regulation of MROS 5 0.36 3.71 0.74 5.00
188 INT266797 Negative_regulation of Negative_regulation of Mmp2 1 0.05 0.96 0.7 5.00
189 INT266789 Positive_regulation of Localization of IL17F 1 0.03 1.05 0.58 5.00
190 INT266795 Negative_regulation of FBXW11 1 0.02 1.07 0.57 5.00
191 INT185520 Regulation of Binding of Vms1 2 0.09 0.86 0.57 5.00
192 INT266796 Regulation of FBXW11 1 0.02 1.07 0.57 5.00
193 INT207475 Binding of LGALS3 6 0.34 2.48 0.57 5.00
194 INT266788 Protein_catabolism of FBXW11 1 0.05 1.07 0.53 5.00
195 INT78661 Positive_regulation of Gene_expression of Dlst 4 0.24 1.23 0.51 5.00
196 INT119991 Regulation of MROS 5 0.23 4.75 0.48 5.00
197 INT266786 Binding of ASAH1 2 0.11 3.87 0.44 5.00
198 INT284164 Localization of Chd7 3 0.25 1.32 0.41 5.00
199 INT266784 Regulation of ERAS 2 0.28 1.73 0.37 5.00
200 INT213186 Localization of Wise 1 0.04 3.72 0.31 5.00
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