D:Amphetamine Dependence

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Disease Term
Synonyms Abuse Amphetamine, Addiction Amphetamine, Amphetamine Abuse, Amphetamine Addiction, Amphetamine Related Disorders, Amphetamine Use Disorder, Amphetamine User, Amphetamine Users, Dependence Amphetamine, DISORDER AMPHETAMINE RELATED, Disorders Amphetamine Related
Documents 64
Hot Single Events 13
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Amphetamine Dependence. They are ordered first by their relevance to Amphetamine Dependence and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT214366 Ins1 Regulation of Slc6a3 1 0.11 0.09 0.25 47.28
2 INT214367 Amph Positive_regulation of Localization of Ubqln1 1 0.01 0 0.21 25.00
3 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43 5.00
4 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41 5.00
5 INT214370 Slc6a3 Regulation of Amph 1 0.14 0.44 0.82 5.00
6 INT214368 Pik3cb Regulation of Ubqln1 1 0.01 0.36 0.68 5.00
7 INT214374 Pik3cb Regulation of Gene_expression of Slc6a3 1 0.37 0.3 0.35 5.00
8 INT214377 Akt1 Regulation of Amph 1 0.15 0 0.33 5.00
9 INT214371 Amph Positive_regulation of Ubqln1 1 0.01 0 0.3 5.00
10 INT214373 Negative_regulation of Amph Positive_regulation of Ubqln1 1 0.01 0 0.3 5.00
11 INT214376 Ubqln1 Regulation of Flvcr2 1 0.00 0 0.19 5.00
12 INT214375 Amph Regulation of Ubqln1 1 0.00 0 0.16 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Amphetamine Dependence. They are ordered first by their pain relevance and then by number of times they were reported in Amphetamine Dependence. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT117459 Positive_regulation of Hmgb2 1 0.23 1.16 2.23 99.40
2 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 97.72
3 INT214347 Binding of Ptprq 2 0.09 0.23 0.26 95.84
4 INT214352 Regulation of Ptprq 1 0.02 0.17 0.2 95.84
5 INT26534 Regulation of Akt1 34 0.61 14.47 11.86 94.48
6 INT214355 Binding of Akt1 13 0.36 3.72 2.59 94.48
7 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 93.84
8 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 93.84
9 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 93.04
10 INT314783 Localization of ORC1 1 0.25 0.62 0.25 92.40
11 INT28728 Regulation of Cfp 49 0.46 13.15 21.43 88.12
12 INT114080 Negative_regulation of Negative_regulation of ABAT 3 0.38 1.53 1.47 87.08
13 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 86.76
14 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 69.28
15 INT314784 Binding of ORC1 1 0.13 0.84 0.1 50.00
16 INT54356 Regulation of Slc6a3 48 0.58 5.86 15.24 47.28
17 INT12398 Regulation of Flvcr2 11 0.39 1.8 9.47 34.56
18 INT353545 Negative_regulation of Olr1740-ps 1 0.11 0.29 0.18 32.16
19 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 25.00
20 INT80791 Gene_expression of Slc6a3 113 0.78 11.89 25.76 25.00
21 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39 25.00
22 INT6110 Negative_regulation of Gene_expression of Ins1 83 0.56 60.59 16.07 25.00
23 INT94573 Negative_regulation of Pik3cb 42 0.50 15.83 15.4 25.00
24 INT30193 Localization of Ubqln1 20 0.12 1.69 11.09 25.00
25 INT139749 Regulation of Ubqln1 10 0.02 2.47 5.38 25.00
26 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08 25.00
27 INT30194 Positive_regulation of Localization of Ubqln1 5 0.08 0 2.99 25.00
28 INT52256 Negative_regulation of Amph 3 0.38 0.42 2.94 25.00
29 INT32675 Regulation of Amph 3 0.39 0.45 2.9 25.00
30 INT93918 Localization of Amph 2 0.62 0.89 2.73 25.00
31 INT32676 Positive_regulation of Amph 4 0.50 0.38 2.36 25.00
32 INT154497 Gene_expression of Ptprq 3 0.04 0.91 1.31 25.00
33 INT214356 Negative_regulation of Localization of Ubqln1 1 0.01 0.17 0.51 25.00
34 INT214353 Negative_regulation of Gene_expression of Ptprq 1 0.03 0 0.27 25.00
35 INT1114 Localization of Ins1 748 0.80 192.95 165.48 5.00
36 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 5.00
37 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 5.00
38 INT19488 Localization of ABAT 56 0.69 21.51 50.56 5.00
39 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43 5.00
40 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 5.00
41 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 5.00
42 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76 5.00
43 INT12392 Regulation of Slc3a1 45 0.36 7.57 25.66 5.00
44 INT61825 Negative_regulation of Slc6a3 47 0.59 6.52 21.27 5.00
45 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 5.00
46 INT30197 Positive_regulation of Ubqln1 26 0.08 2.07 18.28 5.00
47 INT65214 Binding of Slc6a3 54 0.48 4.77 16.79 5.00
48 INT13989 Negative_regulation of Slc3a1 27 0.24 5.34 16.76 5.00
49 INT120966 Positive_regulation of Pik3cb 34 0.68 15.15 16.59 5.00
50 INT2578 Binding of Ins1 74 0.48 33.57 12.92 5.00
51 INT28458 Localization of Slc6a3 31 0.76 2.33 12.49 5.00
52 INT80790 Positive_regulation of Flvcr2 22 0.45 4.92 12.35 5.00
53 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 5.00
54 INT64225 Positive_regulation of Localization of ABAT 15 0.60 4.46 11.28 5.00
55 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 5.00
56 INT30195 Gene_expression of Ubqln1 12 0.10 1.09 5.89 5.00
57 INT71362 Negative_regulation of Ubqln1 5 0.04 1.31 5.63 5.00
58 INT95048 Negative_regulation of ADHD1 61 0.51 56.01 5.62 5.00
59 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 5.00
60 INT97885 Regulation of LOC500077 7 0.16 2.93 4.33 5.00
61 INT183479 Positive_regulation of Gene_expression of Slc6a3 16 0.57 0.91 4.13 5.00
62 INT88274 Positive_regulation of Drd4 7 0.69 3.48 4.1 5.00
63 INT92017 Regulation of Gene_expression of Flvcr2 3 0.18 1.69 3.75 5.00
64 INT214362 Negative_regulation of Gene_expression of Slc6a3 7 0.41 1.58 3.67 5.00
65 INT214348 Regulation of Localization of Ubqln1 3 0.01 0.29 2.57 5.00
66 INT52253 Gene_expression of Amph 4 0.49 0.36 2.2 5.00
67 INT30196 Positive_regulation of Gene_expression of Ubqln1 4 0.08 0.29 2.06 5.00
68 INT149335 Gene_expression of Pik3cb 10 0.57 2.93 1.82 5.00
69 INT157720 Localization of ADHD1 15 0.64 15.84 1.69 5.00
70 INT214351 Regulation of Localization of Amph 1 0.30 0 1.56 5.00
71 INT40771 Positive_regulation of Iars 6 0.36 2.1 1.33 5.00
72 INT227500 Negative_regulation of Gene_expression of ADHD1 5 0.34 4.9 1.32 5.00
73 INT145488 Regulation of Cyp2d4 5 0.45 1.1 1.19 5.00
74 INT117458 Phosphorylation of Slc3a1 1 0.10 0.29 0.79 5.00
75 INT117460 Negative_regulation of Positive_regulation of Hmgb2 1 0.20 0.47 0.72 5.00
76 INT117461 Regulation of Positive_regulation of Hmgb2 1 0.21 0.46 0.69 5.00
77 INT214361 Negative_regulation of Gene_expression of Amph 1 0.28 0.09 0.35 5.00
78 INT214364 Positive_regulation of Negative_regulation of Pik3cb 1 0.42 0.19 0.25 5.00
79 INT214358 Positive_regulation of Regulation of Ubqln1 1 0.01 0.08 0.25 5.00
80 INT282635 Positive_regulation of Binding of ADHD1 4 0.40 3.62 0.24 5.00
81 INT214363 Negative_regulation of Localization of Amph 1 0.28 0.17 0.21 5.00
82 INT332757 Regulation of Binding of ADHD1 1 0.34 1.71 0.13 5.00
83 INT214360 Negative_regulation of Binding of Akt1 2 0.41 0.09 0.12 5.00
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