D:Amputation

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Disease Term
Synonyms Amputation Traumatic, AMPUTATIONS TRAUMATIC, Traumatic Amputation, Traumatic Amputations
Documents 2700
Hot Single Events 200
Hot Interactions 9

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Amputation. They are ordered first by their relevance to Amputation and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT118839 VEGFA Positive_regulation of Mb 1 0.13 0.15 0.03 88.04
2 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86 87.76
3 INT182819 Binding of CD63 and PECAM1 1 0.00 1.63 0.61 85.84
4 INT182815 Binding of CD63 and ICAM1 1 0.00 1.63 0.61 85.84
5 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 85.40
6 INT170127 Binding of ITGAL and PECAM1 2 0.01 2.71 0.75 85.40
7 INT182814 Binding of ICAM1 and PECAM1 2 0.02 3.32 0.77 85.00
8 INT194021 Cysltr1 Negative_regulation of Acc 1 0.02 1.2 0.91 84.84
9 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94 80.40
10 INT348924 Mmp1 Regulation of Gene_expression of Renbp 1 0.03 0.95 0.26 76.04
11 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 73.80
12 INT118838 Gene_expression of Vegfa Positive_regulation of Gene_expression of Mb 1 0.44 0.4 0.22 50.52
13 INT305335 Olfr927-ps1 Negative_regulation of Akr1b3 1 0.02 1.6 0.17 50.24
14 INT244338 Slc12a7 Positive_regulation of SERPINH1 1 0.00 0.26 0.13 46.40
15 INT118840 VEGFA Regulation of Positive_regulation of Mb 1 0.05 0.36 0.23 40.56
16 INT292990 SGCG Positive_regulation of Gene_expression of GABRB3 1 0.01 0.29 0.87 26.96
17 INT292987 SGCG Positive_regulation of NCOR2 1 0.00 0.29 0.87 26.16
18 INT292988 Negative_regulation of SGCG Positive_regulation of GABRB3 1 0.01 0.3 0.89 25.36
19 INT292989 SGCG Positive_regulation of GABRB3 1 0.01 0.29 0.87 25.36
20 INT244656 Binding of S100B and SLC4A1 1 0.14 1.72 0.03 21.60
21 INT323803 NFAT5 Positive_regulation of Regulation of COL5A2 1 0.07 0.46 0.16 13.28
22 INT323805 NFAT5 Regulation of COL5A2 1 0.07 0.46 0.16 13.28
23 INT209591 Car2 Positive_regulation of Positive_regulation of Ltp 1 0.05 0 0.54 7.28
24 INT209592 Car2 Positive_regulation of Localization of Ltp 1 0.05 0 0.54 7.28
25 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
26 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 5.00
27 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 5.00
28 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14 5.00
29 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57 5.00
30 INT231968 Binding of Cpn1 and Rvm 1 0.11 1.57 2.45 5.00
31 INT231970 Binding of Cpn1 and Pag1 1 0.07 1.56 2.44 5.00
32 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28 5.00
33 INT231971 Binding of Cpn1 and Shbdp1 1 0.04 1.39 2.26 5.00
34 INT228454 Ngf Positive_regulation of Phosphorylation of Trpv1 1 0.39 2.97 2.26 5.00
35 INT231967 Binding of Psmd1 and Cpn1 1 0.06 1.39 2.25 5.00
36 INT231969 Binding of Cfp and Cpn1 1 0.05 1.38 2.25 5.00
37 INT351380 Ngf Regulation of TPM1 1 0.44 2.17 2.11 5.00
38 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42 5.00
39 INT190128 Positive_regulation of PTGER1 Negative_regulation of Gene_expression of CPOX 1 0.04 1.21 1.38 5.00
40 INT341336 Binding of Pepd and Nav1 1 0.07 0.92 1.3 5.00
41 INT261841 Mastl Positive_regulation of Trpa1 1 0.00 0.82 1.3 5.00
42 INT190130 Binding of CPOX and MRXS5 1 0.00 1.4 1.23 5.00
43 INT351379 Ngf Positive_regulation of Binding of Ngf and Ntrk1 1 0.38 0.63 1.21 5.00
44 INT334351 Bdnf Regulation of Positive_regulation of Ephb1 1 0.18 1.27 1.2 5.00
45 INT351373 Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18 5.00
46 INT351378 Gene_expression of Ngf Positive_regulation of Ntrk1 1 0.35 0.41 1.18 5.00
47 INT351377 Gene_expression of Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18 5.00
48 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
49 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09 5.00
50 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08 5.00
51 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98 5.00
52 INT219279 Ctss Positive_regulation of Gene_expression of Fam64a 1 0.06 1.39 0.96 5.00
53 INT219273 Fam64a Positive_regulation of Gene_expression of Ctss 1 0.06 1.39 0.96 5.00
54 INT115656 Glp1r Positive_regulation of Localization of Ins1 2 0.42 5.23 0.91 5.00
55 INT334358 Rvm Positive_regulation of Ephb1 1 0.17 0.98 0.82 5.00
56 INT334359 Negative_regulation of Rvm Positive_regulation of Ephb1 1 0.16 0.99 0.82 5.00
57 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78 5.00
58 INT219274 Binding of Cx3cr1 and Cx3cl1 1 0.17 1.08 0.74 5.00
59 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71 5.00
60 INT351374 Mir470 Negative_regulation of Ntrk3 1 0.00 1.55 0.7 5.00
61 INT351375 Mir470 Negative_regulation of Ntrk2 1 0.01 1.54 0.7 5.00
62 INT351376 Mir470 Negative_regulation of Ntrk1 1 0.01 1.54 0.7 5.00
63 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69 5.00
64 INT209593 Negative_regulation of Adcy1 Negative_regulation of Positive_regulation of Ltp 1 0.10 0 0.69 5.00
65 INT209250 TRPV1 Positive_regulation of Localization of DRGX 1 0.06 0.82 0.68 5.00
66 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66 5.00
67 INT184193 HRAS Negative_regulation of Gene_expression of IL1B 1 0.00 1.12 0.65 5.00
68 INT261832 Trpv1 Negative_regulation of Trpa1 1 0.10 0.58 0.64 5.00
69 INT261830 Hspg2 Negative_regulation of Trpa1 1 0.01 0.58 0.63 5.00
70 INT219277 Mapkapk2 Positive_regulation of Pla2g1b 1 0.03 0.46 0.61 5.00
71 INT219278 Mapkapk2 Positive_regulation of Pla2g2a 1 0.05 0.46 0.61 5.00
72 INT219280 Mapk14 Positive_regulation of Pla2g2a 1 0.33 0.46 0.61 5.00
73 INT219282 Mapk14 Positive_regulation of Pla2g1b 1 0.18 0.46 0.61 5.00
74 INT175700 Nos3 Negative_regulation of smc 1 0.01 1.05 0.59 5.00
75 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58 5.00
76 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58 5.00
77 INT182813 EEF1A2 Negative_regulation of ITGAL 1 0.10 1.53 0.51 5.00
78 INT314756 IL6 Positive_regulation of Gene_expression of Crp 2 0.13 4.58 0.48 5.00
79 INT261839 Binding of Car2 and Trpv1 1 0.03 0 0.45 5.00
80 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39 5.00
81 INT166792 Binding of CD44 and HRAS 3 0.12 1.49 0.37 5.00
82 INT334393 IL6 Positive_regulation of Tnf 1 0.16 1.41 0.35 5.00
83 INT333893 Negative_regulation of HDAC9 Negative_regulation of Gene_expression of TNF 1 0.09 1.03 0.34 5.00
84 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3 5.00
85 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3 5.00
86 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28 5.00
87 INT329369 Jun Regulation of Gene_expression of Il12a 1 0.00 1.48 0.27 5.00
88 INT305334 Jun Positive_regulation of Gene_expression of Tcstv1 1 0.00 1.04 0.27 5.00
89 INT220317 Binding of CPB1 and PLEKHM1 1 0.00 0.93 0.26 5.00
90 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25 5.00
91 INT184192 IL1B Positive_regulation of SPAM1 1 0.04 0.49 0.24 5.00
92 INT329368 Ccl2 Negative_regulation of Jun 1 0.01 1.87 0.24 5.00
93 INT334390 ADIPOQ Positive_regulation of Localization of INS 1 0.09 1.3 0.23 5.00
94 INT261842 Pla2g6 Positive_regulation of Trpm8 1 0.03 0 0.23 5.00
95 INT333892 TNF Positive_regulation of Gene_expression of HDAC1 1 0.09 0.46 0.23 5.00
96 INT184191 IL1B Positive_regulation of Gene_expression of SPAM1 1 0.03 0.59 0.23 5.00
97 INT283948 SALL1 Positive_regulation of Positive_regulation of Ptgfrn 1 0.00 0.21 0.22 5.00
98 INT245866 Binding of VEGFA and Fgf1 1 0.07 0.52 0.22 5.00
99 INT298876 RAB7A Positive_regulation of Protein_catabolism of NTRK1 1 0.14 0.44 0.22 5.00
100 INT228457 Negative_regulation of Ins1 Positive_regulation of Gene_expression of Trpv1 1 0.05 1.01 0.21 5.00
101 INT182816 EEF1A2 Negative_regulation of CRP 1 0.28 1.84 0.21 5.00
102 INT334394 ADIPOQ Negative_regulation of Gene_expression of Tnf 1 0.37 1.06 0.18 5.00
103 INT330514 Vegfa Positive_regulation of VEGFA 1 0.18 0.5 0.18 5.00
104 INT184194 Binding of HRAS and SPAM1 1 0.00 0.26 0.17 5.00
105 INT323757 Negative_regulation of ACE2 Negative_regulation of ANG 1 0.18 1.73 0.17 5.00
106 INT323756 Negative_regulation of ACE2 Positive_regulation of ANG 1 0.19 1.73 0.17 5.00
107 INT345999 Binding of Fgf2 and Gfap 1 0.37 0.09 0.16 5.00
108 INT345996 Fgf2 Positive_regulation of Gene_expression of Gfap 1 0.71 0.13 0.15 5.00
109 INT238331 PDGFA Regulation of Gene_expression of GOPC 1 0.04 0 0.14 5.00
110 INT238330 Binding of PDGFA and Regulation of Gene_expression of GOPC 1 0.06 0 0.14 5.00
111 INT238329 EGF Regulation of Negative_regulation of ADAMTS5 1 0.03 0 0.14 5.00
112 INT238338 Binding of EGF and Regulation of Gene_expression of GOPC 1 0.05 0 0.14 5.00
113 INT238333 Binding of PDGFA and Regulation of Gene_expression of ADAMTS1 1 0.06 0 0.14 5.00
114 INT238341 GOPC Regulation of Transcription of ADAMTS1 1 0.04 0 0.14 5.00
115 INT238337 EGF Regulation of Gene_expression of GOPC 1 0.03 0 0.14 5.00
116 INT283947 Positive_regulation of Car1 Positive_regulation of Ptgfrn 1 0.01 0 0.14 5.00
117 INT238336 PDGFA Regulation of Negative_regulation of ADAMTS5 1 0.04 0 0.14 5.00
118 INT238334 GOPC Regulation of Transcription of ADAMTS5 1 0.04 0 0.14 5.00
119 INT238342 Binding of EGF and Regulation of Gene_expression of ADAMTS1 1 0.05 0 0.14 5.00
120 INT345998 Fgf2 Positive_regulation of Gfap 1 0.48 0.09 0.13 5.00
121 INT347868 Ntf3 Negative_regulation of Negative_regulation of Chat 1 0.03 0.22 0.13 5.00
122 INT329371 IL8 Negative_regulation of Jun 1 0.00 0.95 0.13 5.00
123 INT220318 Binding of CPB1 and CCL2 1 0.01 0.46 0.13 5.00
124 INT228453 Igf1 Positive_regulation of Prkca 2 0.12 1.17 0.12 5.00
125 INT228455 Ins1 Positive_regulation of Prkca 1 0.02 0.98 0.12 5.00
126 INT345997 Binding of Gfap and Scq1 1 0.15 0.09 0.12 5.00
127 INT228458 Ins1 Positive_regulation of Trpv1 1 0.06 0.98 0.12 5.00
128 INT228456 Igf1 Positive_regulation of Trpv1 1 0.24 0.97 0.12 5.00
129 INT350164 Binding of DURS1 and ELOVL1 1 0.00 1.47 0.11 5.00
130 INT350163 Regulation of Binding of DURS1 and ELOVL1 1 0.00 1.48 0.11 5.00
131 INT297938 Binding of ICAM1 and PAOD1 1 0.06 0.86 0.11 5.00
132 INT332637 Negative_regulation of Dpp4 Negative_regulation of Localization of Ins1 1 0.06 1.66 0.1 5.00
133 INT242203 GLP1R Regulation of GCG 1 0.04 0.64 0.1 5.00
134 INT242204 DPP4 Positive_regulation of Gene_expression of GLP1R 1 0.03 0.66 0.1 5.00
135 INT336341 Binding of RTCA and ELOVL1 1 0.02 2.15 0.07 5.00
136 INT332639 Glp1r Negative_regulation of Localization of Gcg 1 0.03 0.87 0.07 5.00
137 INT355641 Positive_regulation of MPO Positive_regulation of Gene_expression of ROS1 1 0.24 0.84 0.07 5.00
138 INT238340 IL1B Positive_regulation of Gene_expression of ADAMTS4 1 0.03 0.16 0.07 5.00
139 INT221878 Binding of Ltp and Ctrcts 1 0.00 1.94 0.07 5.00
140 INT246539 EGF Negative_regulation of Gene_expression of PDGFA 1 0.06 0.38 0.07 5.00
141 INT246538 PDGFA Negative_regulation of Gene_expression of EGF 1 0.06 0.38 0.07 5.00
142 INT332641 Binding of PPARG and Ins1 1 0.12 1.05 0.05 5.00
143 INT332631 Negative_regulation of Dpp4 Negative_regulation of Gcg 1 0.05 1 0.05 5.00
144 INT314369 Tnfsf11 Negative_regulation of Gene_expression of Tnfrsf11b 1 0.08 2.2 0.05 5.00
145 INT332628 Negative_regulation of Dpp4 Negative_regulation of Positive_regulation of Gcg 1 0.05 1 0.05 5.00
146 INT323755 IGHG3 Negative_regulation of ACE2 1 0.01 1.09 0.05 5.00
147 INT332638 Gip Regulation of Glp1r 1 0.02 0.47 0.05 5.00
148 INT332633 Glp1r Negative_regulation of Gcg 1 0.04 1.13 0.05 5.00
149 INT238332 TNF Positive_regulation of Gene_expression of ADAMTS4 1 0.07 0.07 0.05 5.00
150 INT332632 Gip Negative_regulation of Localization of Gcg 1 0.05 0.47 0.04 5.00
151 INT245219 Binding of C3AR1 and C5AR1 1 0.34 1.21 0.04 5.00
152 INT331172 Binding of IFNA1 and IL2 1 0.00 0.46 0.04 5.00
153 INT332635 Glp1r Regulation of Localization of Gcg 1 0.03 0.94 0.04 5.00
154 INT323807 NFAT5 Regulation of Gene_expression of COL2A1 1 0.29 0.19 0.04 5.00
155 INT290877 Binding of Bcl2a1c and Lepr 1 0.00 0.87 0.04 5.00
156 INT245216 Binding of C3 and C3AR1 1 0.19 1.21 0.04 5.00
157 INT245218 Binding of C3 and C5AR1 2 0.29 2.94 0.04 5.00
158 INT332640 Glp1r Regulation of Localization of Ins1 1 0.04 0.52 0.04 5.00
159 INT298831 Binding of MTOR and RAB7A Positive_regulation of MTOR 1 0.02 0.35 0.03 5.00
160 INT298878 Binding of MTOR and RAB7A 1 0.07 0.35 0.03 5.00
161 INT256228 EDNRB Positive_regulation of EDN1 1 0.26 0.62 0.03 5.00
162 INT298872 RAB7A Regulation of Protein_catabolism of GFM1 1 0.47 0.22 0.03 5.00
163 INT314370 Adipoq Positive_regulation of Tnfrsf11a 1 0.04 1.26 0.03 5.00
164 INT346331 Binding of Epo and Egf 1 0.19 0.1 0.03 5.00
165 INT354835 Binding of VEGFA and Pdgfa 1 0.00 1.5 0.03 5.00
166 INT314771 Glp1r Positive_regulation of Gene_expression of Ins1 2 0.04 1.23 0.03 5.00
167 INT298873 RAB7A Regulation of Protein_catabolism of NTRK1 1 0.12 0.25 0.03 5.00
168 INT298858 Positive_regulation of Binding of VAPA and RILP 1 0.07 0.54 0 5.00
169 INT298854 Binding of LAMP2 and RAB7A 1 0.16 0.56 0 5.00
170 INT298862 Binding of MCC and VPS13C 1 0.00 0.36 0 5.00
171 INT298879 Binding of MCC and MTG1 1 0.00 0.37 0 5.00
172 INT235649 TP73 Regulation of EFNA1 1 0.09 0.97 0 5.00
173 INT332629 Binding of Glp1r and Positive_regulation of Localization of Gcg 1 0.03 0.47 0 5.00
174 INT180164 Gast Positive_regulation of Nfasc 1 0.02 1.31 0 5.00
175 INT316101 Binding of HIST1H4PS1 and ANGPTL5 1 0.01 0.28 0 5.00
176 INT298863 Binding of VAPB and RILP 1 0.13 0.21 0 5.00
177 INT314373 Binding of Cd34 and Eng 1 0.08 0.9 0 5.00
178 INT303456 Binding of USE1 and PDGFC 1 0.01 0.68 0 5.00
179 INT355637 OLR1 Positive_regulation of Gene_expression of SERPINE1 1 0.03 1.15 0 5.00
180 INT323806 NFAT5 Regulation of Transcription of ACAN 1 0.40 0.07 0 5.00
181 INT355636 OLR1 Positive_regulation of Positive_regulation of F3 1 0.01 0.57 0 5.00
182 INT235645 TP53 Regulation of EPHA2 1 0.10 0.97 0 5.00
183 INT339260 EPAS1 Positive_regulation of VEGFA 1 0.19 3.67 0 5.00
184 INT332636 Binding of Glp1r and Positive_regulation of Localization of Ins1 1 0.03 0.47 0 5.00
185 INT298875 Binding of RAB7A and VPS13C 1 0.21 0.49 0 5.00
186 INT235648 Binding of EFNA1 and EPHA2 1 0.23 1.3 0 5.00
187 INT298845 VAPA Regulation of Negative_regulation of RAB7A 1 0.12 0.32 0 5.00
188 INT298868 Binding of RAB7A and GOPC 1 0.07 1.64 0 5.00
189 INT235647 TP63 Regulation of EPHA2 1 0.15 0.97 0 5.00
190 INT332634 Dpp4 Positive_regulation of Localization of Ins1 1 0.06 0.76 0 5.00
191 INT322413 Binding of ATF1 and EWSR1 1 0.26 1.3 0 5.00
192 INT298848 Binding of SPG21 and RILP 1 0.10 0.21 0 5.00
193 INT187571 Binding of FANCB and Pf4 1 0.00 0.46 0 5.00
194 INT298849 Binding of APOB and MCC 1 0.00 0.38 0 5.00
195 INT298859 Positive_regulation of Binding of MCC and VPS13C 1 0.01 0.36 0 5.00
196 INT298853 Binding of AGFG1 and RILP 1 0.02 0.21 0 5.00
197 INT261833 Binding of Add3 and Trpv4 1 0.00 0.12 0 5.00
198 INT261838 Lyn Regulation of Trpv4 1 0.03 0.19 0 5.00
199 INT298856 Binding of APOB and MTG1 1 0.00 0.38 0 5.00
200 INT314374 Binding of Ptprc and Thy1 1 0.04 0.85 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Amputation. They are ordered first by their pain relevance and then by number of times they were reported in Amputation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT39712 Binding of pad 82 0.48 110.92 10.33 100.00
2 INT23094 Positive_regulation of Positive_regulation of Ca2 29 0.49 6.8 9.35 100.00
3 INT124049 Positive_regulation of Sema5a 1 0.04 1.96 1.81 100.00
4 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 99.98
5 INT50923 Positive_regulation of KRTAP5-8 1 0.32 1.13 0.18 99.98
6 INT7899 Positive_regulation of Gene_expression of Homer1 41 0.70 7.29 25.98 99.98
7 INT163998 Gene_expression of CTSC 9 0.65 11.24 1.69 99.96
8 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 99.92
9 INT197195 Positive_regulation of DURS1 2 0.37 3.81 0.32 99.88
10 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 99.80
11 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.78
12 INT7898 Gene_expression of Homer1 123 0.78 31.52 53.67 99.78
13 INT23088 Phosphorylation of Tnf 15 0.79 9.85 3.82 99.76
14 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 99.68
15 INT48308 Binding of PLP1 7 0.48 9.59 6.09 99.62
16 INT49191 Gene_expression of IFNAR1 14 0.41 9.96 3.84 99.60
17 INT118837 Gene_expression of Mb 7 0.74 2.72 0.4 99.60
18 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.56
19 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 99.56
20 INT67078 Binding of Ifng 7 0.48 4.84 2.73 99.56
21 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 99.44
22 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 99.44
23 INT58287 Gene_expression of Orm1 3 0.66 1.17 2.12 99.44
24 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98 99.42
25 INT100991 Gene_expression of HOMER1 12 0.67 6.96 4.98 99.36
26 INT100992 Regulation of Gene_expression of HOMER1 2 0.10 0.74 1.06 99.36
27 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 99.30
28 INT74449 Positive_regulation of B4GALNT1 53 0.30 34.49 14.96 99.16
29 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.04
30 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23 98.88
31 INT612 Positive_regulation of Orm1 15 0.68 5.24 6.73 98.72
32 INT27627 Binding of Rac1 41 0.41 22.88 13.68 98.72
33 INT11345 Negative_regulation of Sts 4 0.38 2.9 0.65 98.56
34 INT258946 Binding of OFD1 1 0.20 5.35 0 98.42
35 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 98.36
36 INT6852 Localization of TNF 883 0.81 705.95 270.84 98.32
37 INT7105 Gene_expression of pad 54 0.77 63.68 8.8 98.20
38 INT11157 Binding of EGF 88 0.48 53.73 21.25 98.08
39 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 98.04
40 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 98.04
41 INT57876 Positive_regulation of Egr1 46 0.70 25.6 9.41 98.04
42 INT9098 Positive_regulation of DBP 30 0.69 15.77 4.26 98.04
43 INT82055 Positive_regulation of Creb1 176 0.70 60.2 58.39 98.04
44 INT33400 Regulation of CDS1 8 0.29 5.12 1.79 98.04
45 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9 98.00
46 INT194019 Gene_expression of Acc 4 0.65 3.18 2.54 97.76
47 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 97.68
48 INT197196 Negative_regulation of DURS1 2 0.43 30.6 2.37 97.66
49 INT32203 Negative_regulation of Crp 48 0.58 32.77 11.89 97.66
50 INT18925 Gene_expression of Paics 3 0.52 1.25 0.93 97.56
51 INT62688 Binding of Wnk1 2 0.17 2.83 0.63 97.56
52 INT194017 Negative_regulation of Acc 2 0.42 2.48 1.95 97.36
53 INT282300 Regulation of Positive_regulation of ADCY8 1 0.12 0.68 0.69 97.36
54 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59 97.16
55 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 97.08
56 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 97.00
57 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 97.00
58 INT282299 Positive_regulation of ADCY8 2 0.49 0.75 0.78 97.00
59 INT103251 Negative_regulation of Localization of Calca 13 0.43 9.36 8.86 96.80
60 INT345995 Negative_regulation of Gene_expression of Fgf2 1 0.43 0.43 0.29 96.80
61 INT5008 Localization of Calca 204 0.81 80.35 125.16 96.80
62 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 96.76
63 INT28647 Binding of CTD 13 0.31 14.2 1.5 96.72
64 INT143179 Positive_regulation of Arid3a 1 0.39 0.64 0.08 96.68
65 INT102020 Gene_expression of Creb1 190 0.78 57.31 59.77 96.56
66 INT102021 Positive_regulation of Gene_expression of Creb1 66 0.70 24.04 23.28 96.56
67 INT50050 Gene_expression of CSRP1 23 0.76 16.84 5.86 96.56
68 INT240786 Binding of Bcl2a1c 10 0.18 9.47 0.12 96.52
69 INT124050 Binding of Sema5a 1 0.03 2.46 2.3 96.40
70 INT143666 Positive_regulation of ST2 15 0.69 11.76 0.85 96.36
71 INT231961 Gene_expression of Hltf 2 0.28 2.01 1.11 96.32
72 INT231962 Positive_regulation of Gene_expression of Hltf 1 0.25 1.19 0.83 96.32
73 INT18773 Localization of ALB 117 0.80 69.18 13.8 96.12
74 INT251951 Localization of MAK 1 0.18 0.56 0.11 96.08
75 INT84495 Positive_regulation of Positive_regulation of Ephb1 85 0.70 46.12 54.11 96.00
76 INT139646 Positive_regulation of Positive_regulation of Grin2b 4 0.42 3.89 3.74 95.42
77 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12 95.36
78 INT56191 Regulation of Sts 3 0.23 2.28 1.31 95.36
79 INT258948 Positive_regulation of Gene_expression of OFD1 1 0.27 5.05 0 95.28
80 INT258950 Gene_expression of OFD1 1 0.37 7.19 0 95.28
81 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52 95.20
82 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68 94.84
83 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 94.72
84 INT15243 Regulation of Egr1 19 0.61 7.6 2.13 94.64
85 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91 94.36
86 INT93451 Positive_regulation of Gene_expression of Grin2b 43 0.70 29.09 31.89 94.36
87 INT229632 Binding of PADI4 21 0.48 37.45 0.34 94.24
88 INT125190 Regulation of Gene_expression of Trpv1 38 0.62 32.57 23.2 94.20
89 INT238874 Positive_regulation of Binding of pad 1 0.03 1.64 0.05 93.92
90 INT61264 Regulation of Jun 36 0.61 18.42 8.71 93.56
91 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15 93.56
92 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 93.44
93 INT57874 Gene_expression of Egr1 113 0.78 68.46 24.95 93.36
94 INT57878 Positive_regulation of Gene_expression of Egr1 36 0.70 20.42 14.45 93.36
95 INT615 Regulation of Alb 66 0.62 33.43 15.33 93.28
96 INT90937 Negative_regulation of Gene_expression of Trpv1 34 0.59 22.74 18.12 93.04
97 INT10207 Gene_expression of PADI4 22 0.75 23.49 1.74 92.80
98 INT55038 Gene_expression of Adcy8 10 0.77 28.79 9.8 92.76
99 INT106719 Gene_expression of Adcy1 18 0.77 12.18 8.42 92.76
100 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 92.72
101 INT26311 Negative_regulation of ACE2 8 0.59 16.35 1.94 92.56
102 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 92.52
103 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48 92.40
104 INT37227 Regulation of EGF 19 0.45 11.16 5.17 92.24
105 INT86280 Positive_regulation of Nfasc 14 0.62 6.56 3.84 91.88
106 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 91.76
107 INT69591 Positive_regulation of Positive_regulation of PSMD1 2 0.50 3.06 3.99 91.60
108 INT295165 Negative_regulation of Adcy1 1 0.09 1.3 1.13 91.48
109 INT10520 Regulation of Rvm 20 0.24 10.15 20.52 91.36
110 INT24910 Negative_regulation of Enpp3 20 0.57 8.23 4.67 91.28
111 INT305321 Regulation of Negative_regulation of Akr1b3 1 0.14 1.18 0 91.20
112 INT305319 Regulation of Akr1b3 1 0.14 1.17 0 91.20
113 INT119928 Localization of CDS1 3 0.60 1.94 0.26 90.96
114 INT175997 Localization of HEPACAM 6 0.31 5.91 0.39 90.84
115 INT135289 Negative_regulation of Akr1b3 4 0.58 5.35 1.15 90.76
116 INT27188 Negative_regulation of Tcn2 5 0.18 1.33 0.83 90.68
117 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93 90.60
118 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 90.36
119 INT35148 Regulation of ANGPTL5 12 0.28 6.92 1.14 90.32
120 INT95733 Transcription of pad 2 0.68 2.01 0.15 89.56
121 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 89.52
122 INT153329 Gene_expression of Cm9 6 0.67 4.35 0.95 89.40
123 INT69727 Gene_expression of QPCT 18 0.65 5.45 3.05 89.32
124 INT133081 Positive_regulation of Gene_expression of QPCT 1 0.49 1.43 0.26 89.32
125 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 89.20
126 INT337348 Regulation of Gene_expression of Fgf2 2 0.45 0.54 0.44 89.20
127 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 88.72
128 INT18755 Positive_regulation of Rvm 79 0.60 60 92.93 88.52
129 INT63935 Positive_regulation of Gene_expression of Ephb1 52 0.61 24.3 33.05 88.44
130 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11 88.40
131 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 88.40
132 INT242911 Localization of Bcl2a1c 2 0.36 1.48 0.11 88.40
133 INT55647 Binding of Nfasc 5 0.35 5.43 0.94 88.36
134 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72 87.92
135 INT165483 Negative_regulation of Gene_expression of CD63 3 0.49 1.65 0.59 87.92
136 INT63357 Negative_regulation of Gene_expression of ITGAL 3 0.33 1.88 0.56 87.92
137 INT141681 Gene_expression of MBTPS2 1 0.16 0.51 0.09 87.68
138 INT174844 Binding of Fig4 81 0.41 18.03 12.87 87.64
139 INT73829 Positive_regulation of Gene_expression of VCAM1 41 0.61 35.96 11.92 87.60
140 INT19250 Positive_regulation of TAL1 3 0.25 2.51 1.4 87.52
141 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 87.32
142 INT299242 Positive_regulation of Wasf1 1 0.04 0.64 0 87.32
143 INT299244 Positive_regulation of Positive_regulation of Wasf1 1 0.04 0.64 0 87.32
144 INT44872 Localization of Sts 5 0.64 5.2 0.2 87.24
145 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 87.20
146 INT10498 Positive_regulation of Tcn2 7 0.19 1.76 1.87 87.20
147 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 87.16
148 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 87.16
149 INT61417 Gene_expression of ITGAL 36 0.75 29.62 6.15 87.16
150 INT83642 Gene_expression of CD63 22 0.77 10.06 2.63 87.16
151 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 87.08
152 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 87.08
153 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 86.92
154 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 86.80
155 INT10145 Gene_expression of Plg 28 0.62 12.68 7.46 86.40
156 INT201259 Negative_regulation of RAB7A 2 0.41 2.45 0.54 85.92
157 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 85.56
158 INT15786 Gene_expression of AHSP 8 0.78 5.12 0.4 85.44
159 INT305320 Negative_regulation of Olfr927-ps1 1 0.06 0.86 0.28 85.20
160 INT118836 Positive_regulation of Gene_expression of Mb 1 0.66 0.15 0.03 85.12
161 INT194015 Negative_regulation of Negative_regulation of Acc 1 0.41 1.21 0.92 84.84
162 INT183672 Gene_expression of EPAS1 37 0.35 28.68 0.72 84.80
163 INT193015 Positive_regulation of Gene_expression of EPAS1 6 0.32 8.77 0.21 84.80
164 INT197194 Binding of DURS1 3 0.27 4.2 0.33 84.80
165 INT97237 Transcription of TRPV1 33 0.72 10.56 12.4 84.64
166 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 84.56
167 INT339266 Regulation of Gene_expression of EPAS1 3 0.11 2.92 0.14 84.56
168 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96 84.32
169 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 84.16
170 INT298013 Binding of MNS1 1 0.35 1.14 0.13 84.16
171 INT115649 Gene_expression of Camk2a 95 0.78 33.22 38 84.00
172 INT121988 Negative_regulation of Gene_expression of Camk2a 8 0.59 4.76 5.72 84.00
173 INT194016 Negative_regulation of Gene_expression of Acc 1 0.41 1.26 0.87 84.00
174 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 83.92
175 INT164417 Gene_expression of CRLF1 2 0.34 3.71 0.77 83.88
176 INT201549 Regulation of CD99 3 0.23 3.6 0.03 83.84
177 INT110110 Gene_expression of ACCS 85 0.58 75.88 10.2 83.76
178 INT141296 Negative_regulation of WRN 1 0.43 0.95 0.08 83.44
179 INT10173 Binding of Tnf 45 0.48 35.6 14.32 83.16
180 INT118834 Positive_regulation of Mb 6 0.66 1.68 0.79 83.12
181 INT104777 Regulation of DES 4 0.38 2.38 1.2 82.84
182 INT35269 Localization of SGCG 38 0.78 14.68 9.01 82.64
183 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 82.44
184 INT287 Localization of Cck 518 0.81 86.84 364.04 82.20
185 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132 82.08
186 INT44246 Positive_regulation of Sts 9 0.43 6.19 0.45 82.08
187 INT68445 Gene_expression of ENPP1 10 0.70 10.8 3.3 82.08
188 INT172001 Gene_expression of ANKH 2 0.38 11.92 3.12 82.08
189 INT316778 Positive_regulation of Gene_expression of ENPP1 1 0.62 7.2 1.97 82.08
190 INT61548 Positive_regulation of Fgf2 72 0.70 32.18 14.49 81.92
191 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 81.92
192 INT65032 Positive_regulation of Negative_regulation of Fgf2 2 0.47 0.63 0.04 81.92
193 INT35143 Negative_regulation of ANGPTL5 28 0.54 18.59 3.14 81.60
194 INT17021 Negative_regulation of AHSP 5 0.43 3.45 0.72 81.60
195 INT47311 Gene_expression of Sts 12 0.58 11.02 0.44 81.44
196 INT65033 Negative_regulation of Fgf2 21 0.59 12.36 2.94 81.40
197 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96 81.36
198 INT314085 Regulation of Gene_expression of CRLF1 1 0.03 1.22 0.1 81.36
199 INT211972 Regulation of Best1 18 0.33 12.04 0.67 81.20
200 INT12054 Negative_regulation of MIA3 32 0.45 23.2 6.18 81.20
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