D:Anaphylactic Hypersensitivity

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Anaphylactic Shock, Atopic Hypersensitivities, Atopic Hypersensitivity, Hypersensitivities Atopic, Hypersensitivities Ige Mediated, Hypersensitivities Immediate, Hypersensitivities Type I, Hypersensitivity Atopic, Hypersensitivity Ige Mediated, Hypersensitivity Immediate, Hypersensitivity Type I
Documents 64
Hot Single Events 25
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Anaphylactic Hypersensitivity. They are ordered first by their relevance to Anaphylactic Hypersensitivity and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT274170 Il13 Regulation of Il4 3 0.09 2.75 0.51 99.84
2 INT294762 Il4 Regulation of Il13 2 0.09 0.92 0.32 99.84
3 INT319972 App Negative_regulation of Gene_expression of Enpp1 1 0.02 1.87 0.15 82.68
4 INT294766 Cerk Regulation of Gene_expression of Hand2 1 0.13 0.32 0.15 50.72
5 INT270586 Binding of IGHE and IgG-2a 1 0.16 0.75 0.03 34.24
6 INT319974 App Negative_regulation of Enpp1 1 0.02 0.58 0.16 19.80
7 INT294758 Regulation of Cerk Positive_regulation of Hand2 1 0.21 0.16 0.12 14.76
8 INT294760 Cerk Positive_regulation of Hand2 1 0.23 0.16 0.12 13.12
9 INT311872 IGHE Positive_regulation of Localization of Mmp9 1 0.01 1.35 0.22 5.00
10 INT319971 App Regulation of Enpp1 1 0.02 0.72 0.21 5.00
11 INT294763 Binding of Gopc and Cerk 1 0.14 0.37 0.14 5.00
12 INT294764 Binding of Hand2 and Cerk 1 0.17 0.31 0.14 5.00
13 INT294761 Binding of Hand1 and Cerk 1 0.23 0.36 0.14 5.00
14 INT311871 Cav1 Regulation of Mch 1 0.01 0.24 0.11 5.00
15 INT284552 Binding of Cd8a and Mthfd1 2 0.03 1.32 0.1 5.00
16 INT333095 Localization of IL2 Negative_regulation of Negative_regulation of CD8A 1 0.10 0.8 0.09 5.00
17 INT333099 Localization of IL2 Negative_regulation of Negative_regulation of CD4 1 0.14 0.8 0.09 5.00
18 INT270566 IGHE Regulation of IL4 1 0.21 0.99 0.09 5.00
19 INT333094 HIVEP1 Regulation of CD4 1 0.00 0.22 0.09 5.00
20 INT333121 Pol Positive_regulation of CD8A 1 0.00 0.08 0.09 5.00
21 INT181845 Binding of CD8A and IFN1@ 2 0.13 0.65 0.09 5.00
22 INT270567 IGHE Regulation of IL13RA2 1 0.23 0.99 0.09 5.00
23 INT270569 IGHE Regulation of IL5 1 0.18 1.04 0.09 5.00
24 INT228137 Binding of Serpinb1-ps1 and Trav6-3 2 0.02 1.93 0.08 5.00
25 INT333089 CD4 Positive_regulation of ERVW-1 1 0.05 0.07 0.08 5.00
26 INT333097 ERVW-1 Positive_regulation of CD8A 1 0.02 0.08 0.08 5.00
27 INT294757 Binding of Dob1 and Serpinb1-ps1 1 0.00 0.72 0.08 5.00
28 INT270682 Binding of OLR1 and RENBP 1 0.00 0.76 0.08 5.00
29 INT333096 Binding of CD4 and IFN1@ 1 0.12 0.17 0.07 5.00
30 INT333092 Binding of CD4 and IL2 1 0.01 0.17 0.07 5.00
31 INT333098 Binding of CD8A and IL2 1 0.01 0.17 0.07 5.00
32 INT333091 Localization of IFN1@ Negative_regulation of Negative_regulation of CD4 1 0.14 0.4 0.05 5.00
33 INT270568 Binding of UTS2R and STAT6 1 0.04 2 0.05 5.00
34 INT333090 Localization of IFN1@ Negative_regulation of Negative_regulation of CD8A 1 0.10 0.4 0.05 5.00
35 INT294765 Negative_regulation of Serpinb1-ps1 Positive_regulation of Il4 1 0.02 0.24 0.05 5.00
36 INT319973 App Regulation of Gene_expression of Mapk12 1 0.02 0.98 0.04 5.00
37 INT294759 Serpinb1-ps1 Positive_regulation of Il4 1 0.02 0.24 0.04 5.00
38 INT311870 Positive_regulation of Binding of Cd8a and Mthfd1 1 0.00 0.32 0.03 5.00
39 INT270683 Binding of OXA1L and RENBP 1 0.00 0 0 5.00
40 INT333093 AD5 Regulation of CD8A 1 0.00 0.25 0 5.00
41 INT311816 CD79A Positive_regulation of RAB27A 1 0.01 0.47 0 5.00
42 INT270570 Binding of IGHG3 and FCGR2C 1 0.00 0.22 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Anaphylactic Hypersensitivity. They are ordered first by their pain relevance and then by number of times they were reported in Anaphylactic Hypersensitivity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT8775 Binding of IGHE 167 0.48 102.61 23.54 99.78
2 INT701 Localization of IGHE 87 0.80 40.5 10.62 99.60
3 INT35866 Transcription of IGHE 9 0.60 12.83 2.19 99.60
4 INT87235 Negative_regulation of Il4 54 0.48 31.51 13.15 97.82
5 INT4807 Localization of LTC4S 23 0.58 6.89 7.59 97.28
6 INT163794 Localization of CYSLTR1 4 0.45 2.4 1.08 97.28
7 INT18843 Binding of H1 10 0.47 5.44 2.4 95.64
8 INT51685 Gene_expression of LTB4R 87 0.58 68.69 31.72 93.76
9 INT17442 Gene_expression of ALOX5 110 0.75 51.55 18.29 92.16
10 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 91.56
11 INT16814 Negative_regulation of COX5A 74 0.57 33.72 28.63 90.72
12 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 90.56
13 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 88.56
14 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94 87.44
15 INT35448 Negative_regulation of Gene_expression of ALOX5 11 0.57 5.28 3.03 87.12
16 INT34905 Positive_regulation of Gene_expression of ALOX5 18 0.50 7.46 2.46 87.12
17 INT195413 Negative_regulation of ALOX5AP 5 0.37 1.39 0.37 86.56
18 INT195414 Gene_expression of ALOX5AP 65 0.72 31.22 15.25 86.56
19 INT195421 Positive_regulation of Gene_expression of ALOX5AP 12 0.49 5.17 2.82 86.56
20 INT200779 Negative_regulation of Gene_expression of ALOX5AP 7 0.41 3.75 1.79 86.56
21 INT65500 Gene_expression of App 605 0.78 429.94 98.31 85.32
22 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 81.56
23 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 81.36
24 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8 81.20
25 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 81.16
26 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 79.76
27 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 79.76
28 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 79.76
29 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 78.48
30 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 78.04
31 INT217875 Gene_expression of AD5 41 0.40 19.85 2.28 78.00
32 INT259884 Negative_regulation of Binding of ALOX5AP 1 0.10 0.46 0.21 73.04
33 INT259885 Regulation of Binding of ALOX5 1 0.07 0.51 0.16 73.04
34 INT68926 Binding of ALOX5AP 8 0.36 4.02 0.84 72.68
35 INT12992 Negative_regulation of Gene_expression of Ptgs1 33 0.42 20.47 11.77 72.08
36 INT10476 Binding of ALOX5 26 0.36 7.69 3.2 72.00
37 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 70.56
38 INT28165 Positive_regulation of ALOX5 38 0.47 10.8 5.37 69.76
39 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 68.84
40 INT35406 Localization of Tnf 94 0.81 64.63 31.65 68.84
41 INT55886 Negative_regulation of Gene_expression of Il4 47 0.57 26.04 11.42 64.64
42 INT92200 Negative_regulation of Localization of Il4 10 0.51 5.66 3.65 64.64
43 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 64.36
44 INT19134 Gene_expression of TPSAB1 16 0.66 11.61 2.48 62.80
45 INT20379 Localization of Il4 85 0.73 51.22 20.55 62.32
46 INT16794 Binding of App 103 0.48 64.87 19.79 56.80
47 INT186273 Negative_regulation of Il13 33 0.46 22.88 8.65 54.52
48 INT177526 Negative_regulation of Il5 17 0.36 11.13 5.31 54.12
49 INT294751 Negative_regulation of Cerk 1 0.43 2.52 0.57 53.04
50 INT127062 Positive_regulation of Gene_expression of LTB4R 18 0.34 15.9 5.64 51.04
51 INT54826 Binding of LTB4R 7 0.29 1.51 1.59 50.32
52 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 49.76
53 INT16211 Negative_regulation of LTB4R 11 0.29 13 5.62 39.16
54 INT259881 Negative_regulation of Binding of LTB4R 1 0.35 0.16 0.27 39.16
55 INT294750 Negative_regulation of Negative_regulation of Cerk 1 0.43 0.17 0.12 31.88
56 INT137614 Gene_expression of Lgals3 70 0.77 66.13 12.53 28.24
57 INT152308 Binding of Lgals3 13 0.40 6.39 1.44 28.16
58 INT29577 Negative_regulation of Cyp27b1 5 0.37 2.41 1.88 27.16
59 INT26962 Negative_regulation of IgG-2a 12 0.42 6.07 5.31 26.76
60 INT270556 Negative_regulation of Regulation of IgG-2a 1 0.42 0.7 0 26.76
61 INT12818 Regulation of IgG-2a 9 0.37 3.23 6.07 25.92
62 INT181525 Localization of Il13 24 0.66 21.51 6.55 20.88
63 INT39908 Gene_expression of Cyp27b1 16 0.69 4.8 2.83 20.08
64 INT227044 Negative_regulation of Gene_expression of Cyp27b1 2 0.06 0.46 0.15 20.08
65 INT79693 Regulation of Il4 30 0.51 21.96 8.6 14.76
66 INT51741 Regulation of Gene_expression of Il4 23 0.36 12.7 7.39 14.76
67 INT294755 Regulation of Cerk 1 0.45 1.23 0.23 13.12
68 INT151736 Binding of Hand1 15 0.26 9.77 4.04 10.80
69 INT94463 Regulation of Gene_expression of Hand1 10 0.36 5.17 2.72 9.84
70 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 9.40
71 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
72 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
73 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
74 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
75 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
76 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
77 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
78 INT6437 Binding of YY1 154 0.47 26.3 90.46 5.00
79 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
80 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
81 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
82 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
83 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
84 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
85 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
86 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
87 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
88 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
89 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
90 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
91 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 5.00
92 INT29743 Negative_regulation of App 91 0.59 65.56 31.26 5.00
93 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
94 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
95 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
96 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
97 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
98 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
99 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 5.00
100 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 5.00
101 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 5.00
102 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 5.00
103 INT11303 Gene_expression of Avp 116 0.78 39.23 23.88 5.00
104 INT64175 Negative_regulation of Gene_expression of CPOX 66 0.38 39.64 23.07 5.00
105 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
106 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
107 INT11625 Localization of App 98 0.78 55.46 20.86 5.00
108 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
109 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
110 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
111 INT113399 Positive_regulation of Pla2g4a 36 0.67 33.83 18.78 5.00
112 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
113 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35 5.00
114 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 5.00
115 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 5.00
116 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 5.00
117 INT75929 Gene_expression of IL9 61 0.43 24.71 16.17 5.00
118 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
119 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
120 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
121 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 5.00
122 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 5.00
123 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16 5.00
124 INT50671 Regulation of Gene_expression of CPOX 45 0.54 30.99 13.83 5.00
125 INT173505 Localization of Hand2 63 0.57 45.32 13.66 5.00
126 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
127 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 5.00
128 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
129 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 5.00
130 INT22030 Negative_regulation of Cysltr1 31 0.39 21.83 12.49 5.00
131 INT541 Positive_regulation of MBP 31 0.67 28.56 12.24 5.00
132 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
133 INT102272 Regulation of TH1L 41 0.44 30.89 11.63 5.00
134 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48 5.00
135 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36 5.00
136 INT94438 Gene_expression of OLR1 86 0.78 80.38 11.03 5.00
137 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 5.00
138 INT16404 Regulation of CD4 54 0.61 33.05 10.29 5.00
139 INT18833 Positive_regulation of LTB4R 19 0.69 27.61 10.17 5.00
140 INT424 Positive_regulation of TSPO 34 0.61 15.04 10.02 5.00
141 INT17741 Gene_expression of MBP 67 0.78 23.67 9.65 5.00
142 INT85418 Positive_regulation of Gene_expression of IL9 11 0.38 11.47 9.56 5.00
143 INT3366 Localization of PLEK 44 0.78 15.83 9.55 5.00
144 INT97439 Positive_regulation of Il5 46 0.60 25.6 9.47 5.00
145 INT35366 Binding of AR 87 0.47 30.52 8.9 5.00
146 INT113845 Protein_catabolism of PARP1 54 0.88 43.86 8.77 5.00
147 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
148 INT2971 Regulation of IGHE 42 0.61 28.81 7.87 5.00
149 INT93914 Gene_expression of CD80 70 0.75 36.35 7.74 5.00
150 INT39406 Positive_regulation of OLR1 45 0.70 37.8 7.72 5.00
151 INT184281 Binding of AGER 25 0.37 23.06 7.32 5.00
152 INT14637 Negative_regulation of MBP 19 0.43 7.06 7.18 5.00
153 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 5.00
154 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 5.00
155 INT17049 Localization of CD4 57 0.75 35.33 6.89 5.00
156 INT10917 Positive_regulation of ITGAM 31 0.67 16.39 6.69 5.00
157 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61 5.00
158 INT62509 Gene_expression of MCS 58 0.67 21.46 6.57 5.00
159 INT211363 Positive_regulation of RENBP 13 0.22 13.26 6.48 5.00
160 INT60527 Transcription of IL10 16 0.56 13.57 6.42 5.00
161 INT16210 Localization of LTB4R 14 0.54 6.58 6.19 5.00
162 INT22128 Positive_regulation of HIVEP1 61 0.43 70.52 6.07 5.00
163 INT19805 Negative_regulation of Avp 18 0.59 4.57 5.87 5.00
164 INT224530 Positive_regulation of Enpp1 12 0.70 7.03 5.82 5.00
165 INT132573 Negative_regulation of Gene_expression of TH1L 16 0.42 11.52 5.76 5.00
166 INT56149 Localization of CD8A 56 0.74 30.41 5.75 5.00
167 INT83119 Negative_regulation of Gene_expression of IL12A 24 0.42 17.52 5.69 5.00
168 INT28164 Regulation of ALOX5 25 0.60 12.76 5.47 5.00
169 INT164587 Gene_expression of MCL1 94 0.75 124.05 5.39 5.00
170 INT77281 Negative_regulation of HIVEP1 132 0.49 102.78 5.36 5.00
171 INT16405 Regulation of CD8A 38 0.45 19.04 5.31 5.00
172 INT12104 Positive_regulation of PLG 45 0.68 28.94 4.81 5.00
173 INT1539 Positive_regulation of MSMB 22 0.69 9.42 4.62 5.00
174 INT20372 Localization of Il5 26 0.41 18.33 4.27 5.00
175 INT4528 Negative_regulation of Sell 12 0.58 4.76 4.22 5.00
176 INT110343 Negative_regulation of PIK3CD 22 0.40 5.84 4.2 5.00
177 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07 5.00
178 INT3598 Regulation of Pla2g1b 12 0.44 3.45 3.9 5.00
179 INT92653 Gene_expression of IL12B 21 0.75 17.28 3.89 5.00
180 INT132994 Positive_regulation of Localization of Mmp9 12 0.42 9.4 3.75 5.00
181 INT181922 Binding of RENBP 16 0.36 13.92 3.71 5.00
182 INT9223 Localization of Ighg1 22 0.78 11.03 3.67 5.00
183 INT9999 Regulation of Gene_expression of IGHE 32 0.60 15.75 3.53 5.00
184 INT73500 Regulation of IL13 12 0.36 10.37 3.53 5.00
185 INT28528 Gene_expression of MSMB 25 0.65 7.66 3.49 5.00
186 INT12639 Gene_expression of Gnai2 6 0.24 0.35 3.4 5.00
187 INT147572 Gene_expression of Ahr 73 0.75 38.99 3.15 5.00
188 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
189 INT78467 Negative_regulation of IL12A 18 0.38 11.29 2.98 5.00
190 INT207851 Regulation of Enpp1 5 0.45 4.42 2.96 5.00
191 INT126172 Negative_regulation of Pla2g4a 7 0.39 9.01 2.89 5.00
192 INT177760 Negative_regulation of Gene_expression of IFN1@ 21 0.57 16.61 2.89 5.00
193 INT62487 Localization of HIVEP1 35 0.73 36.24 2.72 5.00
194 INT133029 Regulation of TLR2 18 0.56 11.31 2.62 5.00
195 INT9440 Binding of MSMB 4 0.38 3.66 2.61 5.00
196 INT120551 Negative_regulation of Rock2 8 0.52 2.73 2.53 5.00
197 INT184280 Positive_regulation of AGER 8 0.52 9.05 2.43 5.00
198 INT17961 Regulation of Pla2g4a 9 0.25 4.86 2.3 5.00
199 INT3151 Localization of MBP 27 0.80 7.58 2.28 5.00
200 INT211979 Positive_regulation of Localization of Mcpt1 5 0.09 2.68 2.16 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox