D:Anaplasia

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pChart

Disease Term
Synonyms Anaplasias
Documents 45
Hot Single Events 11
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Anaplasia. They are ordered first by their relevance to Anaplasia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT208152 Binding of CDK4 and MDM2 1 0.01 1.11 0 77.88
2 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34 5.00
3 INT204080 HP Negative_regulation of Phosphorylation of Rb1 1 0.00 3.53 0.34 5.00
4 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06 5.00
5 INT204079 HP Positive_regulation of Gene_expression of Cdkn1b 1 0.00 0.6 0.05 5.00
6 INT204073 Binding of Cdkn2a and Cdk4 1 0.02 0.78 0.05 5.00
7 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05 5.00
8 INT204076 HP Positive_regulation of Gene_expression of Fas 1 0.00 1.81 0 5.00
9 INT204078 Binding of CDKN2A and Cdk4 1 0.15 0.72 0 5.00
10 INT231519 Binding of PAX7 and POMT1 1 0.02 0.78 0 5.00
11 INT204077 Binding of CDKN2A and Cdk6 1 0.15 0.72 0 5.00
12 INT231521 Binding of IARS and POMT1 1 0.03 0.72 0 5.00
13 INT231520 Binding of PAX7 and GOPC 1 0.09 0.98 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Anaplasia. They are ordered first by their pain relevance and then by number of times they were reported in Anaplasia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 98.00
2 INT59784 Binding of DES 22 0.47 19.48 2.27 96.76
3 INT96188 Binding of Cd34 11 0.31 10.4 0.82 96.76
4 INT91209 Binding of VIM 15 0.36 12.02 0.53 94.88
5 INT65578 Regulation of GFAP 8 0.26 6.81 2.2 94.16
6 INT132885 Regulation of SYP 4 0.44 3.92 0.44 94.16
7 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 93.88
8 INT36200 Gene_expression of S100A1 9 0.77 9.56 0.75 93.84
9 INT55470 Regulation of Mtor 16 0.24 12.51 2.07 93.52
10 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 87.36
11 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 85.84
12 INT12861 Gene_expression of Cish 40 0.57 23.01 8.48 79.72
13 INT185284 Binding of CDK4 7 0.25 4.79 0.07 77.88
14 INT113346 Binding of MDM2 10 0.35 5.73 0.15 76.76
15 INT70242 Localization of HCC 18 0.66 23.95 2.35 75.92
16 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 75.80
17 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5 75.80
18 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 75.80
19 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 69.72
20 INT231528 Localization of NT5C3 2 0.73 1.78 1.06 69.04
21 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 68.00
22 INT231530 Localization of PAX3 2 0.68 2.52 0 64.96
23 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03 62.16
24 INT104731 Positive_regulation of NEFL 13 0.67 9.22 1.37 61.88
25 INT318035 Positive_regulation of NEURL 1 0.08 1.31 0 61.88
26 INT231531 Localization of FRA5G 1 0.02 1.41 0 60.88
27 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 58.80
28 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 58.80
29 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 58.80
30 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 58.80
31 INT113147 Positive_regulation of Acta2 6 0.34 4.24 1.66 53.76
32 INT100664 Negative_regulation of MKI67 12 0.10 9.77 0 48.44
33 INT177615 Gene_expression of PAX7 20 0.65 13.5 1.03 47.76
34 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 30.48
35 INT5844 Positive_regulation of Gene_expression of Vim 14 0.25 9.64 2.18 20.48
36 INT67191 Gene_expression of Muc3 11 0.29 9.93 0.91 19.36
37 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 19.04
38 INT103683 Gene_expression of Muc2 18 0.73 12.47 2.43 18.56
39 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 18.00
40 INT164210 Gene_expression of Cdx2 3 0.56 2.22 0.25 17.44
41 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 16.88
42 INT43160 Gene_expression of EOS 3 0.65 5.03 0.81 15.20
43 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
44 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
45 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 5.00
46 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
47 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
48 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92 5.00
49 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
50 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
51 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
52 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77 5.00
53 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48 5.00
54 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 5.00
55 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
56 INT76924 Positive_regulation of Slc17a5 71 0.70 41.21 19.31 5.00
57 INT77620 Gene_expression of Fas 146 0.78 72.4 16.61 5.00
58 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02 5.00
59 INT8571 Gene_expression of B3GAT1 54 0.75 36.85 15.98 5.00
60 INT14152 Gene_expression of Slc17a5 46 0.61 20.01 15.9 5.00
61 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
62 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
63 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
64 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
65 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 5.00
66 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
67 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 5.00
68 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85 5.00
69 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 5.00
70 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28 5.00
71 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 5.00
72 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 5.00
73 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
74 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
75 INT88919 Positive_regulation of Casp9 39 0.70 28.64 8.18 5.00
76 INT8669 Positive_regulation of Afp 66 0.70 58.21 7.67 5.00
77 INT88014 Positive_regulation of Gene_expression of Fas 29 0.50 14.84 7.47 5.00
78 INT11154 Binding of EGFR 149 0.48 96.23 6.29 5.00
79 INT92916 Gene_expression of Acta2 50 0.74 17.52 6.11 5.00
80 INT63177 Regulation of HP 71 0.44 39.48 5.86 5.00
81 INT145929 Regulation of Bax 20 0.60 18.12 5.35 5.00
82 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15 5.00
83 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.00
84 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 5.00
85 INT135016 Positive_regulation of Gene_expression of Slc17a5 7 0.55 4.33 3.74 5.00
86 INT93399 Gene_expression of Ccnd1 38 0.58 21 3.65 5.00
87 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45 5.00
88 INT154334 Localization of S100A12 9 0.80 9.32 2.89 5.00
89 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8 5.00
90 INT88852 Protein_catabolism of Casp3 28 0.65 23.57 2.74 5.00
91 INT89543 Gene_expression of NEFL 18 0.75 10.6 2.67 5.00
92 INT195005 Positive_regulation of Aifm1 11 0.29 7.92 2.46 5.00
93 INT111039 Gene_expression of Kras 20 0.60 15.42 2.39 5.00
94 INT105761 Binding of GFAP 13 0.36 14.94 2.32 5.00
95 INT88017 Regulation of Fas 12 0.62 8.27 2.29 5.00
96 INT111038 Gene_expression of Cdkn1b 23 0.75 25.35 2.22 5.00
97 INT33243 Localization of HP 17 0.12 9.7 2.2 5.00
98 INT100620 Localization of VIM 8 0.76 5.47 2.16 5.00
99 INT93398 Negative_regulation of Gene_expression of Ccnd1 5 0.44 2.61 2.12 5.00
100 INT83896 Gene_expression of CD1A 19 0.68 15.58 2.1 5.00
101 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04 5.00
102 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94 5.00
103 INT88918 Gene_expression of Casp8 13 0.67 11.49 1.56 5.00
104 INT133875 Gene_expression of POMT1 26 0.58 17.1 1.48 5.00
105 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48 5.00
106 INT51486 Negative_regulation of GNPTAB 11 0.41 8.18 1.45 5.00
107 INT76477 Positive_regulation of CD99 14 0.50 14.77 1.42 5.00
108 INT53929 Positive_regulation of GNPTAB 12 0.32 6.66 1.4 5.00
109 INT88917 Positive_regulation of Casp8 18 0.60 14.64 1.36 5.00
110 INT97943 Positive_regulation of Protein_catabolism of Casp3 7 0.28 7.4 1.35 5.00
111 INT214073 Binding of TSC1 9 0.37 22 1.34 5.00
112 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23 5.00
113 INT154333 Positive_regulation of Localization of S100A12 4 0.69 3.9 1.19 5.00
114 INT139738 Gene_expression of Ptcra 9 0.63 2.75 1.14 5.00
115 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13 5.00
116 INT183933 Binding of CD68 8 0.31 8.74 1.06 5.00
117 INT111037 Positive_regulation of Gene_expression of Cdkn1b 5 0.39 11.17 1.06 5.00
118 INT111036 Positive_regulation of Cdkn1b 16 0.45 9 1.06 5.00
119 INT204058 Regulation of Gene_expression of Kras 4 0.24 7.54 1.01 5.00
120 INT186520 Gene_expression of CHKA 8 0.56 8.22 1 5.00
121 INT111035 Positive_regulation of Gene_expression of Kras 5 0.31 3.31 0.99 5.00
122 INT58755 Binding of PAM 6 0.34 3.09 0.97 5.00
123 INT51066 Binding of S100B 24 0.48 13.5 0.97 5.00
124 INT255622 Positive_regulation of PAM 7 0.18 4.89 0.87 5.00
125 INT29636 Localization of PAM 5 0.73 2.1 0.87 5.00
126 INT82374 Binding of SYP 13 0.36 13.69 0.85 5.00
127 INT169911 Phosphorylation of Rb1 35 0.73 18.58 0.79 5.00
128 INT195016 Gene_expression of Aifm1 8 0.45 5.92 0.78 5.00
129 INT23054 Binding of Cga 4 0.36 2.17 0.78 5.00
130 INT167381 Localization of DES 4 0.73 4.15 0.77 5.00
131 INT56955 Binding of MYOG 5 0.27 2.92 0.73 5.00
132 INT120494 Protein_catabolism of Fas 3 0.88 0.91 0.69 5.00
133 INT204075 Regulation of Gene_expression of CHKA 3 0.20 3.74 0.63 5.00
134 INT195017 Negative_regulation of Positive_regulation of Aifm1 3 0.24 1.48 0.63 5.00
135 INT177886 Positive_regulation of Gene_expression of Cdkn2a 3 0.67 3.42 0.62 5.00
136 INT76315 Gene_expression of Myog 15 0.41 6.79 0.6 5.00
137 INT53950 Phosphorylation of Tp53 8 0.61 9.4 0.6 5.00
138 INT58989 Gene_expression of Ccne1 2 0.75 0.79 0.58 5.00
139 INT172876 Positive_regulation of Tnfrsf10b 3 0.03 3.66 0.54 5.00
140 INT188724 Gene_expression of IGLV3-1 29 0.75 20.88 0.51 5.00
141 INT102108 Protein_catabolism of Bax 8 0.64 5.69 0.48 5.00
142 INT225355 Gene_expression of Set 15 0.37 2.98 0.47 5.00
143 INT204052 Transcription of Bcl2 5 0.51 3.25 0.45 5.00
144 INT169990 Localization of POMT1 7 0.19 4.09 0.45 5.00
145 INT132516 Gene_expression of NEURL 8 0.35 5.96 0.44 5.00
146 INT196916 Negative_regulation of Rb1 13 0.42 14.29 0.4 5.00
147 INT231524 Localization of PAX7 5 0.56 4.2 0.39 5.00
148 INT130889 Regulation of KRT7 4 0.07 3.74 0.39 5.00
149 INT83212 Positive_regulation of Gene_expression of Mki67 21 0.55 17.53 0.39 5.00
150 INT204069 Negative_regulation of Positive_regulation of Bax 5 0.31 3.08 0.34 5.00
151 INT204065 Regulation of Gene_expression of Cdkn1b 1 0.06 3.49 0.34 5.00
152 INT169918 Negative_regulation of Phosphorylation of Rb1 8 0.37 6.64 0.32 5.00
153 INT172957 Negative_regulation of Mdm2 4 0.14 4.28 0.3 5.00
154 INT157135 Positive_regulation of MKI67 10 0.60 7.51 0.28 5.00
155 INT29141 Binding of Kras 3 0.15 0.81 0.27 5.00
156 INT166125 Gene_expression of PHOSPHO1 4 0.75 3.06 0.24 5.00
157 INT208157 Localization of LOC148709 2 0.73 0.52 0.2 5.00
158 INT228901 Positive_regulation of RPS6KB1 5 0.55 2.44 0.18 5.00
159 INT204054 Negative_regulation of Negative_regulation of Mdm2 2 0.14 2.23 0.15 5.00
160 INT204067 Positive_regulation of Gene_expression of Casp8 3 0.60 2.69 0.12 5.00
161 INT204056 Gene_expression of Cdk2 5 0.35 0.9 0.12 5.00
162 INT204063 Gene_expression of Cdk4 3 0.21 0.9 0.12 5.00
163 INT191073 Negative_regulation of Gene_expression of Mki67 8 0.53 4.99 0.11 5.00
164 INT228902 Gene_expression of RPS6KB1 5 0.75 2.32 0.1 5.00
165 INT265537 Gene_expression of Iva1 1 0.65 0.77 0.08 5.00
166 INT318034 Binding of NEURL 1 0.06 1.7 0.06 5.00
167 INT231525 Negative_regulation of Localization of PAX7 1 0.12 1.05 0.04 5.00
168 INT265535 Negative_regulation of Gene_expression of Ptcra 1 0.05 0.81 0.04 5.00
169 INT231532 Binding of PAX7 3 0.36 3.05 0.03 5.00
170 INT176240 Phosphorylation of Mdm2 2 0.22 1.28 0.03 5.00
171 INT317061 Regulation of Gene_expression of KRT7 2 0.19 0.99 0.03 5.00
172 INT354597 Positive_regulation of Positive_regulation of PAM 1 0.09 1.41 0.03 5.00
173 INT228904 Positive_regulation of PHOSPHO1 1 0.45 0.84 0 5.00
174 INT204059 Positive_regulation of Phosphorylation of Tp53 1 0.07 0.76 0 5.00
175 INT228895 Binding of Tsc2 5 0.30 2.41 0 5.00
176 INT228899 Positive_regulation of Gene_expression of PHOSPHO1 1 0.49 0.84 0 5.00
177 INT204053 Negative_regulation of Transcription of Bcl2 1 0.04 0.86 0 5.00
178 INT204070 Negative_regulation of Positive_regulation of Cdkn1b 1 0.05 0.47 0 5.00
179 INT204062 Negative_regulation of Gene_expression of Cdk4 1 0.12 0.47 0 5.00
180 INT228900 Positive_regulation of Gene_expression of RPS6KB1 2 0.49 1.6 0 5.00
181 INT204064 Negative_regulation of Gene_expression of Cdk2 1 0.11 0.47 0 5.00
182 INT204061 Negative_regulation of Gene_expression of Cdk6 1 0.12 0.47 0 5.00
183 INT204068 Negative_regulation of Gene_expression of Ccne1 1 0.03 0.47 0 5.00
184 INT204055 Positive_regulation of Negative_regulation of Rb1 1 0.03 0.55 0 5.00
185 INT204060 Gene_expression of Cdk6 3 0.26 0.83 0 5.00
186 INT208507 Binding of EOS 2 0.10 2.42 0 5.00
187 INT265536 Regulation of Set 1 0.17 1.11 0 5.00
188 INT228903 Negative_regulation of Gene_expression of PHOSPHO1 1 0.42 0.79 0 5.00
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