D:Anaplastic Large Cell Lymphoma

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Disease Term
Synonyms Cd30 Anaplastic Large Cell Lymphoma, Cd30 Positive Anaplastic Large Cell Lymphoma, Ki 1 Anaplastic Large Cell Lymphoma, Ki 1 Large Cell Lymphoma, KI 1 LARGE CELL LYMPHOMAS, Ki 1 Lymphoma, KI 1 LYMPHOMAS, Ki 1 Positive Anaplastic Large Cell Lymphoma, KI 1 POSITIVE LARGE CELL LYMPHOMA, Ki 1 Positive Large Cell Lymphomas, LARGE CELL LYMPHOMA KI 1
Documents 50
Hot Single Events 66
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Anaplastic Large Cell Lymphoma. They are ordered first by their relevance to Anaplastic Large Cell Lymphoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT276387 ALK Positive_regulation of Gene_expression of Il22ra1 1 0.00 1.55 0 100.00
2 INT92389 ALK Positive_regulation of Gene_expression of Map3k1 1 0.01 1.14 0.09 99.56
3 INT92390 ALK Positive_regulation of Gene_expression of Tnfrsf8 1 0.45 1.14 0.09 99.56
4 INT276333 Binding of Il10rb and Il22ra1 1 0.00 1.25 0 98.84
5 INT276388 Il22 Positive_regulation of STAT3 1 0.03 1.3 0.03 97.28
6 INT94157 CDCP1 Negative_regulation of RB1 1 0.02 0.92 0.03 25.00
7 INT94159 Positive_regulation of CDK1 Negative_regulation of RB1 1 0.45 0.93 0.03 25.00
8 INT94158 CDK1 Negative_regulation of RB1 1 0.41 0.92 0.03 25.00
9 INT204246 ETFA Regulation of CD68 1 0.37 1.05 0.04 18.80
10 INT204247 S100B Regulation of CD68 1 0.03 1.05 0.04 18.80
11 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46 5.00
12 INT276301 Binding of CCL21 and CXCL13 1 0.04 1.85 0.18 5.00
13 INT276304 PRDM1 Regulation of TSC1 1 0.01 1.29 0.09 5.00
14 INT276391 Prdm1 Regulation of TSC1 1 0.00 1.29 0.09 5.00
15 INT276375 Binding of Prdm1 and MIR9-1 1 0.12 1.12 0.08 5.00
16 INT276383 Binding of PRDM1 and Mirlet7a-1 1 0.39 1.12 0.08 5.00
17 INT276334 Binding of Prdm1 and Mirlet7a-1 1 0.12 1.13 0.08 5.00
18 INT276384 Binding of Mirlet7a-1 and MIR9-1 1 0.39 1.12 0.08 5.00
19 INT276337 Timp1 Positive_regulation of Il10 1 0.01 0.76 0.05 5.00
20 INT276386 Gtf3a Regulation of PTPN6 1 0.00 0.86 0.04 5.00
21 INT276381 Timp1 Positive_regulation of CD44 1 0.07 0.72 0.04 5.00
22 INT276392 Timp1 Regulation of PTPN6 1 0.02 0.87 0.04 5.00
23 INT276376 Gtf3a Regulation of CD44 1 0.00 0.86 0.04 5.00
24 INT276385 Timp1 Regulation of CD44 1 0.04 0.87 0.04 5.00
25 INT276377 Binding of Lgals1 and KRT20 1 0.00 1.11 0.03 5.00
26 INT276305 Binding of LGALS1 and KRT20 1 0.01 1.11 0.03 5.00
27 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03 5.00
28 INT276382 Binding of CIB1 and Skp2 1 0.01 0.57 0 5.00
29 INT276300 TAT Regulation of Gene_expression of VEGFA 1 0.14 1.58 0 5.00
30 INT276390 Positive_regulation of CD40 Positive_regulation of Gene_expression of Pdcd1 1 0.01 1.06 0 5.00
31 INT276378 CD40 Positive_regulation of Gene_expression of Pdcd1 1 0.01 1.06 0 5.00
32 INT276380 Binding of PIM1 and Trp53 1 0.01 0.66 0 5.00
33 INT276379 Binding of SKP2 and Cdkn1b 1 0.02 0.57 0 5.00
34 INT276303 Negative_regulation of AKT1 Negative_regulation of CCND1 1 0.01 0.58 0 5.00
35 INT276336 Skp2 Regulation of Cdkn1b 1 0.00 0.57 0 5.00
36 INT276374 Skp2 Regulation of Protein_catabolism of CIB1 1 0.00 0.58 0 5.00
37 INT276335 Binding of Cdkn1b and Skp2 1 0.00 0.57 0 5.00
38 INT276302 Binding of SKP2 and CIB1 1 0.03 0.57 0 5.00
39 INT276393 Skp2 Regulation of CIB1 1 0.00 0.57 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Anaplastic Large Cell Lymphoma. They are ordered first by their pain relevance and then by number of times they were reported in Anaplastic Large Cell Lymphoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT136927 Gene_expression of HGS 18 0.70 14.42 0.6 100.00
2 INT11139 Gene_expression of LBR 20 0.75 5.13 2.78 100.00
3 INT28643 Positive_regulation of Gene_expression of LBR 3 0.11 2.43 1.16 100.00
4 INT92388 Gene_expression of ALK 16 0.78 22.46 2.26 99.96
5 INT62331 Gene_expression of TNFRSF8 26 0.72 17.75 2.08 99.96
6 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 99.86
7 INT276331 Gene_expression of Il22ra1 6 0.46 6.88 1.31 99.60
8 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 99.56
9 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 99.56
10 INT179045 Gene_expression of BLZF1 4 0.04 2.42 0 99.56
11 INT298393 Phosphorylation of TNFRSF8 1 0.29 1.63 0.1 99.50
12 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 99.48
13 INT298387 Positive_regulation of Gene_expression of CYB5B 1 0.69 7.96 0 99.44
14 INT298386 Positive_regulation of CYB5B 1 0.69 4.41 0 99.44
15 INT298395 Transcription of CYB5B 1 0.71 7.33 0 99.36
16 INT298390 Positive_regulation of Transcription of CYB5B 1 0.69 2.58 0 99.36
17 INT298384 Gene_expression of CYB5B 1 0.77 23.1 0.03 99.20
18 INT9903 Gene_expression of CYB5A 9 0.37 2.78 0.53 98.88
19 INT92386 Gene_expression of Tnfrsf8 14 0.54 13.55 1.67 98.76
20 INT92387 Gene_expression of Map3k1 1 0.02 1.13 0.09 98.76
21 INT136102 Positive_regulation of Gene_expression of ALK 3 0.70 3.21 0.59 98.70
22 INT204924 Negative_regulation of Clta 1 0.01 1.37 0 97.96
23 INT68394 Gene_expression of KISS1 15 0.73 5.33 2.03 97.84
24 INT204256 Gene_expression of HCLS1 1 0.03 5.24 0.07 97.24
25 INT298388 Negative_regulation of Gene_expression of CYB5B 1 0.43 1.98 0 96.40
26 INT297259 Regulation of ACVRL1 1 0.18 0.55 0 95.12
27 INT297260 Regulation of ETFA 1 0.33 0.55 0 95.12
28 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 94.28
29 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 94.28
30 INT153260 Gene_expression of CD22 19 0.70 8.35 0.39 94.28
31 INT88070 Binding of Ema 7 0.18 7.39 0.31 92.12
32 INT73091 Binding of TNFRSF8 21 0.44 6.64 0.93 92.12
33 INT61642 Binding of ACVRL1 5 0.31 7.03 0.87 92.12
34 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 90.76
35 INT101168 Gene_expression of Tbpl1 23 0.75 10.88 5.38 90.20
36 INT68228 Positive_regulation of TNFRSF8 5 0.56 6.26 0.84 89.92
37 INT107118 Positive_regulation of ALK 4 0.49 3.64 0.52 89.92
38 INT93659 Positive_regulation of ITGAE 3 0.22 1.9 0.16 89.76
39 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 89.12
40 INT276372 Negative_regulation of Gene_expression of FOXP3 2 0.38 1.49 0.16 89.12
41 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 88.72
42 INT7980 Gene_expression of Fut4 36 0.62 13.37 3.79 88.16
43 INT7981 Positive_regulation of Gene_expression of Fut4 6 0.10 2.82 0 88.16
44 INT217550 Positive_regulation of Gene_expression of Tnfrsf8 1 0.09 1.04 0 88.16
45 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 87.76
46 INT83896 Gene_expression of CD1A 19 0.68 15.58 2.1 87.28
47 INT29441 Negative_regulation of Gene_expression of Cea 6 0.20 5.97 0.55 86.44
48 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 86.12
49 INT87470 Gene_expression of SDC1 27 0.78 24.86 5.81 85.16
50 INT36201 Gene_expression of ETFA 8 0.66 9.18 0.58 85.16
51 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 84.96
52 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 83.68
53 INT167381 Localization of DES 4 0.73 4.15 0.77 83.56
54 INT204254 Localization of KIT 8 0.73 6.78 0.61 83.56
55 INT134223 Localization of CD99 4 0.73 4.42 0.16 83.56
56 INT204255 Localization of MYOG 1 0.18 1.82 0.03 83.56
57 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 83.44
58 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 83.20
59 INT126457 Gene_expression of BCL6 34 0.66 22.45 1.75 82.80
60 INT46333 Positive_regulation of Asrgl1 3 0.49 2.71 0.33 82.36
61 INT204253 Binding of TTF1 1 0.16 1.71 0 82.12
62 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 81.08
63 INT92477 Gene_expression of Tia1 4 0.07 3.25 0.34 80.88
64 INT92476 Gene_expression of Gzmb 19 0.58 7.78 1.94 80.88
65 INT23317 Gene_expression of Spn 20 0.48 14.51 4.01 80.88
66 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11 80.56
67 INT94162 Binding of UCN2 3 0.36 1.8 1.18 77.68
68 INT38674 Regulation of KRT20 32 0.44 19 2.15 75.08
69 INT52937 Gene_expression of Cd68 37 0.67 31.33 7.54 75.00
70 INT159505 Gene_expression of Tnfrsf8 2 0.12 1.35 0.11 75.00
71 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 74.88
72 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 74.00
73 INT107652 Gene_expression of C7 4 0.60 2.06 0.56 72.80
74 INT48888 Localization of Pbrgcsf1 11 0.29 5.04 2.05 72.44
75 INT276338 Negative_regulation of MXI1 1 0.12 0.9 0.05 72.08
76 INT58563 Negative_regulation of S100B 13 0.51 11.75 1.77 71.04
77 INT276318 Negative_regulation of Dusp5 1 0.15 1.01 0.04 68.24
78 INT298389 Negative_regulation of CYB5B 1 0.42 1.12 0 68.04
79 INT218760 Negative_regulation of ZEB1 4 0.38 1.38 0.09 67.44
80 INT8792 Gene_expression of GBA 20 0.78 14.73 1.98 66.96
81 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 62.32
82 INT46148 Binding of LBR 5 0.31 1.58 0.64 61.84
83 INT298394 Positive_regulation of Binding of LBR 1 0.05 0.31 0 61.84
84 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 61.52
85 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08 61.12
86 INT94167 Regulation of CHEK1 1 0.04 1.7 0.16 60.16
87 INT131931 Binding of KRT7 13 0.36 19.24 0.5 59.20
88 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 57.28
89 INT71378 Transcription of LBR 2 0.07 1.34 1.03 53.40
90 INT298391 Binding of CYB5B 1 0.32 0.05 0 46.00
91 INT90584 Gene_expression of GZMB 15 0.14 13.81 1.86 42.84
92 INT154182 Phosphorylation of SYK 6 0.82 5.54 0.43 41.28
93 INT154181 Positive_regulation of Phosphorylation of SYK 4 0.70 4.71 0.37 41.28
94 INT94163 Negative_regulation of UCN2 11 0.57 6.86 1.75 40.96
95 INT94156 Negative_regulation of Crem 1 0.00 1.5 0.15 40.96
96 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 37.44
97 INT298385 Binding of GPHB5 1 0.09 0 0 36.44
98 INT252723 Gene_expression of SYK 3 0.25 2.67 0.23 34.24
99 INT276371 Positive_regulation of Gene_expression of SYK 1 0.22 0.67 0.03 34.24
100 INT197979 Gene_expression of Prdx1 3 0.23 4.14 0.34 32.96
101 INT132324 Localization of SYK 2 0.78 1.9 0.59 31.44
102 INT276373 Localization of ITK 1 0.78 1.42 0.08 31.44
103 INT128161 Gene_expression of DDIT3 20 0.75 17.14 5.13 30.56
104 INT199004 Gene_expression of ARMC9 43 0.58 17.72 1.32 30.56
105 INT126572 Positive_regulation of SYK 3 0.67 2.98 0.83 28.40
106 INT276348 Positive_regulation of Positive_regulation of SYK 1 0.22 0.66 0.04 28.40
107 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 26.64
108 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 25.00
109 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57 25.00
110 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51 25.00
111 INT94166 Phosphorylation of CDK1 10 0.79 4.75 0.2 25.00
112 INT94168 Positive_regulation of Phosphorylation of RB1 12 0.60 6.6 0.15 25.00
113 INT94160 Positive_regulation of Phosphorylation of CDK1 2 0.49 0.93 0.03 25.00
114 INT94161 Negative_regulation of Phosphorylation of CDK1 1 0.41 0.93 0.03 25.00
115 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27 23.76
116 INT57338 Gene_expression of ITGAX 31 0.75 24.62 4.39 23.12
117 INT74863 Gene_expression of PRDX1 3 0.50 2.16 0.1 20.64
118 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 14.00
119 INT122988 Gene_expression of CLU 28 0.75 24.07 1.21 13.36
120 INT87321 Binding of ITGAX 4 0.47 3.72 0.8 13.16
121 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 11.84
122 INT249695 Negative_regulation of Gene_expression of CD19 3 0.26 3.12 0.08 9.64
123 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 5.76
124 INT179023 Gene_expression of FL 4 0.39 3.53 0.63 5.56
125 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
126 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
127 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 5.00
128 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
129 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
130 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
131 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
132 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
133 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
134 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
135 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
136 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
137 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01 5.00
138 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
139 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
140 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
141 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
142 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 5.00
143 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
144 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 5.00
145 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
146 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
147 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
148 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
149 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
150 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
151 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
152 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
153 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
154 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 5.00
155 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 5.00
156 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
157 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
158 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
159 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
160 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
161 INT108479 Positive_regulation of CCL21 18 0.67 19.93 10.76 5.00
162 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43 5.00
163 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
164 INT128159 Positive_regulation of DDIT3 29 0.67 29.5 8.99 5.00
165 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
166 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 5.00
167 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
168 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
169 INT276358 Gene_expression of MIR150 42 0.74 38.44 7.82 5.00
170 INT74520 Positive_regulation of CD68 30 0.61 31.68 7.59 5.00
171 INT39417 Gene_expression of Fcer2a 65 0.76 32.1 7.37 5.00
172 INT26462 Gene_expression of DNAH8 44 0.78 19.36 7.31 5.00
173 INT93003 Binding of CD40 28 0.47 20.25 7.13 5.00
174 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
175 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 5.00
176 INT17551 Positive_regulation of Gene_expression of HLA-DRA 31 0.70 15.39 6 5.00
177 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 5.00
178 INT236839 Positive_regulation of CXCL13 14 0.44 19.27 5.81 5.00
179 INT77146 Binding of IL4 23 0.36 13.69 5.39 5.00
180 INT3165 Gene_expression of LYZ 25 0.65 16.72 5.16 5.00
181 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15 5.00
182 INT34358 Binding of MME 13 0.37 7.25 5.14 5.00
183 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 5.00
184 INT137178 Gene_expression of TLR3 46 0.72 24.97 4.33 5.00
185 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
186 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.00
187 INT13362 Gene_expression of NFKBIL1 12 0.59 3.79 3.99 5.00
188 INT92653 Gene_expression of IL12B 21 0.75 17.28 3.89 5.00
189 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 5.00
190 INT14717 Gene_expression of TAT 20 0.75 10.67 3.66 5.00
191 INT149332 Gene_expression of CD163 19 0.75 13.63 3.65 5.00
192 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53 5.00
193 INT142483 Positive_regulation of Gene_expression of DDIT3 15 0.67 11.39 3.47 5.00
194 INT78284 Positive_regulation of PTPRC 40 0.49 27.17 3.45 5.00
195 INT28359 Gene_expression of Pdcd1 39 0.57 34.09 3.4 5.00
196 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 5.00
197 INT97063 Gene_expression of CD5 16 0.77 13.81 3.13 5.00
198 INT93913 Positive_regulation of CD40 21 0.58 23.47 3.1 5.00
199 INT181386 Positive_regulation of Cxcl12 12 0.69 15.35 2.84 5.00
200 INT24895 Positive_regulation of LYZ 25 0.70 17.92 2.64 5.00
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