D:Anastomotic Leak

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Disease Term
Synonyms Anastomotic Leakage, Anastomotic Leakages, Anastomotic Leaks, LEAK ANASTOMOTIC, LEAKAGE ANASTOMOTIC, Leakages Anastomotic, LEAKS ANASTOMOTIC
Documents 256
Hot Single Events 34
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Anastomotic Leak. They are ordered first by their relevance to Anastomotic Leak and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT336179 Binding of CACNA1F and DLST 1 0.01 1.6 0 83.68
2 INT323352 Binding of F8 and VWF 5 0.08 2.22 0.33 73.56
3 INT343794 Binding of F8 and PTPRC 1 0.00 0.69 0.09 73.20
4 INT336340 Glp2r Positive_regulation of Gene_expression of TGFB1 1 0.14 0.67 0.39 71.60
5 INT343792 Binding of TCF21 and CORO7 1 0.01 0.51 0.07 52.04
6 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18 49.08
7 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35 49.08
8 INT336338 Glp2r Positive_regulation of Gene_expression of Igf1 1 0.14 0.24 0.05 32.64
9 INT336339 Glp2r Positive_regulation of Timp1 1 0.16 1.82 0.36 5.00
10 INT336336 Il10 Regulation of Il13 1 0.04 0.67 0.34 5.00
11 INT336335 Glp2r Regulation of Mmp13 1 0.06 0.68 0.28 5.00
12 INT336337 Glp2r Positive_regulation of Gene_expression of Col2a1 1 0.01 0.7 0.14 5.00
13 INT294065 ANGPT2 Positive_regulation of VEGFA 1 0.02 0.1 0 5.00
14 INT322413 Binding of ATF1 and EWSR1 1 0.26 1.3 0 5.00
15 INT294066 ANGPT1 Positive_regulation of VEGFA 1 0.01 0.1 0 5.00
16 INT293950 Binding of CTNND2 and Spn 1 0.06 1.69 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Anastomotic Leak. They are ordered first by their pain relevance and then by number of times they were reported in Anastomotic Leak. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT860 Regulation of ALB 48 0.60 25.11 8.95 100.00
2 INT270783 Gene_expression of ENDOG 1 0.43 3.17 0 99.66
3 INT72219 Gene_expression of METTL3 45 0.24 9.58 7.61 99.32
4 INT73021 Gene_expression of EGR1 43 0.77 24.65 9.18 99.32
5 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.32
6 INT22973 Gene_expression of Col3a1 22 0.42 15.85 4.32 99.28
7 INT138429 Negative_regulation of Gene_expression of Col3a1 3 0.17 2.51 0.54 99.28
8 INT90004 Gene_expression of TCF21 4 0.65 2.48 2.02 98.20
9 INT8888 Regulation of Col1a1 4 0.13 1.97 0.86 96.08
10 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 93.84
11 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 93.64
12 INT306949 Gene_expression of NAMPT 27 0.67 24.47 2.86 93.64
13 INT11021 Gene_expression of Tme 12 0.52 8.54 0.33 93.08
14 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12 91.00
15 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 89.84
16 INT310951 Positive_regulation of DLST 2 0.43 2.71 0.06 89.24
17 INT185370 Gene_expression of ANC 28 0.65 13.28 0.4 88.56
18 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 88.56
19 INT894 Binding of Avp 84 0.48 29.16 29.63 88.08
20 INT66869 Negative_regulation of EDF1 3 0.38 2.02 0.13 87.76
21 INT60034 Positive_regulation of VWF 40 0.68 30.42 8.15 87.24
22 INT72220 Negative_regulation of METTL3 6 0.10 1.76 0.88 87.20
23 INT49803 Negative_regulation of MUC1 37 0.58 26.37 2.06 86.80
24 INT246514 Negative_regulation of NAMPT 4 0.51 2.98 0.37 86.08
25 INT177459 Negative_regulation of RCT 13 0.25 7.9 2.7 84.72
26 INT53343 Positive_regulation of NAMPT 13 0.60 10.94 1.58 83.64
27 INT68443 Positive_regulation of METTL3 9 0.12 3.54 2.39 83.64
28 INT316154 Positive_regulation of TCF21 4 0.17 1.22 1.23 83.64
29 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62 82.60
30 INT141146 Gene_expression of Mmp13 18 0.38 8.61 5.54 82.28
31 INT157603 Positive_regulation of Gene_expression of Mmp13 3 0.16 0.91 0.21 82.28
32 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 81.20
33 INT306954 Binding of NAMPT 8 0.36 7.98 0.74 81.04
34 INT241037 Regulation of Col3a1 2 0.05 1.94 0.14 80.72
35 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 79.20
36 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 78.20
37 INT32458 Gene_expression of VWF 57 0.78 28.97 5.56 78.20
38 INT104221 Regulation of Gene_expression of CRP 30 0.45 20.01 4.07 77.84
39 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 77.84
40 INT336334 Positive_regulation of Gene_expression of Glp2r 1 0.39 0.87 0.07 77.52
41 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77 77.04
42 INT72218 Regulation of METTL3 5 0.08 1.62 1.14 76.80
43 INT141467 Gene_expression of Glp2r 5 0.77 4.21 1.25 76.60
44 INT201549 Regulation of CD99 3 0.23 3.6 0.03 75.08
45 INT104777 Regulation of DES 4 0.38 2.38 1.2 74.08
46 INT97331 Positive_regulation of Timp1 20 0.45 13.32 8.57 73.96
47 INT139144 Positive_regulation of Glp2r 5 0.69 2.03 1.26 73.96
48 INT336333 Binding of Glp2r 1 0.36 1.5 0.4 72.36
49 INT25240 Negative_regulation of Pcbd1 11 0.43 3.1 1.59 70.92
50 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 69.92
51 INT25123 Negative_regulation of COL7A1 42 0.58 19.98 5.96 68.08
52 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 65.20
53 INT49660 Positive_regulation of EGR1 54 0.69 32.17 9.89 64.08
54 INT294082 Positive_regulation of CORO7 5 0.39 3.14 0.22 62.48
55 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 59.20
56 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 59.20
57 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 57.56
58 INT56955 Binding of MYOG 5 0.27 2.92 0.73 56.40
59 INT88005 Binding of MYOD1 6 0.30 2.08 0.42 56.40
60 INT322423 Negative_regulation of PAX3 1 0.41 1.09 0 55.00
61 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 54.88
62 INT231530 Localization of PAX3 2 0.68 2.52 0 54.56
63 INT15540 Positive_regulation of PDGFA 24 0.47 19.01 2.5 54.48
64 INT135319 Positive_regulation of Positive_regulation of CRP 20 0.50 26.45 5.61 54.16
65 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 53.44
66 INT127273 Gene_expression of AMH 24 0.78 9.53 0.47 50.28
67 INT270785 Negative_regulation of ENDOG 1 0.27 0.87 0.35 50.00
68 INT270784 Binding of ENDOG 1 0.24 0.17 0.21 50.00
69 INT152787 Positive_regulation of epf 4 0.26 0.86 1.42 49.92
70 INT198663 Positive_regulation of HMGB1 14 0.52 11.41 1.58 49.36
71 INT306136 Binding of Tme 3 0.14 2.32 0.32 49.28
72 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 49.16
73 INT58469 Negative_regulation of Positive_regulation of IL6 16 0.42 8.1 2.14 49.16
74 INT343803 Negative_regulation of Positive_regulation of CORO7 1 0.04 0.16 0.04 48.80
75 INT86601 Positive_regulation of KCNH2 7 0.49 1.56 0.52 48.48
76 INT139147 Localization of Glp2r 3 0.80 0.96 0.85 48.28
77 INT336329 Negative_regulation of Glp2r 1 0.42 0.59 0.09 48.28
78 INT98635 Negative_regulation of Gene_expression of EGR1 5 0.58 2.2 1.42 45.84
79 INT98632 Negative_regulation of EGR1 6 0.42 3.38 0.54 45.84
80 INT184269 Gene_expression of HMGB1 51 0.77 42.96 4.55 45.48
81 INT220336 Negative_regulation of HMGB1 3 0.43 0.97 0.21 45.48
82 INT206737 Negative_regulation of Gene_expression of HMGB1 3 0.32 3.48 0.09 45.48
83 INT30382 Negative_regulation of Ednra 21 0.42 12.06 8.19 45.04
84 INT60772 Negative_regulation of Ednrb 8 0.41 4.56 1.39 45.04
85 INT343804 Protein_catabolism of METTL3 1 0.01 0.65 0.12 43.24
86 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 39.76
87 INT336196 Negative_regulation of Gene_expression of DLST 1 0.07 1.03 0 39.56
88 INT16245 Binding of Spn 4 0.31 3.83 0.45 36.00
89 INT74254 Binding of PTPRC 16 0.36 8.37 1.27 35.52
90 INT310950 Gene_expression of DLST 3 0.58 3.03 0.22 35.28
91 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26 29.08
92 INT69702 Positive_regulation of PMAIP1 7 0.35 8.81 1.98 29.08
93 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51 28.48
94 INT23257 Regulation of CRP 127 0.62 100.05 21.87 27.24
95 INT66870 Positive_regulation of EDF1 3 0.60 0.62 0 26.88
96 INT200564 Positive_regulation of Negative_regulation of EDF1 1 0.14 0.38 0 26.88
97 INT200562 Negative_regulation of Positive_regulation of EDF1 1 0.13 0.38 0 26.88
98 INT209118 Regulation of Etfdh 12 0.18 7.77 3.91 25.96
99 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 25.28
100 INT210392 Regulation of PDGFA 10 0.36 11.41 1.12 24.72
101 INT10019 Binding of CD8A 57 0.36 31.49 10.08 24.48
102 INT343806 Gene_expression of CORO7 3 0.57 2.54 1.18 24.20
103 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 22.00
104 INT336325 Phosphorylation of Glp2r 1 0.61 0.5 0.28 20.40
105 INT344582 Gene_expression of OCR1 1 0.06 1.3 0.12 20.00
106 INT23317 Gene_expression of Spn 20 0.48 14.51 4.01 19.68
107 INT200561 Gene_expression of EDF1 1 0.21 0.11 0.03 18.64
108 INT200563 Regulation of Gene_expression of EDF1 1 0.14 0.06 0 18.64
109 INT139146 Positive_regulation of Localization of Glp2r 2 0.67 0.37 0.76 17.64
110 INT306952 Regulation of NAMPT 4 0.53 8.52 0.33 17.20
111 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 13.04
112 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 11.64
113 INT173022 Regulation of Gene_expression of MUC1 9 0.60 7.59 0.44 8.92
114 INT118020 Gene_expression of LRPAP1 9 0.65 0.18 0.07 8.28
115 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 7.92
116 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
117 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
118 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
119 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
120 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 5.00
121 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
122 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
123 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
124 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
125 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
126 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
127 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
128 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
129 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
130 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
131 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
132 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 5.00
133 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
134 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
135 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
136 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
137 INT7678 Localization of Alb 142 0.81 80.93 22.49 5.00
138 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 5.00
139 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
140 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
141 INT69304 Negative_regulation of Il10 47 0.59 36.88 19.79 5.00
142 INT61626 Transcription of IL6 73 0.72 42.04 17.86 5.00
143 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
144 INT6381 Negative_regulation of Chat 51 0.59 19.68 15.86 5.00
145 INT4851 Positive_regulation of Chat 53 0.70 9.21 15.11 5.00
146 INT55740 Gene_expression of Timp1 53 0.75 28.63 13.85 5.00
147 INT6365 Localization of Edn1 56 0.81 18.84 13.83 5.00
148 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
149 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 5.00
150 INT69158 Localization of IL4 48 0.71 31.3 11.98 5.00
151 INT32203 Negative_regulation of Crp 48 0.58 32.77 11.89 5.00
152 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
153 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
154 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 5.00
155 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
156 INT204112 Gene_expression of GEM 43 0.75 38.74 11.23 5.00
157 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
158 INT54834 Gene_expression of Col2a1 48 0.72 13.5 9.41 5.00
159 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28 5.00
160 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
161 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
162 INT49802 Localization of MUC1 75 0.81 44.74 8.87 5.00
163 INT148703 Gene_expression of NOVA2 73 0.65 18.05 8.3 5.00
164 INT32454 Gene_expression of Ptafr 3 0.65 15.19 7.87 5.00
165 INT86867 Regulation of CREB1 15 0.46 4.95 7.28 5.00
166 INT36960 Gene_expression of vs 33 0.43 20.77 6.97 5.00
167 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
168 INT6667 Gene_expression of CREB1 27 0.77 6.29 5.84 5.00
169 INT57376 Transcription of EGR1 20 0.69 12.94 4.84 5.00
170 INT58766 Gene_expression of ANGPT2 41 0.67 21.65 4.82 5.00
171 INT55114 Gene_expression of CRS 42 0.58 26.86 4.69 5.00
172 INT151230 Positive_regulation of IL7 14 0.37 11.89 4.56 5.00
173 INT12194 Gene_expression of Trf 38 0.69 18.1 4.56 5.00
174 INT170604 Negative_regulation of Gene_expression of GOPC 50 0.35 12.71 4.51 5.00
175 INT12111 Negative_regulation of Hbb-ar 11 0.37 6.63 4.22 5.00
176 INT19847 Positive_regulation of Localization of Alb 21 0.70 13.89 4.16 5.00
177 INT99608 Transcription of MMP9 18 0.65 9.67 4.11 5.00
178 INT54886 Negative_regulation of ANGPT2 25 0.42 9.33 3.79 5.00
179 INT5782 Gene_expression of Edn3 17 0.67 3.38 3.65 5.00
180 INT536 Binding of MBP 17 0.48 6.52 3.56 5.00
181 INT51848 Transcription of TGFB1 17 0.69 9.57 3.53 5.00
182 INT16966 Positive_regulation of CRS 23 0.60 22.5 3.49 5.00
183 INT32453 Positive_regulation of Gene_expression of Ptafr 2 0.58 7.01 3.47 5.00
184 INT80779 Positive_regulation of Hbb-ar 10 0.41 2.48 3.29 5.00
185 INT28249 Positive_regulation of HLA-DRA 25 0.70 13.63 3.25 5.00
186 INT18462 Positive_regulation of Pgc 29 0.57 22.55 3.24 5.00
187 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
188 INT21610 Positive_regulation of ANGPT2 23 0.41 13.28 3.03 5.00
189 INT55739 Transcription of Timp1 7 0.67 4.72 3 5.00
190 INT10141 Gene_expression of A2M 11 0.35 9.37 2.75 5.00
191 INT204124 Transcription of CRP 14 0.69 20.79 2.71 5.00
192 INT287307 Binding of ENO1 9 0.48 11.24 2.51 5.00
193 INT205683 Localization of Ptafr 4 0.12 4.63 2.31 5.00
194 INT173005 Transcription of MUC1 11 0.63 10.15 2.24 5.00
195 INT163545 Gene_expression of PDGFRB 39 0.78 25.5 2.2 5.00
196 INT23352 Negative_regulation of A2M 10 0.33 8.35 2.16 5.00
197 INT153718 Gene_expression of ANGPT1 15 0.45 10.82 2.13 5.00
198 INT55810 Negative_regulation of Positive_regulation of Crp 10 0.41 4.95 2.02 5.00
199 INT11033 Positive_regulation of Gene_expression of MUC16 21 0.69 15.75 1.89 5.00
200 INT71644 Gene_expression of MLANA 16 0.75 11.55 1.82 5.00
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