D:Anencephaly

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Disease Term
Synonyms ABSENCE OF BRAIN CONGENITAL, Anencephalia, Anencephalias, Anencephalies Partial, ANENCEPHALUS, ANENCEPHALY HEMICRANIAL, ANENCEPHALY INCOMPLETE, Anencephaly Partial, Aprosencephalies, Aprosencephaly, Brain Congenital Absence
Documents 25
Hot Single Events 3
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Anencephaly. They are ordered first by their relevance to Anencephaly and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT244338 Slc12a7 Positive_regulation of SERPINH1 1 0.00 0.26 0.13 45.60
2 INT209159 Binding of LHCGR and PDE5A 1 0.01 0 0 5.00
3 INT177762 GOPC Negative_regulation of Gene_expression of CHKB 1 0.11 0.08 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Anencephaly. They are ordered first by their pain relevance and then by number of times they were reported in Anencephaly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 87.32
2 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 87.32
3 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 81.24
4 INT621 Positive_regulation of SERPINH1 19 0.57 21.52 8.44 73.68
5 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24 67.00
6 INT10565 Gene_expression of MRXS5 94 0.53 37.35 19.08 61.68
7 INT25463 Negative_regulation of Gene_expression of MRXS5 7 0.38 4.75 2.12 61.68
8 INT68496 Binding of PGR 26 0.48 16.36 2.09 56.04
9 INT39518 Negative_regulation of HBN1 66 0.09 37.54 2.58 53.68
10 INT39415 Gene_expression of HBN1 33 0.43 19.31 0.93 34.56
11 INT71905 Regulation of Gene_expression of PGR 6 0.50 1.3 0.14 33.12
12 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 32.68
13 INT30316 Regulation of CHAT 6 0.43 1.95 0.96 28.40
14 INT209177 Positive_regulation of Transcription of PGR 1 0.50 0.05 0.07 26.52
15 INT202189 Transcription of PGR 5 0.51 0.8 0.4 26.00
16 INT146524 Negative_regulation of AADAC 5 0.04 4.2 0.28 24.08
17 INT5319 Positive_regulation of PTGFR 9 0.32 4.96 1.44 20.40
18 INT209183 Positive_regulation of Positive_regulation of PTGFR 1 0.23 0.08 0.11 20.40
19 INT10353 Positive_regulation of PGR 34 0.70 21.84 3.28 19.12
20 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
21 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 5.00
22 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
23 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
24 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
25 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
26 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
27 INT122041 Binding of Ppara 308 0.48 189.17 51.48 5.00
28 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 5.00
29 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
30 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
31 INT7035 Regulation of CGA 87 0.45 29.04 28.45 5.00
32 INT115385 Negative_regulation of Ppara 154 0.58 129.05 27.58 5.00
33 INT49850 Negative_regulation of PDE4A 105 0.58 76.91 26.59 5.00
34 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
35 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
36 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
37 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 5.00
38 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
39 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 5.00
40 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
41 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 5.00
42 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
43 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11 5.00
44 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 5.00
45 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
46 INT86729 Positive_regulation of CDCP1 37 0.07 18.74 10.76 5.00
47 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84 5.00
48 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 5.00
49 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 5.00
50 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 5.00
51 INT178174 Gene_expression of Tnfsf10 78 0.76 56.83 8.64 5.00
52 INT64815 Binding of Jun 49 0.48 21.47 8.59 5.00
53 INT80034 Positive_regulation of Gene_expression of FAS 32 0.67 30.34 8.51 5.00
54 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48 5.00
55 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37 5.00
56 INT114873 Phosphorylation of Stat3 63 0.82 30.19 8.23 5.00
57 INT113 Positive_regulation of MBD2 33 0.49 6.76 7.49 5.00
58 INT7883 Binding of ADRB2 18 0.47 5.49 7.37 5.00
59 INT6596 Positive_regulation of HLA-DRB1 33 0.61 27.01 7.26 5.00
60 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 5.00
61 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41 5.00
62 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36 5.00
63 INT62270 Positive_regulation of Gene_expression of Cdkn1a 30 0.47 18.73 5.69 5.00
64 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
65 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17 5.00
66 INT47662 Localization of CHKB 34 0.81 22.63 5.14 5.00
67 INT130 Negative_regulation of OXTR 19 0.43 4.63 4.96 5.00
68 INT21650 Regulation of OXTR 29 0.61 5.99 4.91 5.00
69 INT106524 Phosphorylation of Jun 23 0.80 15.35 4.78 5.00
70 INT170604 Negative_regulation of Gene_expression of GOPC 50 0.35 12.71 4.51 5.00
71 INT46121 Negative_regulation of SERPINH1 14 0.38 10.84 4.41 5.00
72 INT10849 Negative_regulation of OXT 14 0.48 2.51 4.19 5.00
73 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
74 INT112692 Localization of Bax 31 0.80 20.97 3.98 5.00
75 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94 5.00
76 INT95423 Negative_regulation of Bcl2l1 26 0.41 21.66 3.81 5.00
77 INT64817 Positive_regulation of Binding of Jun 16 0.69 6.78 3.81 5.00
78 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54 5.00
79 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26 5.00
80 INT15837 Binding of CGA 31 0.41 12.06 3.17 5.00
81 INT73263 Negative_regulation of MYC 20 0.57 12.86 2.95 5.00
82 INT258081 Protein_catabolism of ABAT 5 0.10 2.57 2.86 5.00
83 INT21131 Negative_regulation of Gene_expression of ABAT 6 0.42 4.93 2.83 5.00
84 INT36943 Binding of CHKB 14 0.37 4.09 2.75 5.00
85 INT82798 Regulation of MYC 19 0.60 12.06 2.31 5.00
86 INT178193 Negative_regulation of Stat3 25 0.58 17.82 2.27 5.00
87 INT133648 Regulation of HDAC9 14 0.60 10.01 2.18 5.00
88 INT34500 Positive_regulation of ADRB3 12 0.58 2.59 2.16 5.00
89 INT170469 Gene_expression of THY1 66 0.65 11.9 2.15 5.00
90 INT201652 Positive_regulation of Tnfsf10 26 0.68 26.79 2.14 5.00
91 INT73476 Transcription of MYC 18 0.69 12.14 2.13 5.00
92 INT177778 Gene_expression of SQLE 28 0.40 16.42 2.08 5.00
93 INT27236 Negative_regulation of F13a1 17 0.53 10.79 1.99 5.00
94 INT128030 Gene_expression of GJA1 23 0.75 7.81 1.88 5.00
95 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
96 INT226894 Negative_regulation of Tnfsf10 14 0.57 16.64 1.87 5.00
97 INT20630 Positive_regulation of Gene_expression of CHKB 19 0.47 15.79 1.85 5.00
98 INT192965 Localization of Stat3 15 0.74 7.05 1.68 5.00
99 INT73475 Positive_regulation of Transcription of MYC 7 0.67 5.46 1.66 5.00
100 INT258051 Negative_regulation of Protein_catabolism of ABAT 3 0.04 1.86 1.52 5.00
101 INT126334 Gene_expression of Tnfrsf10b 8 0.58 8.68 1.42 5.00
102 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41 5.00
103 INT121207 Negative_regulation of Phosphorylation of Stat3 16 0.45 9.35 1.4 5.00
104 INT48554 Positive_regulation of SP1 12 0.49 3.64 1.2 5.00
105 INT123303 Gene_expression of Smn1 40 0.71 15.5 1.18 5.00
106 INT174156 Localization of Trp53 16 0.72 13.52 1.18 5.00
107 INT93656 Gene_expression of Hephl1 14 0.22 1.45 1.11 5.00
108 INT110259 Negative_regulation of Vwf 6 0.42 3.3 1.1 5.00
109 INT83479 Gene_expression of KRT18 30 0.65 27.29 1 5.00
110 INT143114 Positive_regulation of Gene_expression of HLA-DRB4 5 0.29 5.2 0.92 5.00
111 INT236104 Positive_regulation of Negative_regulation of Ppara 6 0.59 6.91 0.91 5.00
112 INT85135 Gene_expression of CDCP1 14 0.02 5.1 0.84 5.00
113 INT106523 Positive_regulation of Phosphorylation of Jun 7 0.45 3.1 0.74 5.00
114 INT178116 Phosphorylation of GJA1 7 0.80 4.09 0.74 5.00
115 INT90496 Gene_expression of Dnmt1 9 0.60 5.44 0.7 5.00
116 INT93655 Localization of Hephl1 6 0.26 0.3 0.68 5.00
117 INT75453 Gene_expression of SMN2 4 0.75 2.55 0.67 5.00
118 INT171878 Binding of SQLE 8 0.04 4 0.63 5.00
119 INT307186 Negative_regulation of Phosphorylation of Jun 4 0.10 2.91 0.61 5.00
120 INT260801 Negative_regulation of Gene_expression of Tnfsf10 7 0.42 6.49 0.54 5.00
121 INT272868 Positive_regulation of Hdac2 3 0.27 2.15 0.5 5.00
122 INT70445 Binding of KRT1 10 0.35 5.38 0.47 5.00
123 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45 5.00
124 INT192937 Positive_regulation of Gene_expression of GJA1 4 0.67 0.4 0.44 5.00
125 INT209189 Binding of AVPR1A 5 0.29 1.94 0.43 5.00
126 INT145249 Negative_regulation of Cflar 6 0.42 7.16 0.42 5.00
127 INT209180 Transcription of ABCA1 4 0.47 1.09 0.39 5.00
128 INT177773 Localization of PSEN1 4 0.73 0.89 0.36 5.00
129 INT131017 Positive_regulation of Positive_regulation of Cdkn1a 5 0.67 1.89 0.32 5.00
130 INT152670 Negative_regulation of HAT1 4 0.07 1.04 0.32 5.00
131 INT172625 Regulation of HAT1 9 0.35 9.21 0.28 5.00
132 INT164514 Binding of THY1 3 0.34 1.23 0.27 5.00
133 INT248468 Negative_regulation of Smn1 6 0.39 5.55 0.25 5.00
134 INT132951 Regulation of GJA1 2 0.57 0.79 0.24 5.00
135 INT135543 Negative_regulation of Positive_regulation of Bax 5 0.30 6.4 0.23 5.00
136 INT113913 Binding of Hephl1 23 0.27 1.57 0.19 5.00
137 INT186146 Negative_regulation of GJA1 2 0.41 1.29 0.18 5.00
138 INT178124 Positive_regulation of Phosphorylation of GJA1 2 0.65 1.21 0.18 5.00
139 INT276934 Negative_regulation of Localization of Stat3 4 0.45 1.99 0.15 5.00
140 INT209185 Regulation of Phosphorylation of GJA1 2 0.44 0.09 0.14 5.00
141 INT265376 Gene_expression of Hdac3 4 0.51 1.8 0.13 5.00
142 INT153274 Gene_expression of LHCGR 2 0.67 1.53 0.1 5.00
143 INT170472 Negative_regulation of Gene_expression of THY1 4 0.41 0.26 0.1 5.00
144 INT209182 Regulation of Gene_expression of GJA1 1 0.57 0.09 0.09 5.00
145 INT209164 Positive_regulation of Akap6 1 0.04 0 0.09 5.00
146 INT188177 Localization of GJA1 2 0.75 0.07 0.07 5.00
147 INT209187 Positive_regulation of Localization of GJA1 1 0.65 0.07 0.07 5.00
148 INT178132 Negative_regulation of Gene_expression of GJA1 2 0.35 0.84 0.07 5.00
149 INT328541 Gene_expression of Rqcd1 1 0.01 0.91 0.07 5.00
150 INT209181 Negative_regulation of Binding of CGA 1 0.02 0.07 0.07 5.00
151 INT328553 Positive_regulation of Gene_expression of SMN2 1 0.49 1.03 0.07 5.00
152 INT20623 Negative_regulation of Gene_expression of CHKB 6 0.45 0.57 0.07 5.00
153 INT328542 Regulation of Positive_regulation of Cdkn1a 1 0.03 0.79 0.07 5.00
154 INT209165 Regulation of Akap6 1 0.02 0.06 0.06 5.00
155 INT209160 Regulation of Regulation of Akap6 1 0.02 0.06 0.06 5.00
156 INT209184 Regulation of PRKCI 1 0.02 0.06 0.06 5.00
157 INT209162 Positive_regulation of Phosphorylation of Akap6 1 0.03 0.05 0.05 5.00
158 INT209161 Phosphorylation of Akap6 1 0.05 0.05 0.05 5.00
159 INT209191 Positive_regulation of LHCGR 1 0.28 0.05 0.05 5.00
160 INT291676 Regulation of Gene_expression of Dnmt1 2 0.26 0.57 0.04 5.00
161 INT177775 Negative_regulation of SQLE 7 0.06 5.97 0.04 5.00
162 INT177776 Positive_regulation of Gene_expression of THY1 1 0.16 0.18 0.04 5.00
163 INT328544 Localization of Hsp90aa1 1 0.10 0.17 0.03 5.00
164 INT328554 Regulation of HDAC1 1 0.26 1.12 0.03 5.00
165 INT190057 Positive_regulation of Negative_regulation of TSC1 2 0.01 1.08 0.03 5.00
166 INT265373 Regulation of Hdac3 2 0.17 1.1 0.03 5.00
167 INT328536 Positive_regulation of Kera 1 0.04 1.14 0 5.00
168 INT328545 Binding of Hdac9 1 0.11 0.09 0 5.00
169 INT209190 Negative_regulation of Negative_regulation of GJA1 1 0.40 0 0 5.00
170 INT209178 Regulation of Regulation of LHCGR 1 0.25 0 0 5.00
171 INT328535 Localization of Nacc1 1 0.15 0.68 0 5.00
172 INT177772 Positive_regulation of Hephl1 1 0.02 0.09 0 5.00
173 INT209186 Regulation of LHCGR 1 0.35 0 0 5.00
174 INT177774 Transcription of PSEN1 1 0.33 0.09 0 5.00
175 INT328534 Positive_regulation of Gene_expression of Dnmt1 1 0.10 0.07 0 5.00
176 INT328548 Negative_regulation of Gene_expression of Cbx5 1 0.05 0.08 0 5.00
177 INT177777 Regulation of Localization of THY1 1 0.19 0 0 5.00
178 INT328546 Gene_expression of Cbx5 1 0.07 0.08 0 5.00
179 INT328537 Gene_expression of Cbx1 1 0.02 0.08 0 5.00
180 INT172965 Negative_regulation of Positive_regulation of Cdkn1a 4 0.41 1.84 0 5.00
181 INT209188 Negative_regulation of Positive_regulation of LHCGR 1 0.24 0 0 5.00
182 INT170471 Localization of THY1 7 0.37 0.75 0 5.00
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