D:Animal Disease Models

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Animal Disease Model, Disease Model Animal
Documents 19
Hot Single Events 13
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Animal Disease Models. They are ordered first by their relevance to Animal Disease Models and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT261579 Serpinc1 Negative_regulation of Gene_expression of CYBB 1 0.00 1.69 0.18 80.56
2 INT322966 Binding of IL8 and Darc 1 0.02 0.45 0.27 78.48
3 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17 70.92
4 INT193322 KNG1 Positive_regulation of Prh1 1 0.00 0.51 0.83 58.92
5 INT322964 Binding of IL8 and Cxcl12 1 0.30 0.2 0.32 58.40
6 INT310255 Tlr4 Positive_regulation of Gene_expression of Cd86 2 0.18 0.06 0.27 22.24
7 INT310256 Tlr4 Positive_regulation of Gene_expression of H2 1 0.05 0.06 0.15 22.24
8 INT310257 Tlr4 Positive_regulation of Gene_expression of Cd40 1 0.13 0.06 0.15 22.24
9 INT310258 Tlr4 Positive_regulation of Gene_expression of Cd80 1 0.18 0.06 0.15 22.24
10 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9 5.00
11 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82 5.00
12 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49 5.00
13 INT184291 Binding of AGER and Crp 1 0.01 1.23 0.46 5.00
14 INT184292 Binding of AGER and chromosomal protein 1 1 0.01 0.87 0.41 5.00
15 INT259637 Binding of Mmp12 and COPD 2 0.02 1.71 0.4 5.00
16 INT272925 Ccl2 Positive_regulation of Gene_expression of Col7a1 1 0.00 0.72 0.3 5.00
17 INT272932 Binding of Mmp9 and COPD 1 0.01 0.78 0.29 5.00
18 INT272930 Positive_regulation of Binding of Mmp1a and COPD 1 0.01 0.79 0.29 5.00
19 INT272933 Binding of Mmp1a and COPD 1 0.01 0.78 0.29 5.00
20 INT272929 Positive_regulation of Binding of Mmp9 and COPD 1 0.01 0.79 0.29 5.00
21 INT272928 Positive_regulation of Binding of Mmp12 and COPD 1 0.01 0.79 0.29 5.00
22 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23 5.00
23 INT272931 Binding of IL8 and Cxcr1 1 0.07 0.65 0.18 5.00
24 INT322962 Binding of Darc and Gpbar1 1 0.01 0.69 0.18 5.00
25 INT322965 Binding of IL8 and Cxcr2 1 0.28 0.51 0.18 5.00
26 INT261577 Nos2 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.16 5.00
27 INT171544 PECAM1 Positive_regulation of ICAM1 1 0.01 0.47 0.16 5.00
28 INT272927 Mapk14 Positive_regulation of Gene_expression of TNF 1 0.16 0.53 0.14 5.00
29 INT171547 IL4 Regulation of GSTK1 1 0.03 0.6 0.12 5.00
30 INT171546 IL4 Positive_regulation of IFI27 1 0.14 0.06 0.08 5.00
31 INT171545 IL4 Positive_regulation of PPBP 1 0.01 0 0.05 5.00
32 INT171543 IL4 Positive_regulation of Transcription of C3 1 0.28 0 0.05 5.00
33 INT171542 IL4 Positive_regulation of Gene_expression of C3 1 0.19 0 0.05 5.00
34 INT272867 Binding of NLRP1 and COPD 1 0.00 1.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Animal Disease Models. They are ordered first by their pain relevance and then by number of times they were reported in Animal Disease Models. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 99.46
2 INT10834 Binding of IL8 65 0.48 41.66 16.53 99.28
3 INT184280 Positive_regulation of AGER 8 0.52 9.05 2.43 98.04
4 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41 96.08
5 INT126523 Phosphorylation of Mapkapk2 19 0.79 7.76 0.82 96.02
6 INT139830 Gene_expression of AGER 47 0.75 41.71 16.53 94.84
7 INT184270 Negative_regulation of AGER 8 0.32 10.48 3.45 94.04
8 INT272875 Localization of Mapkapk2 1 0.23 0.9 0.34 94.00
9 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59 88.40
10 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 88.24
11 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 88.24
12 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 84.16
13 INT184281 Binding of AGER 25 0.37 23.06 7.32 80.16
14 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 78.32
15 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 78.32
16 INT184285 Positive_regulation of Binding of AGER 1 0.38 1.04 0.49 75.04
17 INT116433 Gene_expression of CYBB 93 0.70 50.44 11.91 74.08
18 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 72.64
19 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 72.56
20 INT202365 Regulation of Gene_expression of Mapk14 6 0.45 4.89 1.26 71.68
21 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 69.04
22 INT110021 Positive_regulation of Gene_expression of Mapk14 29 0.46 19.06 3.86 69.04
23 INT40128 Binding of Noc2l 7 0.27 0.67 3.03 68.08
24 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 67.92
25 INT110024 Negative_regulation of Gene_expression of Mapk14 19 0.42 7.83 4.21 67.84
26 INT184269 Gene_expression of HMGB1 51 0.77 42.96 4.55 66.04
27 INT184271 Positive_regulation of Gene_expression of HMGB1 7 0.41 6.17 1.53 66.04
28 INT193321 Positive_regulation of Prh1 4 0.02 2.34 2.69 56.68
29 INT172617 Positive_regulation of HAT1 7 0.33 5.47 0.54 56.16
30 INT52196 Negative_regulation of Regulation of Il6 3 0.42 3.42 0.74 54.40
31 INT9655 Regulation of Il6 98 0.62 70.92 31.95 52.80
32 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07 52.80
33 INT205690 Positive_regulation of Positive_regulation of P2rx7 14 0.68 6.26 1.3 52.36
34 INT89309 Negative_regulation of Pde4b 21 0.53 12.81 7.32 48.64
35 INT30169 Negative_regulation of Pde4a 107 0.58 81 36.23 47.84
36 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7 46.96
37 INT96155 Gene_expression of Cd86 134 0.77 50.56 17.13 46.96
38 INT96157 Gene_expression of Cd80 74 0.77 31.19 9.78 46.96
39 INT8793 Gene_expression of H2 58 0.75 26.36 7.07 46.96
40 INT142606 Regulation of Gene_expression of Cd40 13 0.56 6.15 3.27 46.96
41 INT237377 Regulation of Gene_expression of Cd86 10 0.47 3.64 1.52 46.96
42 INT288058 Regulation of Gene_expression of Cd80 6 0.35 2.13 0.55 46.96
43 INT142605 Regulation of Gene_expression of H2 2 0.15 0.99 0.54 46.96
44 INT189836 Regulation of Cd40 10 0.40 3.02 1.1 46.12
45 INT183164 Regulation of Cd80 6 0.33 2.69 0.52 45.88
46 INT184272 Binding of HMGB1 14 0.37 8.78 2.49 45.84
47 INT302544 Regulation of Cd86 10 0.34 1.89 0.62 45.64
48 INT257931 Regulation of H2 7 0.26 5.12 0.3 45.28
49 INT135925 Regulation of Pde4b 5 0.41 1.58 2.24 44.96
50 INT92470 Negative_regulation of Gene_expression of CCL5 15 0.50 5.46 5.86 43.76
51 INT181378 Negative_regulation of Gene_expression of Ccl5 12 0.46 9.64 3.59 43.76
52 INT322958 Negative_regulation of Gene_expression of Darc 1 0.03 0.17 0.34 43.76
53 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 43.36
54 INT130186 Gene_expression of Ccl5 101 0.74 79.96 25.01 43.36
55 INT165773 Gene_expression of Darc 37 0.75 22.28 14.84 43.36
56 INT193320 Positive_regulation of Positive_regulation of Prh1 1 0.02 0.45 0.77 43.04
57 INT184286 Regulation of AGER 1 0.46 6.7 3 42.28
58 INT184273 Localization of AGER 1 0.60 3.59 1.67 42.28
59 INT184290 Regulation of Localization of AGER 1 0.34 1.17 0.59 42.28
60 INT184277 Regulation of Localization of HMGB1 1 0.37 1.15 0.58 40.48
61 INT184288 Localization of HMGB1 20 0.61 14.5 3.84 40.20
62 INT224007 Positive_regulation of PMP2 6 0.40 3.46 0.94 40.08
63 INT246393 Positive_regulation of Ccnd2 2 0.49 1.14 0.11 40.08
64 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92 39.00
65 INT144828 Binding of P2rx7 19 0.47 7.84 3.16 39.00
66 INT304045 Transcription of PTEN 2 0.51 4.12 1.4 38.24
67 INT139829 Negative_regulation of Gene_expression of AGER 2 0.57 3.76 1.3 37.80
68 INT310253 Positive_regulation of Positive_regulation of Cd80 1 0.34 0.08 0.11 35.08
69 INT219578 Negative_regulation of Pde4d 3 0.46 2.95 0.8 35.04
70 INT101594 Positive_regulation of Cd40 36 0.69 16.14 4.56 34.44
71 INT228401 Positive_regulation of Cd86 24 0.53 6.46 1.8 34.44
72 INT252308 Positive_regulation of Cd80 9 0.51 1.24 0.45 34.44
73 INT166218 Positive_regulation of Negative_regulation of H2 2 0.29 1.39 0.43 34.44
74 INT165776 Binding of Darc 11 0.42 3.94 2.4 34.08
75 INT322959 Positive_regulation of Binding of Darc 1 0.03 0.08 0.3 34.08
76 INT26850 Negative_regulation of H2 13 0.32 9.4 1.82 32.64
77 INT176524 Binding of Mapk14 19 0.43 12.54 5.21 31.32
78 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 30.44
79 INT12339 Localization of IL8 437 0.81 251.87 117.39 29.20
80 INT181362 Negative_regulation of Ccl5 21 0.40 15.63 4.96 25.32
81 INT2528 Negative_regulation of Pf4 2 0.19 0.16 0.41 25.32
82 INT205691 Regulation of Gene_expression of P2rx7 5 0.44 3.25 1.42 25.12
83 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 22.04
84 INT119669 Gene_expression of Igh-VS107 9 0.49 3.95 1.31 22.04
85 INT135991 Positive_regulation of Gene_expression of Cd80 19 0.54 6.9 1.71 21.32
86 INT88079 Gene_expression of Chrna4 20 0.76 8.52 6.98 10.56
87 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
88 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
89 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
90 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
91 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
92 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
93 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
94 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
95 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 5.00
96 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 5.00
97 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
98 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
99 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 5.00
100 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 5.00
101 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
102 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
103 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
104 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
105 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
106 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
107 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
108 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
109 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66 5.00
110 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
111 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 5.00
112 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
113 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 5.00
114 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
115 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 5.00
116 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
117 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
118 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
119 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
120 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 5.00
121 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
122 INT117598 Regulation of ACR 118 0.26 41.25 48.01 5.00
123 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
124 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
125 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
126 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
127 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
128 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
129 INT13354 Transcription of TNF 108 0.72 85.81 42.32 5.00
130 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
131 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
132 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43 5.00
133 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
134 INT20210 Localization of Ngf 69 0.79 46.22 38.57 5.00
135 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 5.00
136 INT14009 Gene_expression of Sst 66 0.77 19.6 37.3 5.00
137 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
138 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
139 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
140 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
141 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
142 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
143 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 5.00
144 INT67039 Positive_regulation of Cpox 144 0.65 98.4 33.77 5.00
145 INT132161 Gene_expression of MTX1 48 0.58 26.55 32.32 5.00
146 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 5.00
147 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65 5.00
148 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
149 INT129207 Gene_expression of Cxcl1 114 0.75 68.54 30.82 5.00
150 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
151 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 5.00
152 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 5.00
153 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 5.00
154 INT47075 Positive_regulation of Ptger2 142 0.70 78.55 25.47 5.00
155 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
156 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
157 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25 5.00
158 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 5.00
159 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
160 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 5.00
161 INT58301 Positive_regulation of Mpo 87 0.70 80.19 23.99 5.00
162 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23 5.00
163 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
164 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 5.00
165 INT69993 Positive_regulation of Gene_expression of Cpox 93 0.55 69.4 22.05 5.00
166 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
167 INT78057 Localization of Tlr4 140 0.77 67.75 21.72 5.00
168 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37 5.00
169 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36 5.00
170 INT52106 Negative_regulation of Localization of IL8 57 0.52 22.81 20.8 5.00
171 INT66281 Transcription of Nos2 81 0.71 39.49 20.37 5.00
172 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 5.00
173 INT102545 Gene_expression of Ccr2 42 0.78 61.43 19.81 5.00
174 INT138696 Positive_regulation of Ccl2 57 0.67 59.57 19.58 5.00
175 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
176 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
177 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
178 INT10565 Gene_expression of MRXS5 94 0.53 37.35 19.08 5.00
179 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46 5.00
180 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
181 INT70970 Binding of COPD 144 0.42 180.34 18.29 5.00
182 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22 5.00
183 INT61257 Gene_expression of Sele 79 0.77 70.97 17.78 5.00
184 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
185 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 5.00
186 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
187 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 5.00
188 INT62546 Positive_regulation of Gene_expression of Icam1 60 0.70 59.52 16.9 5.00
189 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
190 INT48238 Regulation of Gene_expression of Ngf 25 0.62 11.48 16.42 5.00
191 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33 5.00
192 INT56447 Positive_regulation of Icam1 64 0.64 64.14 16.16 5.00
193 INT48540 Gene_expression of Kcna5 37 0.77 14.04 16.07 5.00
194 INT3392 Negative_regulation of Sst 23 0.59 8.21 15.82 5.00
195 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07 5.00
196 INT79227 Negative_regulation of Gene_expression of Icam1 45 0.59 41.65 14.97 5.00
197 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
198 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
199 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01 5.00
200 INT83950 Gene_expression of Cxcr1 31 0.59 27.76 13.91 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox