D:Aniridia

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pChart

Disease Term
Synonyms Absence Of Iris, Agenesis Of Iris, Anirida, Aniridia Disorder, APLASIA OF IRIS, Congenital Absence Of Iris, IRIDERAEMIA, Irideremia
Documents 15
Hot Single Events 15
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Aniridia. They are ordered first by their relevance to Aniridia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT262939 PAX6 Regulation of CDH4 1 0.02 0.97 0.08 64.80
2 INT262937 PAX6 Regulation of CDH8 1 0.03 0.98 0.08 64.80
3 INT262944 PAX6 Regulation of CDH6 1 0.03 0.97 0.08 64.80
4 INT306339 Binding of CRX and PAX6 1 0.53 0.27 0 54.96
5 INT181084 Binding of S100a8 and S100a9 6 0.42 2.91 0.62 5.00
6 INT282864 Bpifa2 Positive_regulation of Gene_expression of Serpinf1 1 0.15 1.16 0.2 5.00
7 INT282866 Bpifa2 Negative_regulation of Gene_expression of VEGFA 1 0.11 1.14 0.19 5.00
8 INT282863 Bpifa2 Positive_regulation of Gene_expression of Aggf1 1 0.01 1.07 0.19 5.00
9 INT282858 Bpifa2 Negative_regulation of Akt1 1 0.05 0.91 0.17 5.00
10 INT282859 Bpifa2 Negative_regulation of Mapk1 1 0.01 0.91 0.17 5.00
11 INT282861 Bpifa2 Negative_regulation of Phosphorylation of Akt1 1 0.05 0.91 0.17 5.00
12 INT347334 Binding of S100a9 and Il1 1 0.09 0.45 0.15 5.00
13 INT347335 Binding of S100a4 and S100a9 1 0.39 0.51 0.15 5.00
14 INT347338 Binding of Fgf1 and S100a9 1 0.26 0.46 0.15 5.00
15 INT347333 Binding of S100a9 and Vegfa 1 0.38 0.46 0.15 5.00
16 INT347336 Binding of S100a4 and S100a8 1 0.40 0.51 0.15 5.00
17 INT347332 Binding of S100a8 and Vegfa 1 0.38 0.46 0.15 5.00
18 INT347339 Binding of Il6 and S100a9 1 0.29 0.46 0.15 5.00
19 INT347331 Binding of Fgf1 and S100a8 1 0.26 0.46 0.15 5.00
20 INT347330 Binding of S100a8 and Il1 1 0.09 0.45 0.15 5.00
21 INT347337 Binding of Il6 and S100a8 1 0.29 0.46 0.15 5.00
22 INT282862 Bpifa2 Negative_regulation of Positive_regulation of Akt1 1 0.05 0.75 0.13 5.00
23 INT282860 Bpifa2 Regulation of Mapk1 1 0.01 0.65 0.05 5.00
24 INT219230 Binding of Ecm1 and Ighv10-3 1 0.00 0.26 0.04 5.00
25 INT275667 Binding of CYP1B1 and GLC3C 1 0.27 0.99 0 5.00
26 INT262938 Binding of PAX6 and SIX3 1 0.13 0.9 0 5.00
27 INT225957 Binding of KRT3 and KRT12 1 0.18 0.06 0 5.00
28 INT219229 Binding of Col7a1 and Ighv10-3 1 0.00 0.46 0 5.00
29 INT262940 Regulation of Binding of PAX6 and SIX3 1 0.16 0.91 0 5.00
30 INT262942 Binding of PAX6 and SOX2 1 0.18 0.9 0 5.00
31 INT262943 Regulation of Binding of PAX6 and SOX2 1 0.17 0.91 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Aniridia. They are ordered first by their pain relevance and then by number of times they were reported in Aniridia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT216380 Gene_expression of PAX6 49 0.78 15.63 1.22 99.56
2 INT31991 Gene_expression of NTS 33 0.75 12.98 4.99 93.88
3 INT19763 Gene_expression of CTs 69 0.78 32.92 18.87 93.88
4 INT262963 Negative_regulation of PAX6 4 0.59 4.92 0.04 92.56
5 INT262955 Regulation of PAX6 2 0.27 0.87 0.06 92.32
6 INT262953 Binding of PAX6 13 0.48 5.28 0.06 92.00
7 INT235781 Positive_regulation of PAX6 2 0.50 0.36 0.08 91.64
8 INT262959 Localization of PAX6 2 0.75 1.65 0 89.16
9 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5 87.72
10 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45 87.08
11 INT262958 Localization of PAX2 2 0.32 0.83 0.15 84.48
12 INT262957 Localization of SIX3 1 0.23 0.67 0.09 84.48
13 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 83.68
14 INT262954 Regulation of Transcription of PAX6 1 0.62 2.33 0.03 81.96
15 INT262951 Transcription of PAX6 6 0.72 3.33 0.06 81.52
16 INT262956 Protein_catabolism of PAX6 1 0.66 0.14 0 78.64
17 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 76.84
18 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 76.84
19 INT87240 Gene_expression of Aggf1 14 0.11 8.41 0.93 76.00
20 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 75.00
21 INT262964 Negative_regulation of Binding of PAX6 1 0.43 0.44 0 68.80
22 INT10131 Gene_expression of Serpinf1 53 0.76 35.57 6.42 68.08
23 INT235783 Positive_regulation of Gene_expression of PAX6 7 0.50 1.59 0.03 65.92
24 INT262952 Regulation of Binding of PAX6 1 0.27 0.06 0 58.32
25 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 55.36
26 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 50.00
27 INT60585 Regulation of TP53 59 0.59 54.55 5.21 50.00
28 INT65855 Localization of TP53 18 0.76 17.08 1.89 50.00
29 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03 50.00
30 INT161322 Localization of PTEN 9 0.73 5.65 0.57 50.00
31 INT346708 Regulation of Positive_regulation of RCN1 1 0.43 0.52 0 50.00
32 INT346707 Negative_regulation of Gene_expression of PAX6 1 0.37 0.5 0 50.00
33 INT346712 Localization of RCN1 1 0.72 2.14 0 50.00
34 INT346710 Positive_regulation of RCN1 1 0.48 0.52 0 50.00
35 INT339594 Localization of SOX2 2 0.69 0.7 0 50.00
36 INT346711 Regulation of RCN1 1 0.43 0.51 0 50.00
37 INT346709 Binding of RCN1 1 0.46 1.05 0 50.00
38 INT219224 Gene_expression of Ighv10-3 1 0.03 12.91 0.07 47.68
39 INT151793 Gene_expression of KRT3 36 0.75 2.32 0.26 43.28
40 INT155153 Binding of S100a1 15 0.35 6.42 1.63 38.04
41 INT187628 Gene_expression of KRT14 15 0.75 11.54 0.1 36.16
42 INT262962 Localization of PITX2 1 0.42 0.64 0.06 36.12
43 INT108793 Gene_expression of PITX2 12 0.75 3.91 2.89 35.76
44 INT81311 Gene_expression of FOXC1 9 0.44 3.46 1.18 35.36
45 INT262961 Gene_expression of ELP4 1 0.01 0.16 0.05 25.44
46 INT262960 Gene_expression of TBX5 1 0.23 0.09 0.03 25.16
47 INT96873 Gene_expression of CYP1B1 28 0.78 11.81 1.09 8.00
48 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
49 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 5.00
50 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
51 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
52 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
53 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 5.00
54 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
55 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
56 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
57 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
58 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
59 INT97596 Localization of S100a8 94 0.78 90.69 40.41 5.00
60 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29 5.00
61 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98 5.00
62 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
63 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 5.00
64 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18 5.00
65 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
66 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
67 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 5.00
68 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
69 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25 5.00
70 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59 5.00
71 INT152730 Positive_regulation of S100a8 48 0.68 47.67 15.4 5.00
72 INT85964 Gene_expression of Pecam1 109 0.78 69.73 15.21 5.00
73 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12 5.00
74 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
75 INT152729 Negative_regulation of Gene_expression of S100a8 33 0.42 32.25 13.64 5.00
76 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49 5.00
77 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 5.00
78 INT25608 Regulation of Gene_expression of Il1 37 0.44 27.76 10.1 5.00
79 INT126478 Gene_expression of Cxcl12 78 0.77 58.69 8.01 5.00
80 INT165036 Gene_expression of S100a9 38 0.77 38.33 7.84 5.00
81 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83 5.00
82 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56 5.00
83 INT132246 Negative_regulation of S100a8 19 0.43 22 7.25 5.00
84 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 5.00
85 INT60713 Binding of Col7a1 47 0.43 22.52 6.29 5.00
86 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 5.00
87 INT115370 Gene_expression of PSIP1 22 0.65 9.45 5.68 5.00
88 INT181054 Positive_regulation of S100a9 14 0.56 9.83 4.6 5.00
89 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44 5.00
90 INT134968 Localization of Ecm1 20 0.32 27.27 4.31 5.00
91 INT97598 Negative_regulation of Localization of S100a8 8 0.42 6.52 4.31 5.00
92 INT92678 Positive_regulation of Ecm1 30 0.09 28.41 3.68 5.00
93 INT181018 Binding of S100a8 20 0.45 22.14 3.18 5.00
94 INT61500 Binding of FN1 39 0.48 27.33 3.13 5.00
95 INT88810 Positive_regulation of Gene_expression of FGF2 17 0.50 12.62 2.98 5.00
96 INT114702 Gene_expression of Fgf1 34 0.74 17.39 2.96 5.00
97 INT152861 Binding of S100a9 11 0.37 12.19 2.91 5.00
98 INT161506 Regulation of Gene_expression of S100a8 6 0.45 4.68 2.9 5.00
99 INT145821 Negative_regulation of Gene_expression of Mapk1 16 0.41 8.05 2.77 5.00
100 INT173592 Binding of COL5A2 32 0.33 9.14 2.48 5.00
101 INT181061 Localization of S100a9 9 0.74 4.98 2.19 5.00
102 INT112684 Positive_regulation of Cor 10 0.45 3.48 1.82 5.00
103 INT29568 Negative_regulation of Bpifa2 6 0.50 1.83 1.77 5.00
104 INT204763 Transcription of S100a8 8 0.69 6.22 1.69 5.00
105 INT131228 Regulation of Localization of S100a8 4 0.45 1.81 1.65 5.00
106 INT36689 Gene_expression of Bpifa2 27 0.50 14.92 1.65 5.00
107 INT29566 Positive_regulation of Bpifa2 22 0.46 8.04 1.62 5.00
108 INT128051 Gene_expression of FGF10 9 0.78 2.31 1.56 5.00
109 INT143850 Gene_expression of S100a1 19 0.73 9.52 1.54 5.00
110 INT254252 Localization of Cxcl12 9 0.76 7.17 1.49 5.00
111 INT152728 Negative_regulation of Positive_regulation of S100a8 4 0.43 3.96 1.29 5.00
112 INT205627 Gene_expression of GCM1 5 0.56 1.29 1.24 5.00
113 INT21756 Regulation of Alb 15 0.43 8.21 1.19 5.00
114 INT50444 Negative_regulation of Gene_expression of Alb 11 0.39 7.63 1.06 5.00
115 INT257801 Negative_regulation of S100a9 6 0.35 5.12 0.96 5.00
116 INT145119 Gene_expression of Cor 11 0.65 3.24 0.93 5.00
117 INT56771 Regulation of Cor 7 0.23 1.33 0.93 5.00
118 INT179857 Gene_expression of ATF7IP 14 0.65 4.12 0.89 5.00
119 INT96879 Positive_regulation of CYP1B1 14 0.70 5.73 0.78 5.00
120 INT73433 Gene_expression of S100a6 10 0.71 2.74 0.76 5.00
121 INT10130 Positive_regulation of Serpinf1 10 0.53 5.62 0.7 5.00
122 INT143095 Positive_regulation of Gene_expression of Alb 8 0.40 1.53 0.66 5.00
123 INT145142 Gene_expression of RPL5 3 0.12 1.54 0.62 5.00
124 INT89100 Gene_expression of CNOT1 7 0.65 1.76 0.59 5.00
125 INT204928 Positive_regulation of ATF7IP 4 0.49 1.69 0.54 5.00
126 INT176646 Binding of Bpifa2 15 0.30 7.65 0.5 5.00
127 INT266326 Positive_regulation of S100a4 4 0.65 1.67 0.46 5.00
128 INT282856 Positive_regulation of Aggf1 2 0.02 1.18 0.44 5.00
129 INT266330 Positive_regulation of S100a1 4 0.44 2.98 0.39 5.00
130 INT266342 Negative_regulation of Gene_expression of S100a9 2 0.58 1.65 0.31 5.00
131 INT197585 Positive_regulation of S100a6 3 0.43 1.67 0.29 5.00
132 INT99095 Binding of COL4A4 7 0.37 3.51 0.29 5.00
133 INT282854 Transcription of Serpinf1 1 0.36 1.91 0.29 5.00
134 INT105007 Binding of MOXD1 2 0.03 1.15 0.29 5.00
135 INT336735 Regulation of Gene_expression of S100a9 2 0.45 1.17 0.24 5.00
136 INT347328 Negative_regulation of Positive_regulation of Aggf1 1 0.02 0.49 0.23 5.00
137 INT347325 Positive_regulation of S100a13 1 0.43 0.72 0.21 5.00
138 INT96887 Regulation of Gene_expression of CYP1B1 2 0.45 0.9 0.2 5.00
139 INT206526 Negative_regulation of Transcription of S100a8 1 0.42 0.55 0.18 5.00
140 INT185048 Regulation of Gene_expression of Bpifa2 3 0.24 1.32 0.15 5.00
141 INT347326 Regulation of S100a1 1 0.26 0.79 0.14 5.00
142 INT282857 Positive_regulation of Transcription of Serpinf1 1 0.31 0.96 0.14 5.00
143 INT219227 Localization of Ighv10-3 1 0.03 0.48 0.03 5.00
144 INT219225 Positive_regulation of Ighv10-3 1 0.02 0.38 0 5.00
145 INT262003 Binding of CYP1B1 3 0.48 3.34 0 5.00
146 INT225958 Gene_expression of KRT12 13 0.68 1.57 0 5.00
147 INT222338 Positive_regulation of Gene_expression of S100a1 2 0.44 0.09 0 5.00
148 INT219223 Positive_regulation of Gene_expression of Ighv10-3 1 0.02 3.24 0 5.00
149 INT225961 Gene_expression of GSG1 1 0.01 0.1 0 5.00
150 INT225959 Gene_expression of KRT15 7 0.48 2.01 0 5.00
151 INT347327 Regulation of Gene_expression of S100a1 1 0.43 0.09 0 5.00
152 INT262005 Regulation of CYP1B1 4 0.62 4.52 0 5.00
153 INT219228 Negative_regulation of Gene_expression of CNOT1 1 0.41 0.43 0 5.00
154 INT347323 Positive_regulation of Positive_regulation of Cor 1 0.01 0.09 0 5.00
155 INT225960 Gene_expression of KRT13 4 0.39 2.47 0 5.00
156 INT187627 Gene_expression of KRT4 5 0.37 4.54 0 5.00
157 INT347324 Positive_regulation of S100a3 1 0.40 0.08 0 5.00
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