D:Ankylosing Spondylitis

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Disease Term
Synonyms ANKYLOSING POLYARTHRITIS, ANKYLOSING SPONDYLITIDES, ANKYLOSING SPONDYLITIS DISORDER, AS ANKYLOSING SPONDYLITIS, BECHTEREW DISEASE, Bechterew S Disease, Bechterews Disease, Bekhterev Struempell Marie Syndrome, DISEASE BECHTEREW, Disease Bechterew S, Disease Marie Struempell
Documents 139
Hot Single Events 48
Hot Interactions 7

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Ankylosing Spondylitis. They are ordered first by their relevance to Ankylosing Spondylitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT348174 Binding of STAT3 and IL23R 1 0.40 1.9 0.76 99.76
2 INT348173 Binding of HLA-B and IL23R 1 0.15 0.92 0.49 96.80
3 INT348177 Binding of HLA-B and ERAP1 1 0.14 0.92 0.49 96.52
4 INT264324 Olr614 Regulation of IL-17 1 0.02 2.3 1.03 96.16
5 INT348175 Binding of NIDDM1 and PTPN22 1 0.01 2.36 0.99 93.60
6 INT264332 Olr614 Negative_regulation of Regulation of Igh-6 1 0.01 1.04 0.48 87.68
7 INT162742 Binding of HLA-A and KIR3DL1 1 0.40 0.68 0.58 87.36
8 INT264326 IL-17 Positive_regulation of Gene_expression of Il6 1 0.13 0.83 0.43 79.20
9 INT162743 Binding of HLA-A and TNFRSF10B 1 0.40 0.4 0.25 64.64
10 INT264327 IL-17 Positive_regulation of Gene_expression of Tnfsf11 1 0.07 3.19 1.33 5.00
11 INT202042 CAMK2N2 Negative_regulation of MMP9 1 0.01 0.73 1.25 5.00
12 INT202041 CAMK2N2 Negative_regulation of PPP1R11 1 0.00 0.74 1.25 5.00
13 INT202039 CAMK2N2 Negative_regulation of MMP1 1 0.00 0.73 1.24 5.00
14 INT202036 CAMK2N2 Negative_regulation of MMP3 1 0.00 0.73 1.24 5.00
15 INT202040 CAMK2N2 Negative_regulation of MMP7 1 0.00 0.73 1.24 5.00
16 INT264333 IL-17 Positive_regulation of Gene_expression of Mmp1a 1 0.05 2.88 1.18 5.00
17 INT202037 Binding of CRP and URB1 1 0.01 1.26 0.68 5.00
18 INT264338 Binding of IL-17 and Positive_regulation of Localization of TNF 1 0.04 1.71 0.67 5.00
19 INT264329 Binding of IL-17 and Positive_regulation of Localization of Ccl2 1 0.13 1.65 0.64 5.00
20 INT264334 Binding of IL-17 and Positive_regulation of Localization of Csf3 1 0.13 1.64 0.63 5.00
21 INT264335 Binding of IL-17 and Positive_regulation of Localization of Il6 1 0.13 1.62 0.62 5.00
22 INT202038 MMP9 Positive_regulation of IL8 1 0.05 0.29 0.59 5.00
23 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54 5.00
24 INT264330 Olr614 Negative_regulation of IgG-2a 1 0.00 1.07 0.51 5.00
25 INT45035 Binding of HLA-B and HLA-DRB4 2 0.16 0.74 0.44 5.00
26 INT264328 Olr614 Negative_regulation of Gene_expression of IL-17 1 0.01 0.71 0.39 5.00
27 INT264331 Olr614 Regulation of IgG-2a 1 0.00 0.53 0.29 5.00
28 INT45048 Binding of HLA-B and TNFRSF10B 1 0.21 0.44 0.29 5.00
29 INT264325 Olr614 Negative_regulation of Igh-6 1 0.01 0.54 0.26 5.00
30 INT296712 Binding of H2-K1 and GOPC 1 0.00 0.41 0.04 5.00
31 INT172118 Binding of HSPA1B and C4b 1 0.39 0.92 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Ankylosing Spondylitis. They are ordered first by their pain relevance and then by number of times they were reported in Ankylosing Spondylitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT213886 Binding of IL23R 7 0.46 16.79 6.94 100.00
2 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 99.92
3 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 99.80
4 INT121818 Binding of STAT3 25 0.47 11.16 3.67 99.76
5 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 99.72
6 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 99.68
7 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 99.68
8 INT22838 Gene_expression of Fgg 26 0.25 19.9 3.88 99.68
9 INT74447 Gene_expression of Vwf 39 0.76 21.96 4.66 99.68
10 INT105039 Transcription of Pdlim7 1 0.02 0.2 0.1 99.00
11 INT101441 Positive_regulation of FTH1 15 0.54 7.03 3.22 98.38
12 INT4866 Positive_regulation of GAL 32 0.67 13.02 16.16 97.88
13 INT2249 Negative_regulation of Binding of HLA-B 5 0.54 6.82 2.94 97.38
14 INT348183 Binding of IL12B 1 0.46 0.97 0.33 97.04
15 INT184390 Binding of Arhgap4 13 0.36 3.29 3.35 96.68
16 INT159709 Binding of ERAP1 12 0.47 3.42 2.91 96.52
17 INT10173 Binding of Tnf 45 0.48 35.6 14.32 96.40
18 INT348186 Binding of KIF21B 1 0.31 1.35 0.64 95.04
19 INT231573 Binding of PTPN22 5 0.44 7.94 2.33 94.88
20 INT69398 Regulation of Gene_expression of HLA-E 14 0.60 3.54 1.27 94.52
21 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 94.48
22 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58 94.48
23 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 94.48
24 INT23245 Positive_regulation of Gene_expression of CEL 19 0.69 14.81 4.92 94.48
25 INT151441 Positive_regulation of Gene_expression of Trav6-3 22 0.65 10.21 3.05 94.48
26 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 92.84
27 INT69396 Gene_expression of H2-K1 72 0.65 38.16 4.56 92.52
28 INT69397 Regulation of Gene_expression of H2-K1 9 0.23 6.32 0.91 92.52
29 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 90.40
30 INT93684 Gene_expression of STAT3 66 0.78 34.42 5.94 90.04
31 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 87.04
32 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 86.12
33 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 85.48
34 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 85.48
35 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 85.48
36 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 85.48
37 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 85.08
38 INT24795 Regulation of Igh-6 7 0.51 3.08 2.93 84.88
39 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 84.76
40 INT21678 Negative_regulation of B2m 20 0.55 10.11 3.12 83.96
41 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 82.80
42 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 82.80
43 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 82.80
44 INT271731 Binding of 20S 4 0.47 2.12 0.18 82.08
45 INT284669 Gene_expression of LRRK2 3 0.65 4.58 1.14 80.96
46 INT348185 Gene_expression of MUC19 1 0.62 2.71 1.14 80.96
47 INT670 Gene_expression of B2m 31 0.66 27.32 8.49 80.80
48 INT25236 Binding of REG1A 6 0.47 3.69 0.91 80.64
49 INT92653 Gene_expression of IL12B 21 0.75 17.28 3.89 79.16
50 INT32203 Negative_regulation of Crp 48 0.58 32.77 11.89 78.96
51 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 78.12
52 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 78.12
53 INT115213 Regulation of SFTPA1 13 0.32 6.91 7.11 76.48
54 INT49191 Gene_expression of IFNAR1 14 0.41 9.96 3.84 75.24
55 INT32625 Positive_regulation of Uchl1 2 0.49 1.39 1.4 75.04
56 INT162745 Regulation of KIR3DL1 3 0.45 1.39 0.65 73.60
57 INT348180 Localization of IL23R 1 0.34 0.91 0.36 72.08
58 INT165617 Localization of STAT3 28 0.78 9.04 1.72 72.08
59 INT105041 Positive_regulation of Psmb9 2 0.09 0.35 0.07 71.00
60 INT348181 Phosphorylation of IL23R 1 0.27 0.91 0.36 70.48
61 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42 70.48
62 INT330663 Gene_expression of CDKAL1 3 0.64 1.9 0.16 69.60
63 INT105040 Negative_regulation of Psmb9 1 0.08 0.14 0.07 69.56
64 INT246028 Positive_regulation of IL23R 3 0.46 2.74 1.15 68.96
65 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 68.96
66 INT348182 Binding of CDKAL1 1 0.35 0.48 0.17 66.88
67 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 66.88
68 INT216361 Negative_regulation of Gene_expression of MBP 3 0.43 0.9 0.19 65.88
69 INT17741 Gene_expression of MBP 67 0.78 23.67 9.65 65.36
70 INT5285 Regulation of Gene_expression of HLA-B 4 0.41 3.39 0.68 65.12
71 INT94438 Gene_expression of OLR1 86 0.78 80.38 11.03 64.24
72 INT348184 Localization of LACC1 1 0.57 0.55 0.2 61.24
73 INT264313 Negative_regulation of Olr614 1 0.02 1.35 0.59 61.00
74 INT105042 Positive_regulation of PSMB8 1 0.26 0.12 0.06 59.12
75 INT105043 Negative_regulation of PSMB8 1 0.22 0.11 0.06 57.40
76 INT43721 Gene_expression of Vegfa 49 0.77 36.18 6.63 55.84
77 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 53.12
78 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 53.12
79 INT86437 Binding of IL6 154 0.48 121.22 29.3 50.48
80 INT120895 Binding of CCL2 22 0.37 15.86 6.55 50.48
81 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 50.00
82 INT96850 Negative_regulation of CCL2 42 0.59 24.89 12.55 50.00
83 INT152021 Regulation of Negative_regulation of IL6 3 0.32 1.38 0.98 50.00
84 INT152022 Regulation of Negative_regulation of CCL2 1 0.14 0 0 50.00
85 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 36.00
86 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07 34.64
87 INT168233 Positive_regulation of Transcription of Col2a1 2 0.45 1.78 0.99 30.40
88 INT264311 Positive_regulation of Transcription of Arhgap4 1 0.49 1.53 0.78 30.40
89 INT128714 Transcription of Col2a1 6 0.52 2.13 1.24 30.08
90 INT264312 Transcription of Arhgap4 1 0.67 1.53 0.77 30.08
91 INT247952 Binding of H2-K1 4 0.09 3.32 0.28 21.92
92 INT176892 Binding of MR1 36 0.32 15.55 2.58 21.36
93 INT203272 Positive_regulation of Gvhd1 1 0.01 1.32 0.06 11.16
94 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
95 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
96 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
97 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
98 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
99 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
100 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
101 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
102 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 5.00
103 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 5.00
104 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
105 INT19511 Localization of Il6 212 0.81 118.17 67.67 5.00
106 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
107 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
108 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
109 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
110 INT5307 Regulation of Tnf 87 0.62 78.71 43.4 5.00
111 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.00
112 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
113 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
114 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6 5.00
115 INT99610 Localization of MMP9 126 0.79 48.46 32.67 5.00
116 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
117 INT82882 Localization of Ccl2 61 0.80 41.96 28 5.00
118 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98 5.00
119 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
120 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
121 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
122 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 5.00
123 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 5.00
124 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 5.00
125 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7 5.00
126 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
127 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
128 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 5.00
129 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
130 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 5.00
131 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 5.00
132 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
133 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
134 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06 5.00
135 INT25076 Negative_regulation of Gene_expression of Il1 41 0.52 30.58 13.85 5.00
136 INT69878 Positive_regulation of Gene_expression of Gtf3a 48 0.29 36.78 13.57 5.00
137 INT63361 Gene_expression of CD44 126 0.77 71.58 12.96 5.00
138 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45 5.00
139 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 5.00
140 INT541 Positive_regulation of MBP 31 0.67 28.56 12.24 5.00
141 INT1139 Gene_expression of IgG-2a 35 0.65 19.19 12 5.00
142 INT14867 Gene_expression of Igh-6 47 0.67 30.05 11.75 5.00
143 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
144 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43 5.00
145 INT89282 Regulation of MMP9 39 0.60 25.45 10.34 5.00
146 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
147 INT107606 Negative_regulation of MMP1 38 0.42 11.94 10.01 5.00
148 INT157941 Gene_expression of IL-17 65 0.65 20.39 9.89 5.00
149 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79 5.00
150 INT54834 Gene_expression of Col2a1 48 0.72 13.5 9.41 5.00
151 INT130731 Protein_catabolism of COL2A1 47 0.96 21.86 9.28 5.00
152 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
153 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 5.00
154 INT94125 Gene_expression of Cd28 38 0.67 21.73 7.75 5.00
155 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 5.00
156 INT14637 Negative_regulation of MBP 19 0.43 7.06 7.18 5.00
157 INT16997 Binding of PRTN3 34 0.48 33.44 6.45 5.00
158 INT98148 Negative_regulation of IL17 18 0.49 11.71 5.99 5.00
159 INT26962 Negative_regulation of IgG-2a 12 0.42 6.07 5.31 5.00
160 INT16405 Regulation of CD8A 38 0.45 19.04 5.31 5.00
161 INT107242 Binding of MMP3 14 0.47 12.06 5.11 5.00
162 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72 5.00
163 INT2065 Binding of BTG3 15 0.36 10.9 4.65 5.00
164 INT133905 Gene_expression of Ncam1 24 0.78 10.2 4.62 5.00
165 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39 5.00
166 INT154527 Gene_expression of POU5F1 180 0.78 34.01 4.34 5.00
167 INT129964 Negative_regulation of MMP13 23 0.55 6.48 4.21 5.00
168 INT48518 Gene_expression of ANPEP 51 0.78 22.88 4.18 5.00
169 INT134646 Gene_expression of Tnfsf11 19 0.69 14.77 4.16 5.00
170 INT78023 Gene_expression of DDX41 13 0.65 23.55 3.84 5.00
171 INT202050 Gene_expression of URB1 1 0.07 5.64 3.81 5.00
172 INT130351 Positive_regulation of Vwf 18 0.59 5.99 3.48 5.00
173 INT192298 Negative_regulation of MMP7 7 0.27 3.71 3.29 5.00
174 INT55690 Positive_regulation of Localization of TIMP1 8 0.50 4.77 3.28 5.00
175 INT34809 Gene_expression of Ec 36 0.15 15.7 3.24 5.00
176 INT54832 Negative_regulation of Gene_expression of Col2a1 6 0.50 2.53 3.16 5.00
177 INT10510 Negative_regulation of Igh-6 13 0.45 10.37 2.68 5.00
178 INT202051 Negative_regulation of PPP1R11 1 0.01 1.6 2.51 5.00
179 INT24672 Localization of FGF2 27 0.71 14.59 2.48 5.00
180 INT81989 Positive_regulation of Tnfsf11 11 0.54 7.57 2.4 5.00
181 INT202055 Positive_regulation of URB1 7 0.32 5.41 2.34 5.00
182 INT106616 Gene_expression of PSMB9 35 0.72 28.4 2.29 5.00
183 INT14488 Regulation of MBP 5 0.25 5.17 2.25 5.00
184 INT98149 Transcription of IL-17 4 0.58 3.88 2.19 5.00
185 INT170469 Gene_expression of THY1 66 0.65 11.9 2.15 5.00
186 INT664 Positive_regulation of Fgg 14 0.46 8.75 2.11 5.00
187 INT110807 Gene_expression of Mmp1a 8 0.55 5.78 2.06 5.00
188 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
189 INT264318 Gene_expression of Olr614 1 0.03 4.2 1.71 5.00
190 INT194242 Positive_regulation of Gene_expression of MBP 9 0.45 4.1 1.71 5.00
191 INT243662 Binding of IL-17 4 0.31 3.45 1.57 5.00
192 INT243655 Positive_regulation of Gene_expression of IL-17 11 0.58 3.06 1.45 5.00
193 INT126334 Gene_expression of Tnfrsf10b 8 0.58 8.68 1.42 5.00
194 INT105938 Negative_regulation of Gene_expression of Igh-6 7 0.30 4.7 1.36 5.00
195 INT92245 Negative_regulation of Fgg 13 0.06 9.68 1.35 5.00
196 INT6018 Positive_regulation of PSMB9 7 0.60 4.36 1.33 5.00
197 INT202054 Negative_regulation of CAMK2N2 1 0.01 0.88 1.29 5.00
198 INT88753 Negative_regulation of Adamts7 8 0.11 4.62 1.24 5.00
199 INT264337 Positive_regulation of NCOA5 4 0.03 4.28 1.23 5.00
200 INT174557 Negative_regulation of Gene_expression of Cd28 7 0.43 4.42 1.2 5.00
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