D:Anxiety

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Disease Term
Synonyms Anxieties, Nervousness
Documents 636
Hot Single Events 54
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Anxiety. They are ordered first by their relevance to Anxiety and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT175561 NAA50 Negative_regulation of PRELID1 1 0.00 0.83 0.1 100.00
2 INT175560 Binding of GPER and GHRL 1 0.01 1.14 0.03 46.36
3 INT335173 Binding of ALG10 and TMEM200A 1 0.00 0.22 0.23 40.24
4 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62 5.00
5 INT189859 Binding of SLC6A3 and ADHD1 2 0.32 0.68 0.48 5.00
6 INT349664 PYCARD Negative_regulation of Localization of AR 1 0.05 0 0.32 5.00
7 INT349662 Binding of PYCARD and Negative_regulation of Localization of AR 1 0.05 0 0.32 5.00
8 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25 5.00
9 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25 5.00
10 INT349668 Binding of HRH1 and PYCARD 1 0.00 0.37 0.21 5.00
11 INT287145 Binding of PNN and Shbg 1 0.07 0.14 0.18 5.00
12 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18 5.00
13 INT340447 Negative_regulation of IRF6 Positive_regulation of RELA 1 0.00 0.87 0.18 5.00
14 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18 5.00
15 INT349659 PYCARD Positive_regulation of ADRB2 1 0.06 0.19 0.17 5.00
16 INT274353 DST Regulation of Gopc 1 0.00 0 0.17 5.00
17 INT340448 IRF6 Positive_regulation of RELA 1 0.00 0.86 0.17 5.00
18 INT276438 Binding of OPN1SW and MYP1 1 0.12 1.21 0.09 5.00
19 INT308225 Alb Positive_regulation of Binding of EIF4G2 1 0.02 0.33 0.09 5.00
20 INT349660 Binding of INSR and PYCARD 1 0.01 0 0.09 5.00
21 INT280451 IER5 Positive_regulation of Phc1 1 0.00 0.56 0.09 5.00
22 INT352579 CNTF Negative_regulation of Gene_expression of NPY 1 0.17 0.89 0.07 5.00
23 INT349665 Positive_regulation of Binding of AR and TFPI 1 0.02 0 0.05 5.00
24 INT349667 Binding of AR and TFPI 1 0.02 0 0.05 5.00
25 INT349663 Binding of TFPI and PYCARD 1 0.04 0 0.04 5.00
26 INT349661 PYCARD Positive_regulation of AR 1 0.08 0 0.03 5.00
27 INT199159 Binding of RET and Pheo 1 0.04 1.42 0.03 5.00
28 INT191097 Neu1 Positive_regulation of Shc1 1 0.04 1.96 0 5.00
29 INT349666 Binding of AR and PYCARD 1 0.06 0 0 5.00
30 INT204927 Binding of LGMN and IL33 1 0.00 0.52 0 5.00
31 INT191096 Negative_regulation of Binding of Apc and Esr1 1 0.05 1.07 0 5.00
32 INT191099 Erbb2 Positive_regulation of Shc1 1 0.08 1.95 0 5.00
33 INT191095 Positive_regulation of Binding of Apc and Esr1 1 0.06 1.08 0 5.00
34 INT191098 Binding of Apc and Esr1 1 0.04 1.06 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Anxiety. They are ordered first by their pain relevance and then by number of times they were reported in Anxiety. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 100.00
2 INT175563 Negative_regulation of NAA50 9 0.16 11.35 1.53 100.00
3 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 99.86
4 INT210885 Regulation of SLPI 8 0.44 7.15 4.61 99.80
5 INT90766 Gene_expression of PCS 93 0.77 40.48 14.51 99.46
6 INT66598 Negative_regulation of GPER 8 0.04 3.83 0.72 99.44
7 INT196993 Binding of TMEM200A 9 0.22 1.76 0.39 99.00
8 INT335176 Binding of ALG10 1 0.03 0.67 0 99.00
9 INT95048 Negative_regulation of ADHD1 61 0.51 56.01 5.62 98.92
10 INT105824 Regulation of Casq1 4 0.07 2.66 2.1 98.78
11 INT161501 Binding of PC 20 0.47 5.74 0.72 98.68
12 INT172677 Gene_expression of SHE 65 0.59 25.86 3.85 98.26
13 INT3028 Negative_regulation of Oxt 76 0.58 18.52 24.4 98.00
14 INT163329 Negative_regulation of GHRL 5 0.58 7.34 0.65 97.88
15 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 96.68
16 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 96.68
17 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 96.28
18 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 96.28
19 INT32688 Positive_regulation of Gene_expression of Shbg 14 0.45 7.01 1.6 96.28
20 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 96.16
21 INT69570 Binding of Prnp 75 0.48 44.26 4.37 96.12
22 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 95.92
23 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34 95.72
24 INT937 Positive_regulation of Oxt 195 0.70 37.82 49.3 95.08
25 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 94.56
26 INT1168 Binding of PROC 62 0.38 44.15 9.04 94.28
27 INT134346 Binding of PCS 51 0.37 22.27 5.67 94.24
28 INT200032 Regulation of HIST1H2BE 1 0.05 0.17 0 93.64
29 INT76625 Positive_regulation of Phc1 14 0.36 5.1 3.49 93.34
30 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 93.04
31 INT196995 Gene_expression of TMEM200A 22 0.45 4.02 0.53 91.72
32 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 91.44
33 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 90.80
34 INT6177 Binding of Htr1a 65 0.47 17.65 30.59 90.16
35 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38 89.04
36 INT36491 Gene_expression of mn 2 0.52 2.22 0.89 88.32
37 INT58365 Gene_expression of LTF 51 0.78 44.14 7.25 88.04
38 INT199146 Gene_expression of Pheo 3 0.18 3.57 1.63 87.96
39 INT274343 Localization of Mt1 1 0.11 0.84 0.48 87.40
40 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 86.88
41 INT17674 Localization of Scn2a1 32 0.61 1.73 6.79 86.36
42 INT161500 Gene_expression of PC 42 0.67 9.02 2.2 85.48
43 INT22046 Negative_regulation of IRF6 52 0.43 25.69 14.13 84.32
44 INT5704 Binding of Slc3a1 78 0.43 8.52 51.78 83.36
45 INT2159 Regulation of Localization of Gnrh1 200 0.62 13.28 99.07 82.68
46 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 82.68
47 INT40638 Binding of HRH1 14 0.44 5.81 5.09 82.64
48 INT1793 Localization of CGA 379 0.81 67.38 114.69 82.16
49 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 82.16
50 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 82.16
51 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 81.52
52 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 81.52
53 INT25271 Positive_regulation of MTG1 21 0.67 13.59 5.96 81.48
54 INT187902 Negative_regulation of PC 4 0.48 1.22 0.39 80.24
55 INT83014 Binding of Adora2a 13 0.48 5.57 5.33 79.16
56 INT9821 Binding of Bcl2a1a 9 0.33 4.32 3.47 79.16
57 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 79.12
58 INT211098 Negative_regulation of Msra 1 0.01 1.36 0.16 79.04
59 INT3602 Negative_regulation of Shbg 148 0.53 69.05 11.65 77.96
60 INT244284 Binding of SLC18A2 1 0.23 1.87 1.34 76.40
61 INT125005 Negative_regulation of SLPI 9 0.42 5.79 4.43 76.00
62 INT63112 Binding of Hrh1 6 0.17 3.83 2.76 75.76
63 INT18001 Positive_regulation of Htr2c 21 0.67 7.63 11.39 75.00
64 INT81726 Binding of soc 42 0.42 9.92 1.61 74.92
65 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 74.64
66 INT20950 Positive_regulation of PC 12 0.60 2.76 1.19 74.12
67 INT6133 Negative_regulation of Serpinc1 56 0.58 42.8 8.35 73.84
68 INT69572 Localization of Prnp 96 0.81 38.11 5.45 72.08
69 INT10598 Gene_expression of Ar 10 0.64 3.44 1.61 72.08
70 INT192951 Negative_regulation of AES 15 0.38 6.38 3.5 71.76
71 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 71.24
72 INT154057 Gene_expression of Ear1 14 0.41 9.72 1.12 70.64
73 INT161779 Positive_regulation of Gene_expression of Ear1 3 0.27 1.91 0.22 70.64
74 INT10925 Positive_regulation of PIP 5 0.49 1.28 0.17 70.44
75 INT9098 Positive_regulation of DBP 30 0.69 15.77 4.26 70.44
76 INT28 Regulation of Gast 106 0.62 26.37 29.85 70.24
77 INT123843 Gene_expression of soc 14 0.58 5.22 1.96 70.16
78 INT6357 Positive_regulation of Localization of Gabrg1 53 0.41 7.03 39.21 69.68
79 INT2262 Negative_regulation of Lhb 142 0.59 25.47 44.81 69.60
80 INT52904 Positive_regulation of LTF 21 0.67 15.58 5.78 69.56
81 INT303110 Positive_regulation of Positive_regulation of LTF 1 0.04 0.45 0.03 69.56
82 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 69.20
83 INT101414 Gene_expression of Phc1 27 0.60 9.55 7.58 68.96
84 INT280449 Positive_regulation of Gene_expression of Phc1 1 0.05 1.79 1.09 68.96
85 INT85260 Negative_regulation of ATF7IP 14 0.41 7.08 3.17 68.64
86 INT161504 Positive_regulation of Gene_expression of PC 4 0.44 1.75 0.39 68.48
87 INT5359 Protein_catabolism of Abat 12 0.62 5.11 8.54 68.36
88 INT199533 Gene_expression of Csda 2 0.06 0.65 0.32 68.32
89 INT47909 Binding of CPP 32 0.48 24.9 13.79 68.24
90 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 67.88
91 INT303113 Negative_regulation of Positive_regulation of PSD 1 0.03 0.58 0 67.88
92 INT7883 Binding of ADRB2 18 0.47 5.49 7.37 67.32
93 INT227075 Negative_regulation of Gene_expression of soc 2 0.29 0.57 0.09 67.08
94 INT203646 Gene_expression of STIP1 26 0.63 23.57 1.14 66.88
95 INT100064 Regulation of DBP 17 0.45 6.06 1.85 66.40
96 INT17685 Negative_regulation of Cog1 23 0.42 15.65 3.56 66.00
97 INT262325 Localization of D10Jhu49 1 0.06 0.35 0 65.68
98 INT80782 Positive_regulation of PSD 5 0.18 0.72 0 65.56
99 INT2613 Negative_regulation of Positive_regulation of Ren 16 0.59 8.2 5.62 65.56
100 INT33517 Gene_expression of TSHR 20 0.71 14.65 1.45 64.68
101 INT186523 Binding of ETFDH 10 0.25 5.63 0.72 63.92
102 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 62.88
103 INT184852 Positive_regulation of Gene_expression of ADHD1 6 0.40 5.06 1.66 62.84
104 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 62.24
105 INT273471 Negative_regulation of PTBP1 7 0.34 9.2 1.1 62.24
106 INT27652 Gene_expression of TG 36 0.78 22.36 2.74 59.44
107 INT171432 Negative_regulation of Gene_expression of TG 3 0.42 2.15 0.3 59.44
108 INT211904 Negative_regulation of Localization of RYR1 1 0.37 0.64 0 58.68
109 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 58.48
110 INT11713 Localization of RYR1 22 0.76 10.42 1.64 58.12
111 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 58.08
112 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 57.12
113 INT227630 Binding of TSPAN12 2 0.13 0.73 0.11 55.76
114 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 55.28
115 INT173445 Positive_regulation of TAB1 3 0.49 0.9 0 55.28
116 INT199532 Binding of Csda 1 0.00 0.54 0.07 55.04
117 INT229111 Localization of SLC6A3 5 0.68 1.12 2.48 54.88
118 INT17562 Negative_regulation of Lipg 32 0.51 16.91 3.17 54.56
119 INT201959 Positive_regulation of Gene_expression of DPP4 13 0.53 6.24 3.4 54.28
120 INT193069 Positive_regulation of Gene_expression of CD38 4 0.15 4.06 1.01 54.28
121 INT73524 Positive_regulation of Ear1 7 0.27 4.82 0.54 54.28
122 INT131373 Positive_regulation of NDRG1 9 0.67 4.78 1.11 54.00
123 INT84464 Gene_expression of DPP4 101 0.78 56.15 17.53 53.88
124 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27 53.88
125 INT215032 Positive_regulation of TMEM200A 7 0.33 2.23 0.26 53.76
126 INT252 Localization of GH1 529 0.80 227.4 122.05 53.68
127 INT255 Regulation of Localization of GH1 89 0.62 18.71 35.3 53.68
128 INT175562 Gene_expression of ENHO 1 0.10 2.85 0.37 53.44
129 INT231013 Protein_catabolism of Socs6 1 0.17 0.93 0.03 53.00
130 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 52.64
131 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 52.36
132 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 52.36
133 INT83451 Positive_regulation of Gene_expression of CD40LG 26 0.60 22.81 6.25 52.36
134 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45 52.32
135 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11 52.24
136 INT181589 Binding of OPN1SW 13 0.32 9.47 4.07 52.24
137 INT87340 Negative_regulation of BCAR1 8 0.38 6.96 2.63 52.08
138 INT183819 Negative_regulation of Positive_regulation of BCAR1 1 0.38 2.04 0.05 52.08
139 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 51.72
140 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 51.72
141 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 51.68
142 INT19606 Negative_regulation of Ear1 3 0.22 3.25 0.61 51.44
143 INT28088 Binding of Alb 34 0.47 11.06 5.48 51.28
144 INT57178 Regulation of REG1A 4 0.38 1.77 1.34 50.68
145 INT157720 Localization of ADHD1 15 0.64 15.84 1.69 48.36
146 INT133038 Binding of DNMT3B 26 0.40 5.97 2.83 48.24
147 INT256640 Transcription of Ubxn11 1 0.69 0.25 0 47.80
148 INT193504 Positive_regulation of OPN1SW 11 0.58 7.44 1.47 46.88
149 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 46.72
150 INT88947 Positive_regulation of Gene_expression of Pgr 22 0.64 7 4.39 46.72
151 INT157892 Binding of PNLIP 5 0.25 4.58 0.65 46.48
152 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 45.96
153 INT1705 Gene_expression of pCA 126 0.65 88.65 34.81 45.64
154 INT84077 Gene_expression of Hmox2 18 0.77 6.41 10.66 45.60
155 INT97914 Negative_regulation of Gene_expression of Hmox2 3 0.49 1.73 2.26 45.60
156 INT6508 Gene_expression of RYR1 34 0.77 11.11 2.04 43.36
157 INT32552 Negative_regulation of Pnp 9 0.52 5.31 1.63 42.96
158 INT80174 Positive_regulation of Gene_expression of Neu1 23 0.37 17.82 1.12 42.60
159 INT45142 Gene_expression of DCPS 109 0.56 84.71 16.87 42.56
160 INT78199 Gene_expression of Neu1 65 0.75 62.88 7.16 42.20
161 INT91106 Negative_regulation of LTF 9 0.51 5.73 1.09 41.08
162 INT81725 Regulation of soc 8 0.39 2.48 0.32 41.00
163 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 40.68
164 INT30693 Binding of Ggt1 3 0.36 1.76 0.33 40.68
165 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15 40.64
166 INT162109 Negative_regulation of Gene_expression of Esr1 4 0.16 2.41 0.12 40.64
167 INT79168 Binding of TNC 39 0.47 16.51 7.55 40.28
168 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 39.76
169 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 39.76
170 INT15648 Positive_regulation of RYR1 30 0.67 12.03 3.26 39.64
171 INT80636 Positive_regulation of Localization of RYR1 2 0.47 0.78 0.29 39.64
172 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 39.32
173 INT920 Localization of PLOD1 223 0.81 42.25 78.7 38.64
174 INT162 Regulation of Prl 794 0.62 165.01 322.24 38.24
175 INT7994 Gene_expression of Lta 113 0.67 69.81 19.59 35.72
176 INT812 Localization of INS 1026 0.81 515.6 145.31 35.60
177 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 34.72
178 INT203644 Negative_regulation of Gene_expression of STIP1 2 0.37 0.54 0 33.04
179 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 32.48
180 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 32.48
181 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 32.48
182 INT256636 Negative_regulation of Ubxn11 1 0.43 0.08 0.08 32.24
183 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 28.92
184 INT183668 Binding of SGCA 15 0.36 9.86 2.42 28.40
185 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 27.68
186 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 25.76
187 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 25.76
188 INT2122 Negative_regulation of Localization of Gnrh1 226 0.59 26.92 92.04 25.00
189 INT11246 Binding of Grin1 65 0.48 14.53 36.93 25.00
190 INT204930 Gene_expression of LGMN 1 0.07 0.48 0.31 24.44
191 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 23.88
192 INT2242 Negative_regulation of Localization of GAST 12 0.58 5.55 4.22 23.76
193 INT2463 Localization of CCK 101 0.81 37.54 47.59 23.28
194 INT2243 Localization of GAST 67 0.81 34.54 16.19 23.28
195 INT164920 Gene_expression of IL33 22 0.76 13.63 3.16 22.04
196 INT30610 Localization of PCa 35 0.65 13.91 4.25 21.92
197 INT48882 Binding of GRIN3B 9 0.46 5.12 7.66 21.60
198 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 21.12
199 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 21.04
200 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 21.04
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