D:Aortic Aneurysms

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Disease Term
Synonyms Aneurysm Aortic, Aneurysms Aortic, Aortic Aneurism, Aortic Aneurisms, AORTIC ANEURYSM
Documents 171
Hot Single Events 21
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Aortic Aneurysms. They are ordered first by their relevance to Aortic Aneurysms and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT213062 PTGS1 Regulation of Gene_expression of MMP9 1 0.04 0.25 0.3 97.36
2 INT213061 PTGER2 Regulation of Gene_expression of MMP9 1 0.03 0.25 0.23 97.36
3 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87 10.00
4 INT182771 ROS1 Positive_regulation of NFKB1 Positive_regulation of CRP 1 0.00 3.83 0.28 10.00
5 INT182772 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL1B 1 0.00 1.89 0.14 10.00
6 INT182773 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL6 1 0.00 1.9 0.14 10.00
7 INT182780 NFKB1 Positive_regulation of IL1B 1 0.00 1.8 0.14 7.24
8 INT182782 NFKB1 Positive_regulation of IL6 1 0.00 1.8 0.14 7.24
9 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58 5.00
10 INT329369 Jun Regulation of Gene_expression of Il12a 1 0.00 1.48 0.27 5.00
11 INT329368 Ccl2 Negative_regulation of Jun 1 0.01 1.87 0.24 5.00
12 INT329670 Csf2 Regulation of Col7a1 1 0.03 0.4 0.17 5.00
13 INT198307 IL10 Positive_regulation of Gene_expression of IGHG3 2 0.01 1.21 0.15 5.00
14 INT329371 IL8 Negative_regulation of Jun 1 0.00 0.95 0.13 5.00
15 INT294725 Binding of LTB4R and LTB4R2 1 0.00 0 0.1 5.00
16 INT182775 Binding of PTH and ROS1 1 0.04 1.73 0.04 5.00
17 INT182784 IGF1 Positive_regulation of Gene_expression of INS 1 0.02 1.87 0 5.00
18 INT182804 Binding of ETV3 and T2DM 1 0.10 2.62 0 5.00
19 INT182778 IGF1 Positive_regulation of Gene_expression of ETV3 1 0.03 1.89 0 5.00
20 INT182774 Binding of ETV3 and SAE1 1 0.00 1.17 0 5.00
21 INT182783 INS Positive_regulation of Gene_expression of ETV3 1 0.01 1.89 0 5.00
22 INT182777 IAPP Positive_regulation of Gene_expression of ETV3 1 0.06 1.88 0 5.00
23 INT182776 IAPP Positive_regulation of Gene_expression of INS 1 0.03 1.87 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Aortic Aneurysms. They are ordered first by their pain relevance and then by number of times they were reported in Aortic Aneurysms. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 99.84
2 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 99.84
3 INT339055 Binding of Tgfbr2 1 0.07 0.92 0 99.40
4 INT339058 Binding of Fbn1 1 0.48 3.13 0.03 98.52
5 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 97.36
6 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 96.28
7 INT61643 Gene_expression of ACVRL1 9 0.51 9.04 1.03 94.56
8 INT1763 Regulation of Gene_expression of PTGER2 43 0.36 23.98 10.95 94.40
9 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 94.40
10 INT1764 Negative_regulation of Gene_expression of PTGER2 81 0.34 34.74 19.45 93.96
11 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79 93.96
12 INT50491 Regulation of Gene_expression of PTGS1 17 0.47 6 5.4 93.76
13 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 93.76
14 INT101487 Gene_expression of Fbn1 3 0.77 3.54 0 92.96
15 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 92.56
16 INT174029 Protein_catabolism of BSG 5 0.01 2.5 0.95 88.48
17 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 86.16
18 INT9095 Regulation of Gene_expression of COL7A1 24 0.57 10.55 4.88 86.16
19 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 83.48
20 INT574 Negative_regulation of C1S 9 0.47 11.25 1.41 81.24
21 INT92396 Protein_catabolism of Vwa2 1 0.01 0.39 0.17 80.80
22 INT60142 Negative_regulation of Serpinb1a 2 0.42 0.59 2.46 79.92
23 INT212411 Negative_regulation of NCOA5 2 0.17 1.14 0.31 79.92
24 INT54848 Protein_catabolism of SGCG 12 0.96 3.8 3.78 79.20
25 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 78.48
26 INT2848 Localization of ABCA1 23 0.70 10.64 4.73 72.64
27 INT81444 Positive_regulation of Gene_expression of Vcam1 40 0.70 46.38 8.58 71.56
28 INT62546 Positive_regulation of Gene_expression of Icam1 60 0.70 59.52 16.9 71.56
29 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 71.56
30 INT63169 Positive_regulation of Gene_expression of Selp 35 0.69 21.95 7.16 71.56
31 INT81880 Positive_regulation of Gene_expression of Sele 30 0.48 27.54 7.05 71.56
32 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 71.16
33 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 71.16
34 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 71.16
35 INT49141 Gene_expression of Selp 157 0.78 85.22 24.78 71.16
36 INT61257 Gene_expression of Sele 79 0.77 70.97 17.78 71.16
37 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 70.84
38 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 70.64
39 INT192269 Regulation of Lts1 5 0.08 3.53 0.75 60.52
40 INT203153 Negative_regulation of Gene_expression of Lts1 3 0.07 3.71 0.91 59.40
41 INT127022 Gene_expression of Lts1 43 0.23 28.29 12.64 59.40
42 INT169542 Negative_regulation of Lts1 5 0.12 2.74 1.23 56.40
43 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 54.24
44 INT339057 Positive_regulation of Gene_expression of Fbn1 1 0.50 0.52 0 51.40
45 INT339056 Negative_regulation of Gene_expression of Fbn1 1 0.42 1.17 0 51.16
46 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 50.56
47 INT51685 Gene_expression of LTB4R 87 0.58 68.69 31.72 49.08
48 INT38788 Negative_regulation of CYSLTR1 8 0.42 4.5 1.16 46.40
49 INT13634 Gene_expression of CYSLTR1 19 0.75 11.24 2.88 38.08
50 INT258548 Positive_regulation of Meta 10 0.67 5.05 1.42 30.40
51 INT176445 Protein_catabolism of Gopc 23 0.76 7.57 0.75 28.96
52 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18 23.48
53 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 23.24
54 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 22.72
55 INT163794 Localization of CYSLTR1 4 0.45 2.4 1.08 19.76
56 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25 18.12
57 INT103603 Negative_regulation of Gene_expression of Mmp2 16 0.51 12.29 2.47 18.12
58 INT3512 Gene_expression of Igha 9 0.60 7.71 1.13 15.28
59 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 14.64
60 INT212412 Gene_expression of NCOA5 3 0.27 1.7 0.68 12.28
61 INT317979 Positive_regulation of Transcription of Mmp2 4 0.46 2.63 1.37 12.12
62 INT187295 Gene_expression of Serpinb1a 6 0.58 13.73 5.05 11.96
63 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75 11.80
64 INT105985 Transcription of Mmp9 11 0.66 8.55 3.02 11.12
65 INT138141 Transcription of Mmp2 10 0.64 6.52 2.99 11.12
66 INT116280 Transcription of Mmp13 11 0.67 6.52 2.06 11.12
67 INT192268 Regulation of Gene_expression of Lts1 6 0.06 3.78 1.49 10.92
68 INT192267 Binding of Lts1 3 0.06 1.11 0.23 9.68
69 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 9.64
70 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
71 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
72 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
73 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
74 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
75 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
76 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
77 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
78 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
79 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
80 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
81 INT3214 Localization of Ins1 527 0.80 196.9 79.26 5.00
82 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
83 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
84 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
85 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 5.00
86 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
87 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 5.00
88 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
89 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
90 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
91 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
92 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
93 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
94 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
95 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
96 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
97 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
98 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
99 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
100 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
101 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 5.00
102 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
103 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
104 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 5.00
105 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
106 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 5.00
107 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75 5.00
108 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 5.00
109 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 5.00
110 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
111 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
112 INT12681 Regulation of Trib3 76 0.53 23.92 26.58 5.00
113 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
114 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
115 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
116 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
117 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
118 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
119 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7 5.00
120 INT4535 Localization of PROC 106 0.73 76.24 21.1 5.00
121 INT89484 Gene_expression of TNFRSF11B 119 0.76 53.57 19.67 5.00
122 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
123 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
124 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
125 INT113602 Positive_regulation of Gene_expression of Ccl2 48 0.70 48.71 17.85 5.00
126 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1 5.00
127 INT1767 Positive_regulation of PROC 83 0.67 54.14 17 5.00
128 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31 5.00
129 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89 5.00
130 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46 5.00
131 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
132 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 5.00
133 INT20378 Localization of Hand1 53 0.71 41.96 13.31 5.00
134 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
135 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 5.00
136 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39 5.00
137 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
138 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
139 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44 5.00
140 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35 5.00
141 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68 5.00
142 INT94784 Binding of ROS1 113 0.40 71.57 10.26 5.00
143 INT113605 Negative_regulation of Gene_expression of Mmp9 25 0.41 22.92 9.98 5.00
144 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93 5.00
145 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
146 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
147 INT1168 Binding of PROC 62 0.38 44.15 9.04 5.00
148 INT25381 Localization of Csf2 62 0.76 47.48 9.03 5.00
149 INT158796 Positive_regulation of SMUG1 67 0.70 38.97 8.98 5.00
150 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 5.00
151 INT75932 Binding of Csf2 45 0.37 33.2 8.01 5.00
152 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92 5.00
153 INT162393 Gene_expression of SMUG1 58 0.75 38.78 7.7 5.00
154 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2 5.00
155 INT5822 Gene_expression of Ltb4r1 51 0.76 37.43 7.2 5.00
156 INT16722 Negative_regulation of MPO 25 0.59 18.55 6.99 5.00
157 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74 5.00
158 INT104909 Binding of Pias1 11 0.37 3.67 6.72 5.00
159 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 5.00
160 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 5.00
161 INT60713 Binding of Col7a1 47 0.43 22.52 6.29 5.00
162 INT127023 Negative_regulation of Gene_expression of Vcam1 24 0.59 20.39 6.28 5.00
163 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16 5.00
164 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12 5.00
165 INT19916 Gene_expression of GPHA2 18 0.48 9.78 6.04 5.00
166 INT16211 Negative_regulation of LTB4R 11 0.29 13 5.62 5.00
167 INT93484 Negative_regulation of Positive_regulation of Jun 30 0.58 9.31 5.18 5.00
168 INT181186 Binding of Rxra 78 0.35 14.93 4.87 5.00
169 INT60066 Positive_regulation of NPEPPS 17 0.22 11.99 4.83 5.00
170 INT51679 Negative_regulation of Gene_expression of LTB4R 12 0.29 7.21 4.74 5.00
171 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 5.00
172 INT87632 Positive_regulation of Gene_expression of PECAM1 32 0.45 29.47 4.66 5.00
173 INT97878 Positive_regulation of Pias1 6 0.50 2.73 4.65 5.00
174 INT2065 Binding of BTG3 15 0.36 10.9 4.65 5.00
175 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 5.00
176 INT101594 Positive_regulation of Cd40 36 0.69 16.14 4.56 5.00
177 INT170988 Positive_regulation of CYSLTR1 15 0.34 6.23 4.44 5.00
178 INT239217 Gene_expression of Agtrap 47 0.78 48.8 4.44 5.00
179 INT118835 Positive_regulation of Vegfa 18 0.59 11.2 3.91 5.00
180 INT62386 Negative_regulation of Gene_expression of IGHG3 12 0.20 7.94 3.62 5.00
181 INT536 Binding of MBP 17 0.48 6.52 3.56 5.00
182 INT10106 Positive_regulation of Msr1 16 0.50 5.86 3.52 5.00
183 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
184 INT184060 Negative_regulation of Stat1 28 0.58 17.44 3.19 5.00
185 INT110755 Negative_regulation of Positive_regulation of Mapk8 15 0.46 9.91 2.98 5.00
186 INT16130 Binding of IGF1 67 0.48 27.43 2.95 5.00
187 INT104035 Gene_expression of LTB4R2 12 0.66 7.41 2.76 5.00
188 INT26996 Positive_regulation of Gene_expression of Crp 21 0.68 21.55 2.75 5.00
189 INT143952 Regulation of Gene_expression of MMP9 14 0.53 10.16 2.73 5.00
190 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 5.00
191 INT96151 Negative_regulation of Gene_expression of Cd40 20 0.58 6.06 2.58 5.00
192 INT100427 Binding of SERPINA1 9 0.36 9.63 2.51 5.00
193 INT5180 Binding of Serpinc1 27 0.36 13.39 2.47 5.00
194 INT190081 Gene_expression of Abca1 21 0.65 18.18 2.45 5.00
195 INT248297 Negative_regulation of Cd40 14 0.58 8.96 2.34 5.00
196 INT12618 Positive_regulation of IAPP 54 0.68 32.03 2.29 5.00
197 INT112784 Positive_regulation of Positive_regulation of IFNG 11 0.49 7.84 2.18 5.00
198 INT181396 Transcription of Csf2 15 0.48 6.38 2.17 5.00
199 INT82166 Regulation of NOS3 14 0.54 7.57 2.08 5.00
200 INT171070 Positive_regulation of Hey2 8 0.05 10.12 1.96 5.00
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