D:Aortic Valve Insufficiency

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Disease Term
Synonyms AORTIC INCOMPETENCE, AORTIC REGURGITATION, Aortic Valve Incompetence, Incompetence Aortic, INCOMPETENCE AORTIC VALVE, INSUFFICIENCY AORTIC VALVE, Regurgitation Aortic, Regurgitation Aortic Valve
Documents 392
Hot Single Events 23
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Aortic Valve Insufficiency. They are ordered first by their relevance to Aortic Valve Insufficiency and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT68482 Cga Regulation of Gh 1 0.00 1.89 0.31 71.44
2 INT68479 Gnrh1 Regulation of Lhb 1 0.00 1.58 0.25 69.24
3 INT68480 Negative_regulation of Gnrh1 Regulation of Lhb 1 0.00 0.67 0.15 33.56
4 INT354544 Avp Positive_regulation of ADCY1 1 0.24 2.23 0.22 5.00
5 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19 5.00
6 INT223088 Binding of ELF3 and NAGLU 1 0.14 0.84 0.09 5.00
7 INT223089 Binding of IDS and NAGLU 1 0.26 0.72 0.09 5.00
8 INT296893 Nps Negative_regulation of Gene_expression of REN 1 0.00 1.05 0.04 5.00
9 INT192618 Atrx Regulation of Gene_expression of Hba-a1 1 0.08 0.45 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Aortic Valve Insufficiency. They are ordered first by their pain relevance and then by number of times they were reported in Aortic Valve Insufficiency. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT70615 Binding of TXNRD1 25 0.36 12.15 1.27 100.00
2 INT67953 Gene_expression of SPEG 1 0.00 1.8 0.1 100.00
3 INT35765 Gene_expression of TXNRD1 47 0.56 9.16 4.43 100.00
4 INT3182 Negative_regulation of PPY 12 0.42 4.65 2.28 99.90
5 INT637 Positive_regulation of MRAP 23 0.67 21.13 9.97 98.04
6 INT39507 Positive_regulation of TXNRD1 37 0.68 12.47 14.25 96.96
7 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 94.60
8 INT928 Positive_regulation of Aebp1 2 0.35 1.53 0.8 91.08
9 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15 87.64
10 INT239083 Binding of PPY 9 0.32 7.59 2.9 87.64
11 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 87.12
12 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 87.12
13 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 87.12
14 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 87.00
15 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51 86.72
16 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 86.72
17 INT269104 Positive_regulation of AOX1 1 0.19 4.25 0.4 86.58
18 INT2105 Negative_regulation of Rhd 10 0.41 4.9 3.4 86.28
19 INT15610 Localization of GOPC 223 0.65 68.26 28.7 85.00
20 INT251520 Localization of NEO1 1 0.78 0.86 0.07 85.00
21 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 84.72
22 INT89519 Negative_regulation of COL1A2 10 0.36 6.26 2.17 81.32
23 INT2836 Positive_regulation of PAEP 51 0.67 26.69 4.57 81.16
24 INT131877 Negative_regulation of Nps 12 0.39 8.19 3.56 79.04
25 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26 78.84
26 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9 78.16
27 INT3811 Negative_regulation of PAEP 36 0.50 23.7 5.18 77.08
28 INT141785 Negative_regulation of GALNS 3 0.59 1.92 0.09 75.60
29 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 72.88
30 INT103260 Positive_regulation of Nps 35 0.48 23.8 5.67 72.24
31 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 71.44
32 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 70.64
33 INT5126 Positive_regulation of Positive_regulation of Lhb 16 0.48 2.12 5.23 70.64
34 INT7224 Positive_regulation of Gene_expression of Lhb 18 0.45 10.22 3.4 70.64
35 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 69.24
36 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 69.12
37 INT23367 Positive_regulation of Positive_regulation of Gnrh1 9 0.50 0.97 2.97 68.80
38 INT2123 Positive_regulation of Gnrh1 209 0.70 24.2 68.97 68.32
39 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 64.28
40 INT200219 Positive_regulation of VHL 18 0.50 15.38 0.67 64.28
41 INT269103 Gene_expression of AOX1 2 0.26 1.97 0.46 62.88
42 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 62.68
43 INT117754 Gene_expression of NHS 34 0.57 9.27 3.28 58.84
44 INT3590 Positive_regulation of AVL9 7 0.40 7.94 2.36 58.24
45 INT339057 Positive_regulation of Gene_expression of Fbn1 1 0.50 0.52 0 57.12
46 INT101487 Gene_expression of Fbn1 3 0.77 3.54 0 56.84
47 INT202591 Regulation of AVL9 2 0.02 1.58 0.19 56.48
48 INT269105 Localization of AOX1 1 0.31 2.16 0.5 53.84
49 INT3925 Negative_regulation of HLA-B 29 0.42 20.19 9.46 52.16
50 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 48.24
51 INT190190 Protein_catabolism of ELN 5 0.22 2.81 1.27 46.52
52 INT1530 Regulation of Gh 382 0.61 115.96 112.47 43.44
53 INT93789 Gene_expression of Tnnc1 28 0.76 17.3 1.99 41.12
54 INT17056 Gene_expression of DLD 37 0.57 13.15 5.47 37.28
55 INT171772 Binding of CPB1 13 0.32 9.92 0.75 34.52
56 INT29424 Negative_regulation of Positive_regulation of Lhb 21 0.56 4.58 4.03 33.56
57 INT9785 Negative_regulation of Positive_regulation of Gnrh1 18 0.43 1.88 7.35 33.44
58 INT258990 Localization of Emb 1 0.21 0.98 0.21 33.32
59 INT258989 Binding of Emb 1 0.10 0.98 0.21 31.84
60 INT291342 Negative_regulation of Mpeg1 3 0.40 5.76 0.2 30.32
61 INT192619 Regulation of SMARCA2 1 0.06 0.3 0 28.84
62 INT192620 Regulation of BTAF1 1 0.06 0.3 0 28.84
63 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98 23.24
64 INT338987 Regulation of Binding of Cpb1 1 0.03 0.6 0.05 21.08
65 INT127363 Binding of Cpb1 8 0.32 2.5 1.14 19.64
66 INT178830 Negative_regulation of MR1 16 0.50 7.63 0.44 18.16
67 INT192614 Gene_expression of Atrx 1 0.77 1.75 0 16.96
68 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02 16.16
69 INT258991 Gene_expression of Emb 2 0.43 2.55 0.23 9.76
70 INT157226 Positive_regulation of Gene_expression of Tnnc1 11 0.49 6.21 0.57 8.80
71 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
72 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
73 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
74 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
75 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
76 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
77 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
78 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.00
79 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
80 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
81 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
82 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
83 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
84 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 5.00
85 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
86 INT8836 Positive_regulation of SFTPA1 36 0.47 28.37 23.59 5.00
87 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
88 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
89 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 5.00
90 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
91 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 5.00
92 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 5.00
93 INT81486 Localization of MMP3 31 0.81 12.94 15.21 5.00
94 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
95 INT10585 Localization of NAGLU 53 0.80 23.32 12.75 5.00
96 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 5.00
97 INT159127 Gene_expression of Nps 49 0.75 16.91 12.06 5.00
98 INT661 Gene_expression of REN 100 0.78 48.21 11.36 5.00
99 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14 5.00
100 INT81929 Negative_regulation of Gene_expression of IL10 41 0.57 27.99 9.87 5.00
101 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
102 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96 5.00
103 INT10879 Positive_regulation of Avp 39 0.65 14.01 8.76 5.00
104 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
105 INT63401 Gene_expression of Il5 33 0.72 18.66 8.2 5.00
106 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 5.00
107 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 5.00
108 INT43727 Negative_regulation of Gene_expression of MMP3 16 0.40 4.81 7.18 5.00
109 INT21579 Negative_regulation of Gene_expression of TIMP1 25 0.57 12.41 6.94 5.00
110 INT31226 Localization of PPY 20 0.78 9.93 6.8 5.00
111 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 5.00
112 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 5.00
113 INT63957 Positive_regulation of Tnnt2 33 0.69 18.56 5.41 5.00
114 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
115 INT3163 Gene_expression of NAGLU 28 0.75 15.23 4.98 5.00
116 INT58766 Gene_expression of ANGPT2 41 0.67 21.65 4.82 5.00
117 INT78995 Negative_regulation of Agtr2 26 0.42 13.05 4.56 5.00
118 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 5.00
119 INT30031 Gene_expression of Hba-a1 7 0.60 7.46 4.41 5.00
120 INT54886 Negative_regulation of ANGPT2 25 0.42 9.33 3.79 5.00
121 INT173849 Positive_regulation of Localization of MMP3 7 0.49 4.6 3.65 5.00
122 INT159472 Localization of NPPB 32 0.79 33.67 3.59 5.00
123 INT22502 Gene_expression of Hal 21 0.53 9.8 3.32 5.00
124 INT55690 Positive_regulation of Localization of TIMP1 8 0.50 4.77 3.28 5.00
125 INT146758 Gene_expression of LCN2 45 0.78 38.29 2.97 5.00
126 INT7142 Positive_regulation of DLD 22 0.60 7.69 2.76 5.00
127 INT45272 Regulation of Nps 15 0.39 8.08 2.69 5.00
128 INT155889 Binding of Nps 22 0.42 9.79 2.6 5.00
129 INT105993 Gene_expression of IDS 26 0.78 10.83 2.41 5.00
130 INT150476 Positive_regulation of ELF3 32 0.56 13.61 2.39 5.00
131 INT183675 Negative_regulation of ETFDH 11 0.37 5.62 2.18 5.00
132 INT55470 Regulation of Mtor 16 0.24 12.51 2.07 5.00
133 INT68829 Binding of ELF3 14 0.47 7.96 2 5.00
134 INT14586 Gene_expression of Cpb1 23 0.58 6.18 1.99 5.00
135 INT18007 Positive_regulation of C6orf25 23 0.66 14.98 1.95 5.00
136 INT84264 Regulation of NPPB 22 0.61 21.18 1.94 5.00
137 INT194074 Regulation of NAGLU 5 0.38 2.93 1.87 5.00
138 INT76416 Positive_regulation of Gene_expression of Il5 9 0.08 4.16 1.65 5.00
139 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56 5.00
140 INT216932 Positive_regulation of Negative_regulation of Il6 3 0.38 4.88 1.55 5.00
141 INT237862 Positive_regulation of Gene_expression of Nps 8 0.43 3.82 1.52 5.00
142 INT37485 Regulation of RAPGEF5 10 0.44 6.64 1.51 5.00
143 INT140245 Binding of Gli3 3 0.36 2.65 1.46 5.00
144 INT9784 Binding of B2M 9 0.47 6.18 1.44 5.00
145 INT47734 Positive_regulation of RAPGEF5 19 0.56 13.16 1.41 5.00
146 INT47434 Gene_expression of Tnnt2 14 0.60 10.4 1.37 5.00
147 INT22871 Gene_expression of ELN 30 0.68 14.86 1.33 5.00
148 INT274750 Gene_expression of Mpeg1 4 0.55 6.1 1.3 5.00
149 INT146759 Positive_regulation of LCN2 18 0.69 18.44 1.08 5.00
150 INT224722 Binding of Mcpt1 6 0.10 4.82 1.03 5.00
151 INT200462 Binding of IDS 13 0.31 4.95 1 5.00
152 INT169472 Gene_expression of PDIA2 15 0.58 7.88 0.96 5.00
153 INT101687 Positive_regulation of AVPR1B 6 0.40 2.95 0.95 5.00
154 INT77856 Binding of Cps1 6 0.30 2.32 0.95 5.00
155 INT23921 Negative_regulation of NPPB 13 0.58 16.19 0.9 5.00
156 INT70027 Positive_regulation of Gene_expression of C6orf25 10 0.62 7.21 0.83 5.00
157 INT58765 Positive_regulation of Gene_expression of ANGPT2 11 0.38 8.2 0.81 5.00
158 INT173422 Gene_expression of ETFDH 11 0.45 5.78 0.78 5.00
159 INT251459 Binding of Ie 18 0.20 6.62 0.75 5.00
160 INT2108 Localization of Mif 5 0.77 2.7 0.73 5.00
161 INT63958 Regulation of Tnnt2 7 0.45 5.36 0.7 5.00
162 INT237866 Positive_regulation of Positive_regulation of Nps 5 0.48 2.67 0.69 5.00
163 INT137850 Gene_expression of PKD2 9 0.65 6.68 0.63 5.00
164 INT274748 Positive_regulation of Gene_expression of Mpeg1 3 0.41 0.59 0.61 5.00
165 INT164595 Binding of LCN2 8 0.37 6.03 0.6 5.00
166 INT74016 Binding of VHL 20 0.48 15.49 0.54 5.00
167 INT241243 Gene_expression of Pkd2 30 0.77 9.05 0.53 5.00
168 INT239247 Positive_regulation of APOA5 7 0.37 3.68 0.51 5.00
169 INT11118 Gene_expression of RAPGEF5 13 0.65 9.35 0.43 5.00
170 INT72717 Gene_expression of Nppc 8 0.51 6.25 0.39 5.00
171 INT241236 Negative_regulation of Pkd2 11 0.43 1.82 0.39 5.00
172 INT150826 Positive_regulation of Pkd1 9 0.37 3.65 0.35 5.00
173 INT269102 Binding of AOX1 1 0.21 1.99 0.35 5.00
174 INT236270 Binding of Hhex 2 0.07 1.55 0.29 5.00
175 INT241240 Gene_expression of Pkd1 18 0.54 12.2 0.27 5.00
176 INT291341 Phosphorylation of Ifnar1 2 0.03 0.99 0.22 5.00
177 INT132459 Binding of FABP3 4 0.35 2.19 0.2 5.00
178 INT208476 Binding of Pkd1 13 0.39 7.23 0.17 5.00
179 INT218167 Positive_regulation of Gene_expression of ETFDH 1 0.33 1.19 0.15 5.00
180 INT192194 Positive_regulation of FBXW11 3 0.34 0.84 0.14 5.00
181 INT218168 Transcription of ETFDH 2 0.44 0.87 0.14 5.00
182 INT354535 Regulation of Negative_regulation of Pkd2 1 0.15 1.03 0.14 5.00
183 INT183125 Negative_regulation of SULF1 2 0.42 2.26 0.13 5.00
184 INT251522 Positive_regulation of MED13L 1 0.35 0.82 0.11 5.00
185 INT311275 Regulation of Gene_expression of Tnnt2 2 0.34 1.33 0.1 5.00
186 INT121284 Positive_regulation of Gene_expression of Tnnt2 2 0.46 0.89 0.1 5.00
187 INT251521 Positive_regulation of GDF1 1 0.14 0.82 0.1 5.00
188 INT121285 Regulation of Positive_regulation of Tnnt2 2 0.45 0.84 0.09 5.00
189 INT291340 Phosphorylation of Mpeg1 1 0.51 0.36 0.08 5.00
190 INT354534 Binding of Havcr1 1 0.03 0.81 0.08 5.00
191 INT354537 Positive_regulation of Positive_regulation of Pkd1 1 0.29 1.7 0.06 5.00
192 INT261879 Binding of PKD2 3 0.13 2.59 0.05 5.00
193 INT203006 Positive_regulation of Gene_expression of Cpb1 4 0.06 1.01 0.05 5.00
194 INT168933 Positive_regulation of Car5b 2 0.15 0.64 0.05 5.00
195 INT199746 Gene_expression of REV1 17 0.33 9.53 0.05 5.00
196 INT354536 Positive_regulation of Hhex 1 0.08 0.62 0.04 5.00
197 INT286543 Localization of Pkd1 5 0.52 3.74 0.04 5.00
198 INT156365 Gene_expression of Hhex 4 0.67 1.63 0.03 5.00
199 INT339058 Binding of Fbn1 1 0.48 3.13 0.03 5.00
200 INT192611 Negative_regulation of Gene_expression of Hba-a1 1 0.07 0.86 0 5.00
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