D:Aphasia

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Disease Term
Synonyms Acquired Aphasia, AGEUSIC APHASIA, Ageusic Aphasias, ALOGIA, Alogias, Anepia, Anepias, Aphasia Acquired, Aphasia Ageusic, Aphasia Auditory Discriminatory, Aphasia Commisural
Documents 509
Hot Single Events 36
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Aphasia. They are ordered first by their relevance to Aphasia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT285568 Binding of TNF and Tnfsf10 1 0.12 1.39 0.36 66.64
2 INT306339 Binding of CRX and PAX6 1 0.53 0.27 0 24.60
3 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 5.00
4 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46 5.00
5 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 5.00
6 INT262367 Tcas1 Positive_regulation of Localization of Adh4 1 0.01 1.91 1.01 5.00
7 INT285561 Il23a Positive_regulation of Gene_expression of Il22 2 0.06 2.45 0.93 5.00
8 INT285562 Binding of Il27ra and Il27 1 0.10 2.19 0.67 5.00
9 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61 5.00
10 INT356199 GOPC Positive_regulation of Acot7 1 0.04 0.33 0.4 5.00
11 INT353836 Binding of CEACAM7 and ICA1 1 0.08 0.32 0.39 5.00
12 INT285560 Il23a Positive_regulation of Il17a 1 0.09 1.45 0.39 5.00
13 INT285571 Binding of IL8 and Il17a 1 0.04 1.03 0.38 5.00
14 INT285557 Eae2 Positive_regulation of Cia1 1 0.02 1.85 0.36 5.00
15 INT285465 IL7 Positive_regulation of TNF 1 0.04 0.67 0.35 5.00
16 INT285570 Binding of IL8 and Cdkn1c 1 0.11 0.76 0.34 5.00
17 INT285565 Positive_regulation of Zeb1 Negative_regulation of IL2 1 0.02 0.62 0.33 5.00
18 INT285558 Binding of Il11ra1 and Il27 1 0.05 1.1 0.33 5.00
19 INT285566 F8 Negative_regulation of IL2 1 0.00 0.62 0.33 5.00
20 INT285563 Zeb1 Negative_regulation of IL2 1 0.01 0.62 0.33 5.00
21 INT285567 Binding of IL1B and Cdc42 1 0.03 0.77 0.31 5.00
22 INT285564 Binding of IL1B and Ripk2 1 0.04 0.76 0.31 5.00
23 INT270433 PLAT Positive_regulation of Positive_regulation of Gsk3b 1 0.04 0.5 0.21 5.00
24 INT258456 PYCARD Negative_regulation of Localization of Tms 1 0.02 0.05 0.21 5.00
25 INT258455 Tms Negative_regulation of Localization of PYCARD 1 0.02 0.05 0.21 5.00
26 INT270416 PLAT Negative_regulation of Positive_regulation of PLG 1 0.00 0.48 0.15 5.00
27 INT302676 Binding of OPA1 and MFN2 1 0.46 1.12 0.14 5.00
28 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
29 INT336341 Binding of RTCA and ELOVL1 1 0.02 2.15 0.07 5.00
30 INT332588 Binding of RAPH1 and MND1 1 0.01 3.88 0.07 5.00
31 INT251944 Binding of GH1 and PRNP 1 0.09 1.14 0.05 5.00
32 INT270432 Lhb Positive_regulation of APP 1 0.03 0.51 0.03 5.00
33 INT332587 MND1 Positive_regulation of Binding of RAPH1 and MND1 1 0.00 2.21 0.03 5.00
34 INT270431 Gnrh1 Positive_regulation of APP 1 0.06 0.51 0.03 5.00
35 INT218240 Binding of SAE1 and Dync1h1 1 0.00 0.17 0 5.00
36 INT302675 Binding of OPA1 and PLAA 1 0.15 0.73 0 5.00
37 INT195460 Binding of CHM and CEBPZ 1 0.03 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Aphasia. They are ordered first by their pain relevance and then by number of times they were reported in Aphasia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT52180 Binding of Aes 38 0.42 23.16 6.7 99.68
2 INT158070 Localization of Aes 23 0.65 19.93 10.9 99.08
3 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 99.08
4 INT275875 Negative_regulation of Localization of Aes 2 0.19 3.87 1.8 99.08
5 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 97.84
6 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 97.84
7 INT51840 Positive_regulation of Localization of CD40LG 8 0.69 9.59 1.58 97.84
8 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 97.52
9 INT127 Positive_regulation of ACOT1 16 0.32 5.12 6.57 97.32
10 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 97.10
11 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3 95.72
12 INT80033 Binding of FAS 37 0.48 41.19 5.67 94.88
13 INT27207 Gene_expression of Psd 31 0.73 15.44 2.75 94.88
14 INT96542 Negative_regulation of SMN1 14 0.51 10.72 3.11 94.24
15 INT53594 Binding of Csrp1 5 0.32 11.87 3.84 94.20
16 INT103328 Binding of F8 9 0.44 11.89 0.93 93.80
17 INT136185 Positive_regulation of Binding of F8 2 0.64 1.4 0.14 93.80
18 INT44323 Positive_regulation of F8 32 0.60 24.88 3.89 93.44
19 INT26583 Positive_regulation of Cd4 40 0.54 21.96 4.83 93.20
20 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 92.92
21 INT43707 Positive_regulation of CCBE1 11 0.07 8.22 4.86 92.92
22 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 92.00
23 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 92.00
24 INT170604 Negative_regulation of Gene_expression of GOPC 50 0.35 12.71 4.51 92.00
25 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 87.88
26 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 86.04
27 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 85.72
28 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 85.64
29 INT44608 Gene_expression of C2 45 0.75 15.84 5.05 85.16
30 INT142404 Gene_expression of THPO 18 0.77 4.39 0.56 85.16
31 INT52349 Gene_expression of CHM 7 0.77 17.33 0.28 85.16
32 INT272256 Protein_catabolism of Psd 3 0.49 2.66 0.19 84.16
33 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 82.36
34 INT3530 Regulation of BCHE 18 0.60 5.47 4.12 81.84
35 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12 80.56
36 INT267653 Gene_expression of Kctd1 3 0.09 3.56 0.16 80.28
37 INT256742 Positive_regulation of Cdr1 10 0.27 2.89 0.81 79.80
38 INT66002 Binding of LAMC2 9 0.47 4.5 2.54 79.60
39 INT2544 Localization of PTH 39 0.81 30.55 2.22 79.28
40 INT192808 Negative_regulation of Localization of PTH 6 0.59 7.31 0.45 79.28
41 INT161766 Localization of Psd 7 0.75 3.53 0.96 77.84
42 INT38564 Binding of AIS 36 0.38 27.77 9.31 77.76
43 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68 77.64
44 INT262325 Localization of D10Jhu49 1 0.06 0.35 0 77.32
45 INT153326 Binding of ETV1 2 0.29 1.25 0.11 76.80
46 INT71418 Binding of CES1 42 0.40 29.78 5.01 75.88
47 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 75.00
48 INT97216 Positive_regulation of Psd 13 0.45 7.04 1.25 74.96
49 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 73.16
50 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 71.12
51 INT107307 Transcription of IFNA1 30 0.52 18.16 9.61 70.92
52 INT69350 Gene_expression of RAC1 23 0.77 12.16 5.54 69.84
53 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 69.28
54 INT23126 Regulation of HTR3A 10 0.60 5.42 4.81 69.16
55 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 68.80
56 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 68.44
57 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 68.44
58 INT184895 Gene_expression of MCRS1 46 0.42 56.03 19.44 67.40
59 INT72924 Negative_regulation of MCRS1 27 0.19 33.59 10.29 67.40
60 INT79555 Positive_regulation of Ptcra 10 0.49 4.23 1.72 66.56
61 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 66.40
62 INT283245 Gene_expression of MND1 2 0.11 1.94 0.07 66.24
63 INT175904 Localization of RAC1 7 0.41 5.05 0.86 65.68
64 INT240280 Gene_expression of IGFALS 14 0.42 20.38 0.95 65.16
65 INT27785 Regulation of HTR2A 11 0.44 8 8.18 64.08
66 INT125338 Regulation of HTR2C 2 0.26 1.32 1.18 64.08
67 INT745 Gene_expression of Afp 65 0.78 52.89 4.24 63.12
68 INT47062 Gene_expression of ANTXR1 10 0.66 4.63 1.93 62.92
69 INT260576 Negative_regulation of olt 1 0.37 1.88 0.2 60.88
70 INT329148 Gene_expression of CNTNAP2 17 0.76 6 2.95 60.76
71 INT11679 Negative_regulation of F13A1 55 0.54 33.69 9.43 60.36
72 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 60.36
73 INT19578 Negative_regulation of Gene_expression of F13A1 8 0.42 7.71 1.23 60.36
74 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4 60.28
75 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 60.04
76 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 60.00
77 INT167182 Binding of Psd 9 0.41 13.08 1.06 59.68
78 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 58.88
79 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 58.88
80 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 58.88
81 INT56494 Localization of Ide 73 0.68 22.9 11.26 58.44
82 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 56.88
83 INT146355 Negative_regulation of Aes 15 0.51 7.83 4.25 56.40
84 INT70987 Binding of RAC1 14 0.37 12.14 2.13 55.84
85 INT65072 Gene_expression of TKT 16 0.65 17.58 3.55 55.60
86 INT65071 Positive_regulation of Gene_expression of TKT 4 0.18 4.44 0.14 55.60
87 INT56497 Negative_regulation of Localization of Ide 12 0.44 5.34 1.42 55.44
88 INT64743 Positive_regulation of olt 19 0.40 16.46 3.86 55.20
89 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13 54.72
90 INT2921 Positive_regulation of F8 53 0.59 41.56 8.56 54.72
91 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47 50.96
92 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 50.00
93 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 50.00
94 INT6481 Binding of TNF 624 0.48 510.2 214.82 50.00
95 INT9660 Regulation of TNF 363 0.62 312.94 139.99 50.00
96 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 50.00
97 INT3911 Gene_expression of TNFAIP1 29 0.65 21.68 1.85 50.00
98 INT211271 Regulation of Igh-VS107 1 0.01 1.96 0.44 47.24
99 INT10889 Gene_expression of F8 60 0.78 41.36 5.06 46.16
100 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 45.60
101 INT221276 Gene_expression of Napb 1 0.06 1.1 0.06 43.44
102 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 41.44
103 INT252166 Negative_regulation of Cdr1 6 0.17 2.42 0.69 41.36
104 INT272837 Phosphorylation of Kctd1 1 0.11 1.56 0.07 40.04
105 INT87988 Gene_expression of ASAH1 9 0.77 9.75 1.18 38.80
106 INT229301 Gene_expression of NR0B2 3 0.18 3.49 0.16 38.48
107 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 36.60
108 INT285475 Regulation of Isg15 1 0.13 1.11 0.26 36.32
109 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 35.60
110 INT285486 Regulation of Ifit1 1 0.13 1.06 0.23 35.44
111 INT285508 Regulation of Mx2 1 0.08 1.05 0.23 34.88
112 INT187050 Localization of RENBP 8 0.35 6.92 0.61 34.84
113 INT216380 Gene_expression of PAX6 49 0.78 15.63 1.22 34.64
114 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 34.24
115 INT130727 Regulation of C2 12 0.32 5.95 0.81 34.24
116 INT56305 Regulation of OR2D2 2 0.18 0.37 0.1 34.24
117 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 33.92
118 INT87239 Localization of Il12a 51 0.75 31.95 12.05 33.80
119 INT237772 Localization of Il23a 5 0.42 4.16 1.34 33.80
120 INT54565 Binding of SCLC1 12 0.31 20.41 0.81 32.80
121 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 32.32
122 INT175556 Regulation of Positive_regulation of PTH 3 0.39 2.34 0.12 32.32
123 INT242351 Regulation of Positive_regulation of Psd 1 0.37 1.34 0.46 32.28
124 INT275878 Positive_regulation of Gene_expression of Aes 4 0.23 4.54 3.39 32.00
125 INT266786 Binding of ASAH1 2 0.11 3.87 0.44 32.00
126 INT36479 Binding of NR0B2 2 0.36 3.5 0.21 32.00
127 INT332592 Binding of MND1 1 0.08 9.21 0.16 30.48
128 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 30.44
129 INT241191 Positive_regulation of Kctd1 2 0.06 4.28 0.16 28.64
130 INT254724 Negative_regulation of DHFR 2 0.42 3.92 1.39 27.20
131 INT228469 Negative_regulation of Il17a 19 0.54 18.76 6.43 27.16
132 INT30039 Negative_regulation of HAL 7 0.42 4.32 1.61 27.16
133 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 26.72
134 INT17182 Binding of Cea 25 0.48 14.98 4.16 23.56
135 INT541 Positive_regulation of MBP 31 0.67 28.56 12.24 23.28
136 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36 23.20
137 INT35584 Binding of ACLY 22 0.35 31.78 7.17 22.80
138 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 22.28
139 INT98871 Regulation of Psd 8 0.42 4.55 2.57 22.28
140 INT43085 Negative_regulation of Ide 28 0.39 19.96 3.45 22.16
141 INT72947 Binding of CHM 9 0.42 5.86 0.06 20.84
142 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 19.64
143 INT156827 Localization of MRI1 25 0.65 16.06 8.33 19.16
144 INT286615 Phosphorylation of Ide 7 0.31 5.22 0.7 17.72
145 INT20260 Positive_regulation of Chkb 41 0.64 21.48 18.53 16.56
146 INT38255 Localization of Chkb 32 0.80 10.98 11.07 16.56
147 INT67182 Gene_expression of Tms 10 0.53 5.14 4.29 12.68
148 INT275877 Positive_regulation of Positive_regulation of Chkb 1 0.07 0.35 0.68 12.08
149 INT33008 Gene_expression of Dync1h1 41 0.68 23.85 3.82 11.40
150 INT302687 Regulation of PLAA 1 0.19 0.24 0 10.00
151 INT142488 Positive_regulation of Gene_expression of Chkb 7 0.23 4.09 4.54 8.92
152 INT20264 Gene_expression of Chkb 29 0.46 13.14 13.65 8.76
153 INT97516 Binding of PYCARD 46 0.36 7.06 7.85 8.48
154 INT159409 Gene_expression of PLAA 2 0.54 6.14 0.89 8.04
155 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
156 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 5.00
157 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
158 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
159 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
160 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
161 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
162 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
163 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
164 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
165 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
166 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 5.00
167 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
168 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
169 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
170 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
171 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
172 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
173 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 5.00
174 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
175 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 5.00
176 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
177 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
178 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
179 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
180 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
181 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54 5.00
182 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27 5.00
183 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
184 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
185 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
186 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 5.00
187 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 5.00
188 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
189 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
190 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
191 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26 5.00
192 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 5.00
193 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 5.00
194 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
195 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
196 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1 5.00
197 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
198 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 5.00
199 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
200 INT102020 Gene_expression of Creb1 190 0.78 57.31 59.77 5.00
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