D:Appendicitis

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Disease Term
Synonyms APPENDICITIS PERFORATED, APPENDICITIS RUPTURED, Perforated Appendicitis, Ruptured Appendicitis
Documents 1883
Hot Single Events 93
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Appendicitis. They are ordered first by their relevance to Appendicitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT227418 Binding of DLAT and Pdc 1 0.05 1.01 0.07 29.48
2 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
3 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
4 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9 5.00
5 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69 5.00
6 INT168295 PROC Regulation of Gene_expression of VEGFA 2 0.00 1.6 0.67 5.00
7 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58 5.00
8 INT215101 Hmgb1 Positive_regulation of Localization of Il6 4 0.16 1.18 0.54 5.00
9 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52 5.00
10 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49 5.00
11 INT253766 Binding of Apex1 and Tlr4 1 0.03 0.53 0.32 5.00
12 INT253762 Binding of Apex1 and Hmgb1 1 0.09 1.29 0.32 5.00
13 INT229635 SPINK5 Positive_regulation of NF1 1 0.01 2.17 0.3 5.00
14 INT253765 Apex1 Positive_regulation of Hmgb1 1 0.09 1.27 0.24 5.00
15 INT253771 Gopc Positive_regulation of Hmgb1 1 0.03 1.27 0.24 5.00
16 INT253773 TNF Positive_regulation of Hmgb1 1 0.09 1.21 0.23 5.00
17 INT283520 Binding of DLAT and Pain1 1 0.27 0.65 0.22 5.00
18 INT229634 GOPC Positive_regulation of GAST 1 0.09 0.47 0.19 5.00
19 INT253776 Binding of THBD and F2 1 0.00 1.15 0.18 5.00
20 INT253761 Hmgb1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.73 0.12 5.00
21 INT253772 Binding of THBD and Hmgb1 1 0.05 0.95 0.12 5.00
22 INT253775 Negative_regulation of Binding of THBD and Hmgb1 1 0.06 0.69 0.12 5.00
23 INT227400 Binding of DLAT and HCC 1 0.01 2.82 0.11 5.00
24 INT294681 Tlr4 Positive_regulation of Positive_regulation of NFKB1 1 0.02 0.27 0.1 5.00
25 INT283460 Binding of CTLA4 and DLAT 1 0.06 3.14 0.09 5.00
26 INT253774 THBD Regulation of F2 1 0.00 0.61 0.08 5.00
27 INT253764 Atp9a Positive_regulation of Apex1 1 0.00 0.39 0.08 5.00
28 INT294679 GPI Positive_regulation of Gene_expression of Il12a 1 0.00 0.69 0.08 5.00
29 INT283521 PREB Regulation of Fam89b 1 0.00 1.08 0.07 5.00
30 INT266082 PROC Regulation of Localization of VEGFA 1 0.00 0.84 0.05 5.00
31 INT294680 Binding of TLR2 and Tlr4 1 0.09 0.58 0.04 5.00
32 INT283464 Binding of CD4 and DLAT 1 0.07 0.69 0.04 5.00
33 INT266078 VEGFA Positive_regulation of DBI 1 0.10 0.45 0.04 5.00
34 INT266074 LGALS1 Regulation of Gene_expression of PAEP 1 0.14 0.43 0.03 5.00
35 INT266075 LIF Regulation of Gene_expression of PAEP 1 0.19 0.43 0.03 5.00
36 INT266070 LIF Regulation of Gene_expression of PAPPA 1 0.35 0.49 0.03 5.00
37 INT283463 Binding of DLAT and GAGE4 1 0.00 1.1 0.03 5.00
38 INT266072 LGALS1 Regulation of Gene_expression of LIF 1 0.17 0.43 0.03 5.00
39 INT266067 PAPPA Regulation of Gene_expression of LIF 1 0.35 0.49 0.03 5.00
40 INT266076 LIF Regulation of Gene_expression of LGALS1 1 0.17 0.43 0.03 5.00
41 INT283462 Binding of DLAT and HLA-DRB1 1 0.07 1.06 0.03 5.00
42 INT266081 PAPPA Regulation of Gene_expression of LGALS1 1 0.24 0.49 0.03 5.00
43 INT266077 LGALS1 Regulation of Gene_expression of PAPPA 1 0.24 0.49 0.03 5.00
44 INT266073 PAPPA Regulation of Gene_expression of PAEP 1 0.27 0.49 0.03 5.00
45 INT253769 Binding of Hmgb1 and Il1 1 0.01 0.27 0 5.00
46 INT266080 Binding of PAPPA and MUC16 1 0.40 0.74 0 5.00
47 INT266068 Binding of CHKB and MUC16 1 0.22 0.74 0 5.00
48 INT283461 Binding of IL2 and SLC4A2 1 0.01 0.98 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Appendicitis. They are ordered first by their pain relevance and then by number of times they were reported in Appendicitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 100.00
2 INT65489 Regulation of Gene_expression of Crp 28 0.59 29.17 7.56 100.00
3 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 99.98
4 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.90
5 INT100861 Binding of CRP 179 0.48 175.2 26.45 99.80
6 INT86437 Binding of IL6 154 0.48 121.22 29.3 99.80
7 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 99.76
8 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.72
9 INT8669 Positive_regulation of Afp 66 0.70 58.21 7.67 99.66
10 INT22454 Regulation of Crp 213 0.62 160.67 49.24 99.60
11 INT2774 Binding of Crp 241 0.48 195.89 44.39 99.40
12 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 99.28
13 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 99.28
14 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 99.28
15 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 99.28
16 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96 99.20
17 INT10706 Regulation of Il6 150 0.62 93.23 62.34 99.04
18 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 98.96
19 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 98.84
20 INT135274 Positive_regulation of RQCD1 2 0.36 1.24 0.08 98.82
21 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 98.80
22 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 98.76
23 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 98.72
24 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 98.60
25 INT108710 Gene_expression of HAL 36 0.58 14.75 2.16 98.24
26 INT210916 Regulation of Gene_expression of HAL 3 0.18 2.22 0.14 98.24
27 INT61171 Gene_expression of S100A8 92 0.76 57.74 9.98 97.88
28 INT184309 Positive_regulation of Llph 3 0.22 2.43 0.57 97.88
29 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 97.84
30 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 97.76
31 INT138872 Gene_expression of SPINK5 21 0.58 30.11 4.12 97.56
32 INT15888 Positive_regulation of Nbr1 42 0.69 35.76 10.48 96.72
33 INT194023 Gene_expression of RQCD1 3 0.52 3.99 0.12 96.72
34 INT180497 Binding of MRI1 45 0.42 28.35 14.77 96.36
35 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 95.96
36 INT158764 Binding of SPINK5 7 0.35 8.84 0.37 95.64
37 INT15887 Gene_expression of Nbr1 39 0.77 23.91 7.34 94.76
38 INT63536 Gene_expression of Syncrip 7 0.67 7.23 5.44 94.72
39 INT62112 Binding of S100A8 37 0.36 17.18 3.16 94.68
40 INT35539 Positive_regulation of Positive_regulation of Nbr1 2 0.47 2.52 0.41 94.28
41 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 94.20
42 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 94.04
43 INT156827 Localization of MRI1 25 0.65 16.06 8.33 93.72
44 INT129565 Negative_regulation of Cuzd1 5 0.43 0.65 1.24 93.44
45 INT9549 Regulation of CHKB 25 0.47 13.61 3.2 93.44
46 INT6852 Localization of TNF 883 0.81 705.95 270.84 93.40
47 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 93.16
48 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01 93.16
49 INT72188 Gene_expression of Cxcl10 22 0.65 12.93 15.35 93.16
50 INT1928 Negative_regulation of Lpl 18 0.51 11.22 2.49 93.16
51 INT22404 Regulation of DBI 7 0.39 3.66 2.24 92.96
52 INT113456 Binding of Lpl 2 0.36 0.81 0.28 92.72
53 INT32624 Regulation of LBP 15 0.60 11.48 8.71 92.40
54 INT32431 Gene_expression of HTC2 17 0.75 9.72 1.93 91.76
55 INT8824 Regulation of Vip 95 0.62 15.7 43.63 91.68
56 INT16475 Regulation of GAP43 3 0.44 1.25 1.43 91.68
57 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 91.08
58 INT20611 Gene_expression of Asap1 55 0.65 23.71 14.62 91.08
59 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 91.08
60 INT93168 Gene_expression of Ttf1 24 0.63 17.18 1.14 91.08
61 INT101209 Gene_expression of Wt1 19 0.72 25.77 0.7 91.08
62 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 90.48
63 INT194022 Negative_regulation of RQCD1 4 0.33 3.18 0.13 88.72
64 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 88.68
65 INT71870 Positive_regulation of Gene_expression of Mme 6 0.48 4.27 2 88.68
66 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 88.64
67 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 88.64
68 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 88.60
69 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 88.60
70 INT35059 Protein_catabolism of PLAUR 5 0.88 4.61 0.61 86.92
71 INT124943 Regulation of NCAM1 10 0.44 5.25 1.27 86.88
72 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 86.52
73 INT126457 Gene_expression of BCL6 34 0.66 22.45 1.75 86.36
74 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 85.88
75 INT75311 Gene_expression of Cd79a 5 0.77 5.13 0.58 85.84
76 INT219879 Positive_regulation of SPINK5 4 0.30 7.64 1.16 84.72
77 INT105884 Binding of Bcl2 19 0.35 15.67 3 84.52
78 INT38672 Binding of KRT20 69 0.39 48.01 6.31 84.00
79 INT73091 Binding of TNFRSF8 21 0.44 6.64 0.93 84.00
80 INT103585 Gene_expression of MANEA 4 0.75 2.12 0.31 83.80
81 INT8159 Binding of ELL 7 0.36 12.62 0.84 83.44
82 INT152437 Localization of SPINK5 4 0.54 3.97 0.69 83.36
83 INT20630 Positive_regulation of Gene_expression of CHKB 19 0.47 15.79 1.85 83.32
84 INT35540 Negative_regulation of Positive_regulation of Nbr1 1 0.25 1.03 0.31 83.16
85 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 82.88
86 INT37390 Regulation of Crp 39 0.46 28.74 11.45 82.72
87 INT22456 Localization of Nbr1 4 0.70 2.71 0.95 82.44
88 INT38558 Positive_regulation of DBT 9 0.31 1.59 0.86 81.60
89 INT10677 Positive_regulation of Gene_expression of DBI 3 0.24 6.2 0.64 81.44
90 INT10675 Gene_expression of DBI 28 0.67 19.74 6.07 80.88
91 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 80.76
92 INT102251 Positive_regulation of Positive_regulation of Crp 24 0.58 29.62 7.5 80.16
93 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 80.12
94 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 79.96
95 INT44920 Negative_regulation of IK 18 0.41 9.9 7.16 79.56
96 INT182807 Localization of Cuzd1 2 0.49 1.38 0.14 78.88
97 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 78.64
98 INT266087 Positive_regulation of Positive_regulation of DBI 1 0.09 1.35 0.06 77.48
99 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 77.36
100 INT22402 Positive_regulation of DBI 17 0.59 7.77 2.91 77.08
101 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 76.92
102 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 76.92
103 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 76.32
104 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 75.00
105 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 75.00
106 INT227413 Gene_expression of DLAT 12 0.44 13.21 1.36 74.72
107 INT21873 Positive_regulation of Gene_expression of Nbr1 5 0.50 2.09 0.51 74.08
108 INT38625 Gene_expression of ELL 8 0.58 12.53 1 70.40
109 INT136531 Binding of Men1 8 0.47 9.62 0.65 70.32
110 INT192684 Negative_regulation of vs 15 0.19 9.18 1.75 70.08
111 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 69.84
112 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 69.84
113 INT73572 Positive_regulation of S100A8 10 0.67 6.6 1 68.68
114 INT246502 Negative_regulation of Men1 2 0.30 8.9 0.33 66.36
115 INT131808 Localization of Apex1 2 0.16 13.46 4.61 65.44
116 INT19775 Localization of Il1 183 0.78 145.5 50.91 65.44
117 INT253751 Localization of Lif 3 0.73 3.94 1.58 65.44
118 INT142708 Gene_expression of CTSH 1 0.75 1.51 0.18 64.76
119 INT182667 Binding of DLAT 11 0.31 40.75 2.8 63.92
120 INT15610 Localization of GOPC 223 0.65 68.26 28.7 61.20
121 INT36133 Binding of pid 22 0.42 31.34 4.1 61.20
122 INT58857 Positive_regulation of Positive_regulation of CHKB 5 0.43 2.77 0.19 60.08
123 INT189750 Negative_regulation of Positive_regulation of CHKB 4 0.26 2.36 0.38 57.64
124 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 57.20
125 INT170604 Negative_regulation of Gene_expression of GOPC 50 0.35 12.71 4.51 57.04
126 INT266085 Negative_regulation of Positive_regulation of DBI 1 0.07 1.09 0.03 56.56
127 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 56.32
128 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 56.00
129 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 54.28
130 INT50050 Gene_expression of CSRP1 23 0.76 16.84 5.86 53.92
131 INT6481 Binding of TNF 624 0.48 510.2 214.82 53.04
132 INT14 Regulation of LDHA 22 0.57 15.26 2.14 51.08
133 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 50.00
134 INT8388 Positive_regulation of Vip 142 0.70 39.72 67.61 50.00
135 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 50.00
136 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 50.00
137 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 50.00
138 INT21990 Negative_regulation of Ctrc 17 0.42 8.45 4.47 50.00
139 INT22092 Gene_expression of SERPINA3 17 0.75 11.57 3.16 50.00
140 INT97063 Gene_expression of CD5 16 0.77 13.81 3.13 50.00
141 INT54072 Gene_expression of GAP43 14 0.67 5.04 2.83 50.00
142 INT38967 Positive_regulation of Ctrc 12 0.40 2.55 2.75 50.00
143 INT4953 Positive_regulation of CGB5 16 0.60 7.63 2.49 50.00
144 INT62331 Gene_expression of TNFRSF8 26 0.72 17.75 2.08 50.00
145 INT61643 Gene_expression of ACVRL1 9 0.51 9.04 1.03 50.00
146 INT54073 Positive_regulation of Gene_expression of GAP43 3 0.51 0.74 0.86 50.00
147 INT104005 Negative_regulation of Gene_expression of DES 6 0.42 4.82 0.37 50.00
148 INT11261 Positive_regulation of PTPLA 3 0.50 4.4 3.74 48.08
149 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 45.28
150 INT17489 Regulation of F13A1 28 0.45 15.79 4.93 44.56
151 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16 44.32
152 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 36.56
153 INT253756 Gene_expression of Apex1 1 0.14 7.47 1.84 30.56
154 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 30.32
155 INT247569 Positive_regulation of Regulation of VEGFA 6 0.48 4.15 0.07 30.32
156 INT118217 Regulation of Cuzd1 2 0.30 2.36 0.91 29.12
157 INT153015 Positive_regulation of Gene_expression of nct 3 0.24 0.9 0.74 29.12
158 INT46383 Negative_regulation of TRGC1 42 0.55 44.03 6.2 29.04
159 INT153016 Gene_expression of nct 4 0.32 0.97 0.89 28.68
160 INT77955 Negative_regulation of PCS 55 0.43 39.32 5.76 28.28
161 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 28.00
162 INT47662 Localization of CHKB 34 0.81 22.63 5.14 26.96
163 INT25499 Localization of DBI 14 0.52 5.31 1.7 25.48
164 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05 25.00
165 INT227415 Regulation of DLAT 2 0.29 2.93 0.28 24.00
166 INT182810 Gene_expression of Cuzd1 5 0.44 1.49 0.53 19.32
167 INT5454 Localization of CRH 124 0.79 79.18 41.53 17.00
168 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 15.80
169 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08 15.80
170 INT3034 Localization of Ngf 126 0.81 50.81 72.84 15.80
171 INT19078 Binding of Ngf 78 0.48 31.03 44.33 15.80
172 INT75997 Positive_regulation of Localization of Ngf 14 0.69 7.78 9.41 15.80
173 INT210578 Gene_expression of PAX5 5 0.44 3.46 0.12 9.96
174 INT279952 Binding of MBLAC2 1 0.37 0.82 0 9.96
175 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 9.68
176 INT34367 Negative_regulation of MBLAC2 2 0.43 1.21 0 9.40
177 INT252156 Gene_expression of MUM1 1 0.32 2.22 0.12 9.00
178 INT227401 Gene_expression of Nup210 2 0.51 1.26 0.12 8.48
179 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17 7.92
180 INT25356 Positive_regulation of S100A12 18 0.69 17.62 3.38 7.00
181 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
182 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
183 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
184 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
185 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
186 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
187 INT1562 Localization of Crh 499 0.81 126.74 236.68 5.00
188 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
189 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
190 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46 5.00
191 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 5.00
192 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
193 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
194 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
195 INT1438 Localization of Pomc 360 0.81 101.26 116.47 5.00
196 INT90 Localization of Gast 400 0.81 137.67 113 5.00
197 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
198 INT4936 Localization of Tacr1 125 0.80 35.7 107.7 5.00
199 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
200 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
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