D:Appetite Loss

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Disease Term
Synonyms Anorectic, Anorexia, Appetite Control, APPETITE REGULATION, Appetite Stimulant, Appetite Stimulation, Appetite Suppression, CACHEXIA, CACHEXY, Eating Control, Eating Disorder
Documents 4748
Hot Single Events 200
Hot Interactions 87

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Appetite Loss. They are ordered first by their relevance to Appetite Loss and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT245333 ATR Negative_regulation of Protein_catabolism of DCD 1 0.10 0.93 0.14 100.00
2 INT104352 Agrp Regulation of Positive_regulation of Etohcta1 1 0.01 0.42 0.29 100.00
3 INT104353 Agrp Negative_regulation of Positive_regulation of Oxt 1 0.02 0.45 0.3 99.92
4 INT253410 ATIC Regulation of Lep 1 0.03 0.7 0 99.64
5 INT292968 Fto Regulation of Gene_expression of Th 1 0.30 1.11 0 99.60
6 INT91720 Binding of BDNF and CNTF 1 0.09 1.71 0.38 98.68
7 INT292969 Fto Regulation of Gene_expression of Arc 1 0.24 0.55 0 98.56
8 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06 98.44
9 INT275850 Binding of NDUFAB1 and SNCA 1 0.00 3.78 3.16 98.16
10 INT91719 Binding of BDNF and LIF 1 0.09 1.65 0.38 98.04
11 INT220289 MARS Regulation of CEBPZ 1 0.02 0.93 0.11 97.76
12 INT316203 Ghsr Positive_regulation of Transcription of Agrp 1 0.02 1.5 0.19 97.12
13 INT352579 CNTF Negative_regulation of Gene_expression of NPY 1 0.17 0.89 0.07 96.72
14 INT204087 IL1B Positive_regulation of Gene_expression of LEP 1 0.09 2.6 0.54 96.52
15 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4 96.08
16 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09 96.04
17 INT351076 IK Positive_regulation of Gene_expression of Ucp3 1 0.00 0.8 0.58 95.84
18 INT354097 Timp1 Negative_regulation of Localization of NFKB2 1 0.04 0.94 0 95.24
19 INT354096 Timp1 Negative_regulation of Positive_regulation of NFKB2 1 0.04 0.94 0 95.24
20 INT245329 ATR Negative_regulation of DCD 1 0.10 0.91 0.05 95.16
21 INT245331 ATR Regulation of IL1B 1 0.03 0.91 0.05 95.16
22 INT245330 ATR Regulation of TNF 1 0.04 0.9 0.05 95.16
23 INT292970 Fto Regulation of Th 1 0.18 0.48 0 95.08
24 INT340555 Igf1 Positive_regulation of Mapk1 1 0.24 0.65 0.09 94.72
25 INT328298 GHRH Negative_regulation of Localization of GHS 1 0.08 0.84 0 94.36
26 INT328296 GHRH Negative_regulation of Localization of GH1 1 0.03 0.84 0 94.36
27 INT226123 Cnr1 Regulation of Prkag1 1 0.05 0.09 0.18 94.32
28 INT340562 Mstn Positive_regulation of Mapk1 1 0.16 1.16 0.17 93.92
29 INT340565 Gopc Regulation of Phosphorylation of Mapk8 1 0.04 0.92 0 93.60
30 INT340563 Gopc Regulation of Phosphorylation of Mapk14 1 0.04 0.91 0 93.28
31 INT309888 INS Positive_regulation of Gene_expression of FAAH 1 0.04 1.19 0.25 92.72
32 INT327814 Rab8a Regulation of Regulation of Lep 1 0.01 0.15 0.19 91.84
33 INT327813 Rab8a Regulation of Lep 1 0.01 0.15 0.19 91.84
34 INT214146 Msx1 Positive_regulation of Gene_expression of Nucb2 1 0.05 0.19 0.05 91.60
35 INT226118 Ghrl Regulation of Prkag1 1 0.08 0.72 2.72 91.24
36 INT226128 Positive_regulation of Ghrl Regulation of Prkag1 1 0.06 0.28 0.97 91.24
37 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68 90.64
38 INT231116 Ros1 Positive_regulation of Protein_catabolism of Psmb8 1 0.00 1.14 0 90.60
39 INT253834 Cck Regulation of Lep 1 0.19 0.23 0.55 89.88
40 INT253368 Positive_regulation of Lep Positive_regulation of Prkaa2 1 0.26 0.19 0 89.60
41 INT253379 Lep Positive_regulation of Prkaa2 1 0.39 0.19 0 89.60
42 INT63122 Binding of APC and Man2a2 1 0.01 0.15 0.3 89.24
43 INT253382 Il6 Positive_regulation of Prkaa2 1 0.42 0.19 0 89.16
44 INT132318 Ghrl Positive_regulation of Localization of GH1 5 0.32 4.49 0.84 89.12
45 INT352961 Ghrl Positive_regulation of Localization of GHSR 1 0.18 1.19 0.21 89.12
46 INT162419 Binding of Abpa and Cftr 1 0.04 1.66 1.19 89.08
47 INT253359 Positive_regulation of Prkaa2 Negative_regulation of Mtor 1 0.26 0.27 0 89.08
48 INT58249 CCK Positive_regulation of Regulation of GAST 1 0.48 0.86 0.5 88.64
49 INT105542 PTGES Positive_regulation of DNTT 1 0.00 0.62 0.25 88.64
50 INT253369 Prkaa2 Negative_regulation of Mtor 1 0.24 0.27 0 88.52
51 INT226122 Ghrl Regulation of Cnr1 1 0.25 0.09 0.76 88.40
52 INT339393 Tlr4 Positive_regulation of Nfkb1 1 0.24 2.06 0.61 88.32
53 INT292090 Negative_regulation of Binding of KIT and TXK 1 0.02 1.54 0.04 87.68
54 INT292085 Negative_regulation of Binding of FLT3 and TXK 1 0.02 1.54 0.04 87.68
55 INT292095 Negative_regulation of Binding of KDR and TXK 1 0.04 1.53 0.04 87.68
56 INT292079 Negative_regulation of Binding of PDGFRB and TXK 1 0.06 1.54 0.04 87.68
57 INT292086 Negative_regulation of Binding of FLT1 and TXK 1 0.04 1.48 0.04 87.68
58 INT292093 Negative_regulation of Binding of FLT4 and TXK 1 0.03 1.53 0.04 87.68
59 INT214152 Binding of Mc4r and Msx1 1 0.03 0.24 0.11 87.40
60 INT292089 Binding of KIT and TXK 1 0.02 1.54 0.04 87.08
61 INT292084 Binding of FLT3 and TXK 1 0.02 1.53 0.04 87.08
62 INT292083 Binding of KDR and TXK 1 0.04 1.52 0.04 87.08
63 INT292092 Binding of PDGFRB and TXK 1 0.05 1.53 0.04 87.08
64 INT292094 Binding of FLT4 and TXK 1 0.02 1.53 0.04 87.08
65 INT292080 Binding of FLT1 and TXK 1 0.04 1.47 0.04 87.08
66 INT104764 Binding of WAS and IL1RAPL1 1 0.00 0.17 0.15 87.04
67 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15 86.08
68 INT98816 Crhr2 Positive_regulation of Negative_regulation of Ucn 1 0.33 0.09 0.28 85.60
69 INT275461 Binding of Atxn1 and Atxn2 1 0.39 1.1 0.17 85.52
70 INT226124 Ghrl Positive_regulation of Prkag1 1 0.06 0.24 0.33 85.52
71 INT253374 Lep Positive_regulation of Phosphorylation of Eif4ebp1 1 0.04 0.16 0.03 85.44
72 INT253375 Lep Positive_regulation of Phosphorylation of Rps6kb1 1 0.41 0.16 0.03 85.44
73 INT323502 Ghrl Positive_regulation of Localization of Ins1 1 0.15 1.58 0.33 85.16
74 INT328309 GHS Positive_regulation of Localization of GH1 1 0.04 0.99 0.12 84.52
75 INT1390 Trh Positive_regulation of Prl 14 0.67 4.42 4.39 83.68
76 INT253360 Lep Positive_regulation of Eif4ebp1 1 0.01 0.08 0 83.36
77 INT214150 Binding of Mc3r and Msx1 1 0.03 0.5 0.12 83.20
78 INT253364 Lep Positive_regulation of Rps6kb1 1 0.30 0.08 0 82.56
79 INT98815 Binding of Crhr2 and Ucn 3 0.32 0.5 0.56 82.36
80 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91 82.24
81 INT340561 Mapk1 Negative_regulation of Gene_expression of Pax7 1 0.23 0.25 0 82.24
82 INT328371 Ghrl Negative_regulation of INS 1 0.03 0.13 0.05 82.08
83 INT328376 Ghrl Negative_regulation of SST 1 0.03 0.13 0.05 82.08
84 INT253370 Lep Negative_regulation of Prkaa2 1 0.29 0.18 0.03 82.00
85 INT182839 Camk4 Positive_regulation of Creb1 3 0.49 1.81 0.79 81.52
86 INT168110 Binding of Cnr1 and Dbh 1 0.04 0.64 0.47 80.48
87 INT168111 Dbh Positive_regulation of Cnr1 1 0.05 0.64 0.47 80.48
88 INT214170 Binding of DST and Lep 1 0.02 0.17 0.18 79.60
89 INT17528 Prl Regulation of Gh 2 0.28 1.28 0.73 79.12
90 INT214168 Msx1 Positive_regulation of Gene_expression of DST 1 0.00 0.13 0.09 79.04
91 INT253376 Lep Regulation of Mtor 1 0.17 0.08 0.04 78.88
92 INT253363 Lep Regulation of Prkaa2 1 0.15 0.08 0.04 78.88
93 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 78.72
94 INT277995 TNF Positive_regulation of Gene_expression of Tnfrsf1a 1 0.03 1.48 0.22 78.52
95 INT277996 TNF Positive_regulation of Tnfrsf1a 1 0.03 1.48 0.22 78.52
96 INT237471 Ltp Regulation of Bdnf 1 0.02 0.13 0.42 78.40
97 INT285290 TNF Positive_regulation of Gene_expression of H2-D1 1 0.01 1.41 0.06 77.72
98 INT182837 Binding of Creb1 and Crebbp 1 0.12 0.57 0.32 77.60
99 INT25375 Trh Regulation of Gh 1 0.04 1.01 0.28 77.04
100 INT253366 Il6 Positive_regulation of Phosphorylation of Jak2 1 0.31 0.2 0 76.48
101 INT319963 Binding of IGFALS and Vcan 1 0.03 2.99 0.13 76.24
102 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0 76.00
103 INT289520 Lep Regulation of Prkag1 1 0.00 0.08 0 76.00
104 INT275849 PES1 Positive_regulation of Gene_expression of TNFAIP1 1 0.01 1.28 0.42 75.08
105 INT253361 Il6 Negative_regulation of Phosphorylation of Prkaa2 1 0.26 0.16 0 75.00
106 INT176131 Binding of AKT1 and PIK3CG 2 0.15 1.08 0 74.00
107 INT262753 Binding of MTOR and PIK3CG 1 0.20 0.82 0 74.00
108 INT224404 Binding of GYPC and PYY 1 0.04 1.48 1.42 73.68
109 INT224403 Binding of CCK and GYPC 1 0.04 0.83 0.77 73.68
110 INT354926 IL6 Regulation of Gene_expression of ALB 1 0.14 1.3 0.23 73.64
111 INT354924 IL6 Positive_regulation of Gene_expression of ALB 1 0.26 1.3 0.23 73.64
112 INT328305 GHS Positive_regulation of Localization of INS 1 0.02 0.07 0.05 73.32
113 INT94745 Tlr4 Positive_regulation of Transcription of Il1b 1 0.15 0.48 0.56 73.00
114 INT246466 GHS Positive_regulation of GHS Regulation of Gh 1 0.01 0.6 0.1 72.88
115 INT246468 GHS Regulation of Gh 1 0.05 1.12 0.19 72.56
116 INT41024 Nts Negative_regulation of Ins1 1 0.14 0.22 0.22 72.24
117 INT214139 Lep Regulation of Localization of Pomc 1 0.20 0.4 0 72.16
118 INT214155 Lep Regulation of Gene_expression of Pomc 1 0.20 0.4 0 72.16
119 INT266811 Binding of HRH1 and HTR2C 1 0.23 2.06 1.4 71.20
120 INT262756 STAT3 Positive_regulation of NFE2L2 1 0.31 1.55 0 70.88
121 INT18965 TNF Positive_regulation of IL2RA 1 0.06 0.83 0.2 70.80
122 INT18966 TNF Positive_regulation of NEUROD1 1 0.53 0.83 0.2 70.80
123 INT18972 TNF Positive_regulation of Alb 1 0.01 0.83 0.2 70.80
124 INT303393 Binding of Jag1 and Tceb2 1 0.03 0.29 0.04 70.72
125 INT303389 Binding of Jag1 and Cul5 1 0.20 0.29 0.04 70.72
126 INT328299 Binding of GHRH and GHS 1 0.07 2.21 0.31 68.92
127 INT226127 Regulation of Ghrl Regulation of Prkag1 1 0.05 0.07 0.42 68.76
128 INT226129 Ghrl Regulation of Localization of Prkag1 1 0.05 0.07 0.4 68.76
129 INT126922 Ins1 Positive_regulation of Localization of Slc2a4 1 0.23 0.75 0.11 68.48
130 INT262760 Binding of TEP1 and CD163L1 1 0.00 1.65 0.37 68.40
131 INT262758 MRGPRF Positive_regulation of Transcription of NFE2L3 1 0.01 1.25 0.09 68.16
132 INT121713 WAS Positive_regulation of Gene_expression of SELP 1 0.30 0.49 0.63 67.72
133 INT260438 Binding of Cd4 and Mx1 1 0.00 1.52 0.29 67.36
134 INT221814 Mastl Positive_regulation of Ppara 1 0.04 0.68 0.37 67.04
135 INT309887 Positive_regulation of CNR1 Positive_regulation of Localization of INS 1 0.05 1.04 0 67.00
136 INT260434 Binding of Cd8a and Mx1 1 0.00 1.52 0.29 66.92
137 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0 66.80
138 INT289527 Lep Regulation of Rps6kb1 1 0.10 0.07 0 66.80
139 INT214156 Pomc Negative_regulation of Gene_expression of Npy 1 0.39 0.07 0.09 66.24
140 INT262755 MRGPRF Positive_regulation of NFE2L2 1 0.18 1.24 0.09 66.24
141 INT1151 Binding of CCK and GAST 7 0.49 0.73 3.08 65.80
142 INT328374 GHRH Positive_regulation of Ghrl 1 0.13 0.26 0.13 65.68
143 INT262754 MRGPRF Positive_regulation of NFE2L3 1 0.01 1.24 0.09 65.68
144 INT214166 DST Negative_regulation of Gene_expression of Npy 1 0.02 0.07 0.09 65.52
145 INT77367 IFNA1 Positive_regulation of Positive_regulation of Crh 1 0.05 0.76 0.57 65.20
146 INT253380 Il6 Positive_regulation of Phosphorylation of Rps6kb1 1 0.29 0.07 0 65.04
147 INT253417 ATIC Positive_regulation of Prkaa2 1 0.02 0.31 0.04 64.48
148 INT340553 Pik3r1 Regulation of Gene_expression of Fbxo32 1 0.04 0.52 0.07 64.16
149 INT340564 Akt1 Regulation of Gene_expression of Fbxo32 1 0.05 0.52 0.07 64.16
150 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18 64.12
151 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35 64.12
152 INT246467 GHS Regulation of Localization of Gh 1 0.03 0.52 0.09 63.76
153 INT227137 Binding of HBS1L and BDNF-AS 1 0.00 1.32 0.08 63.56
154 INT224308 INSRR Regulation of VEGFA 1 0.00 1.42 0.16 63.44
155 INT214165 Agrp Negative_regulation of Localization of Npy 1 0.23 0.06 0.1 63.40
156 INT247439 Binding of APOA1 and HSD11B1 3 0.32 5.01 0.03 62.84
157 INT226125 Ghrl Positive_regulation of Cnr1 1 0.44 0.06 0.46 62.68
158 INT253367 Il6 Regulation of Gene_expression of Lep 1 0.31 1.66 0 62.16
159 INT214153 Lep Regulation of Transcription of Nucb2 1 0.35 0.15 0.06 62.00
160 INT328306 GH1 Positive_regulation of Localization of INS 1 0.01 0.12 0.07 61.80
161 INT276438 Binding of OPN1SW and MYP1 1 0.12 1.21 0.09 61.56
162 INT253377 Lep Negative_regulation of Phosphorylation of Prkaa2 1 0.24 1.24 0.06 61.36
163 INT231118 Tlr4 Positive_regulation of Gene_expression of Trim63 1 0.20 0.67 0.11 61.28
164 INT173948 Gh Positive_regulation of Gene_expression of IGF1 2 0.36 0.77 0.1 60.24
165 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03 59.32
166 INT251775 AGK Negative_regulation of INSRR 1 0.00 1.1 0.07 58.96
167 INT340556 Binding of Akt1 and Myh1 1 0.04 0.27 0.04 58.76
168 INT340558 Gene_expression of Fst Positive_regulation of Akt1 1 0.09 0.41 0.03 57.84
169 INT214374 Pik3cb Regulation of Gene_expression of Slc6a3 1 0.37 0.3 0.35 55.84
170 INT294094 Binding of TXK and Eltd1 1 0.00 0.56 0 55.72
171 INT340552 Binding of Mapk1 and Mapk14 1 0.07 0.27 0.03 55.56
172 INT203016 CCK Positive_regulation of Localization of PYY 3 0.68 1.19 1.17 55.52
173 INT352547 Binding of CFTR and DMD 1 0.01 1.42 0.35 55.44
174 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0 54.48
175 INT340568 Fgf1 Positive_regulation of Mapk1 1 0.06 1.02 0.04 54.44
176 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 0.10 0.75 0.19 54.32
177 INT351089 FOXO3 Positive_regulation of Gene_expression of ESR1 1 0.04 0.74 0.19 54.32
178 INT62748 Crh Regulation of Gal 1 0.27 0.36 0.12 54.28
179 INT275851 PES1 Negative_regulation of CP 1 0.01 1.96 1.83 52.12
180 INT302883 Binding of TXN and Alb 1 0.06 4.13 0.1 51.24
181 INT292082 MIR1200 Negative_regulation of KDR 1 0.00 1.24 0 51.12
182 INT292091 MIR1200 Negative_regulation of PDGFRB 1 0.01 1.24 0 51.12
183 INT299013 Il18 Regulation of Ltp 1 0.05 0.39 0.25 50.92
184 INT44442 GNRH1 Positive_regulation of Localization of PLOD1 3 0.50 0.78 0.86 50.64
185 INT351088 Negative_regulation of ERBB2 Positive_regulation of FOXO3 1 0.17 0.66 0.18 50.16
186 INT245332 ATR Regulation of IL6 1 0.03 0.35 0.17 50.00
187 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56 49.92
188 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35 49.44
189 INT217075 Binding of Acsm3 and Slc26a4 1 0.04 2.11 0.04 49.00
190 INT218731 Lep Positive_regulation of Gene_expression of Trh 1 0.19 0.07 0 48.40
191 INT253828 Creb1 Positive_regulation of Gene_expression of Cartpt 1 0.19 0.15 0.72 48.24
192 INT253829 Atf6b Positive_regulation of Gene_expression of Cartpt 1 0.24 0.15 0.72 47.76
193 INT253833 Positive_regulation of Atf6b Positive_regulation of Gene_expression of Cartpt 1 0.24 0.15 0.72 47.76
194 INT288214 Lep Negative_regulation of Gene_expression of Ins1 1 0.35 0.05 0 47.60
195 INT262759 PIK3CG Positive_regulation of MTOR 1 0.38 0.54 0 47.52
196 INT294095 Binding of TXK and Gtf3a 1 0.00 2.33 0 46.64
197 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17 46.40
198 INT253413 ATIC Positive_regulation of Gene_expression of Prkaa2 1 0.02 0 0.04 45.92
199 INT301632 Binding of Dbi and Fabp1 1 0.13 0.49 0.07 45.12
200 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36 44.40

Single Events

The table below shows the top 200 pain related interactions that have been reported for Appetite Loss. They are ordered first by their pain relevance and then by number of times they were reported in Appetite Loss. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 100.00
2 INT148602 Regulation of Mgll 3 0.41 3.94 1.1 100.00
3 INT26972 Negative_regulation of Tenc1 57 0.57 56.71 16.87 100.00
4 INT43910 Regulation of Gene_expression of Gcg 3 0.27 3.71 0.41 100.00
5 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76 100.00
6 INT17425 Regulation of Gene_expression of Ins1 23 0.45 18.99 5.61 100.00
7 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 100.00
8 INT3948 Regulation of Cck 291 0.62 58.07 255.88 100.00
9 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 100.00
10 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 100.00
11 INT141285 Positive_regulation of Localization of Ghrl 11 0.63 9.38 3.86 100.00
12 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56 100.00
13 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 100.00
14 INT48911 Binding of NOS1 24 0.40 11.21 5.89 100.00
15 INT104350 Regulation of Agrp 9 0.52 3.53 0.81 100.00
16 INT253809 Positive_regulation of Mgll 1 0.15 1.13 0 100.00
17 INT96047 Positive_regulation of Localization of NOS1 6 0.38 4.24 1.47 100.00
18 INT104351 Positive_regulation of Etohcta1 2 0.01 1.14 0.99 100.00
19 INT48912 Localization of NOS1 52 0.77 24.14 10.92 100.00
20 INT234 Binding of Alb 151 0.48 52.34 32.97 100.00
21 INT245336 Protein_catabolism of DCD 2 0.52 1.76 0.16 100.00
22 INT308144 Gene_expression of Rhox5 2 0.11 1.21 0 100.00
23 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 100.00
24 INT354093 Negative_regulation of Ccdc135 1 0.01 1.04 0.18 100.00
25 INT125147 Binding of Mc4r 10 0.41 3.55 1.08 100.00
26 INT354095 Protein_catabolism of NFKB2 1 0.12 0.99 0 100.00
27 INT89180 Gene_expression of Agrp 54 0.78 14.29 8.84 100.00
28 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 100.00
29 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4 100.00
30 INT9655 Regulation of Il6 98 0.62 70.92 31.95 100.00
31 INT214118 Positive_regulation of Binding of Mc4r 1 0.43 1.01 0.08 100.00
32 INT5464 Regulation of CALCRL 24 0.16 4.2 11.19 100.00
33 INT214109 Regulation of Binding of Mc4r 1 0.39 0.78 0.08 100.00
34 INT51028 Regulation of Il1b 28 0.60 21.15 12.47 100.00
35 INT297709 Positive_regulation of Gene_expression of Ucp3 5 0.56 4.67 1.28 100.00
36 INT15190 Regulation of Npy 17 0.61 5.33 5.84 100.00
37 INT70715 Regulation of Il4i1 3 0.07 0.56 1.63 100.00
38 INT27266 Regulation of Gene_expression of Pomc 41 0.62 6.74 14.59 100.00
39 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 100.00
40 INT462 Regulation of Pomc 157 0.62 41.67 67.27 100.00
41 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53 100.00
42 INT66868 Positive_regulation of Ceacam3 40 0.69 26.61 28.9 100.00
43 INT187303 Regulation of ARIH1 2 0.20 1.53 0.08 100.00
44 INT214098 Regulation of Gene_expression of Agrp 2 0.38 1.63 0.08 100.00
45 INT18773 Localization of ALB 117 0.80 69.18 13.8 100.00
46 INT214106 Gene_expression of Cartpt 21 0.73 3.68 7.84 100.00
47 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31 100.00
48 INT2435 Negative_regulation of Cyp1a1 15 0.58 3.32 5.16 100.00
49 INT45975 Positive_regulation of SAA1 17 0.67 19.7 4.15 100.00
50 INT14030 Regulation of Gene_expression of Npy 7 0.47 5.58 2.49 100.00
51 INT69981 Positive_regulation of Negative_regulation of Il1rn 2 0.09 3.28 2.48 100.00
52 INT209368 Positive_regulation of GSX1 1 0.49 0.51 0.67 100.00
53 INT101534 Gene_expression of Etohcta1 1 0.53 0.1 0.15 100.00
54 INT154092 Positive_regulation of Localization of Mc2r 1 0.14 0.47 0.15 100.00
55 INT3659 Negative_regulation of Gcg 26 0.51 10.08 7.39 99.98
56 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 99.98
57 INT39375 Positive_regulation of Reg1a 7 0.70 2.42 1.72 99.98
58 INT84358 Positive_regulation of Positive_regulation of Reg1a 1 0.50 0.74 0.37 99.98
59 INT11732 Negative_regulation of Gtf3a 25 0.30 15.73 8.5 99.98
60 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1 99.98
61 INT185184 Gene_expression of Vapa 1 0.01 1.12 0.22 99.98
62 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09 99.98
63 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 99.96
64 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 99.96
65 INT91721 Binding of IL18 21 0.48 21.17 6.56 99.96
66 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 99.96
67 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 99.96
68 INT2843 Gene_expression of Epo 100 0.78 62.01 14.66 99.96
69 INT142491 Positive_regulation of Positive_regulation of SCN10A 6 0.61 3.48 0.35 99.96
70 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 99.92
71 INT325380 Positive_regulation of Positive_regulation of Ghrl 2 0.45 1.35 0.35 99.92
72 INT144614 Binding of CNTF 2 0.36 1.44 0.07 99.92
73 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 99.92
74 INT937 Positive_regulation of Oxt 195 0.70 37.82 49.3 99.90
75 INT1375 Negative_regulation of Pde4dl1 13 0.57 5.54 4.63 99.90
76 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 99.88
77 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 99.88
78 INT172171 Gene_expression of IL15 47 0.37 46.23 13.41 99.88
79 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 99.84
80 INT14513 Localization of Ghrl 52 0.78 29.26 11.63 99.84
81 INT252 Localization of GH1 529 0.80 227.4 122.05 99.84
82 INT6110 Negative_regulation of Gene_expression of Ins1 83 0.56 60.59 16.07 99.84
83 INT3658 Regulation of Gcg 28 0.53 12.89 8.58 99.84
84 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 99.84
85 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 99.84
86 INT91463 Positive_regulation of NFKB2 19 0.40 17.7 4.6 99.84
87 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 99.84
88 INT73641 Regulation of Lep 45 0.62 26.2 12.59 99.84
89 INT185188 Gene_expression of Pif 1 0.77 23.21 2.95 99.84
90 INT185194 Gene_expression of DCD 7 0.65 6.65 1.14 99.84
91 INT255 Regulation of Localization of GH1 89 0.62 18.71 35.3 99.84
92 INT164400 Positive_regulation of CNTF 3 0.49 1.66 0.96 99.84
93 INT3564 Positive_regulation of Aip 11 0.58 15.38 3.62 99.84
94 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 99.80
95 INT181829 Binding of Ppargc1a 16 0.48 9.61 0.34 99.80
96 INT986 Negative_regulation of Localization of GHRH 16 0.58 8.57 3.16 99.80
97 INT71003 Regulation of CHRM3 4 0.07 2.03 1.06 99.80
98 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48 99.78
99 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51 99.78
100 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.76
101 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 99.76
102 INT86646 Positive_regulation of SCN10A 71 0.69 50.61 13.24 99.76
103 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 99.76
104 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 99.76
105 INT77801 Negative_regulation of Binding of Tnf 5 0.42 3.93 1.77 99.76
106 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 99.74
107 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 99.74
108 INT6906 Negative_regulation of SCN5A 64 0.43 20.64 7.3 99.74
109 INT57191 Negative_regulation of Binding of Ltp 4 0.34 0.81 2.24 99.74
110 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 99.72
111 INT158596 Binding of Tlr3 24 0.47 11.66 3.69 99.72
112 INT336418 Negative_regulation of Binding of Tlr3 1 0.36 0.59 0.16 99.72
113 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 99.70
114 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 99.68
115 INT770 Regulation of Localization of Gnrhr 127 0.61 17.91 58.23 99.68
116 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 99.68
117 INT44413 Regulation of Fen1 2 0.39 0.44 0.6 99.68
118 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 99.68
119 INT989 Negative_regulation of Trh 90 0.59 15.45 43.63 99.68
120 INT85829 Gene_expression of CA9 14 0.68 12.59 1.4 99.68
121 INT85830 Positive_regulation of Gene_expression of CA9 4 0.41 5.47 1.02 99.68
122 INT85831 Positive_regulation of CA9 5 0.60 8.29 1.02 99.68
123 INT107291 Positive_regulation of Ghrl 58 0.67 44.6 9.68 99.66
124 INT82079 Positive_regulation of Lep 79 0.70 40 11.07 99.66
125 INT86437 Binding of IL6 154 0.48 121.22 29.3 99.66
126 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 99.66
127 INT198616 Gene_expression of Gvhd1 6 0.50 8.06 0.67 99.66
128 INT198617 Positive_regulation of Gene_expression of Gvhd1 2 0.37 3.17 0.07 99.66
129 INT3656 Positive_regulation of Gene_expression of Ins1 74 0.54 44.94 17.36 99.64
130 INT177775 Negative_regulation of SQLE 7 0.06 5.97 0.04 99.64
131 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 99.64
132 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 99.64
133 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 99.64
134 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29 99.64
135 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97 99.62
136 INT171070 Positive_regulation of Hey2 8 0.05 10.12 1.96 99.62
137 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 99.62
138 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62 99.60
139 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 99.60
140 INT153878 Negative_regulation of Negative_regulation of Il1b 1 0.42 0.78 0.36 99.60
141 INT4740 Gene_expression of Th 298 0.78 61.27 154.03 99.60
142 INT181833 Negative_regulation of Ppargc1a 14 0.57 6.01 0.52 99.60
143 INT325379 Regulation of Positive_regulation of Ghrl 1 0.26 0.23 0.17 99.60
144 INT10929 Positive_regulation of FLII 46 0.67 13.17 24.63 99.58
145 INT73642 Positive_regulation of Ctse 12 0.44 5.57 6.79 99.58
146 INT18480 Positive_regulation of ANPEP 9 0.59 5.18 2.13 99.58
147 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 99.56
148 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 99.56
149 INT9660 Regulation of TNF 363 0.62 312.94 139.99 99.56
150 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79 99.56
151 INT1562 Localization of Crh 499 0.81 126.74 236.68 99.56
152 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.56
153 INT105609 Negative_regulation of Mc4r 10 0.58 10.4 5.04 99.54
154 INT316200 Regulation of Negative_regulation of Mc4r 1 0.43 1.05 0.03 99.54
155 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79 99.52
156 INT9782 Binding of HTR1B 43 0.47 12.08 19.83 99.52
157 INT22161 Regulation of Gene_expression of Oxt 10 0.52 3.96 2.59 99.52
158 INT935 Localization of Gtf3a 124 0.70 35.72 43.3 99.50
159 INT8632 Regulation of Nfasc 15 0.54 2.87 9.08 99.50
160 INT1634 Gene_expression of Gcg 25 0.75 14.98 4.42 99.48
161 INT3002 Binding of SUGT1 62 0.24 55.9 14.91 99.48
162 INT43909 Positive_regulation of Gene_expression of Gcg 3 0.48 1.45 0.45 99.48
163 INT4207 Regulation of Avp 267 0.62 63.72 115.33 99.48
164 INT183668 Binding of SGCA 15 0.36 9.86 2.42 99.48
165 INT66599 Gene_expression of MC4R 16 0.78 12.37 3.12 99.46
166 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 99.46
167 INT231014 Negative_regulation of MC4R 4 0.43 5.52 0.58 99.46
168 INT158 Localization of Prl 2431 0.81 378.96 952.2 99.44
169 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 99.44
170 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93 99.44
171 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58 99.44
172 INT5987 Positive_regulation of Positive_regulation of Oprl1 11 0.49 2.81 12.57 99.44
173 INT10360 Positive_regulation of Ifng 33 0.68 21.73 15.19 99.44
174 INT35251 Regulation of Ghrl 21 0.60 8.26 2.6 99.42
175 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.40
176 INT117731 Binding of MYP1 7 0.30 10.61 0.67 99.40
177 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 99.40
178 INT3214 Localization of Ins1 527 0.80 196.9 79.26 99.40
179 INT164017 Negative_regulation of Localization of Ghrl 2 0.53 3.12 1.88 99.40
180 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51 99.40
181 INT3216 Positive_regulation of Localization of Ins1 170 0.69 56.78 35.63 99.40
182 INT84464 Gene_expression of DPP4 101 0.78 56.15 17.53 99.40
183 INT25175 Gene_expression of Msh2 2 0.55 0.4 0.52 99.40
184 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 99.40
185 INT69980 Negative_regulation of Il1rn 11 0.33 7.75 6.7 99.40
186 INT32545 Localization of Gsk3b 9 0.07 2.88 1.11 99.36
187 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 99.36
188 INT345254 Positive_regulation of Localization of Gsk3b 2 0.01 0.91 0.24 99.36
189 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98 99.36
190 INT69993 Positive_regulation of Gene_expression of Cpox 93 0.55 69.4 22.05 99.36
191 INT284 Positive_regulation of Ggt6 18 0.67 13.56 4.62 99.36
192 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 99.36
193 INT108780 Positive_regulation of Gene_expression of Ptger2 94 0.49 59.71 16.22 99.36
194 INT58477 Gene_expression of Chdh 33 0.74 39.48 19.78 99.36
195 INT943 Negative_regulation of Cck 205 0.59 38.42 174.78 99.32
196 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 99.32
197 INT76623 Negative_regulation of Fen1 1 0.33 0.63 0.62 99.32
198 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 99.32
199 INT15238 Positive_regulation of NPY 24 0.67 11.86 11.26 99.32
200 INT17099 Regulation of GPT 9 0.44 5.5 1.2 99.32
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