D:Arteritic Anterior Ischaemic Optic Neuropathy

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Disease Term
Synonyms AION, Anterior Ischemic Optic Neuropathy, Arteritic Anterior Ischemic Optic Neuropathy, ISCHEMIA OPTIC NERVE, Ischemias Optic Nerve, Ischemic Optic Neuropathies, Ischemic Optic Neuropathy, Nerve Ischemia Optic, Nerve Ischemias Optic, Neuropathies Ischemic Optic, Neuropathy Ischemic Optic
Documents 164
Hot Single Events 19
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Arteritic Anterior Ischaemic Optic Neuropathy. They are ordered first by their relevance to Arteritic Anterior Ischaemic Optic Neuropathy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT274080 Binding of ARHGAP4 and Map3k5 1 0.41 1.92 0.2 61.96
2 INT259716 Loxl1 Regulation of Loxl1 1 0.00 1.84 0.08 50.00
3 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9 23.44
4 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35 16.56
5 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69 5.00
6 INT329015 Binding of APCS and SRGN 1 0.08 1.14 0.04 5.00
7 INT274078 Binding of Mapk8 and Gmcl1 1 0.05 0.68 0.04 5.00
8 INT213207 Negative_regulation of ASAP2 Negative_regulation of PVR 1 0.01 0.45 0.04 5.00
9 INT213206 ASAP2 Negative_regulation of PVR 1 0.01 0.44 0.04 5.00
10 INT274076 Binding of Map3k5 and Gmcl1 1 0.06 1.23 0 5.00
11 INT274077 Binding of Tnfrsf1b and Positive_regulation of Mapk8 1 0.14 0.97 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Arteritic Anterior Ischaemic Optic Neuropathy. They are ordered first by their pain relevance and then by number of times they were reported in Arteritic Anterior Ischaemic Optic Neuropathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT293958 Gene_expression of PION 1 0.49 1.69 0.06 100.00
2 INT293957 Localization of PION 1 0.55 2 0.53 100.00
3 INT45444 Binding of VSX1 5 0.30 3.38 0.5 99.64
4 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 99.56
5 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 98.28
6 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 97.70
7 INT200009 Binding of TFCP2 1 0.04 0.8 0.08 94.92
8 INT213218 Negative_regulation of USP33 1 0.01 0.92 0.15 93.92
9 INT28182 Gene_expression of Acla1 1 0.56 1.15 0.4 93.20
10 INT64052 Positive_regulation of FGFR1 26 0.52 28.47 6.36 90.80
11 INT63444 Regulation of Gene_expression of Abat 26 0.51 14.65 26.29 90.12
12 INT57188 Regulation of Gene_expression of Chat 4 0.45 1.89 1.12 90.12
13 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 89.68
14 INT4736 Gene_expression of Chat 67 0.77 17.15 14.24 89.32
15 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 87.92
16 INT33854 Localization of OPA1 19 0.65 10.55 5.04 86.16
17 INT34870 Positive_regulation of OPA1 18 0.59 10.66 5 83.40
18 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 83.20
19 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 82.52
20 INT28929 Negative_regulation of PVR 22 0.57 16.64 1.07 79.48
21 INT213221 Negative_regulation of ASAP2 1 0.01 5.83 0.46 79.48
22 INT213212 Localization of ASAP2 1 0.01 0.78 0.13 79.48
23 INT211827 Localization of PVR 3 0.61 1.33 0.13 79.48
24 INT213211 Regulation of Localization of PVR 1 0.23 0.78 0.13 79.48
25 INT157959 Binding of AQP4 32 0.48 43.44 7.44 78.76
26 INT112267 Positive_regulation of Rgc32 10 0.39 8.1 2.09 77.04
27 INT259719 Negative_regulation of Regulation of NARFL 1 0.01 1.67 0 76.80
28 INT22454 Regulation of Crp 213 0.62 160.67 49.24 76.72
29 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 76.48
30 INT119525 Negative_regulation of Positive_regulation of Camk2a 14 0.43 5.15 8.45 72.96
31 INT119528 Positive_regulation of Camk2a 135 0.70 26.13 54.7 72.48
32 INT132468 Positive_regulation of Positive_regulation of Camk2a 20 0.70 2.76 6.7 72.48
33 INT28183 Positive_regulation of Acla1 1 0.66 0.88 0.23 70.48
34 INT151127 Regulation of Gene_expression of Litaf 3 0.18 2.1 0.72 70.08
35 INT30014 Positive_regulation of HPSE 22 0.70 20.91 4.09 70.00
36 INT94863 Gene_expression of Litaf 27 0.65 10.21 4.35 68.80
37 INT140413 Gene_expression of AQP4 113 0.78 139.25 25.53 68.48
38 INT151122 Positive_regulation of Litaf 7 0.35 3.58 0.92 66.96
39 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 66.40
40 INT219216 Positive_regulation of Fxc1 2 0.06 1.74 0.1 66.40
41 INT2774 Binding of Crp 241 0.48 195.89 44.39 65.96
42 INT37296 Binding of Esr1 117 0.43 62.51 27.33 65.96
43 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 64.72
44 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 62.88
45 INT78057 Localization of Tlr4 140 0.77 67.75 21.72 62.88
46 INT57502 Positive_regulation of Gene_expression of CRH 30 0.70 23.37 5.7 59.64
47 INT219218 Positive_regulation of Negative_regulation of Rgc32 3 0.06 2.96 0.03 58.56
48 INT219217 Negative_regulation of Positive_regulation of Rgc32 1 0.06 0.67 0 58.56
49 INT116824 Negative_regulation of Rgc32 21 0.31 21.62 2.46 58.16
50 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 57.44
51 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 55.04
52 INT443 Localization of POMC 1020 0.81 284.52 443.17 54.92
53 INT5913 Binding of OPA1 12 0.41 9.33 2.92 52.24
54 INT142908 Localization of FGFR1 18 0.38 11.46 2.57 50.72
55 INT114472 Regulation of Izumo1 13 0.48 7.95 3.2 48.84
56 INT24068 Localization of Hspb1 6 0.78 6.11 2.75 43.84
57 INT24069 Negative_regulation of Localization of Hspb1 3 0.14 3.93 1.3 43.84
58 INT242208 Regulation of Gene_expression of SRGN 7 0.29 3.15 0.52 39.04
59 INT329016 Regulation of Gene_expression of GON4L 1 0.06 1.12 0.05 39.04
60 INT329020 Regulation of GON4L 1 0.06 1.12 0.05 39.04
61 INT8637 Negative_regulation of Dbp 112 0.50 33.28 8.4 38.56
62 INT105571 Gene_expression of SRGN 33 0.58 14.68 1.19 36.96
63 INT227780 Gene_expression of GON4L 2 0.13 2.72 0.05 36.64
64 INT79599 Protein_catabolism of PDE5A 7 1.00 3.16 0.39 34.56
65 INT213222 Negative_regulation of Protein_catabolism of PDE5A 1 0.24 0.65 0.16 34.56
66 INT165058 Negative_regulation of MID1 14 0.37 10.82 4.67 32.40
67 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 26.84
68 INT23094 Positive_regulation of Positive_regulation of Ca2 29 0.49 6.8 9.35 26.84
69 INT202360 Positive_regulation of Map2k4 2 0.48 9.89 0.29 25.44
70 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34 23.04
71 INT11064 Positive_regulation of NPR1 24 0.49 14.63 4.78 22.08
72 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51 16.84
73 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 16.44
74 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 15.36
75 INT274069 Binding of Map3k5 1 0.29 2.68 0.49 14.60
76 INT274074 Binding of Map2k4 1 0.08 1.98 0.36 14.16
77 INT21569 Binding of Mapk8 8 0.48 5.55 3.44 13.76
78 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 8.52
79 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 5.00
80 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
81 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
82 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 5.00
83 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
84 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
85 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
86 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
87 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
88 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
89 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 5.00
90 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07 5.00
91 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
92 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
93 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
94 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 5.00
95 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
96 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
97 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 5.00
98 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 5.00
99 INT7627 Negative_regulation of Positive_regulation of Ltp 162 0.50 41.2 106.27 5.00
100 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
101 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 5.00
102 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
103 INT13036 Positive_regulation of Positive_regulation of Ltp 105 0.51 23.71 77.66 5.00
104 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 5.00
105 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
106 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
107 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
108 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
109 INT13276 Regulation of Ltp 107 0.53 30.78 69.13 5.00
110 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 5.00
111 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17 5.00
112 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5 5.00
113 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
114 INT3920 Localization of Ldha 241 0.81 83.08 58.72 5.00
115 INT96533 Gene_expression of Slc1a3 72 0.78 26.85 55.31 5.00
116 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34 5.00
117 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21 5.00
118 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
119 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
120 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
121 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6 5.00
122 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 5.00
123 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
124 INT5307 Regulation of Tnf 87 0.62 78.71 43.4 5.00
125 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
126 INT5454 Localization of CRH 124 0.79 79.18 41.53 5.00
127 INT16261 Transcription of Bdnf 101 0.72 49.41 40.64 5.00
128 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14 5.00
129 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98 5.00
130 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
131 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
132 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
133 INT104392 Gene_expression of Cxcl10 113 0.75 106.86 34.12 5.00
134 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 5.00
135 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
136 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52 5.00
137 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
138 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
139 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82 5.00
140 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
141 INT73314 Gene_expression of Arc 133 0.78 67.78 27.44 5.00
142 INT80470 Negative_regulation of Gene_expression of Grin1 33 0.59 10.22 27.15 5.00
143 INT32826 Positive_regulation of Gene_expression of Ltp 52 0.45 10.34 26.8 5.00
144 INT276 Regulation of Ache 83 0.62 16.75 25.99 5.00
145 INT130186 Gene_expression of Ccl5 101 0.74 79.96 25.01 5.00
146 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
147 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37 5.00
148 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25 5.00
149 INT93485 Negative_regulation of Slc1a2 27 0.59 10.65 20.9 5.00
150 INT101188 Gene_expression of Rela 81 0.56 23.43 19.15 5.00
151 INT107930 Gene_expression of Slc17a7 39 0.78 6.53 18.86 5.00
152 INT90612 Positive_regulation of Grin2a 33 0.65 15.11 18.84 5.00
153 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
154 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 5.00
155 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
156 INT4340 Positive_regulation of Localization of Ldha 46 0.70 14.52 15.66 5.00
157 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 5.00
158 INT11945 Regulation of Chat 38 0.62 7.75 14.97 5.00
159 INT79227 Negative_regulation of Gene_expression of Icam1 45 0.59 41.65 14.97 5.00
160 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82 5.00
161 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 5.00
162 INT20071 Positive_regulation of HTR2A 33 0.67 10.89 14 5.00
163 INT7342 Positive_regulation of Positive_regulation of Grin1 18 0.50 9.22 13.76 5.00
164 INT173505 Localization of Hand2 63 0.57 45.32 13.66 5.00
165 INT144646 Positive_regulation of Rela 53 0.67 27.78 13.2 5.00
166 INT12191 Negative_regulation of Localization of Ldha 35 0.59 13.71 12.35 5.00
167 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 5.00
168 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 5.00
169 INT15756 Positive_regulation of Gene_expression of Jun 29 0.69 16.58 12.06 5.00
170 INT69158 Localization of IL4 48 0.71 31.3 11.98 5.00
171 INT56048 Positive_regulation of Transcription of Bdnf 24 0.70 8.33 11.83 5.00
172 INT54466 Negative_regulation of Gene_expression of Ltp 19 0.38 5.44 10.91 5.00
173 INT121796 Gene_expression of NeuN 92 0.78 23.18 10.53 5.00
174 INT9027 Positive_regulation of Ddc 24 0.66 6.04 10.19 5.00
175 INT72789 Gene_expression of Cpa1 29 0.50 12.36 9.47 5.00
176 INT25834 Positive_regulation of Dbp 59 0.68 24.34 9.32 5.00
177 INT138700 Negative_regulation of Gene_expression of Ccl2 27 0.57 24.1 9.08 5.00
178 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98 5.00
179 INT7090 Gene_expression of pcp 50 0.66 13.54 8.96 5.00
180 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 5.00
181 INT22383 Binding of IL2 59 0.48 39.06 8.56 5.00
182 INT61628 Negative_regulation of Gene_expression of IL4 31 0.55 20.96 8.18 5.00
183 INT119940 Positive_regulation of Gene_expression of Arc 36 0.70 18.87 7.85 5.00
184 INT98178 Localization of Casp3 32 0.65 21.01 7.77 5.00
185 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58 5.00
186 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 5.00
187 INT116428 Gene_expression of Cybb 68 0.76 35.81 7.07 5.00
188 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 5.00
189 INT8101 Binding of INCENP 42 0.31 16.2 6.68 5.00
190 INT132822 Localization of IL13 26 0.67 22.85 6.66 5.00
191 INT256345 Phosphorylation of Rela 21 0.75 9.51 6.56 5.00
192 INT91721 Binding of IL18 21 0.48 21.17 6.56 5.00
193 INT116641 Phosphorylation of Gsk3a 12 0.71 4.3 6.22 5.00
194 INT37764 Positive_regulation of Izumo1 21 0.61 8.75 5.79 5.00
195 INT132573 Negative_regulation of Gene_expression of TH1L 16 0.42 11.52 5.76 5.00
196 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 5.00
197 INT15367 Gene_expression of OPA1 35 0.67 24.9 5.45 5.00
198 INT157622 Positive_regulation of Localization of Tlr4 34 0.48 22.63 5.09 5.00
199 INT8786 Negative_regulation of ALDH7A1 27 0.52 12.81 4.76 5.00
200 INT37652 Positive_regulation of Pgr 29 0.59 9.09 4.67 5.00
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